公开(公告)号：EP3242723A4

公开(公告)日：2018-07-25

申请号：EP16735544

申请日：2016-01-11

申请人： UNIV ILLINOIS

发明人： BURKE MARTIN D ,  GRILLO ANTHONY S

IPC分类号： A61K31/122 ,  A61K31/7048 ,  A61K45/06 ,  A61P7/06 ,  A61P39/04 ,  G01N33/50

CPC分类号： A61K31/122 ,  A61K45/06 ,  A61P7/06 ,  A61P39/04 ,  G01N33/5008 ,  G01N2800/22

摘要： Provided are methods of treating a disease or condition characterized by a deficiency of or a defect in an iron transporter using a small molecule. For example, the method may increase transepithelial iron transport, or it may increase iron release. Additionally, the small molecule may be hinokitiol, or it may be selected from the group consisting of amphotericin B, calcimycin, nonactin, deferiprone, purpurogallin, and maltol. Also provided is a method of identifying a compound capable of treating a disease or condition characterized by a deficiency of or a defect in an iron transporter.

公开(公告)号：EP3242554A4

公开(公告)日：2018-06-06

申请号：EP16735456

申请日：2016-01-08

申请人： UNIV ILLINOIS

发明人： BURKE MARTIN D ,  DAVIS STEPHEN

IPC分类号： A01N43/04 ,  A01P3/00 ,  C07H17/08

CPC分类号： A01N43/90 ,  A01N47/18 ,  A01N47/22 ,  A01N47/36 ,  A01N47/42 ,  A01N55/00 ,  C07H17/08

摘要： Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti -fungal activity. Certain of the derivatives are C16 urea derivatives and C16 carbamate derivatives of AmB. Also provided are methods of making the AmB derivatives.

公开(公告)号：EP3218467A4

公开(公告)日：2018-04-11

申请号：EP15858164

申请日：2015-11-13

申请人： UNIV ILLINOIS

发明人： HA TAEKJIP ,  ARSLAN SINAN

IPC分类号： C12N9/14 ,  C12N9/90

CPC分类号： C12N9/14 ,  C12N9/90 ,  C12P19/34 ,  C12Y306/04012

摘要： Conformationally-constrained helicases having improved activity and strength are provided. Methods of making conformationally-constrained helicases having improved activity and strength are provided. Methods of using conformationally-constrained helicases having improved activity and strength are provided. The present invention is based on the discovery of novel modified helicases that show dramatically enhanced helicase activity and increased strength as compared to unmodified helicases. As described further herein, it has been surprisingly discovered that, by controlling the conformation of certain subdomains such that the helicase remains in a closed form (e.g., by covalently crosslinking the 2B domain to the 1A domain or the 1B domain in a Rep helicase), a highly active and strong form of the helicase is achieved

公开(公告)号：EP3294415A1

公开(公告)日：2018-03-21

申请号：EP16793492

申请日：2016-05-12

申请人： UNIV ILLINOIS ,  UNIV NORTH CAROLINA CHAPEL HILL

发明人： WANG ANDREW ,  EBLAN MICHAEL ,  HONG SEUNGPYO ,  MYUNG JA HYE

IPC分类号： A61N5/10 ,  G01N33/566 ,  G01N33/574

CPC分类号： G01N33/57488 ,  A61N5/10 ,  G01N33/56966 ,  G01N2800/52

摘要： Methods for monitoring efficacy of cancer therapies, e.g., radiation therapy, using circulating tumor cell kinetics as a predictive marker are described.

公开(公告)号：EP3114484A4

公开(公告)日：2017-08-30

申请号：EP15759126

申请日：2015-03-09

申请人： UNIV ILLINOIS

发明人： HONG SEUNGPYO ,  MYUNG JA HYE

IPC分类号： G01N33/574

CPC分类号： G01N33/57492 ,  B01L3/5027 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0877

摘要： A method of capturing a Circulating Tumor Cell (CTC) and Circulating Cancer Cells (CSC) from a sample includes introducing a sample into a flow based multichannel device having a cell capture surface and a flow modification surface under conditions that allow a CTC to bind to a cell rolling-inducing agent and a capturing agent disposed on the cell capture surface. The invention also provides for flow based multichannel devices to capture CTCs and CSCs from a sample.

摘要翻译： 从样品中捕获循环肿瘤细胞（CTC）和循环癌细胞（CSC）的方法包括将样品引入基于流动的多通道装置中，所述多通道装置具有细胞捕获表面和流动修饰表面，所述条件允许CTC结合 细胞卷动诱导剂和设置在细胞捕获表面上的捕获剂。 本发明还提供了基于流的多通道设备来捕获样品中的CTC和CSC。

公开(公告)号：EP2984910A4

公开(公告)日：2017-01-04

申请号：EP14782878

申请日：2014-04-11

申请人： UNIV ILLINOIS

发明人： ROGERS JOHN A ,  KANG SEUNG-KYUN ,  HWANG SUKWON ,  CHENG JIANJUN ,  ZHANG YANFENG ,  YING HANZE

IPC分类号： H05K1/09 ,  A61B5/00 ,  A61M5/44 ,  G06K19/077 ,  H01L21/70 ,  H01L23/00 ,  H01L23/06 ,  H05K1/02 ,  H05K1/03 ,  H05K3/02 ,  H05K3/22 ,  H05K3/28

CPC分类号： H05K1/185 ,  A61B5/686 ,  A61B2562/125 ,  A61M5/44 ,  G06K19/0775 ,  H01L21/02164 ,  H01L21/0217 ,  H01L21/02274 ,  H01L21/0228 ,  H01L21/31111 ,  H01L21/31133 ,  H01L21/56 ,  H01L23/291 ,  H01L23/3121 ,  H01L23/3192 ,  H01L23/49894 ,  H01L25/0655 ,  H01L2924/0002 ,  H05K1/0275 ,  H05K1/0286 ,  H05K1/0306 ,  H05K3/22 ,  H05K3/285 ,  H05K3/287 ,  H05K3/288 ,  H05K5/069 ,  H05K13/0023 ,  H05K2201/10151 ,  H05K2201/10196 ,  H05K2201/10212 ,  H05K2203/0271 ,  H05K2203/0292 ,  H05K2203/0769 ,  H05K2203/0776 ,  H05K2203/0786 ,  H05K2203/17 ,  H05K2203/175 ,  H05K2203/178 ,  Y10T29/49124 ,  Y10T137/0318 ,  Y10T428/239 ,  H01L2924/00

摘要： The invention provides transient devices, including active and passive devices that physically, chemically and/or electrically transform upon application of at least one internal and/or external stimulus. Incorporation of degradable device components, degradable substrates and/or degradable encapsulating materials each having a programmable, controllable and/or selectable degradation rate provides a means of transforming the device. In some embodiments, for example, transient devices of the invention combine degradable high performance single crystalline inorganic materials with selectively removable substrates and/or encapsulants.

摘要翻译： 本发明提供瞬态装置，包括在应用至少一个内部和/或外部刺激时物理，化学和/或电转化的有源和无源装置。 每个具有可编程，可控和/或可选择的降解速率的可降解装置组件，可降解底物和/或可降解封装材料的结合提供了改变装置的手段。 在一些实施例中，例如，本发明的瞬态装置将可降解的高性能单晶无机材料与选择性可移除的基底和/或密封剂结合。

公开(公告)号：EP2911660A4

公开(公告)日：2016-10-19

申请号：EP13848425

申请日：2013-10-24

申请人： UNIV ILLINOIS ,  THATCHER GREG R ,  TONETTI DEBRA ,  MOLLOY MARY ELLEN ,  MICHALSEN BRADLEY ,  QIN ZIHUI

发明人： THATCHER GREGORY R ,  TONETTI DEBRA ,  MOLLOY MARY ELLEN ,  MICHALSEN BRADLEY ,  QIN ZIHUI

IPC分类号： A61K31/381 ,  A61K31/38 ,  A61P35/00

CPC分类号： A61K31/381 ,  C07D333/64 ,  G01N33/57496 ,  G01N2333/91205 ,  G01N2800/52

摘要： Disclosed herein are methods for treatment of estrogen-related medical disorders. The methods of treatment may comprise administering to a subject in need of such treatment a composition comprising a therapeutically effective amount of at least one compound of formula (I) or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP2825885A4

公开(公告)日：2016-01-27

申请号：EP13760958

申请日：2013-03-11

申请人： UNIV ILLINOIS

发明人： BAILEY RYAN C ,  MCCLELLAN MELINDA S

IPC分类号： G01N33/53 ,  G01N27/74

CPC分类号： G01N27/72 ,  G01N27/745 ,  G01N33/54326

公开(公告)号：EP2790722A4

公开(公告)日：2015-09-09

申请号：EP12858050

申请日：2012-08-20

申请人： UNIV ILLINOIS

发明人： JAIN SANDEEP

IPC分类号： A61K38/43 ,  A61K9/08 ,  A61P27/00 ,  A61P27/02

CPC分类号： A61K38/465 ,  A61K9/0048 ,  A61K31/465 ,  A61K45/05 ,  A61K45/06 ,  C12Q1/6816 ,  C12Y301/21001 ,  A61K2300/00

摘要： Provided herein is a composition and a method for treating nucleic acid-related eye disease.

公开(公告)号：EP2646048A4

公开(公告)日：2015-02-11

申请号：EP11845856

申请日：2011-11-30

申请人： UNIV ILLINOIS

发明人： CHENG JIANJUN ,  LU HUA

IPC分类号： A61K39/00

CPC分类号： C08G69/48 ,  A01N43/36 ,  A61K31/785 ,  A61K47/34 ,  A61K47/595 ,  C07K14/001 ,  C08G63/08 ,  C08G63/68 ,  C08G69/08 ,  C08G69/10 ,  C08G69/22 ,  C08L77/02 ,  C08L77/04

摘要： The invention provides polymers comprising Formula I: wherein monomer is a repeating unit comprising 2, 3, 4, 5, 6 or 7 carbon atoms and the monomers are linked together through amide or ester bonds; n is about 6 to about 1000; and Linker is an optionally substituted carbon chain that is optionally interrupted by moieties such as oxygen, nitrogen, sulfur, phosphorus, or silicon. Charge is a moiety having a positive or negative charge on a heteroatom, such as nitrogen, oxygen, phosphorus, or sulfur; where the Linker separates the monomer and the Charge by at least six linear atoms. The invention also provides methods of preparing the polymers and the copolymers and methods of using the polymers and copolymers, for example, as drug delivery systems, as membrane penetrating peptides, and as therapeutic agents.

摘要翻译： 本发明提供包含式I的聚合物：其中单体是包含2,3,4,5,6或7个碳原子的重复单元，并且单体通过酰胺或酯键连接在一起; n为约6至约1000; 并且连接子是任选被取代的碳链，其任选地被诸如氧，氮，硫，磷或硅的部分中断。 电荷是在杂原子上具有正电荷或负电荷的部分，例如氮，氧，磷或硫; 其中连接器将单体和电荷分离至少六个线性原子。 本发明还提供了制备聚合物和共聚物的方法以及使用聚合物和共聚物的方法，例如作为药物递送系统，作为膜穿透肽，以及作为治疗剂。