公开(公告)号：EP3141598A3

公开(公告)日：2017-06-21

申请号：EP16180193.1

申请日：2016-07-19

申请人： Cj Cheiljedang Corporation

发明人： PARK, Su Jin ,  YANG, Young Lyeol ,  UM, Hye Won ,  LI, Hong Xian ,  LEE, Kyoung Min ,  LEE, Baek Seok ,  LEE, Hyo Hyoung ,  JUNG, Hee Kyoung

IPC分类号： C12N1/21 ,  C12N9/80 ,  C12N9/10 ,  C12N15/52 ,  C12P13/00

CPC分类号： C12N9/1029 ,  C12N9/1217 ,  C12N9/80 ,  C12N9/88 ,  C12N9/93 ,  C12N15/52 ,  C12P13/001 ,  C12P13/10 ,  C12Y203/01001 ,  C12Y203/01008 ,  C12Y207/02001 ,  C12Y305/01016 ,  C12Y401/01017 ,  C12Y602/01001

摘要： Disclosed is a modified microorganism producing putrescine or ornithine, and a method for producing putrescine or ornithine using the same.

摘要翻译： 公开了产生腐胺或鸟氨酸的修饰微生物，以及使用该微生物产生腐胺或鸟氨酸的方法。

公开(公告)号：EP3047030A4

公开(公告)日：2017-02-22

申请号：EP14846017

申请日：2014-09-17

申请人： ZYMOCHEM INC

发明人： CHOKHAWALA HARSHAL

IPC分类号： C12P7/18 ,  C12N15/52 ,  C12P7/42 ,  C12P7/44 ,  C12P13/00 ,  C12P17/08 ,  C12P17/10

CPC分类号： C12N15/52 ,  C12N9/00 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/0016 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/1205 ,  C12N9/13 ,  C12N9/16 ,  C12N9/2402 ,  C12N9/88 ,  C12N9/93 ,  C12P7/04 ,  C12P7/18 ,  C12P7/24 ,  C12P7/40 ,  C12P7/42 ,  C12P7/44 ,  C12P7/6409 ,  C12P13/001 ,  C12P13/005 ,  C12P17/08 ,  C12P17/10 ,  C12Y101/01001 ,  C12Y101/01002 ,  C12Y101/01035 ,  C12Y101/01078 ,  C12Y101/01268 ,  C12Y101/01269 ,  C12Y102/01003 ,  C12Y102/01005 ,  C12Y102/01022 ,  C12Y102/01024 ,  C12Y102/01026 ,  C12Y102/01048 ,  C12Y102/01063 ,  C12Y102/07005 ,  C12Y102/99006 ,  C12Y103/01044 ,  C12Y103/01045 ,  C12Y103/01086 ,  C12Y104/01 ,  C12Y203/01001 ,  C12Y203/01032 ,  C12Y203/01035 ,  C12Y203/01057 ,  C12Y206/01008 ,  C12Y206/01009 ,  C12Y206/01036 ,  C12Y206/01043 ,  C12Y206/01048 ,  C12Y206/01076 ,  C12Y206/01082 ,  C12Y207/01031 ,  C12Y207/01165 ,  C12Y208/03 ,  C12Y301/03 ,  C12Y301/03002 ,  C12Y301/03008 ,  C12Y301/03019 ,  C12Y301/0302 ,  C12Y302/01 ,  C12Y401/01001 ,  C12Y401/02 ,  C12Y401/02014 ,  C12Y401/0202 ,  C12Y401/02021 ,  C12Y401/03016 ,  C12Y401/03017 ,  C12Y402/01002 ,  C12Y402/01003 ,  C12Y402/01028 ,  C12Y402/0103 ,  C12Y402/01079 ,  C12Y402/0112 ,  C12Y602/01 ,  Y02E50/343

摘要： Provided herein are methods, compositions, and non-naturally occurring microbial organism for preparing compounds such as 1-butanol, butyric acid, succinic acid, 1,4-butanediol, 1-pentanol, pentanoic acid, glutaric acid, 1,5-pentanediol, 1-hexanol, hexanoic acid, adipic acid, 1,6-hexanediol, 6-hydroxy hexanoic acid, ε-Caprolactone, 6-amino-hexanoic acid, ε-Caprolactam, hexamethylenediamine, linear fatty acids and linear fatty alcohols that are between 7-25 carbons long, linear alkanes and linear α-alkenes that are between 6-24 carbons long, sebacic acid and dodecanedioic acid comprising: a) converting a CN aldehyde and pyruvate to a CN+3 β-hydroxyketone intermediate through an aldol addition; and b) converting the CN+3β-hydroxyketone intermediate to the compounds through enzymatic steps, or a combination of enzymatic and chemical steps.

公开(公告)号：EP3141598B1

公开(公告)日：2018-10-31

申请号：EP16180193.1

申请日：2016-07-19

申请人： CJ Cheiljedang Corporation

发明人： PARK, Su Jin ,  YANG, Young Lyeol ,  UM, Hye Won ,  LI, Hong Xian ,  LEE, Kyoung Min ,  LEE, Baek Seok ,  LEE, Hyo Hyoung ,  JUNG, Hee Kyoung

IPC分类号： C12N1/21 ,  C12N9/80 ,  C12N9/10 ,  C12N15/52 ,  C12P13/00

CPC分类号： C12N9/1029 ,  C12N9/1217 ,  C12N9/80 ,  C12N9/88 ,  C12N9/93 ,  C12N15/52 ,  C12P13/001 ,  C12P13/10 ,  C12Y203/01001 ,  C12Y203/01008 ,  C12Y207/02001 ,  C12Y305/01016 ,  C12Y401/01017 ,  C12Y602/01001

摘要： Disclosed is a modified microorganism producing putrescine or ornithine, and a method for producing putrescine or ornithine using the same.

公开(公告)号：EP3227440A1

公开(公告)日：2017-10-11

申请号：EP15816329.5

申请日：2015-12-04

申请人： Synlogic, Inc.

发明人： FALB, Dean ,  ISABELLA, Vincent, M. ,  KOTULA, Jonathan, W. ,  MILLER, Paul, F.

IPC分类号： C12N9/10 ,  C12R1/19 ,  C12N15/52 ,  C12N15/70 ,  C12P13/10 ,  C12R1/01

CPC分类号： C12N9/1029 ,  A61K35/741 ,  C07K14/245 ,  C12N9/1025 ,  C12N15/52 ,  C12N15/70 ,  C12P13/10 ,  C12R1/01 ,  C12R1/19 ,  C12Y203/01001

摘要： Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating disorders associated with hyperammonemia are disclosed.

摘要翻译： 公开了基因工程细菌，其药物组合物以及调节和治疗与高氨血症相关的病症的方法。

公开(公告)号：EP3047030A2

公开(公告)日：2016-07-27

申请号：EP14846017.3

申请日：2014-09-17

申请人： Zymochem Inc.

发明人： CHOKHAWALA, Harshal

IPC分类号： C12P7/40

CPC分类号： C12N15/52 ,  C12N9/00 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/0016 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/1205 ,  C12N9/13 ,  C12N9/16 ,  C12N9/2402 ,  C12N9/88 ,  C12N9/93 ,  C12P7/04 ,  C12P7/18 ,  C12P7/24 ,  C12P7/40 ,  C12P7/42 ,  C12P7/44 ,  C12P7/6409 ,  C12P13/001 ,  C12P13/005 ,  C12P17/08 ,  C12P17/10 ,  C12Y101/01001 ,  C12Y101/01002 ,  C12Y101/01035 ,  C12Y101/01078 ,  C12Y101/01268 ,  C12Y101/01269 ,  C12Y102/01003 ,  C12Y102/01005 ,  C12Y102/01022 ,  C12Y102/01024 ,  C12Y102/01026 ,  C12Y102/01048 ,  C12Y102/01063 ,  C12Y102/07005 ,  C12Y102/99006 ,  C12Y103/01044 ,  C12Y103/01045 ,  C12Y103/01086 ,  C12Y104/01 ,  C12Y203/01001 ,  C12Y203/01032 ,  C12Y203/01035 ,  C12Y203/01057 ,  C12Y206/01008 ,  C12Y206/01009 ,  C12Y206/01036 ,  C12Y206/01043 ,  C12Y206/01048 ,  C12Y206/01076 ,  C12Y206/01082 ,  C12Y207/01031 ,  C12Y207/01165 ,  C12Y208/03 ,  C12Y301/03 ,  C12Y301/03002 ,  C12Y301/03008 ,  C12Y301/03019 ,  C12Y301/0302 ,  C12Y302/01 ,  C12Y401/01001 ,  C12Y401/02 ,  C12Y401/02014 ,  C12Y401/0202 ,  C12Y401/02021 ,  C12Y401/03016 ,  C12Y401/03017 ,  C12Y402/01002 ,  C12Y402/01003 ,  C12Y402/01028 ,  C12Y402/0103 ,  C12Y402/01079 ,  C12Y402/0112 ,  C12Y602/01 ,  Y02E50/343

摘要： Provided herein are methods, compositions, and non-naturally occurring microbial organism for preparing compounds such as1-butanol, butyric acid, succinic acid, 1,4-butanediol, 1-pentanol, pentanoic acid, glutaric acid, 1,5-pentanediol, 1-hexanol, hexanoic acid, adipic acid, 1,6-hexanediol, 6-hydroxy hexanoic acid, ε-Caprolactone, 6-amino-hexanoic acid, ε-Caprolactam, hexamethylenediamine, linear fatty acids and linear fatty alcohols that are between 7-25 carbons long, linear alkanes and linear -alkenes that are between 6-24 carbons long, sebacic acid and dodecanedioic acid comprising: a) converting a C
N aldehyde and pyruvate to a C
N+3 -hydroxyketone intermediate through an aldol addition; and b) converting the C
N+3 -hydroxyketone intermediate to the compounds through enzymatic steps, or a combination of enzymatic and chemical steps.

摘要翻译： 例如1-丁醇，丁酸，琥珀酸，1,4-丁二醇，1-戊醇，戊酸，戊二酸，1,5-戊二醇：在一些方法，组合物，和非天然存在的微生物有机体制备化合物提供 ，1-己醇，己酸，己二酸，1,6-己二醇，6-羟基己酸，ε己内酯，6-氨基己酸，ε己内酰胺，六亚甲基二胺，直链脂肪酸和直链脂肪醇是没之间 7-25个碳原子的长的，直链烷烃和直链α烯烃没有被之间6-24个碳原子长，癸二酸和十二烷二酸包括：a）通过醛醇加成转换CN醛和丙酮酸到CN + 3β羟基中间体 ; 和b）将所述CN +3β羟基酮的中间产物以通过酶促步骤的化合物中，或酶和化学步骤的组合。

公开(公告)号：EP2522720B1

公开(公告)日：2018-03-28

申请号：EP10842313.8

申请日：2010-12-29

申请人： CJ Cheiljedang Corp.

发明人： CHO, Jin-Man ,  KIM, Hye-Won ,  LEE, Ji-Hye ,  CHO, Jae-Yong

IPC分类号： C12N9/00 ,  C12N15/52 ,  C12P13/10

CPC分类号： C12P13/10 ,  C12N9/1029 ,  C12N9/80 ,  C12Y203/01001 ,  C12Y305/01016

摘要： The present invention relates to a polynucleotide that is active to an acetyl glutamate synthase and acetyl ornithinase which are associated with ornithine or arginine biosynthesis from Corynebacterium glutamicum. The present invention also relates to a polypeptide encoded by said polynucleotide, a recombinant vector comprising said polynucleotide, to a transformant obtained by introducing said recombinant vector to a host microorganism for producing L-ornithine or L-arginine, and transforming the recombinant vector, and to a method for producing L-ornithine or L-arginine by culturing said transformant. The activity of the transformant of the present invention to an acetyl glutamate synthase and acetyl ornithinase is increased as compared to an intrinsic activity, and thus L-ornithine or L-arginine can be produced, at a high yield rate, from the transformant of the present invention.

公开(公告)号：EP3141598A2

公开(公告)日：2017-03-15

申请号：EP16180193.1

申请日：2016-07-19

申请人： Cj Cheiljedang Corporation

发明人： PARK, Su Jin ,  YANG, Young Lyeol ,  UM, Hye Won ,  LI, Hong Xian ,  LEE, Kyoung Min ,  LEE, Baek Seok ,  LEE, Hyo Hyoung ,  JUNG, Hee Kyoung

IPC分类号： C12N1/21 ,  C12N9/80 ,  C12N9/10 ,  C12N15/52 ,  C12P13/00

CPC分类号： C12N9/1029 ,  C12N9/1217 ,  C12N9/80 ,  C12N9/88 ,  C12N9/93 ,  C12N15/52 ,  C12P13/001 ,  C12P13/10 ,  C12Y203/01001 ,  C12Y203/01008 ,  C12Y207/02001 ,  C12Y305/01016 ,  C12Y401/01017 ,  C12Y602/01001

摘要： Disclosed is a modified microorganism producing putrescine or ornithine, and a method for producing putrescine or ornithine using the same.

摘要翻译： 本发明公开了经修饰的微生物生产腐胺或鸟氨酸，和用于使用相同的鸟氨酸生产腐胺或方法。

公开(公告)号：EP3041820A1

公开(公告)日：2016-07-13

申请号：EP14765893.4

申请日：2014-09-02

申请人： Stegmann, Efthimia ,  Wohlleben, Wolfgang ,  Spohn, Marius ,  Weber, Tilman

发明人： Stegmann, Efthimia ,  Wohlleben, Wolfgang ,  Spohn, Marius ,  Weber, Tilman

IPC分类号： C07C227/18 ,  C07K14/195

CPC分类号： C12P13/04 ,  C07K14/195 ,  C12N9/0016 ,  C12N9/0069 ,  C12N9/1029 ,  C12N9/80 ,  C12N9/88 ,  C12Y113/1102 ,  C12Y203/01001 ,  C12Y401/0102

摘要： The present invention relates to isolated nucleic acids and proteins or peptides for the biosynthesis of [S,S]-ethylenediamine disuccinate ([S,S]-EDDS), expression and deletion vectors, host cells and deletion mutants, a method and a kit for the biosynthesis of [S,S]-EDDS.

摘要翻译： 分离的蛋白质或肽，其用于[S，S] - 乙二胺 - 二琥珀酸盐的生物合成的部分合成步骤，包括或由选自SEQ ID No.39，SEQ ID No.39所示的氨基酸序列组成 第41号，SEQ ID No.43，SEQ ID No.45，SEQ ID No.47，SEQ ID No.49，SEQ ID No.51，SEQ ID No.53及其组合。

公开(公告)号：EP2522720A4

公开(公告)日：2013-06-12

申请号：EP10842313

申请日：2010-12-29

申请人： CJ CHEILJEDANG CORP

发明人： CHO JIN-MAN ,  KIM HYE-WON ,  LEE JI-HYE ,  CHO JAE-YONG

IPC分类号： C12N9/00 ,  C12N15/52 ,  C12P13/10

CPC分类号： C12P13/10 ,  C12N9/1029 ,  C12N9/80 ,  C12Y203/01001 ,  C12Y305/01016

摘要： The present invention relates to a polynucleotide that is active to an acetyl glutamate synthase and acetyl ornithinase which are associated with ornithine or arginine biosynthesis from Corynebacterium glutamicum. The present invention also relates to a polypeptide encoded by said polynucleotide, a recombinant vector comprising said polynucleotide, to a transformant obtained by introducing said recombinant vector to a host microorganism for producing L-ornithine or L-arginine, and transforming the recombinant vector, and to a method for producing L-ornithine or L-arginine by culturing said transformant. The activity of the transformant of the present invention to an acetyl glutamate synthase and acetyl ornithinase is increased as compared to an intrinsic activity, and thus L-ornithine or L-arginine can be produced, at a high yield rate, from the transformant of the present invention.

摘要翻译： 本发明涉及与谷氨酸棒杆菌的鸟氨酸或精氨酸生物合成相关的乙酰谷氨酸合成酶和乙酰鸟氨酸酶有活性的多核苷酸。 本发明还涉及由所述多核苷酸编码的多肽，包含所述多核苷酸的重组载体，通过将所述重组载体导入用于产生L-鸟氨酸或L-精氨酸的宿主微生物和转化重组载体而获得的转化体，以及 涉及通过培养所述转化体生产L-鸟氨酸或L-精氨酸的方法。 与内在活性相比，本发明的转化体对乙酰谷氨酸合成酶和乙酰鸟氨酸酶的活性增加，因此L-鸟氨酸或L-精氨酸可以高产率从 本发明。

公开(公告)号：EP2522720A2

公开(公告)日：2012-11-14

申请号：EP10842313.8

申请日：2010-12-29

申请人： CJ Cheiljedang Corp.

发明人： CHO, Jin-Man ,  KIM, Hye-Won ,  LEE, Ji-Hye ,  CHO, Jae-Yong

IPC分类号： C12N9/00 ,  C12N15/52 ,  C12P13/10

CPC分类号： C12P13/10 ,  C12N9/1029 ,  C12N9/80 ,  C12Y203/01001 ,  C12Y305/01016

摘要： The present invention relates to a polynucleotide that is active to an acetyl glutamate synthase and acetyl ornithinase which are associated with ornithine or arginine biosynthesis from Corynebacterium glutamicum. The present invention also relates to a polypeptide encoded by said polynucleotide, a recombinant vector comprising said polynucleotide, to a transformant obtained by introducing said recombinant vector to a host microorganism for producing L-ornithine or L-arginine, and transforming the recombinant vector, and to a method for producing L-ornithine or L-arginine by culturing said transformant. The activity of the transformant of the present invention to an acetyl glutamate synthase and acetyl ornithinase is increased as compared to an intrinsic activity, and thus L-ornithine or L-arginine can be produced, at a high yield rate, from the transformant of the present invention.