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公开(公告)号：EP3149023A4
公开(公告)日：2017-11-22
申请号：EP14893573
申请日：2014-05-29
CPC分类号： C07K14/4702 , B01D15/12 , B01D15/34 , B01D15/363 , C07K1/36 , C07K14/4703
摘要： Methods are provided for extracting DNA-compaction proteins from biological samples.
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公开(公告)号：EP3113865A4
公开(公告)日：2017-11-01
申请号：EP15758427
申请日：2015-03-09
发明人： GAGNON PETER STANLEY
CPC分类号： B01D61/58 , B01D61/142 , B01D61/18 , B01D2311/04 , B01D2311/08 , B01D2311/12 , B01D2311/25 , B01D2311/2623 , B01D2311/2626 , B01D2315/10 , B01D2315/16 , B01D2317/04 , B01D2325/42 , C07K1/34 , C07K16/00
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公开(公告)号：EP3057617A4
公开(公告)日：2017-08-23
申请号：EP14854108
申请日：2014-10-20
CPC分类号： A61K33/38 , A61K9/0014 , A61K9/06 , A61K9/14 , A61K9/146 , A61K47/42 , A61L15/32 , A61L15/46 , A61L15/60 , A61L27/446 , A61L27/52 , A61L27/54 , A61L29/085 , A61L29/145 , A61L29/16 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/102 , A61L2400/12 , A61L2420/04 , C07K7/06 , C07K17/04 , C08L77/04
摘要： There is provided a nanoparticle-containing hydrogel comprising metal nanoparticles and at least one peptide. The nanoparticle-containing hydrogel may possess antibacterial activity. There is also provided a method for preparing the nanoparticle-containing hydrogel, and compositions and uses thereof.
摘要翻译： 提供了包含金属纳米颗粒和至少一种肽的含纳米颗粒的水凝胶。 含纳米粒子的水凝胶可具有抗菌活性。 还提供了用于制备含纳米粒子的水凝胶的方法，以及其组合物和用途。
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公开(公告)号：EP3076860A4
公开(公告)日：2017-05-31
申请号：EP14868398
申请日：2014-12-08
发明人： OLIVO MALINI , HO JUN HUI , UNNIMADHAVA KURUP SOUDAMINI AMMA DINISH , WONG CHI LOK , BALASUNDARAM GHAYATHRI
CPC分类号： A61B5/0095 , A61B8/481 , A61K49/003 , A61K49/0036 , A61K49/0093 , A61K49/22 , G01N33/4833
摘要： A method of imaging living tissue is provided. The method includes introducing a photoacoustic contrast agent comprising or consisting of a photosensitizer into living tissue; and obtaining an image of the living tissue by photoacoustic imaging. Use of a photoacoustic contrast agent comprising or consisting of a photosensitizer in photoacoustic imaging is also provided.
摘要翻译： 提供了一种对活组织进行成像的方法。 该方法包括将包含光敏剂或由光敏剂组成的光声对比剂引入活组织中; 并通过光声成像获得活组织的图像。 还提供了在光声成像中使用包含光敏剂或由光敏剂组成的光声造影剂。
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5.发明公开METHOD FOR DIFFERENTIATING INDUCED PLURIPOTENT STEM CELLS INTO RENAL PROXIMAL TUBULAR CELL-LIKE CELLS 审中-公开DISTINCTION的干细胞肾近曲诱导多能干PIPE细胞样细胞的方法
公开(公告)号：EP3068871A4
公开(公告)日：2017-05-03
申请号：EP14859928
申请日：2014-11-11
发明人： ZINK DANIELE , YING JACKIE Y
CPC分类号： C12N5/0686 , A61K35/22 , A61K35/545 , A61L27/3604 , A61L27/3641 , A61L27/3839 , A61L27/3895 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/64 , A61L2430/26 , A61L2430/40 , C12N2501/155 , C12N2501/727 , C12N2506/45 , C12N2533/90
摘要： A population of renal proximal tubular cell (PTC)-like cells differentiated from a population of induced pluripotent stem cells (iPSCs) seeded at a density of about 5 000 to about 10 000 viable cells/cm 2 , in renal epithelial cell culture medium in the presence of one or more extracellular matrix molecule, bone morphogenic protein 2, and bone morphogenic protein 7, for a period of from about 7 to about 10 days. A bioengineered tissue graft comprising a matrix, seeded with the population of cells. A bioartificial kidney device containing the population of cells for use in the treatment of a renal related disorder in a subject. The population of cells or the bioengineered tissue graft for use in treatment of a renal related disorder in a subject.
摘要翻译： 提供了分化为诱导的多能干细胞（IPSC）样细胞引入肾近端小管细胞（PTC）的方法。 该方法从关于包括未分化的iPSC的培养在一个或多种细胞外基质（ECM）分子，骨形态发生蛋白2（BMP2）和骨形态发生蛋白7（BMP-7）的存在下，肾上皮细胞培养基，持续一段 8至约10天的条件下足以诱导的iPSC分化成PTC样细胞。 因此分化的PTC样细胞的细胞群体被提供，以及用途和使用该细胞群体的方法。
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6.发明公开POLYMER-FLAVONOID CONJUGATES AND HYDROGELS FOR BIOMEDICAL APPLICATIONS 审中-公开聚合物 - 佛波酯 - 氢氧化钠在氢化物生物降解化学
公开(公告)号：EP3041830A4
公开(公告)日：2017-04-05
申请号：EP14842488
申请日：2014-09-01
发明人： KURISAWA MOTOICHI , BAE KI HYUN
IPC分类号： C07D311/32 , A61K8/04 , A61K8/49 , A61K8/73 , A61K8/81 , A61K9/00 , A61K9/06 , A61K31/353 , A61K38/00 , A61K39/00 , A61K47/32 , A61K47/36 , A61K47/42 , A61Q19/00
CPC分类号： A61K47/4823 , A61K8/042 , A61K8/498 , A61K8/735 , A61K8/8147 , A61K9/0019 , A61K9/06 , A61K31/353 , A61K47/32 , A61K47/36 , A61K47/61 , A61K2800/57 , A61K2800/91 , A61Q19/00 , C07D311/32
摘要： There is provided polymer-flavonoid conjugates. Flavonoid-grafted and flavonoid-terminated polymer conjugates are disclosed according to the invention. The linkage of flavonoids to the polymers has been achieved via thiol linkages. The inventive processes allow for making of the conjugates in high yield avoiding complex purification steps. The conjugates can be easily autoxidized to hydrogels with uses in many biomedical applications where a higher stability of the flavonoid is necessary. The hydrogels can be potentially used as viscosupplement, anti-adhesion film or dermal filler.
摘要翻译： 提供聚合物 - 类黄酮轭合物。 根据本发明公开了类黄酮接枝和类黄酮封端的聚合物缀合物。 类黄酮与聚合物的连接已经通过硫醇键来实现。 本发明的方法允许以高产率制备缀合物，避免了复杂的纯化步骤。 缀合物可以容易地自动氧化成水凝胶，其用途在许多生物医学应用中，其中黄酮类化合物的稳定性更高。 水凝胶可以用作粘稠补充剂，抗粘连膜或真皮填料。
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公开(公告)号：EP3052501A4
公开(公告)日：2017-03-29
申请号：EP14851209
申请日：2014-10-03
IPC分类号： C07D487/04 , A61K31/437 , A61K31/519 , A61K31/535 , A61P3/10 , A61P35/00 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： The present invention relates to certain compounds (e.g., imidazopyrazine, imidazopyridine, imidazopyridazine and imidazopyrimidine compounds) that act as inhibitors of the MAP kinase interacting kinases MNK2a, MNK2b, MNK1a, and MNK1b. The present invention further relates to pharmaceutical compositions comprising these compounds, and to the use of the compounds for the prevention and treatment of diseases (e.g., proliferative diseases (e.g., cancer), inflammatory diseases, autoimmune diseases, metabolic diseases, and neurodegenerative diseases (e.g. autism, autism spectrum disorders, Alzheimer's disease)), as well as methods of treating these diseases.
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8.发明公开
公开(公告)号：EP2583524A4
公开(公告)日：2017-03-15
申请号：EP11798276
申请日：2011-06-20
发明人： NISHIKAWA DAISUKE , ABE TETSUSHI , TANNO MOTOHIRO , LEI ZHONGDING , WONG SAI HO , CHIN FRANCOIS PO SHIN
CPC分类号： H04W72/082 , H04W72/0426 , H04W72/1215 , H04W84/045
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公开(公告)号：EP2906724A4
公开(公告)日：2016-12-14
申请号：EP13845996
申请日：2013-10-11
IPC分类号： C12Q1/68 , A61K39/395 , A61K48/00 , G01N33/48
CPC分类号： C12Q1/6886 , C12N15/111 , C12N2310/141 , C12N2320/10 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
摘要： A method for the prognosis of overall survival or prediction of therapeutic outcome for a patient suffering from epithelial ovarian cancer (EOC), comprising: a. providing a metabolism response sample from the patient, b. determining the expression level of microRNA family lethal-7b (let-7b) in the sample; c. using the expression level of the let-7b to obtain the prognosis of overall survival or prediction of therapeutic outcome for the patient.
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10.发明公开CHROMATOGRAPHIC PURIFICATION OF VIRUS PREPARATIONS WITH NEGATIVELY CHARGED PARTICLES 审中-公开色谱清洗的，带负电荷的粒子病毒制备
公开(公告)号：EP2958995A4
公开(公告)日：2016-11-23
申请号：EP13875750
申请日：2013-02-22
发明人： GAGNON PETER
CPC分类号： C12N7/00 , B01D15/22 , B01D15/34 , B01D15/362 , B01D15/363 , B01D15/3847 , B01D15/424 , B01D61/145 , C12N2710/00051 , C12N2750/00051 , C12N2795/10151 , C12N2795/14151
摘要： A method of purifying a sample that includes a desired virus includes the steps of (i) providing a packed chromatographic column having negatively charged porous particles, (ii) equilibrating the column to the conditions to which the desired virus in the sample is to elute, (iii) contacting the sample with the packed chromatographic column such that the sample volume applied to the packed chromatographic column is less than or equal to the interparticle space of the negatively charged porous particles within the packed chromatographic column, (iv) eluting the desired virus from the packed chromatographic column, where the desired virus is in a purer state and in the conditions to which the packed chromatographic column was equilibrated.
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