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1.发明授权
公开(公告)号：EP1397429B1
公开(公告)日：2015-04-01
申请号：EP02732849.1
申请日：2002-05-06
发明人： ELAISSARI, Abdelhamid , MONTAGNE, Franck , BOSC, Eric , PICHOT, Christian , MANDRAND, Bernard , BIBETTE, Jérôme , MONDAIN-MONVAL, Olivier
CPC分类号： C08K9/08 , A61K41/0052 , A61K49/1854 , A61K49/1857 , A61K49/1887 , C08F291/00 , C08F292/00 , Y10T428/2991 , Y10T428/2998
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公开(公告)号：EP1226438B1
公开(公告)日：2004-05-06
申请号：EP00974662.9
申请日：2000-11-06
发明人： ELAISSARI, Abdelhamid , BOSC, Eric , PICHOT, Christian , MANDRAND, Bernard , BIBETTE, Jérôme , MONDAIN-MONVAL, Olivier
IPC分类号： G01N33/543 , G01N33/546
CPC分类号： G01N33/5434 , G01N2446/20 , G01N2446/64 , G01N2446/66 , Y10T428/2982 , Y10T428/2984 , Y10T428/2985 , Y10T428/2987
摘要： The invention concerns composite nanospheres having a diameter ranging between about 50 and 1000 nm plus or minus 5 %, preferably between about 100 and 500 nm plus or minus 5 % and advantageously between 100 and 200 nm plus or minus 5 %, and comprising an essentially liquid core consisting of an organic phase and inorganic nanoparticles, distributed inside the organic phase, and a skin consisting of at least a hydrophilic polymer derived from the polymerisation of at least one water soluble monomer, in particular N-alkylacrylamide or a N-N-dialkylacrylamide; conjugates derived from said nanospheres; their preparation methods and their uses.
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3.发明公开
公开(公告)号：EP1397429A1
公开(公告)日：2004-03-17
申请号：EP02732849.1
申请日：2002-05-06
发明人： ELAISSARI, Abdelhamid , MONTAGNE, Franck , BOSC, Eric , PICHOT, Christian , MANDRAND, Bernard , BIBETTE, Jérôme , MONDAIN-MONVAL, Olivier
CPC分类号： C08K9/08 , A61K41/0052 , A61K49/1854 , A61K49/1857 , A61K49/1887 , C08F291/00 , C08F292/00 , Y10T428/2991 , Y10T428/2998
摘要： The invention relates to composite particles comprising a hydrophobic polymer core and inorganic nanoparticles. Said hydrophobic polymer forms a polymer matrix inside which the inorganic nanoparticles are stabilised and distributed in a relatively homogenous manner. Said particles are at least partially surrounded by an amphiphilic copolymer comprising a hydrophobic part and a hydrophilic part, said hydrophobic part being at least partially immobilised in the polymer matrix. The invention also relates to the preparation method thereof, the conjugates comprising such particles and a ligand and the use of same in reactants and therapeutic compositions.
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公开(公告)号：EP3080247A1
公开(公告)日：2016-10-19
申请号：EP14815303.4
申请日：2014-12-12
申请人： Etablissement Français du Sang , Université Pierre et Marie Curie (Paris 6) , Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris , Assistance Publique Hôpitaux de Paris , Centre National de la Recherche Scientifique (C.N.R.S.)
发明人： GIARRATANA, Maria Catalina , DOUAY, Luc , DOMEJEAN, Hugo , BREMOND, Nicolas , BROUCHON, Julie Victoire , BAUDRY, Jean , BIBETTE, Jérôme
IPC分类号： C12N5/078
CPC分类号： C12N5/0012 , C12M25/01 , C12N5/0641 , C12N2500/25 , C12N2501/125 , C12N2501/14 , C12N2501/145 , C12N2501/155 , C12N2501/165 , C12N2501/2303 , C12N2501/2306 , C12N2501/26 , C12N2501/91 , C12N2533/74
摘要： The present invention concerns a capsule comprising at least one cell with blood-forming potential, said capsule being formed of a liquid core and at least one gelled shell completely encapsulating the liquid core at the periphery of same, the use of such a capsule to produce enucleated erythroid cells
ex vivo , as well as an
ex vivo method of producing enucleated erythroid cells using said capsule.-
公开(公告)号：EP2131869A2
公开(公告)日：2009-12-16
申请号：EP08775556.7
申请日：2008-02-14
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE , Centre National de la Recherche Scientifique , UNIVERSITE PIERRE ET MARIE CURIE (PARIS VI)
发明人： GOUTAYER, Mathieu , TEXIER-NOGUES, Isabelle , FATTACCIOLI, Jacques , BIBETTE, Jérôme , DA SILVA, Anabela
IPC分类号： A61K49/00
CPC分类号： A61K49/0078 , A61K9/1075 , A61K49/0032 , A61K49/0056 , B01F17/0078
摘要： The invention relates to a fluorescent emulsion, to a diagnostic reagent containing the same, and to the use thereof in the preparation of a diagnostic reagent for in vivo fluorescence imaging.
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6.发明公开
公开(公告)号：EP0930933A1
公开(公告)日：1999-07-28
申请号：EP98941547.0
申请日：1998-08-05
CPC分类号： A61K9/113 , B01D17/047 , B01F3/0811 , B01F2003/0826 , B01F2003/0838 , Y10S514/873 , Y10S514/885 , Y10S514/904 , Y10S514/913 , Y10S514/937 , Y10S514/938 , Y10S514/941 , Y10S514/942 , Y10S514/943 , Y10S514/969 , Y10S514/974 , Y10S514/975
摘要： The invention concerns a method for the controlled release of an active principle contained in a multiple water-in-oil-in-water emulsion characterised in that: said multiple emulsion comprises an invert emulsion Ei with a aqueous phase A1 containing at least a hydrophilic active principle, said emulsion Ei being dispersed in the form of direct emulsion droplets Ed, in a continuous aqueous phase A2, with the two emulsions Ed and Ei stabilised by at least a surfactant, present in their respective continuous phases; and said multiple emulsion is brought in the presence of an effective amount of an agent for transforming it into a direct emulsion and induce the release of the active principle, contained in the aqueous phase A1 of emulsion Ei, in the aqueous phase A2.
摘要翻译： 本发明涉及包含在多重水包油包水乳液中的活性成分受控释放的方法，其特征在于：所述多重乳液包含反相乳液Ei，其中含有至少含有亲水性活性成分 原理，所述乳液E 1以连续水相A 2分散成直接乳液液滴Ed的形式，两种乳液Ed和E i通过至少一种表面活性剂稳定化，存在于它们各自的连续相中; 并且所述多重乳液在有效量的试剂存在下转化成直接乳液并诱导包含在乳液Ei的水相A1中的活性成分释放到水相A2中。
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公开(公告)号：EP3177401B1
公开(公告)日：2020-06-24
申请号：EP15744611.3
申请日：2015-08-05
申请人： Etablissements J. Soufflet , Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris , Centre National de la Recherche Scientifique (CNRS) , Sorbonne Université
发明人： GARNICA RODRIGUEZ, Jairo Ivan , BOITARD, Laurent , DREVELLE, Antoine, Serge, Dominique , BREMOND, Nicolas, Pierre , BIBETTE, Jérôme
IPC分类号： B01L3/00
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8.发明公开METHOD FOR MANIPULATING THE EVOLUTION OF COLLECTIVES OF SELF-REPLICATING ENTITIES AND VARIATION BETWEEN COLLECTIVES OF SELF-REPLICATING ENTITIES 审中-公开进行操纵的开发方法和差异之间的实体自我复制自我复制的实体社区
公开(公告)号：EP3103862A1
公开(公告)日：2016-12-14
申请号：EP15305891.2
申请日：2015-06-11
申请人： Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris , Centre National de la Recherche Scientifique (C.N.R.S.) , Ecole Normale Supérieure
发明人： RAINEY, Paul , BIBETTE, Jérôme , BAUDRY, Jean , BREMOND, Nicolas , BOITARD, Laurent , GARNICA, Jairo , COTTINET, Denis
摘要： The present invention relates to a method for manipulating the evolution of collectives of self-replicating entities and/or variation between collectives of self-replicating entities, in a high throughput droplet milli-fluidic system.
摘要翻译： 本发明涉及一种用于操纵自我复制的实体和/或自我复制实体的集体之间的变化的集体的演变，以高通量液滴毫流体系统。
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9.发明授权
公开(公告)号：EP3019590B8
公开(公告)日：2017-09-27
申请号：EP14739774.9
申请日：2014-07-10
申请人： Etablissements J. Soufflet , Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris , Centre National de la Recherche Scientifique (CNRS) , Université Pierre et Marie Curie
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10.发明公开PROCÉDÉ DE CRIBLAGE HAUT DÉBIT DE GOUTTES PAR ÉCHANGE OSMOTIQUE ET VARIATION DE DENSITÉ 审中-公开DROP通过渗透交换和密度变化的高通量筛选方法
公开(公告)号：EP2689012A1
公开(公告)日：2014-01-29
申请号：EP12709345.8
申请日：2012-03-21
申请人： Centre National de la Recherche Scientifique (CNRS) , Université Pierre et Marie Curie (Paris 6) , Ecole Normale Supérieure de Lyon , Université Paris Diderot - Paris 7
发明人： YVERT, Gaël , BIBETTE, Jérôme , BAUDRY, Jean-Marie , BOITARD, Laurent , BREMOND, Nicolas , COTTINET, Denis
IPC分类号： C12N15/00 , C12P1/00 , C12Q1/04 , B01D17/02 , B01D17/04 , G01N15/02 , B03D1/00 , B04B5/04 , G01N15/04 , G01N15/10
CPC分类号： B01D61/002 , B01D19/0036 , B01D61/38 , C12N1/00 , G01N15/0255 , G01N15/04 , G01N2015/1081
摘要： This method comprises bringing drops to be separated into contact with an interface (40) suitable for allowing an osmotic equilibrium between the content of each drop to be separated. The method comprises an osmotic flow between the drops (20A) of the first group of drops through the interface (40) in order to modify the density of each drop (20A) of the first group of drops and the separation of the drops (20A, 20B) according to the density thereof or a combination of the density and the volume in order to isolate the drops (20A) of the first group of drops from the drops (20B) of a second group of drops.
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