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公开(公告)号：EP2016189A4
公开(公告)日：2010-12-08
申请号：EP06847588
申请日：2006-12-11
CPC分类号： B01L3/502792 , B01F11/0071 , B01F13/0071 , B01F13/0076 , B01L3/502715 , B01L3/502761 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/0668 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/089 , B01L2300/1827 , B01L2400/0406 , B01L2400/0415 , B01L2400/043 , B01L2400/0436 , B01L2400/0442 , B01L2400/0448 , C12Q1/6869 , G01N33/49 , C12Q2565/629 , C12Q2565/301
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公开(公告)号：EP2021103A4
公开(公告)日：2011-02-23
申请号：EP07867113
申请日：2007-05-09
发明人： PAIK PHILIP Y , BRAFFORD KEITH R , STURMER RYAN A , SMITH GREGORY F , POLLACK MICHAEL G , PAMULA VAMSEE K , WEST RICHARD M , SRINIVASAN VIJAY
CPC分类号： B01F13/0076 , B01F13/0071 , B01L3/502792 , B01L7/52 , B01L7/525 , B01L7/54 , B01L2200/0673 , B01L2200/14 , B01L2200/143 , B01L2200/16 , B01L2300/027 , B01L2300/0819 , B01L2300/089 , B01L2300/1827 , B01L2400/0421 , B01L2400/0427 , B01L2400/0448 , G01N33/49 , G01N2035/1034
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公开(公告)号：EP2016091A4
公开(公告)日：2009-09-09
申请号：EP06849949
申请日：2006-12-11
发明人： POLLACK MICHAEL G , PAMULA VAMSEE K , SRINIVASAN VIJAY , PAIK PHILIP Y , ECKHARDT ALLEN E , FAIR RICHARD B
CPC分类号： B01L3/502792 , B01F11/0071 , B01F13/0071 , B01F13/0076 , B01L3/502715 , B01L3/502761 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/0668 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/089 , B01L2300/1827 , B01L2400/0406 , B01L2400/0415 , B01L2400/043 , B01L2400/0436 , B01L2400/0442 , B01L2400/0448 , C12Q1/6869 , G01N33/49 , C12Q2565/629 , C12Q2565/301
摘要： The present invention relates to a droplet microactuator and to systems, apparatuses and methods employing the droplet microactuator for executing various protocols using discrete droplets. The invention includes a droplet microactuator or droplet microactuator system having one or more input reservoirs loaded with reagents for conducting biochemical reactions, such as the reagents described for use in nucleic acid amplification protocols, affinity-based assay protocols, sequencing protocols, and protocols for analyses of biological fluids.
摘要翻译： 本发明涉及一种液滴微致动器，并涉及采用液滴微致动器用于使用离散液滴执行各种方案的系统，设备和方法。 本发明包括具有一个或多个装载有用于进行生物化学反应的试剂的输入储存器的液滴微致动器或液滴微致动器系统，诸如用于核酸扩增方案，基于亲和力的测定方案，测序方案和分析方案 的生物流体。
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公开(公告)号：EP3007819A4
公开(公告)日：2017-01-18
申请号：EP14810860
申请日：2014-06-13
发明人： PAMULA VAMSEE K , SRINIVASAN VIJAY
CPC分类号： G01N27/44791 , B01J19/0093 , B01J2219/0084 , B01J2219/00853 , B01L3/502784 , B01L3/502792 , B01L2200/0673 , B01L2200/0684 , B01L2300/0816 , B01L2300/165 , B01L2300/1827 , B01L2400/0427 , B01L2400/043 , G01N27/44704
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公开(公告)号：EP2109774A4
公开(公告)日：2014-11-12
申请号：EP08730019
申请日：2008-02-15
CPC分类号： B01L3/50273 , B01L3/502715 , B01L3/502784 , B01L2200/0605 , B01L2300/0627 , B01L2300/0636 , B01L2300/0645 , B01L2300/0809 , B01L2400/0427 , G01N27/22 , G01N27/223 , G01N27/227 , G01N2203/00 , G01V3/02
摘要： A method, circuit and apparatus for detecting capacitance on a droplet actuator, inter alia, for determining the presence, partial presence or absence of a droplet at an electrode on a droplet actuator by: (a) providing a droplet actuator comprising: (i) a substrate comprising electrodes arranged on the substrate for conducting droplet operations on a surface of the substrate; (ii) a capacitance detection circuit for detecting capacitance at the droplet operations surface at one or more of the electrodes; (b) detecting capacitance at the droplet operations surface at one or more of the electrodes; and (c) determining from the capacitance the presence, partial presence or absence of a droplet at the droplet operations surface at the electrode.
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公开(公告)号：EP2516669A4
公开(公告)日：2013-06-19
申请号：EP10842658
申请日：2010-12-17
发明人： ECKHARDT ALLEN E , GRAHAM CARRIE , SISTA RAMAKRISHNA , PAMULA VAMSEE K , WINGER THEODORE , WANG TONG , XIONG YALIN , WU NING , SAHA SANJAY , RAOLJI GAJENDRASINH BALVANTSINH , DAYAM RAVEENDRA
IPC分类号： C12Q1/34 , C07D311/06 , C07D311/18 , C12M1/34 , C12Q1/25 , G01N33/52
CPC分类号： C12Q1/40 , B01L3/502784 , B01L2300/0654 , B01L2300/0816 , B01L2300/18 , B01L2400/0427 , B01L2400/043 , C07D311/16 , C07D311/18 , C07D311/20 , C07D405/12 , C07D413/12 , C07H15/203 , C07H17/075 , C12Q1/25 , C12Q1/34 , C12Q1/44 , C12Q1/54 , C12Y302/01023 , G01N21/6452 , G01N33/5438 , G01N2333/916 , G01N2333/926 , G01N2333/938 , G01N2800/04
摘要： The invention is directed to droplet actuator devices and assay methods. The method may include immobilization of the enzymatic substrate including forming an inclusion complex with the substrate within an aqueous environment in contact with an oil.
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公开(公告)号：EP2121329A4
公开(公告)日：2011-09-14
申请号：EP08731243
申请日：2008-03-03
CPC分类号： B01L3/502792 , B01L3/0241 , B01L3/50273 , B01L2200/06 , B01L2300/06 , B01L2400/0427 , B41J2/14
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8.发明公开DROPLET ACTUATOR DEVICES, CONFIGURATIONS, AND METHODS FOR IMPROVING ABSORBANCE DETECTION 有权TROPFENAKTUATORVORRICHTUNGEN，配置和方法吸收好转检测
公开(公告)号：EP2122327A4
公开(公告)日：2010-06-16
申请号：EP08743832
申请日：2008-03-13
CPC分类号： G01N21/0303 , G01N21/031 , G01N2021/035 , G01N2021/036 , G01N2201/08
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9.发明公开APPARATUSES AND METHODS FOR MANIPULATING DROPLETS ON A PRINTED CIRCUIT BOARD 有权器件和方法滴在电路板上MANIPULATION
公开(公告)号：EP1859330A4
公开(公告)日：2008-02-27
申请号：EP06734056
申请日：2006-01-30
申请人： UNIV DUKE
CPC分类号： G01N27/44769 , B01F13/0071 , B01F13/0076 , B01L3/502707 , B01L3/502792 , B01L7/52 , B01L2200/0673 , B01L2200/10 , B01L2200/12 , B01L2300/0645 , B01L2300/0663 , B01L2300/0819 , B01L2300/0864 , B01L2300/0867 , B01L2300/0887 , B01L2300/089 , B01L2300/12 , B01L2300/1827 , B01L2400/0415 , B01L2400/0424 , B81B3/0021 , B81B2201/058 , B81C1/00119 , C12Q1/6846 , G01N27/447 , G01N27/44791 , G05D7/0694 , H01L21/6715 , Y10T436/2575
摘要： Apparatuses and methods for manipulating droplets on a printed circuit board (PCB) are disclosed. Droplets are actuated upon a printed circuit board substrate surface by the application of electrical potentials to electrodes defined on the PCB. The use of soldermask as an electrode insulator for droplet manipulation as well techniques for adapting other traditional PCB layers and materials for droplet-based microfluidics are also disclosed.
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10.发明公开METHODS AND APPARATUS FOR MANIPULATING DROPLETS BY ELECTROWETTING-BASED TECHNIQUES 有权方法和设备技术操作对ELEKTROBENÜSSUNGSBASIS液滴
公开(公告)号：EP1554568A4
公开(公告)日：2005-12-07
申请号：EP03751751
申请日：2003-04-24
申请人： UNIV DUKE
发明人： PAMULA VAMSEE K , POLLACK MICHAEL G , PAIK PHILIP Y , REN HONG , FAIR RICHARD B
IPC分类号： B01F11/00 , B01F13/00 , B01L3/00 , G01N1/00 , G01N1/10 , G01N15/06 , G01N21/00 , G01N35/00 , G01N27/403
CPC分类号： B01L3/50273 , B01F11/0071 , B01F13/0071 , B01F13/0076 , B01F13/0084 , B01L3/00 , B01L3/5027 , B01L3/502784 , B01L3/502792 , B01L2200/06 , B01L2200/0605 , B01L2200/10 , B01L2300/089 , B01L2300/161 , B01L2300/165 , B01L2400/0415 , B01L2400/0427 , B41J2002/14395 , C25B9/00 , G01N27/44791 , G02B26/005
摘要： A method for splitting a droplet into two or more droplets includes providing a starting droplet on a surface comprising an array of electrodes and a substantially co-planar array of reference elements. The electrode array comprises at least three electrodes comprising a first outer electrode, a medial electrode adjacent to the first outer electrode, and a second outer electrode adjacent to medial electrode. The starting droplet is initially disposed on at least one of the three electrodes and at least partially overlaps at least one other of the three electrodes. The method further includes activating each of the three electrodes to spread the starting droplet across the three electrodes, and de-activating the medial electrode to split the starting droplet into first and second split droplets. The first split droplet is thereby disposed on the first outer electrode and the second split droplet is disposed on the second outer electrode.
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