公开(公告)号：EP1797045A1

公开(公告)日：2007-06-20

申请号：EP05782757.8

申请日：2005-09-10

申请人： Bayer HealthCare AG

发明人： DITTRICH-WENGENROTH, Elke ,  BÄRFACKER, Lars ,  KRETSCHMER, Axel ,  HIRTH-DIETRICH, Claudia ,  ELLINGHAUS, Peter ,  RAABE, Martin ,  BISCHOFF, Hilmar ,  PILGER, Christian ,  ROSENTRETER, Ulrich ,  BARTEL, Stephan ,  LUSTIG, Klemens ,  KERN, Armin ,  LANG, Dieter ,  BAUSER, Marcus

IPC分类号： C07D239/42 ,  A61K31/505 ,  A61K31/506 ,  C07D239/46 ,  C07D239/48 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

CPC分类号： C07D239/42 ,  C07D405/12

摘要： The invention relates to novel pyrimidine derivatives of general formula (I), methods for the production thereof, their use for treating and/or preventing diseases, and to their use for producing medicaments for treating and/or preventing diseases, preferably for treating and/or preventing cardiovascular diseases, particularly dyslipidemia, arteriosclerosis, insufficiency of the heart, thrombosis and metabolic syndrome.

公开(公告)号：EP1742942A1

公开(公告)日：2007-01-17

申请号：EP05716395.8

申请日：2005-03-26

申请人： Bayer HealthCare AG

发明人： BISCHOFF, Hilmar ,  DITTRICH-WENGENROTH, Elke ,  GRIEBENOW, Nils ,  KRETSCHMER, Axel ,  KRÜGER, Joachim ,  WOLTERING, Elisabeth

IPC分类号： C07D413/12 ,  C07D271/06 ,  C07D405/12 ,  C07D417/12 ,  C07D263/32 ,  C07D413/14 ,  C07D277/28 ,  C07D231/28 ,  C07D231/12 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4192 ,  A61K31/42 ,  A61K31/421 ,  A61K31/4245 ,  A61K31/427

CPC分类号： C07D405/12 ,  C07D231/12 ,  C07D249/04 ,  C07D263/32 ,  C07D271/06 ,  C07D277/28 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： The invention relates to novel phenylthioacetic acid derivatives of formula (I), to a method for the production thereof, to the use thereof for the treatment and/or prophylaxis of diseases, in addition to the use thereof in the production of medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prevention of cardiovascular diseases, in particular dyslipidaemia and arteriosclerosis. The compounds act as modulators for the PRAR-alpha receptor.

公开(公告)号：EP2079708A2

公开(公告)日：2009-07-22

申请号：EP07818862.0

申请日：2007-10-10

申请人： Bayer HealthCare AG

发明人： BAUSER, Marcus ,  BUCHMÜLLER, Anja ,  VON DEGENFELD, Georges ,  DITTRICH-WENGENROTH, Elke ,  GERDES, Christoph ,  GNOTH, Mark, Jean ,  GOTTSCHLING, Dirk ,  HEITMEIER, Stefan ,  HENDRIX, Martin ,  KÖBBERLING, Johannes ,  LANG, Dieter ,  RESTER, Ulrich ,  SAATMANN, Uwe ,  TERSTEEGEN, Adrian ,  BRÜNS, Astrid

IPC分类号： C07D233/88

CPC分类号： C07D233/88 ,  C07D277/20 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D417/12

摘要： The invention relates to acyl aminoimidazoles and acyl aminothiazoles, to a method for producing same and to the use thereof for producing medicaments for the treatment and/or prevention of diseases, in particular cardiovascular diseases, preferably thromboembolic diseases.

摘要翻译： 本发明涉及酰基氨基咪唑和酰基氨基噻唑，其制备方法及其用于制备用于治疗和/或预防疾病，特别是心血管疾病，优选血栓栓塞性疾病的药物。

公开(公告)号：EP1866289A1

公开(公告)日：2007-12-19

申请号：EP06707442.7

申请日：2006-03-07

申请人： Bayer HealthCare AG

发明人： WOLTERING, Elisabeth ,  TUCH, Arounarith ,  DITTRICH-WENGENROTH, Elke ,  KRETSCHMER, Axel ,  BÄRFACKER, Lars ,  BAUSER, Marcus ,  ELLINGHAUS, Peter ,  LUSTIG, Klemens ,  POOK, Elisabeth ,  WEBER, Olaf

IPC分类号： C07D239/34 ,  C07D239/28 ,  A61K31/515 ,  A61P3/06

CPC分类号： C07D239/28 ,  C07D239/34

摘要： The invention relates to pyrimidine carboxylic acid derivatives of formula (I), to methods for the production thereof, to their use for treating and/or preventing diseases, and their use for producing medicaments for treating and/or preventing diseases, preferably for treating and/or preventing cardiovascular diseases, in particular, dyslipidemias and arteriosclerosis.

公开(公告)号：EP1519919A1

公开(公告)日：2005-04-06

申请号：EP03762547.2

申请日：2003-06-30

申请人： Bayer HealthCare AG

发明人： BISCHOFF, Hilmar ,  DITTRICH-WENGENROTH, Elke ,  WUTTKE, Martina ,  HECKROTH, Heike ,  THIELEMANN, Wolfgang ,  WOLTERING, Michael ,  OTTENEDER, Michael

IPC分类号： C07D209/96 ,  C07D209/10 ,  C07D209/12 ,  A61P3/06 ,  A61K31/404

CPC分类号： C07D471/04 ,  C07D209/08 ,  C07D209/96

摘要： The invention relates to novel substituted indolin phenylsulfonamide derivatives, to a method for the production thereof and to the use thereof in medicaments, especially as potent PPAR-delta activating compounds for the prophylaxis and/or treatment of cardiovascular diseases, especially dyslipidaemia and coronary heart diseases.

公开(公告)号：EP1675825A2

公开(公告)日：2006-07-05

申请号：EP04764167.5

申请日：2004-08-16

申请人： Bayer HealthCare AG

发明人： DITTRICH-WENGENROTH, Elke ,  SIEGEL, Stephan ,  WOLTERING, Michael

IPC分类号： C07D209/10 ,  A61K31/404

CPC分类号： C07D209/08

摘要： The invention relates to novel indoline derivatives, a method for the preparation and use thereof for drugs, in particular in the form of powerful compounds activating PPAR-delta for preventing and/or treating cardiovascular diseases, in particular dyslipidemias, arteriosclerosis and coronaropathy.

公开(公告)号：EP2173744A1

公开(公告)日：2010-04-14

申请号：EP08759099.8

申请日：2008-06-07

申请人： Bayer HealthCare AG

发明人： ALLERHEILIGEN, Swen ,  BAUSER, Marcus ,  SCHIROK, Hartmut ,  RESTER, Ulrich ,  HEITMEIER, Stefan ,  GERDES, Christoph ,  VON DEGENFELD, Georges ,  DITTRICH-WENGENROTH, Elke ,  SAATMANN, Uwe ,  STRASSBURGER, Julia ,  MÜNTER, Klaus ,  GNOTH, Mark, Jean ,  LANG, Dieter

IPC分类号： C07D413/14 ,  A61K31/4439 ,  A61P7/00

CPC分类号： C07D413/14

摘要： The invention relates to novel substituted oxazolidinones, methods for the production thereof, use thereof for treating and/or for the prophylaxis of diseases and use thereof for producing medicaments for treating and/or for the prophylaxis of diseases, in particular thromboembolic disorders.

摘要翻译： 本发明涉及新的取代的恶唑烷酮，其制备方法，其用于治疗和/或预防疾病的用途以及用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。

公开(公告)号：EP2170877A1

公开(公告)日：2010-04-07

申请号：EP08773372.1

申请日：2008-06-07

申请人： Bayer HealthCare AG

发明人： ALLERHEILIGEN, Swen ,  BAUSER, Marcus ,  HEIMBACH, Dirk ,  HEITMEIER, Stefan ,  GNOTH, Mark, Jean ,  GERDES, Christoph ,  VON DEGENFELD, Georges ,  RÖHRIG, Susanne ,  RESTER, Ulrich ,  DITTRICH-WENGENROTH, Elke ,  SAATMANN, Uwe ,  TERSTEEGEN, Adrian

IPC分类号： C07D413/14 ,  A61K31/4439 ,  A61P7/00

CPC分类号： C07D413/14

摘要： The invention relates to novel substituted oxazolidinones, methods for the production thereof, use thereof for treating and/or for the prophylaxis of diseases and use thereof for producing medicaments for treating and/or for the prophylaxis of diseases, in particular thromboembolic disorders.

公开(公告)号：EP1802594A1

公开(公告)日：2007-07-04

申请号：EP05786857.2

申请日：2005-09-27

申请人： Bayer HealthCare AG

发明人： DITTRICH-WENGENROTH, Elke ,  BÄRFACKER, Lars ,  KRETSCHMER, Axel ,  HIRTH-DIETRICH, Claudia ,  ELLINGHAUS, Peter ,  RAABE, Martin ,  BISCHOFF, Hilmar ,  PILGER, Christian ,  ROSENTRETER, Ulrich ,  BARTEL, Stephan ,  LUSTIG, Klemens ,  KERN, Armin ,  LANG, Dieter

IPC分类号： C07D273/04 ,  A61K31/5395 ,  C07D413/12

CPC分类号： C07D273/04 ,  C07D413/12

摘要： The invention relates to novel 1,3,4-oxadiazine-5-on derivatives of general formula (I), methods for the production thereof, the use thereof for treating and/or preventing diseases, and the use thereof for producing medicaments used for the treatment and/or prevention of diseases, preferably cardiovascular diseases, especially dyslipidemia and arteriosclerosis.

公开(公告)号：EP1583743A1

公开(公告)日：2005-10-12

申请号：EP03789417.7

申请日：2003-12-24

申请人： Bayer HealthCare AG

发明人： WOLTERING, Michael ,  BISCHOFF, Hilmar ,  DITTRICH-WENGENROTH, Elke ,  HECKROTH, Heike ,  OTTENEDER, Michael

IPC分类号： C07D209/08 ,  C07D209/12 ,  C07D209/14 ,  C07D417/04 ,  A61K31/404 ,  A61P3/06 ,  A61K31/427

CPC分类号： C07D417/04 ,  C07D209/08 ,  C07D209/12 ,  C07D209/14

摘要： The invention relates to novel indole-phenylsulfonamide derivatives, to methods for the production thereof, and to their use in medicaments, particularly as potent PPAR-delta activating compounds, for the prevention and/or treatment of cardiovascular diseases, particularly dyslipidemias and coronary heart diseases.