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    Multi-channel fluorescence measuring optical system and multi-channel fluorescence sample analyzer
    2.
    发明公开
    Multi-channel fluorescence measuring optical system and multi-channel fluorescence sample analyzer 审中-公开
    Optisches Mehrkanal-Fluoreszenzmesssystem und Mehrkanal-Fluoreszenz probenanysator

    公开(公告)号：EP1688734A1

    公开(公告)日：2006-08-09

    申请号：EP06000070.0

    申请日：2006-01-03

    申请人： Samsung Electronics Co., Ltd.

    发明人： Ok, Gyeong-sik ,  Kim, Su-hyeon ,  Kim, Jin-tae ,  Oh, Kwang-wook

    IPC分类号： G01N21/64 ,  G01N21/05 ,  G01J3/44 ,  C12M1/34 ,  C12Q1/68

    CPC分类号： G01J3/10 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/4406 ,  G01J2003/1213 ,  G01N21/05 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2021/0346 ,  G01N2021/3174 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0221 ,  G01N2201/0407 ,  G01N2201/0461 ,  G01N2201/0612 ,  G01N2201/0627 ,  G01N2201/0631 ,  G01N2201/0806 ,  G01N2201/0833

    摘要： A multi-channel fluorescence measuring optical system and a multi-channel fluorescence sample analyzer using the optical system are provided. The multi-channel fluorescence measuring optical system, which irradiates light onto a plurality of sample channels and detecting fluorescence radiated from samples (m), includes: a light source (10); an integrator (20) for giving the light irradiated from the light source a uniform intensity distribution; a sample holder (30) having a plurality of sample channels on which the samples (m) are mounted, wherein the samples (m) are exited by the light emitted from the integrator (20); a beam splitter (25) between the integrator (20) and the sample holder (30) for dividing the incident light in a predetermined ratio; and a light detecting unit (40) for detecting fluorescence from the samples (m) through the beam splitter (25). Preferably, the light intensities of fluorescence images are detected using optical fiber bundles and photodiodes, the manufacturing cost can be greatly reduced, and the optical system can be miniaturized.

    摘要翻译： 提供多通道荧光测量光学系统和使用该光学系统的多通道荧光样品分析仪。 将光照射到多个样品通道上并检测从样品（m）辐射的荧光的多通道荧光测量光学系统包括：光源（10）; 用于给从光源照射的光均匀的强度分布的积分器（20）; 具有安装有样品（m）的多个样品通道的样品保持器（30），其中所述样品（m）由所述积分器（20）发射的光退出; 在积分器（20）和样品保持器（30）之间的分光器（25），用于以预定比例对入射光进行分光; 以及用于通过分束器（25）检测来自样品（m）的荧光的光检测单元（40）。 优选地，使用光纤束和光电二极管检测荧光图像的光强度，可以大大降低制造成本，并且可以使光学系统小型化。

    Method of Reducing Temperature Difference Between a Pair of Substrates and Fluid Reaction Device Using the Same
    6.
    发明公开
    Method of Reducing Temperature Difference Between a Pair of Substrates and Fluid Reaction Device Using the Same 审中-公开
    减少两个衬底之间的温度差的方法，和使用该流体反应装置

    公开(公告)号：EP1894884A1

    公开(公告)日：2008-03-05

    申请号：EP07104705.4

    申请日：2007-03-22

    申请人： Samsung Electronics Co., Ltd.

    发明人： Namkoong, Kak ,  Kim, Su-hyeon ,  Kim, Jin-tae ,  Park, Chin-sung ,  Lee, Young-sun

    IPC分类号： B81B3/00

    CPC分类号： B81B3/0081 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00873 ,  B01L3/5027 ,  B01L7/5255 ,  B01L2200/14 ,  B01L2200/147 ,  B01L2300/1805 ,  B01L2300/1827 ,  B81B2201/051 ,  F28F21/02 ,  F28F2013/006

    摘要： Provided is a method of reducing the temperature difference between a pair of substrates (103, 121), which are a high-temperature substrate (103) and a low-temperature substrate (121), including a heat transfer facilitating layer (110) which has a higher thermal conductivity than air and can hold particles (150) between those substrates (103, 121), and maintaining close contacts among the high-temperature substrate (103), the heat transfer facilitating layer (110), and the low-temperature substrate (121) so that the formation of an air layer can be prevented both between the high-temperature substrate (103) and the heat transfer facilitating layer (110), and between the low-temperature substrate (121) and the heat transfer facilitating layer (110). In addition, provided is a fluid reaction device (100) comprising: a microfluidic reaction chip (120) that accommodates a fluid (F); a heater (101) that heats the microfluidic reaction chip (120); and a heat transfer facilitating layer (110) that is interposed between the microfluidic reaction chip (120) and the heater (101), has a higher thermal conductivity than air and can hold particles (150), wherein the heater (101), the heat transfer facilitating layer (110), and the microfluidic reaction chip (120) are fixed to one another so that the formation of an air layer can be prevented both between the heater (101) and the heat transfer facilitating layer (110), and between the microfluidic reaction chip (120) and the heat transfer facilitating layer (110).

    摘要翻译： 提供了减少的一对衬底之间的温度差（103，121），这是一个高温的基材（103）和一个低温衬底（121），其包括传热促进层（110）的方法，其 具有比空气更高的导热性，并且可以保持这些基片（103，121），和维护高温基板（103）之间的密切接触，传热促进层（110），并且所述低之间的颗粒（150） 温度的基板（121），以便做了一个空气层的形成，可以防止两者高温基板（103）和所述传热促进层（110）之间以及在低温衬底（121）和所述传热之间 促进层（110）。 此外，提供了一种流体反应装置（100），包括：（120）做了微流控反应芯片容纳的流体（F）; 加热器（101）加热做微流体反应芯片（120）; 和传热促进层（110），其被所述微流体反应芯片（120）和所述加热器（101）之间插入具有比空气更高的导热性，并且可以保持粒子（150），其中，所述加热器（101），所述 传热促进层（110），并且所述微流体反应芯片（120）被固定到彼此所以没有空气层的形成，可以防止两者的加热器（101）和所述传热促进层（110）之间，并且 微流体反应芯片（120）和所述传热促进层（110）之间。

    Apparatus and method for printing biomolecular droplet on substrate
    7.
    发明公开
    Apparatus and method for printing biomolecular droplet on substrate 审中-公开
    在基质上印刷生物分子液滴的设备和方法

    公开(公告)号：EP1844852A1

    公开(公告)日：2007-10-17

    申请号：EP07101420.3

    申请日：2007-01-30

    申请人： Samsung Electronics Co., Ltd.

    发明人： Kim, Kui-hyun ,  Kim, Byung-chul ,  Kim, Su-hyeon

    IPC分类号： B01J19/00 ,  C40B60/14

    CPC分类号： C40B60/14 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00369 ,  B01J2219/00371 ,  B01J2219/00385 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00574 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00655 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  B01J2219/00731 ,  B01J2219/00743 ,  B01L3/0268 ,  B01L2400/027 ,  B01L2400/043 ,  G01N2035/1034 ,  Y10T436/25

    摘要： Provided is an apparatus for printing a biomolecular droplet onto a substrate (30, 70) using an electric charge concentration effect, the apparatus including: an electric field forming electrode (20) that is needle-shaped, is made of a conductive material, is disposed vertically, and includes an accommodating area (22) in which the biomolecular droplet including micro magnetic beads is accommodated and a nozzle (23) formed on a bottom end of the accommodating area (22) through which the biomolecular droplet is discharged; a substrate (30, 70) that is disposed below the electric field forming electrode (20), includes a target surface (31, 72) onto which the biomolecular droplet discharged from the nozzle (23) of the electric field forming electrode (20) is deposited, and is grounded; a magnet (40) that is disposed below the substrate (30, 70) to attract the micro magnetic beads by a magnetic force towards the substrate (30, 70); and an open circuit type voltage applying unit (60) which is electrically connected to the electric field forming electrode (20) to apply a charge to the electric field forming electrode (20), and causes the biomolecular droplet to be ejected onto the target surface (31, 72) of the substrate (30, 70) due to the force generated by the charge in the electric field forming electrode (20) and a charge induced by the charge in the electric field forming electrode (20) in the substrate (30, 70).

    摘要翻译： 本发明提供一种使用电荷集中效应将生物分子液滴印刷到基板（30,70）上的设备，该设备包括：针状的电场形成电极（20），由导电材料制成，是 并且包括容纳包含微珠的生物分子液滴的容纳区域（22）和形成在容纳区域（22）的底端上的喷嘴（23），生物分子液滴通过该底部释放; 配置在电场形成用电极20的下方的基板30,70具有从电场形成用电极20的喷嘴23喷出的生物分子的液滴被照射到的目标面31,72， 沉积并接地; 磁体（40），其设置在所述基板（30,70）下方以通过朝向所述基板（30,70）的磁力吸引所述微型磁珠; 和开路型电压施加单元（60），其电连接到电场形成电极（20），以将电荷施加到电场形成电极（20），并使生物分子液滴被喷射到目标表面上 由于电场形成电极（20）中的电荷产生的力以及由基板（30,70）中的电场形成电极（20）中的电荷引起的电荷而导致基板（30,70） 30，70）。

    Fluorescence detector for detecting microfluid
    8.
    发明公开
    Fluorescence detector for detecting microfluid 有权
    系统umfassend einen Fluoreszenznachweissystem und einen Mikrofluidchip mit einer Mikrokammer

    公开(公告)号：EP1550858A1

    公开(公告)日：2005-07-06

    申请号：EP04020439.8

    申请日：2004-08-27

    申请人： Samsung Electronics Co., Ltd.

    发明人： Kim, Su-hyeon ,  Kim, Jin-tae

    IPC分类号： G01N21/64

    CPC分类号： G01N21/645 ,  G01N2021/6482

    摘要： An ultra small fluorescence detector capable of detecting in real time reaction undergoing in a micro chamber having a predetermined volume and disposed on a microfluid chip is provided. The fluorescence detector for detecting in real time PCR amplification undergoing in the microfluid chip having a micro chamber with a predetermined volume includes a light source generating an excitation beam, a first optical system capable of irradiating the excitation beam having a predetermined spot size to the micro chamber, a first detector, and a second optical system reflecting a fluorescent beam derived from the excitation beam having the predetermined spot size in the micro chamber to the first detector. Accordingly, the fluorescence detector is designed such that light emitted by a light source is focused between a first mirror and an objective lens. Therefore, the spot size of an excitation beam transmitted by the objective lens is largely formed so that the excitation beam can be irradiated on the whole micro chamber of the microfluid chip, thereby detecting a fluorescent beam on a broader area.

    摘要翻译： 提供了能够实时检测在具有预定体积的微室中进行反应并设置在微流体芯片上的超小荧光检测器。 用于实时检测在具有预定体积的微室的微流体芯片中进行PCR扩增的荧光检测器包括产生激发光束的光源，能够将具有预定光斑尺寸的激发光束照射到微细的第一光学系统 室，第一检测器和第二光学系统，其将来自具有在微室中的预定光斑尺寸的激发光束的荧光束反射到第一检测器。 因此，荧光检测器被设计成使得由光源发射的光聚焦在第一反射镜和物镜之间。 因此，由物镜透射的激发光束的光斑尺寸大部分形成为使得激发光束能够照射在微流体芯片的整个微室上，从而在更广泛的区域上检测荧光束。