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    COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC SYNDROME
    2.
    发明公开
    COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC SYNDROME 审中-公开
    ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG DES STOFFWECHSELSYNDROMS

    公开(公告)号：EP2847152A1

    公开(公告)日：2015-03-18

    申请号：EP13788579.4

    申请日：2013-02-03

    申请人： Cellixbio Private Limited

    发明人： KANDULA, Mahesh

    IPC分类号： C07C23/00 ,  C07C22/00 ,  A61K31/381 ,  A61K31/429 ,  A61K31/11 ,  A61K31/12 ,  A61K31/192 ,  A61P3/02 ,  A61P3/04 ,  A61P3/06 ,  A61P3/08 ,  A61P9/00 ,  A61P9/10 ,  A61P13/00 ,  A61P13/12

    CPC分类号： A61K31/198 ,  A61K31/202 ,  A61K31/216 ,  A61K31/385 ,  C07C57/02 ,  C07C59/68 ,  C07D339/04

    摘要： The invention relates to the compounds of formula (I) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula (I), and methods for the treatment of metabolic syndrome may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of hyperuricemia, gout; dyslipidemia, obesity, urea cycle disorders, hyperglycemia, insulin resistance, diabetes mellitus, diabetes insipidus, type 1 diabetes, type 2 diabetes, microvascular complications,.macrovascular complications, lipid disorders, prediabetes., obesity, arrhythmia, myocardial infarction, stroke, neuropathy, renal complications, hypertriglyceridemia, cardiovascular complications, and post prandial hyperglycemia.

    摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映体，立体异构体和水合物。 包含有效量的式（I）化合物的药物组合物和治疗代谢综合征的方法可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。 此类组合物可用于治疗高尿酸血症，痛风; 血脂异常，肥胖症，尿素循环障碍，高血糖症，胰岛素抵抗，糖尿病，尿崩症，1型糖尿病，2型糖尿病，微血管并发症，血管并发症，脂质障碍，糖尿病前期，肥胖，心律失常，心肌梗死，中风，神经病 肾脏并发症，高甘油三酯血症，心血管并发症和餐后高血糖症。

    VERBESSERTES VERFAHREN ZUR HERSTELLUNG VON CYCLOPROPYLACETYLEN
    9.
    发明公开
    VERBESSERTES VERFAHREN ZUR HERSTELLUNG VON CYCLOPROPYLACETYLEN 失效

    公开(公告)号：EP0973708A1

    公开(公告)日：2000-01-26

    申请号：EP98910701.6

    申请日：1998-02-18

    申请人： BASF AKTIENGESELLSCHAFT

    发明人： HENNINGSEN, Michael ,  STAMM, Armin ,  FISCHER, Martin ,  SIEGEL, Wolfgang

    IPC分类号： C07C17/18 ,  C07C22/00 ,  C07C1/30 ,  C07C13/04 ,  C07F9/535

    CPC分类号： C07F9/535 ,  C07C1/30 ,  C07C17/00 ,  C07C17/18 ,  C07C2601/02 ,  C07C13/04 ,  C07C22/00

    摘要： The invention concerns a process for halogenating cyclopropylmethyl ketone with at least one dihalogen triorganophosphorane of the general formula (I): R3PHal2, in which the R groups can be the same or different and designate a saturated or unsaturated aliphatic C1-C20 hydrocarbon group, a phenyl or C1-C4 alkylphenyl group which can optionally be further substituted by one to two fluorine, chlorine and/or nitro groups, P means phosphorus and Hal means chlorine, bromine or iodine, at 80 to 130 °C, the dihalogen triorganophosphorane of the general formula (I) being prepared in situ from triorganophosphane oxide or triorganophosphane sulphide of the general formula (II), R3PA, in which R has the meaning given under formula (I) and A stands for oxygen or sulphur, with a halogenation reagent. The process is characterized in that the triorganophosphane oxide or triorganophosphane sulphide is used in catalytic amounts. The invention also concerns the halogenation product of the cyclopropyl ketone obtained according to this process and a process for reacting it to form cyclopropylacetylene.

    摘要翻译： 本发明涉及一种用至少一种通式Iin的二卤代三有机基磷烷卤化环丙基甲基酮的方法，其中基团R可以相同或不同，表示饱和或不饱和的脂族C 1 -C 20烃基，苯基或 （C 1 -C 4烷基）苯基，其可任选被一个或两个氟，氯和/或硝基取代，P代表磷，Hal代表氯，溴或碘，温度为800°至130° ℃，其中通式（I）的二卤代三有机膦原位由通式IIin的三有机膦氧化物或三有机膦烷硫化物原位合成，其中R如上文关于式I所定义，A表示氧或硫，使用 一种卤化剂，其中三有机膦氧化物或三有机基硫化物以催化量使用于在所述方法中得到的环丙基甲基酮的卤化产物，t o将所述卤化产物转化为环丙基乙烯基的方法。