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公开(公告)号：EP3189129A1
公开(公告)日：2017-07-12
申请号：EP15838851.2
申请日：2015-08-04
摘要： Tissue dissociators configured to disrupt a biological tissue sample are provided. Aspects of the tissue dissociators may include a housing having a distal end and a proximal end, a cutting blade positioned at the distal end of the housing and a tissue actuator configured to be displaced along a longitudinal axis within the housing. Also provided are methods of using the tissue dissociators, as well as kits including the tissue dissociators.
摘要翻译： 提供了构造成破坏生物组织样品的组织解离器。 组织解离器的各方面可以包括具有远端和近端的壳体，定位在壳体的远端处的切割刀片以及构造成沿着壳体内的纵向轴线移位的组织致动器。 还提供了使用组织解离剂的方法以及包括组织解离剂的试剂盒。
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公开(公告)号：EP2760413B1
公开(公告)日：2017-12-06
申请号：EP12835543.5
申请日：2012-09-28
发明人： WARNER, Brian David , DUNNE, John
CPC分类号： A61J3/00 , A61J1/10 , A61J1/2003 , A61J1/2089 , A61K9/0019 , A61K35/12 , A61M1/3678 , A61M1/3692 , A61M1/3693 , A61M5/1407 , A61M5/1413 , A61M5/19 , A61M37/00 , A61M2205/10 , B65B3/003 , C12N13/00
摘要： Methods and devices for exchanging therapeutic agents, such as cells, from one liquid medium to another liquid medium are provided. Aspects of embodiments of the methods include transferring a therapeutic agent from a first medium, such as a freezing, storage or shipping buffer, into a second medium, such as a sterile physiologically compatible buffer. In certain aspects, the transfer of the therapeutic agent from a first medium to a second medium involves the use of acoustic-focusing, or acoustophoresis. Embodiments of the subject methods may facilitate the transfer of a therapeutic agent from a storage medium to an infusion medium, and in certain embodiments include administering the therapeutic agent contained in the infusion medium to the subject. Also provided by the present disclosure are devices for practicing the subject methods.
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公开(公告)号：EP3087194A1
公开(公告)日：2016-11-02
申请号：EP14874631.6
申请日：2014-12-11
CPC分类号： G01N1/286 , B01L3/502753 , B01L3/502776 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B01L2400/043 , B01L2400/0436 , B01L2400/0487 , G01N2001/4094 , G01N2015/1006 , G01N2015/1418
摘要： Aspects of the present disclosure include methods for processing a biological sample. Methods according to certain embodiments include disrupting a biological sample to produce a disrupted biological sample and acoustically separating larger components from smaller components in the disrupted biological sample. In certain embodiments, methods may include monitoring aggregation while the biological sample is being processed. Methods, in certain instances, also include acoustically separating cells from cellular debris and non-cellular macromolecules as well as magnetically separating magnetically labelled moieties from unlabeled moieties. Systems, including a disrupter, one or more acoustic concentrator devices, feedback monitors and magnetic separation devices suitable for practicing the subject methods are also described.
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公开(公告)号：EP2912189A1
公开(公告)日：2015-09-02
申请号：EP13849103.0
申请日：2013-10-23
CPC分类号： G01N15/1404 , B01L3/502761 , B01L2200/0652 , B01L2300/0877 , B01L2400/043 , B01L2400/0439 , B03C1/02 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N1/34 , G01N1/4077 , G01N15/02 , G01N15/1056 , G01N15/14 , G01N15/1425 , G01N15/1459 , G01N33/54326 , G01N2001/4038 , G01N2001/4094 , G01N2015/008 , G01N2015/0288 , G01N2015/1006 , G01N2015/142 , G01N2015/149
摘要： Devices for sorting components (e.g., cells) contained in a liquid sample are provided. In certain aspects, the devices include a magnetic separation device and an acoustic concentrator device fluidically coupled to magnetic separation device. Aspects of the invention further include methods for sorting cells in a liquid sample, and systems, and kits for practicing the subject methods.
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5.发明公开FLOW CYTOMETRIC SYSTEMS FOR STERILE SEPARATION OF MAGNETICALLY LABELED SAMPLE COMPONENTS 审中-公开流式细胞仪系统磁性标记的样品含量无菌分离
公开(公告)号：EP2795289A1
公开(公告)日：2014-10-29
申请号：EP12859016.3
申请日：2012-11-26
发明人： WARNER, Brian David , YU, Liping
CPC分类号： G01N15/0656 , G01N35/0098 , G01N2015/0065 , G01N2015/1006 , G01N2015/1409 , G01N2015/149
摘要： Systems for sterile separation of magnetically labeled sample components and methods for using the same are provided. Embodiments of the systems include a magnetic separation device and a pliant sample container, where a portion of the pliant sample container is operatively coupled under pressure to the magnetic separation device. Also provided are methods of using the systems, as well as pliant sample containers configured for use with the subject systems and methods.
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