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    POLYMERE BIOCOMPATIBLE POUR LA FIXATION DE LIGANDS BIOLOGIQUES
    7.
    发明授权
    POLYMERE BIOCOMPATIBLE POUR LA FIXATION DE LIGANDS BIOLOGIQUES 有权
    生物相容聚合物对生物配体的结合

    公开(公告)号：EP1290052B1

    公开(公告)日：2006-05-03

    申请号：EP01940627.1

    申请日：2001-05-29

    申请人： BIO MERIEUX

    发明人： CHARREYRE, Marie-Thérèse ,  D'AGOSTO, Franck ,  FAVIER, Arnaud ,  PICHOT, Christian ,  MANDRAND, Bernard

    IPC分类号： C08F293/00 ,  C08L53/00 ,  G01N33/545

    CPC分类号： C08L53/00 ,  C08F293/005

    摘要： The invention concerns a biocompatible polymer having a mole weight more than 50000 g/mole, preferably 90000 g/mole for fixing biological ligands comprising at least a first linear segment consisting of a hydrophobic homopolymer derived from polymerisation of a hydrophobic monomer A; a second linear segment consisting of a hydrophilic polymer derived from copolymerisation of a monomer B bearing a reactive function X and a hydrophilic monomer C not bearing any reactive function, said second segment being covalently bound to one end of the first segment. The invention also concerns a biological polymer-ligand-conjugate, a device for capturing a target molecule comprising a solid support whereon is immobilised a biological polymer-ligand conjugate and methods for preparing said polymer. The invention is mainly applicable in the field of diagnosis.

    PROCEDE POUR ISOLER, NOTAMMENT DETECTER OU QUANTIFIER UN ANALYTE DANS UN MILIEU
    8.
    发明授权
    PROCEDE POUR ISOLER, NOTAMMENT DETECTER OU QUANTIFIER UN ANALYTE DANS UN MILIEU 失效
    法分离，检测或定量的分析物的方法在一个中型

    公开(公告)号：EP0965045B1

    公开(公告)日：2002-01-09

    申请号：EP98905473.9

    申请日：1998-01-30

    申请人： BIO MERIEUX

    发明人： PERRIN, Agnès ,  THERETZ, Alain ,  MANDRAND, Bernard

    IPC分类号： G01N33/553 ,  G01N33/548 ,  G01N33/543

    CPC分类号： G01N33/54326 ,  B01J2219/00648 ,  B01J2219/00659 ,  G01N33/54306 ,  Y10S436/801 ,  Y10S436/805 ,  Y10S436/806 ,  Y10S436/807 ,  Y10S436/824 ,  Y10T436/24

    摘要： The invention concerns a method for isolating at least an analyte (4) in a medium, in which it is distributed, consisting in: (a) providing at least one reagent (3) comprising a free support, in discrete form, exhibiting at least a receptor of the analyte; (b) providing another capture support, the accessible surface of which comprises at least an effective or active zone, of limited surface, exhibiting at least another receptor (10) of an entity to be captured, viz. of said analyte or said receptor; (c) contacting the reagent (3) with a liquid sample obtained from the medium containing the analyte, for forming an intermediate medium comprising, also in discrete form and distributed in said medium, a complex between said support, the receptor and the analyte; (d) contacting the accessible surface of said other support with at least a capture reactant, viz. the reagent that has not reacted during step (c) or the complex, for binding said capture reactant to said accessible surface, and obtaining a concentrated deposit in said effective zone, fixed on said other support by the bond of said other receptor with said receptor or analyte; (e) concentrating the deposit of said capture reactant in said effective zone, by increasing the amount of said reactant per surface unit in said effective zone.