公开(公告)号：EP0785425B1

公开(公告)日：2003-05-07

申请号：EP97300255.3

申请日：1997-01-16

申请人： Agilent Technologies, Inc. (a Delaware corporation)

发明人： Yin, Hongfeng ,  Keely-Templin, Catherine A. ,  McManigill, Douglass ,  Holloway, Robert R.

IPC分类号： G01N27/447

CPC分类号： G01N27/44704

公开(公告)号：EP1350759A3

公开(公告)日：2004-07-28

申请号：EP02021747.7

申请日：2002-09-25

申请人： Agilent Technologies Inc. (a Delaware Corporation)

发明人： Roitman, Daniel B. ,  Killeen, Kevin P. ,  Seaward, Karen L. ,  Yin, Hongfeng ,  Robotti, Karla

IPC分类号： B81C1/00 ,  B29C59/02 ,  B29C65/00 ,  C09J179/08

CPC分类号： B29C66/82661 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/123 ,  B01L2400/0622 ,  B01L2400/0644 ,  B29C43/56 ,  B29C59/02 ,  B29C59/14 ,  B29C59/142 ,  B29C65/48 ,  B29C65/4835 ,  B29C65/521 ,  B29C66/001 ,  B29C66/02 ,  B29C66/026 ,  B29C66/1122 ,  B29C66/53461 ,  B29C66/536 ,  B29C66/54 ,  B29C66/71 ,  B29C66/73115 ,  B29C66/73117 ,  B29C66/73771 ,  B29C66/73772 ,  B29C66/73774 ,  B29C66/73775 ,  B29C66/73776 ,  B29C66/73921 ,  B29C66/73941 ,  B29C66/7465 ,  B29C66/91411 ,  B29C66/91445 ,  B29C66/919 ,  B29C66/9192 ,  B29C66/91941 ,  B29C66/91943 ,  B29C2071/022 ,  B29K2071/00 ,  B29K2079/08 ,  B29K2309/08 ,  B29K2995/0039 ,  B29K2995/0041 ,  B29L2031/756 ,  B81B1/00 ,  B81C1/00357 ,  B81C2201/019 ,  G01N27/44791 ,  G01N30/60 ,  G01N30/6052 ,  G01N30/6095 ,  Y10T156/1023 ,  Y10T428/24479

摘要： A fabrication and adhesion method for a polyaryl-ether-ketone (PAEK) device, such as a microfluidic device (400), is disclosed. At least one glassy uncrystallized PAEK substrate (250) is heated up to near or above the glass transition temperature to allow the substrate (250) to crystallize from the glass state, while embossing the substrate (250) with patterns (325). Bonding the PAEK substrate (250) to another substrate (255) is accomplished using a solvent-resistant adhesive (270), such as a polyimide-based adhesive, in combination with an adhesion enhancement treatment. In certain embodiments, the adhesion enhancement treatment is a plasma treatment or a chemical sulfonation treatment.

摘要翻译： 公开了一种聚芳醚醚酮（PAEK）器件如微流器件（400）的制造和粘附方法。 将至少一个玻璃状未结晶的PAEK基底（250）加热到接近或高于玻璃化转变温度，以允许基底（250）从玻璃状态结晶，同时用图案（325）压印基底（250）。 使用耐溶剂粘合剂（270），例如聚酰亚胺基粘合剂，结合粘合增强处理，将PAEK基底（250）粘合到另一基底（255）上。 在某些实施方案中，粘合增强处理是等离子体处理或化学磺化处理。

公开(公告)号：EP1350759A2

公开(公告)日：2003-10-08

申请号：EP02021747.7

申请日：2002-09-25

申请人： Agilent Technologies Inc. (a Delaware Corporation)

发明人： Roitman, Daniel B. ,  Killeen, Kevin P. ,  Seaward, Karen L. ,  Yin, Hongfeng ,  Robotti, Karla

IPC分类号： B81C1/00 ,  B29C59/02 ,  B29C65/00 ,  C09J179/08

CPC分类号： B29C66/82661 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/123 ,  B01L2400/0622 ,  B01L2400/0644 ,  B29C43/56 ,  B29C59/02 ,  B29C59/14 ,  B29C59/142 ,  B29C65/48 ,  B29C65/4835 ,  B29C65/521 ,  B29C66/001 ,  B29C66/02 ,  B29C66/026 ,  B29C66/1122 ,  B29C66/53461 ,  B29C66/536 ,  B29C66/54 ,  B29C66/71 ,  B29C66/73115 ,  B29C66/73117 ,  B29C66/73771 ,  B29C66/73772 ,  B29C66/73774 ,  B29C66/73775 ,  B29C66/73776 ,  B29C66/73921 ,  B29C66/73941 ,  B29C66/7465 ,  B29C66/91411 ,  B29C66/91445 ,  B29C66/919 ,  B29C66/9192 ,  B29C66/91941 ,  B29C66/91943 ,  B29C2071/022 ,  B29K2071/00 ,  B29K2079/08 ,  B29K2309/08 ,  B29K2995/0039 ,  B29K2995/0041 ,  B29L2031/756 ,  B81B1/00 ,  B81C1/00357 ,  B81C2201/019 ,  G01N27/44791 ,  G01N30/60 ,  G01N30/6052 ,  G01N30/6095 ,  Y10T156/1023 ,  Y10T428/24479

摘要： A fabrication and adhesion method for a polyaryl-ether-ketone (PAEK) device, such as a microfluidic device (400), is disclosed. At least one glassy uncrystallized PAEK substrate (250) is heated up to near or above the glass transition temperature to allow the substrate (250) to crystallize from the glass state, while embossing the substrate (250) with patterns (325). Bonding the PAEK substrate (250) to another substrate (255) is accomplished using a solvent-resistant adhesive (270), such as a polyimide-based adhesive, in combination with an adhesion enhancement treatment. In certain embodiments, the adhesion enhancement treatment is a plasma treatment or a chemical sulfonation treatment.

公开(公告)号：EP1564779A3

公开(公告)日：2006-04-19

申请号：EP04029244.3

申请日：2004-12-09

申请人： Agilent Technologies Inc. a Delaware Corporation

发明人： Sobek, Daniel ,  Cai, Jing ,  Killeen, Kevin ,  Yin, Hongfeng

IPC分类号： H01J27/02 ,  H01J49/04 ,  H02M3/28

CPC分类号： H01J49/165

摘要： An ion source for an analytical instrument is described. The ion source comprises a capillary tip (105) and counter-electrode (103) interface and a feedback loop control device (400) connected to the capillary tip and counter-electrode interface. The feedback loop control device comprises a transimpedance amplifier (401), a DC de-coupler (403), a frequency to voltage converter (405), a controller (407), and a voltage-controlled high-voltage power supply (409) that provides a tip to counter-electrode voltage to the capillary tip and counter-electrode interface. The feedback loop control device measures the modulation frequency of ionization currents and provides a feedback adjustment of the tip-to-counter-electrode voltage to maintain ionization efficiency.

公开(公告)号：EP0964428A3

公开(公告)日：2002-08-21

申请号：EP99111534.6

申请日：1999-06-14

申请人： Agilent Technologies, Inc. (a Delaware corporation)

发明人： Yin, Hongfeng ,  Chakel, John A. ,  Swedberg, Sally A.

IPC分类号： H01J49/04

CPC分类号： G01N30/7233 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/027 ,  B01L2400/0421 ,  B01L2400/0487 ,  G01N30/6095 ,  H01J49/0018 ,  H01J49/0431

摘要： A miniaturized planar device is described for use in a liquid phase analysis system. The device comprises a separation compartment that is in fluidic communication with a make-up flow channel and a channel compartment that terminates in a on-device mass spectrometer delivery means. The device is formed by microfabrication of microstructures in novel support substrates. The invention herein is used for the analysis of small and/or macromolecular and/or other solutes in the liquid phase.

公开(公告)号：EP1564779A2

公开(公告)日：2005-08-17

申请号：EP04029244.3

申请日：2004-12-09

申请人： Agilent Technologies Inc. a Delaware Corporation

发明人： Sobek, Daniel ,  Cai, Jing ,  Killeen, Kevin ,  Yin, Hongfeng

IPC分类号： H01J27/02 ,  H01J49/04

CPC分类号： H01J49/165

摘要： An ion source for an analytical instrument is described. The ion source comprises a capillary tip (105) and counter-electrode (103) interface and a feedback loop control device (400) connected to the capillary tip and counter-electrode interface. The feedback loop control device comprises a transimpedance amplifier (401), a DC de-coupler (403), a frequency to voltage converter (405), a controller (407), and a voltage-controlled high-voltage power supply (409) that provides a tip to counter-electrode voltage to the capillary tip and counter-electrode interface. The feedback loop control device measures the modulation frequency of ionization currents and provides a feedback adjustment of the tip-to-counter-electrode voltage to maintain ionization efficiency.

摘要翻译： 描述了用于分析仪器的离子源。 离子源包括毛细管尖端（105）和对电极（103）接口以及连接到毛细管尖端和对电极界面的反馈回路控制装置（400）。 反馈回路控制装置包括跨阻抗放大器（401），DC去耦合器（403），频率 - 电压转换器（405），控制器（407）和压控高压电源（409） 这提供了对毛细管尖端和对电极界面的对电极电压的尖端。 反馈回路控制装置测量电离电流的调制频率，并提供针对对电极电压的反馈调整，以维持电离效率。