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    COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF RETROVIRAL INFECTION
    1.
    发明授权
    COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF RETROVIRAL INFECTION 有权
    组合物和用于鉴定复古抑制剂病毒感染

    公开(公告)号：EP2201118B1

    公开(公告)日：2012-04-18

    申请号：EP08830668.3

    申请日：2008-09-12

    申请人： Trana Discovery

    发明人： GUENTHER, Richard, H.

    IPC分类号： A61K31/7105 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/569

    CPC分类号： C12Q1/703 ,  C12N9/99 ,  C12N2740/10011 ,  C12N2740/16011 ,  C12Q2600/136 ,  C12Q2537/161 ,  C12Q2527/127 ,  C12Q2521/107

    摘要： Methods of identifying inhibitors of retroviral propagation, tRNA used in the methods, and kits, including the tRNA, which can be used in the methods, are disclosed. Methods of treating or preventing retroviral infections by administering an effective amount of the inhibitors, and pharmaceutical compositions including the inhibitors, are also disclosed. The methods involve forming a mixture comprising a linear sequence of a tRNA anticodon stem loop fragment that is not capable of forming a stem-loop, a target nucleic acid molecule capable of binding to the tRNA anticodon stem loop fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule.

    COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF RETROVIRAL INFECTION
    4.
    发明公开
    COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF RETROVIRAL INFECTION 有权
    组合物和用于鉴定复古抑制剂病毒感染

    公开(公告)号：EP2201118A4

    公开(公告)日：2010-10-20

    申请号：EP08830668

    申请日：2008-09-12

    申请人： TRANA DISCOVERY

    发明人： GUENTHER RICHARD H

    IPC分类号： A61K31/7105 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/569

    CPC分类号： C12Q1/703 ,  C12N9/99 ,  C12N2740/10011 ,  C12N2740/16011 ,  C12Q2600/136 ,  C12Q2537/161 ,  C12Q2527/127 ,  C12Q2521/107

    摘要： Methods of identifying inhibitors of retroviral propagation, tRNA used in the methods, and kits, including the tRNA, which can be used in the methods, are disclosed. Methods of treating or preventing retroviral infections by administering an effective amount of the inhibitors, and pharmaceutical compositions including the inhibitors, are also disclosed. The methods involve forming a mixture comprising a linear sequence of a tRNA anticodon stem loop fragment that is not capable of forming a stem-loop, a target nucleic acid molecule capable of binding to the tRNA anticodon stem loop fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule.

    COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF RETROVIRAL INFECTION
    5.
    发明公开
    COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF RETROVIRAL INFECTION 有权
    确定复方感染抑制剂的组合物和方法

    公开(公告)号：EP2201118A2

    公开(公告)日：2010-06-30

    申请号：EP08830668.3

    申请日：2008-09-12

    申请人： Trana Discovery

    发明人： GUENTHER, Richard, H.

    IPC分类号： C12N15/34 ,  C12Q1/68

    CPC分类号： C12Q1/703 ,  C12N9/99 ,  C12N2740/10011 ,  C12N2740/16011 ,  C12Q2600/136 ,  C12Q2537/161 ,  C12Q2527/127 ,  C12Q2521/107

    摘要： Methods of identifying inhibitors of retroviral propagation, tRNA used in the methods, and kits, including the tRNA, which can be used in the methods, are disclosed. Methods of treating or preventing retroviral infections by administering an effective amount of the inhibitors, and pharmaceutical compositions including the inhibitors, are also disclosed. The methods involve forming a mixture comprising a linear sequence of a tRNA anticodon stem loop fragment that is not capable of forming a stem-loop, a target nucleic acid molecule capable of binding to the tRNA anticodon stem loop fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule.

    摘要翻译： 公开了鉴定逆转录病毒繁殖抑制剂，方法中使用的tRNA和可用于该方法的试剂盒（包括tRNA）的方法。 还公开了通过施用有效量的抑制剂治疗或预防逆转录病毒感染的方法，以及包含该抑制剂的药物组合物。 该方法包括形成包含不能形成茎环的tRNA反密码子茎环片段，能够结合tRNA反密码子茎环片段的靶核酸分子和测试化合物的线性序列的混合物。 在允许tRNA反密码子茎环片段和靶核酸分子在不存在测试化合物的情况下结合的条件下孵育混合物。 然后可以进行测定，检测测试化合物是否抑制tRNA反密码子茎环片段与靶核酸分子的结合。