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1.发明公开THERAPEUTICALLY USEFUL SUBSTITUTED HYDROPYRIDO Ý3,2,1-IJ¨QUINOLINE COMPOUNDS 有权THERAPEUTIC的取代的HYDROPYRIDO [3,2,1-IJ]喹啉化合物
公开(公告)号：EP2294069A1
公开(公告)日：2011-03-16
申请号：EP09743667.9
申请日：2009-05-07
申请人： Allergan, Inc. , Sinha, Santosh C. , Bhat, Smita , Chow, Ken , Beard, Richard L. , Donello, John E. , Garst, Michael E.
发明人： SINHA, Santosh, C. , BHAT, Smita , CHOW, Ken , BEARD, Richard, L. , DONELLO, John, E. , GARST, Michael, E.
IPC分类号： C07D471/04 , C07D471/06 , C07D471/16 , A61P27/00 , A61P9/00 , A61K31/4745
CPC分类号： C07D471/06 , C07D471/04 , C07D471/16
摘要： Disclosed herein are compounds represented by the structural formula (I): therapeutic methods, compositions, and medicaments related thereto are also disclosed.
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2.发明授权THERAPEUTICALLY USEFUL SUBSTITUTED HYDROPYRIDO[3,2,1-IJ]QUINOLINE COMPOUNDS 有权THERAPEUTIC的取代的HYDROPYRIDO [3,2,1-IJ]喹啉化合物
公开(公告)号：EP2294069B1
公开(公告)日：2015-09-02
申请号：EP09743667.9
申请日：2009-05-07
申请人： ALLERGAN, INC. , Sinha, Santosh C. , Bhat, Smita , Chow, Ken , Beard, Richard L. , Donello, John E. , Garst, Michael E.
发明人： SINHA, Santosh, C. , BHAT, Smita , CHOW, Ken , BEARD, Richard, L. , DONELLO, John, E. , GARST, Michael, E.
IPC分类号： C07D471/04 , C07D471/06 , C07D471/16 , A61P27/00 , A61P9/00 , A61K31/4745
CPC分类号： C07D471/06 , C07D471/04 , C07D471/16
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3.发明授权SUBSTITUTED 3-AMINO-1-OXO OR THIOXO-1,2,5,6,7,8-HEXAHYDRO-2,7-NAPHTHYRIDINE-4-CARBONITRILES AS SELECTIVE ALPHA 2B ANTAGONISTS 有权取代的3-氨基-1-氧代或硫代-1,2,5,6,7,8-六氢-2,7-萘啶-4-甲腈，为选择性拮抗剂ALPHA 2B
公开(公告)号：EP2334676B1
公开(公告)日：2016-07-06
申请号：EP09792255.3
申请日：2009-09-04
申请人： ALLERGAN, INC.
发明人： CAPPIELLO, John, R. , CHOW, Ken , HEIDELBAUGH, Todd, M. , TAKEUCHI, Janet, A. , GARST, Michael, E. , GIL, Daniel, W. , KEDZIE, Karen, M. , DONELLO, John, E.
IPC分类号： C07D471/04 , A61K31/4745 , A61P29/00
CPC分类号： C07D471/04
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4.发明公开IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS N-FORMYL PEPTIDE RECEPTOR 2 MODULATORS 审中-公开咪唑烷-2,4-二酮衍生物作为N-甲酰基肽受体-2-调节剂
公开(公告)号：EP2814815A1
公开(公告)日：2014-12-24
申请号：EP13705710.5
申请日：2013-02-12
申请人： ALLERGAN, INC.
发明人： BEARD, Richard, L. , VULIGONDA, Vidyasagar , DONELLO, John, E. , VISWANATH, Veena , GARST, Michael, E.
IPC分类号： C07D233/72 , C07D233/78 , C07D471/04 , C07D487/04 , A61K31/4166 , A61K31/4188 , A61K31/4184 , A61P27/02 , A61P27/04 , A61P27/06 , A61P27/14
CPC分类号： A61K31/4353 , A61K31/4164 , A61K31/4178 , C07D233/02 , C07D233/72 , C07D233/78 , C07D471/04 , C07D471/06 , C07D487/04 , C07D487/10
摘要： The present invention relates to novel imidazolidine-2,4-dione derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor 2 (FPR2).
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公开(公告)号：EP2714016A1
公开(公告)日：2014-04-09
申请号：EP12728145.9
申请日：2012-06-01
申请人： Allergan, Inc.
发明人： DONELLO, John, E. , YANG, Rong
IPC分类号： A61K9/50 , A61K9/00 , A61K31/4436 , A61P17/08 , A61P17/10
CPC分类号： A61K9/0014 , A61K9/5031 , A61K31/4436
摘要： Disclosed herein are topical dermal compositions comprising particles, wherein the particles comprise a) a biodegradable polymer, and b) a retinoid selected from the group consisting of: (I) and (II), or a pharmaceutically acceptable salt thereof, wherein the particles have an average diameter between 0.1 μιτι and 10 μιτι, and wherein the variables are as defined in the specification. The compositions are useful for treating a condition associated with excess sebum production.
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6.发明授权INDOLE-3-CARBOXYLIC ACID AMIDE, ESTER, THIOAMIDE AND THIOL ESTER COMPOUNDS BEARING ARYL OR HETEROARYL GROUPS HAVING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ANTAGONIST BIOLOGICAL ACTIVITY 有权吲哚-3-甲酰胺，酯，硫代酰胺和THIOLESTERVERBINDUNGEN与具有生物鞘氨醇-1-磷酸的芳基或杂芳基（S1P）-REZEPTORANTAGONISTENWIRKUNG
公开(公告)号：EP1984334B1
公开(公告)日：2014-04-09
申请号：EP07756963.0
申请日：2007-02-14
申请人： ALLERGAN, INC.
发明人： BEARD, Richard, L. , DONELLO, John, E. , YUAN, Haiqing , LIU, Xiaoxia , DUONG, Tien , COLON, Diana, F. , HU, Yihui
IPC分类号： C07D209/42 , C07D401/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04
CPC分类号： C07D209/42 , C07D401/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06
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公开(公告)号：EP2188260A1
公开(公告)日：2010-05-26
申请号：EP08798329.2
申请日：2008-08-21
申请人： ALLERGAN, INC.
IPC分类号： C07D215/52 , C07D277/34 , C07D401/04 , C07D409/04 , A61K31/4709 , A61P35/00
CPC分类号： C07D277/34 , C07D215/52 , C07D401/04 , C07D409/04
摘要： Disclosed herein is a stable compound having a structure formula (I): therapeutic methods, compositions, and medicaments related thereto are also disclosed.
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8.发明公开PYRROLE COMPOUNDS HAVING SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONIST OR ANTAGONIST BIOLOGICAL ACTIVITY 审中-公开WITH激动或拮抗生物效应ON鞘氨醇-1-磷酸受体吡咯
公开(公告)号：EP2185506A1
公开(公告)日：2010-05-19
申请号：EP08798326.8
申请日：2008-08-21
申请人： ALLERGAN, INC.
IPC分类号： C07D207/32 , C07D207/34 , C07D233/90 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12
CPC分类号： C07D207/33 , C07D207/34 , C07D233/90 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12
摘要： Disclosed herein are compounds represented by: therapeutic methods, compositions, and medicaments related thereto are also disclosed.
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9.发明授权USE OF 1- BENZYL-1- HYDROXY-2, 3-DIAMINO-PROPYL AMINES, 3-BENZYL-3-HYDROXY-2-AMINO PROPIONIC ACID AMIDES AND RELATED COMPOUNDS AS ANALGESICS 有权用1-苄基-1-羟基-2-，3-二氨基丙胺，3-苄基-3-羟基-2-氨基 - PROPIONSÄUREAMIDEN和相关化合物作为止痛药
公开(公告)号：EP1841423B1
公开(公告)日：2010-03-10
申请号：EP06719390.4
申请日：2006-01-25
申请人： ALLERGAN, INC.
发明人： LEBLOND, Bertrand , BEAUSOLEIL, Eric , TAVERNE, Thierry , DONELLO, John, E. , SCHWEIGHOFFER, Fabien (Jacques)
IPC分类号： A61K31/40 , A61K31/4025 , A61K31/5375 , A61P25/04 , A61P29/00
CPC分类号： C07D265/30 , A61K31/40 , A61K31/4025 , A61K31/4409 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K31/541 , C07D207/09 , C07D213/64 , C07D295/12 , C07D295/13 , C07D295/15 , C07D319/18 , C07D405/06
摘要： The present invention relates to pharmaceutical compositions having an analgesic effect and containing 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides or related compounds.
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公开(公告)号：EP1993584A2
公开(公告)日：2008-11-26
申请号：EP07848839.2
申请日：2007-02-02
申请人： ALLERGAN, INC.
发明人： DONELLO, John, E. , MCLAUGHLIN, Anne, P. , SCHWEIGHOFFER, Fabien, J. , MAHE, Florence , RODRIGUES, Gerard, A.
CPC分类号： A61K31/4439 , A61K38/1793 , A61K38/195 , A61K48/00 , A61K2039/505 , C07K16/2866 , C12N15/1136 , C12N15/1138 , C12N2310/14
摘要： Compositions and methods of treating ocular disorders comprising CXCR4 inhibitory compositions.
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