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公开(公告)号：EP1755785A1
公开(公告)日：2007-02-28
申请号：EP05749873.5
申请日：2005-05-16
发明人： KNAPP, Michael, R. , BAKER, Jill, M. , CHOW, Andrea, W. , KOPF-SILL, Anne, R. , SPAID, Michael, A.
CPC分类号： C12Q1/6851 , B01L3/5027 , B01L3/502761 , B01L7/52 , B01L7/525 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/1822 , B01L2300/1827 , B01L2300/1833 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , C12Q1/6818 , C12Q1/6837 , C12Q1/686 , C12Q1/6869 , G01N21/6428 , G01N2021/6441 , C12Q2565/102 , C12Q2537/143 , C12Q2545/113 , C12Q2531/113 , C12Q2565/629 , C12Q2527/143
摘要： Methods and systems for performing single molecule amplification for detection, quantification and statistical analysis of nucleic acids are provided. Methods and systems are provided for determining and quantifying lengths of nucleic acids of interest.
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公开(公告)号：EP1163369B1
公开(公告)日：2011-05-04
申请号：EP00913566.6
申请日：2000-02-22
发明人： PARCE, J., Wallace , NIKIFOROV, Theo, T. , BURD MEHTA, Tammy , KOPF-SILL, Anne , CHOW, Andrea, W. , KNAPP, Michael, R.
CPC分类号： C12Q1/6874 , B01F13/0059 , B01J2219/00317 , B01J2219/00459 , B01J2219/00468 , B01L3/5027 , B01L3/502715 , B01L3/502761 , B01L2200/0668 , B01L2400/0409 , B01L2400/0415 , B01L2400/043 , B01L2400/0487 , C07H21/02 , C07H21/04 , C12Q1/6869 , C40B60/14 , G01N27/44756 , G01N35/0098 , G01N2035/00574 , Y10T436/143333 , C12Q2565/629 , C12Q2535/101 , C12Q2563/173 , C12Q2525/186 , C12Q2527/125
摘要： Arrays of flowable or fixed particle sets are used in microfluidic systems for performing assays and modifying hydrodynamic flow. Also provided are assays utilizing flowable or fixed particle sets within a microfluidic system, as well as kits, apparatus and integrated systems comprising arrays and array members. The application particularly focusses on methods of performing a plurality of chemical reactions, for instance nucleic acid synthesis and sequencing reactions, in said microfluidic devices.
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3.发明公开METHOD AND APPARATUS FOR GENERATING THERMAL MELTING CURVES IN A MICROFLUIDIC DEVICE 审中-公开方法和装置用于产生热量熔解曲线的微流体装置
公开(公告)号：EP1987163A2
公开(公告)日：2008-11-05
申请号：EP07763208.1
申请日：2007-02-09
发明人： SUNDBERG, Steven, A. , KNAPP, Michael, R. , KNIGHT, Ivor, T. , BOLES, Deborah, J. , RULISON, Aaron , DONG, Wesley, B. , FABANS, Andrew , BORANKAY, Allen , DOLON, Edward , MOTI, Robert , SLATER, Michael
IPC分类号： C12Q1/68
CPC分类号： G01N25/04 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L7/52 , B01L7/525 , B01L2200/10 , B01L2300/0627 , B01L2300/0816 , B01L2300/14 , B01L2300/18 , B01L2300/1833 , B01L2400/0409 , B01L2400/0415 , B01L2400/0487 , C12Q1/68 , C12Q1/6844 , C12Q1/686 , C12Q1/6862 , G01N21/33 , G01N21/6428 , Y10T436/143333 , C12Q2565/629 , C12Q2565/101 , C12Q2527/107 , C12Q2527/101
摘要： The present invention provides novel methods and devices that employ microfluidic technology to generate molecular melt curves. In particular, the devices and methods in accordance with the invention are useful in providing for the analysis of PCR amplification products.
摘要翻译： 本发明提供了新颖的方法和设备没有采用微流控技术，以产生分子熔体曲线。 特别地，所述装置和方法在雅舞蹈与本发明可用于提供PCR扩增产物的分析是有用的。
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公开(公告)号：EP1163052B1
公开(公告)日：2010-06-02
申请号：EP00911913.2
申请日：2000-02-22
发明人： BURD MEHTA, Tammy , KOPF-SILL, Anne, R. , PARCE, J., Wallace , CHOW, Andrea, W. , BOUSSE, Luc, J. , KNAPP, Michael, R. , NIKIFOROV, Theo, T. , GALLAGHER, Steve
CPC分类号： C12Q1/6874 , B01F13/0059 , B01J2219/00317 , B01J2219/00459 , B01J2219/00468 , B01L3/5027 , B01L3/502715 , B01L3/502761 , B01L2200/0668 , B01L2400/0409 , B01L2400/0415 , B01L2400/043 , B01L2400/0487 , C07H21/02 , C07H21/04 , C12Q1/6869 , C40B60/14 , G01N27/44756 , G01N35/0098 , G01N2035/00574 , Y10T436/143333 , C12Q2565/629 , C12Q2535/101 , C12Q2563/173 , C12Q2525/186 , C12Q2527/125
摘要： Arrays of flowable or fixed particle sets are used in microfluidic systems for performing assays and modifying hydrodynamic flow. Also provided are assays utilizing flowable or fixed particle sets within a microfluidic system, as well as kits, apparatus and integrated systems comprising arrays and array members. The application particularly focusses on methods of performing a plurality of chemical reactions, for instance nucleic acid synthesis and sequencing reactions, in said microfluidic devices.
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公开(公告)号：EP0909385B1
公开(公告)日：2008-09-10
申请号：EP97931369.9
申请日：1997-06-25
IPC分类号： B01L3/00 , G01N27/447
CPC分类号： B01F13/0071 , B01F13/0084 , B01F13/0086 , B01J19/0093 , B01J2219/00891 , B01L3/021 , B01L3/502715 , B01L3/50273 , B01L3/502784 , B01L2200/027 , B01L2400/0415 , B01L2400/0418 , B01L2400/0421 , F04B17/00 , F04B19/006 , G01N27/44704 , G01N27/44743 , G01N27/44791 , H02N11/006 , Y10S366/02 , Y10T436/113332 , Y10T436/2575
摘要： A channel (140) is divised into portions (142, 144). The sidewalls of each channel portion (142, 144) have surface charges of opposite polarity. The two channel portions (142, 144) are physically connected together by a salt bridge (133), such as a glass frit or gel layer. The salt bridge (133) separates the fluids in channel (140) from an ionic fluid reservoir (135). To impart electroosmotic and electrophoretic forces along the channel (140) between parts A and B, respectively. Additionally, a third electrode (137) is placed in the reservoir (135).
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公开(公告)号：EP1587940A1
公开(公告)日：2005-10-26
申请号：EP03812089.5
申请日：2003-12-19
IPC分类号： C12P19/34
CPC分类号： C12Q1/686 , B01L3/5027 , B01L7/52 , B01L2200/10 , B01L2200/16 , B01L2300/1827 , B01L2400/0406 , C12Q1/6837 , C12Q1/6851 , C12Q2531/113 , C12Q2565/629 , C12Q2527/143 , C12Q2547/107 , C12Q2537/157
摘要： Methods and systems for performing single molecule amplification for detection, quantification and statistical analysis of rare nucleic acids are provided.
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