公开(公告)号：EP2309251A1

公开(公告)日：2011-04-13

申请号：EP10009248.5

申请日：2010-09-06

Applicant: Siemens Healthcare Diagnostics Products GmbH

Inventor： Meller, Paul, Dr. ,  Pufahl, Holger, Dr.

IPC: G01N21/25 ,  G01N35/00 ,  G01N1/38

CPC classification number: G01N21/253 ,  G01N21/0332 ,  G01N21/255 ,  G01N35/02 ,  G01N2021/0325 ,  G01N2021/825 ,  G01N2035/00534 ,  G01N2201/0407 ,  G01N2201/0423 ,  G01N2201/0453 ,  G01N2201/0627

Abstract: Die vorliegende Erfindung bezieht sich auf eine Vorrichtung (10,30,40,50,60) zur photometrischen Untersuchung von Proben. Sie weist eine Probenhalterungseinrichtung (11,31,41,51,61) für mindestens zwei Probengefäße sowie eine Messeinrichtung und eine bewegbare Einrichtung (14,34,44,54) auf. Die Probenhalterungseinrichtung ist dabei stationär ausgebildet, und die Messeinrichtung ist an der bewegbaren Einrichtung angeordnet, so dass sie mittels der bewegbaren Einrichtung verfahrbar ist.

Abstract translation: 装置（10）具有固定的样品保持器装置（11），其包括用于容纳两个样品容器的保持单元（15）。 测量装置布置在可移动装置（14）上并由可移动装置移位。 保持单元以弧形的方式设置在样品保持器装置上，并且测量装置以旋转的方式围绕弧形布置移位。 测量装置包括光源（12） LED或激光二极管，以及光电检测器（13）。 磁力搅拌器设置在样品架上。 还包括以下独立权利要求：（1）样品的光度检测方法（2）用于自动检查液体样品的分析仪器，包括样品的光度检测装置。

公开(公告)号：EP1902306A1

公开(公告)日：2008-03-26

申请号：EP06739501.2

申请日：2006-03-24

Applicant: 3M Innovative Properties Company

Inventor： BEDINGHAM, William ,  LUDOWISE, Peter D., ,  ROBOLE, Barry W.,

IPC: G01N21/64 ,  G01N35/00

CPC classification number: F16K99/003 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2200/025 ,  B01L2300/021 ,  B01L2300/0806 ,  B01L2400/0409 ,  B01L2400/0677 ,  F16K99/0001 ,  F16K99/004 ,  F16K2099/0084 ,  G01N21/0332 ,  G01N21/07 ,  G01N21/359 ,  G01N21/6428 ,  G01N21/6452 ,  G01N35/00069 ,  G01N35/1097 ,  G01N2021/0325 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2035/00267 ,  G01N2035/00415 ,  G01N2035/0474 ,  G01N2201/0407 ,  G01N2201/0415 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/0833 ,  Y10T436/11 ,  Y10T436/111666

Abstract: Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules that are optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector. In addition, the device may control the flow of fluid in the disk by locating and selectively opening valves separating chambers by heating the valves with a laser.

公开(公告)号：EP1899067A1

公开(公告)日：2008-03-19

申请号：EP06739539.2

申请日：2006-03-24

Applicant: 3M Innovative Properties Company

Inventor： BEDINGHAM, William D., ,  LUDOWISE, Peter D., ,  ROBOLE, Barry W.,

IPC: B01L7/00

CPC classification number: G01N21/645 ,  B01L3/5027 ,  B01L7/52 ,  B01L7/54 ,  B01L2200/147 ,  B01L2300/0806 ,  B01L2300/1805 ,  B01L2300/1844 ,  B01L2300/1872 ,  G01N21/07 ,  G01N21/6428 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/04 ,  G01N2201/0407 ,  G01N2201/08 ,  G01N2201/10 ,  G01N2201/101

Abstract: Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules that are optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector. The device further includes a heating element for heating one or more process chambers on the disk. In addition, the device may control the flow of fluid in the disk by locating and selectively opening valves separating chambers by heating the valves with a laser.

公开(公告)号：EP1830174A3

公开(公告)日：2007-09-12

申请号：EP07011773.4

申请日：2006-01-03

Applicant: Samsung Electronics Co., Ltd

Inventor： Ok, Gyeong-sik ,  Kim, Su-hyeon ,  Kim, Jin-tae ,  Oh, Kwang-wook

IPC: G01N21/64 ,  G01N21/05 ,  G01J3/44 ,  C12M1/34 ,  C12Q1/68

CPC classification number: G01J3/10 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/4406 ,  G01J2003/1213 ,  G01N21/05 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2021/0346 ,  G01N2021/3174 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0221 ,  G01N2201/0407 ,  G01N2201/0461 ,  G01N2201/0612 ,  G01N2201/0627 ,  G01N2201/0631 ,  G01N2201/0806 ,  G01N2201/0833

Abstract: A multi-channel fluorescence measuring optical system and a multi-channel fluorescence sample analyzer using the optical system are provided. The multi-channel fluorescence measuring optical system, which irradiates light onto a plurality of sample channels and detecting fluorescence radiated from samples, includes: a light source (60a-d); an integrator (70) for giving the light irradiated from the light source a uniform intensity distribution; a sample holder (80) having a plurality of sample channels on which the samples (m) are mounted, wherein the samples are exited by the light emitted from the integrator; and a beam splitter (75) between the integrator and the sample holder for dividing the incident light in a predetermined ratio. Since the light intensities of fluorescence images are detected using optical fiber bundles (85a-d) and photodiodes (89a-d), the manufacturing cost can be greatly reduced, and the optical system can be miniaturized.

公开(公告)号：EP0240219A2

公开(公告)日：1987-10-07

申请号：EP87302454.1

申请日：1987-03-23

Applicant: IBG Systems Limited

Inventor： Bowley, Alan Reginald

IPC: G01N21/82 ,  G01N21/25

CPC classification number: G01N21/253 ,  G01N2201/0407 ,  G01N2201/0446 ,  G01N2201/0621

Abstract: A photometric reading device comprises a plurality of reading elements (30), each comprising a light emitting diode and a corresponding photodiode on opposing sides of a sample pathway along which a sample microplate (l0) can travel. The microplate (l0) includes rows of sample wells arranged transverse to the line of relative motion of the microplate (l0) and the reading elements (30).
The reading elements (30) are arranged such that, during continuous relative motion of the reading elements (30) and the microplate (l0), the reading elements (30) come into registration sequentially with the wells in the first row of wells in the microplate (l0), then with the wells in the second row of wells, and so on.

Abstract translation: 光度读取装置包括多个读取元件（30），每个读取元件（30）包括发光二极管和相应的光电二极管，所述对应的光电二极管位于样品通路的相对侧，样品微孔板可以沿着样本路径行进。 微板（10）包括横列于微板（10）和读取元件（30）的相对运动线的样本阱排。 读取元件（30）被布置成使得在读取元件（30）和微板（10）的连续相对运动期间，读取元件（30）顺序地与第一排孔中的孔对准 微孔板（10），然后用第二排孔中的孔等等。

公开(公告)号：EP0173021A2

公开(公告)日：1986-03-05

申请号：EP85107877.4

申请日：1985-06-25

Applicant: WAKO PURE CHEMICAL INDUSTRIES, LTD.

Inventor： Sakata, Yoshitsugu ,  Oishi, Haruki ,  Hatayama, Yasumichi ,  Shiraishi, Hirome ,  Yanagisawa, Kazuya

IPC: G01N33/50

CPC classification number: G01N33/579 ,  G01N21/83 ,  G01N33/50 ,  G01N2201/0407 ,  Y10S436/805

Abstract: 57 Endotoxin contents in samples can be determined qualitatively or quantitatively, singly or in parallel, with high precision in a short time by a process comprising applying a light to each sample solution, measuring an initial transmitted light amount l o and a transmitted light amount at a time t, I(t), to give a ratio R(t) = l(t)/l o , and judging a gelation point by a threshold value of R(t), or further obtaining a gelation time from the gelation point. An apparatus used therefore is also disclosed.

Abstract translation: 样品中的内毒素含量可以通过包括向每个样品溶液施加光，一次测量初始透射光量I0和透射光量的方法，在短时间内以高精度定性或定量地，单独或并行地测定 t，I（t），得到比例R（t）= I（t）/ I0，并且通过R（t）的阈值判断凝胶化点，或进一步从凝胶化点获得凝胶化时间。 还公开了一种用于其的设备。

公开(公告)号：EP1991860A4

公开(公告)日：2011-08-03

申请号：EP07717653

申请日：2007-02-23

Applicant: GEN ELECTRIC

Inventor： FOMITCHOV PAVEL A ,  BARASH EUGENE ,  YEKTA AHMAD ,  MASINO JOSEPH

IPC: G01N23/00 ,  G02B21/00

CPC classification number: G01N21/6458 ,  G01N21/47 ,  G01N2201/0407 ,  G01N2201/1042 ,  G02B21/0048 ,  G02B21/0076 ,  G02B21/367

公开(公告)号：EP0565700B1

公开(公告)日：1996-08-21

申请号：EP92923464.9

申请日：1992-10-27

Applicant: Dade MicroScan Inc.

Inventor： GARAND, Steven, A. ,  DANIEL, Carl, P.

IPC: H02P8/00

CPC classification number: G01N35/1002 ,  G01N35/025 ,  G01N35/028 ,  G01N2021/1759 ,  G01N2035/00079 ,  G01N2035/00455 ,  G01N2035/042 ,  G01N2035/0425 ,  G01N2035/0463 ,  G01N2035/0475 ,  G01N2201/0407 ,  G01N2201/0446 ,  G01N2201/08 ,  G01N2201/1283

Abstract: An improved control system for a stepper motor coil (190) includes a flyback circuit (192) that dissipates coil energy slowly while the coil is energized and operated in the chopping mode, while dissipating coil energy rapidly when the coil is switched to its de-energized phase.

公开(公告)号：EP0449900B1

公开(公告)日：1996-04-10

申请号：EP90900766.8

申请日：1989-12-21

Applicant: RADIOMETER MEDICAL A/S

Inventor： LUNDSGAARD, Finn, Chresten ,  ANDERSEN, Willy ,  JENSEN, Niels-Henrik

IPC: G01N21/11 ,  G01N33/49

CPC classification number: G01N21/03 ,  G01N21/05 ,  G01N21/251 ,  G01N21/255 ,  G01N21/276 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/80 ,  G01N33/4925 ,  G01N33/497 ,  G01N2021/0346 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3148 ,  G01N2021/3166 ,  G01N2021/6417 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/7786 ,  G01N2021/8405 ,  G01N2035/00306 ,  G01N2035/00316 ,  G01N2035/1062 ,  G01N2201/0407 ,  G01N2201/0476 ,  G01N2201/0618 ,  G01N2201/1288

Abstract: The method is a method of photometric in vitro determination of a blood gas parameter in a blood sample. The blood sample is transferred directly from an in vivo locality to an at least partially transparent sample container, whereafter the connection between the sample containing sample container and the blood circulation is broken. Subsequently the sample container with its content of blood sample is brought into optical communication with an optical system comprising a radiation source and a radiation detector interacting therewith, preferably by placing the sample container in a sample container system in an analyzer. The blood gas parameter is determined on the basis of the radiation detected by the radiation detector. A system for photometric in vitro determination of a blood gas parameter in a blood sample is also described.

公开(公告)号：EP0449899B1

公开(公告)日：1994-09-28

申请号：EP90900765.0

申请日：1989-12-21

Applicant: RADIOMETER MEDICAL A/S

Inventor： LUNDSGAARD, Finn, Chresten ,  ANDERSEN, Willy ,  JENSEN, Niels-Henrik

IPC: G01N21/64 ,  G01N33/48

CPC classification number: G01N21/03 ,  G01N21/05 ,  G01N21/251 ,  G01N21/255 ,  G01N21/276 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/80 ,  G01N33/4925 ,  G01N33/497 ,  G01N2021/0346 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3148 ,  G01N2021/3166 ,  G01N2021/6417 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/7786 ,  G01N2021/8405 ,  G01N2035/00306 ,  G01N2035/00316 ,  G01N2035/1062 ,  G01N2201/0407 ,  G01N2201/0476 ,  G01N2201/0618 ,  G01N2201/1288

Abstract: The method according to the invention is a method of photometric in vitro determination of the content of oxygen in a blood sample. The blood sample is transferred directly from an in vivo locality to an at least partially transparent sample container of a sampling device. The sample container has a measuring chamber wherein a luminophor is provided, whereof the luminescence is quenched in the presence of oxygen. The oxygen content is determined on the basis of the radiation detected by the radiation detector. A sampling device and a system for photometric in vitro determination of oxygen in a blood sample is also described.