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1.发明授权NOVEL COMPOUNDS AS HIF-1ALPHA INHIBITORS AND MANUFACTURING PROCESS THEREOF 有权作为HIF-1ALPHA抑制剂的新化合物及其制造方法
公开(公告)号：EP2760823B1
公开(公告)日：2017-11-08
申请号：EP12837558.1
申请日：2012-09-27
申请人： Dongguk University Industry-Academic Cooperation Foundation , Korea Research Institute of Bioscience and Biotechnology
发明人： LEE, Kyeong , WON, Mi-Sun , KIM, Hwan-Mook , PARK, Song-Kyu , LEE, Ki-Ho , LEE, Chang-Woo , KIM, Bo-Kyung , BAN, Hyun-Seung , CHUNG, Kyung-Sook , RAVI, Naik
IPC分类号： C07C235/18 , C07D241/04 , A61K31/165 , A61P35/00 , C07D487/04 , C07C231/02 , C07C235/22 , C07D295/108 , A61K31/495 , A61K31/4985 , A61K31/5375 , C07D295/073 , C07D279/12 , C07C235/20 , C07D295/182 , C07D295/185 , C07D295/104 , C07D307/46
CPC分类号： A61K31/5375 , A61K31/495 , A61K31/4985 , C07C231/02 , C07C235/20 , C07C235/22 , C07D241/04 , C07D279/12 , C07D295/073 , C07D295/104 , C07D295/108 , C07D295/182 , C07D295/185 , C07D307/46 , C07D487/04
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公开(公告)号：EP2423176A4
公开(公告)日：2012-11-07
申请号：EP10767073
申请日：2010-04-21
申请人： ASTELLAS PHARMA INC
发明人： NEGORO KENJI , OHNUKI KEI , YONETOKU YASUHIRO , KURAMOTO KAZUYUKI , URANO YASUHARU , WATANABE HIDEYUKI
IPC分类号： C07D207/06 , A61K31/40 , A61K31/4015 , A61P3/10 , C07C43/225 , C07C49/417 , C07C69/76 , C07C235/18 , C07C303/36 , C07D207/27 , C07D239/34 , C07D305/06 , C07D307/94 , C07D309/06 , C07D309/10 , C07D317/22 , C07D405/12 , C07K14/705 , C12N15/09
CPC分类号： C07D207/06 , A61K31/40 , A61K31/4015 , C07C49/417 , C07C59/68 , C07C59/72 , C07C69/732 , C07C69/734 , C07C229/42 , C07C233/18 , C07C235/20 , C07C255/37 , C07C271/30 , C07C311/04 , C07C2603/18 , C07C2603/94 , C07D207/27 , C07D239/34 , C07D305/06 , C07D307/94 , C07D309/06 , C07D309/10 , C07D317/22 , C07D319/06 , C07D405/12
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3.发明授权
公开(公告)号：EP0205327B1
公开(公告)日：1990-09-26
申请号：EP86304357.6
申请日：1986-06-06
申请人： SUNTORY LIMITED
IPC分类号： C07C235/18 , C07C235/20 , C07C279/14 , C07D303/36 , A01N39/04 , A01N43/02
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4.发明公开NOVEL COMPOUNDS AS HIF-1ALPHA INHIBITORS AND MANUFACTURING PROCESS THEREOF 有权NEER VERBINDUNGEN ALS HIF-1-HEMMER UND HERSTELLUNGSVERFAHRENDAFÜR
公开(公告)号：EP2760823A4
公开(公告)日：2015-05-20
申请号：EP12837558
申请日：2012-09-27
发明人： LEE KYEONG , WON MI-SUN , KIM HWAN-MOOK , PARK SONG-KYU , LEE KI-HO , LEE CHANG-WOO , KIM BO-KYUNG , BAN HYUN-SEUNG , CHUNG KYUNG-SOOK , RAVI NAIK
IPC分类号： C07C235/18 , A61K31/165 , A61P35/00 , C07D241/04
CPC分类号： A61K31/5375 , A61K31/495 , A61K31/4985 , C07C231/02 , C07C235/20 , C07C235/22 , C07D241/04 , C07D279/12 , C07D295/073 , C07D295/104 , C07D295/108 , C07D295/182 , C07D295/185 , C07D307/46 , C07D487/04
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5.发明公开Chiral binaphtol derivatives as alanine racemase mimics with powerful hydrogen bond donors: their use for optical resolution and optical inversion 审中-公开手性联萘酚衍生物具有强大Wasserstoffbindungsdonoren丙氨酸消旋仿：他们对Stereomerentrennung和stereoinversion使用
公开(公告)号：EP2189433A1
公开(公告)日：2010-05-26
申请号：EP10156417.7
申请日：2008-02-07
发明人： Kim, Kwan Mook. , Tang, Lijun.
IPC分类号： C07B55/00 , C07B57/00 , C07C227/34 , C07C229/22 , C07C229/36 , C07D233/64 , C07C231/20 , C07C237/06 , C07C213/10 , C07C215/08 , C07C215/28 , C07C235/18
CPC分类号： C07C279/18 , C07B55/00 , C07B57/00 , C07B2200/07 , C07C213/10 , C07C217/48 , C07C227/34 , C07C275/32 , C07D233/02 , C07D235/18 , C07C215/08 , C07C215/28 , C07C229/22 , C07C229/36
摘要： Disclosed is an alanine racemase chiral binaphthol derivative having the ability to recognize amino alcohols selectively on the basis of chirality and transform amino acids from an L-form into a D-form. Methods for the optical resolution of amino acid or amino alcohol and for the optical transformation of D- and L-forms of amino acids using the binaphthol derivative are also provided.
摘要翻译： 公开的是具有以识别选择性的手性的基础上的氨基醇，并从L形变换氨基酸为D形状的能力丙氨酸消旋手性联萘酚衍生物。 提供了用于的氨基酸或氨基醇的光学分辨率和对于D-和使用所述联萘酚衍生物因而氨基酸L型的光学变换方法。
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公开(公告)号：EP1817296B1
公开(公告)日：2009-11-04
申请号：EP05824423.7
申请日：2005-11-15
发明人： AICHER, Thomas, Daniel , CORTEZ, Guillermo, S. , GROENDYKE, Todd, Michael , KHILEVICH, Albert , KNOBELSDORF, James, Allen , MARMSATER, Fredrik, Pehr , SCHKERYANTZ, Jeffrey, Michael , TANG, Tony, Pisal
IPC分类号： C07D257/04 , A61K31/4427 , A61P25/00 , A61P37/08 , C07C235/18
CPC分类号： C07C229/60 , C07C317/44 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/79 , C07D213/80 , C07D213/84 , C07D213/85 , C07D257/04 , C07D401/04 , C07D401/12
摘要： The present invention provides a compound of formula (I): pharmaceutical compositions thereof, and methods of using the same, processes for preparing the same, and intermediates thereof.
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公开(公告)号：EP1496838A4
公开(公告)日：2008-07-02
申请号：EP03714051
申请日：2003-03-07
申请人： MERCK & CO INC
发明人： HAGMANN WILLIAM K , LIN LINUS S , SHAH SHRENIK K , GUTHIKONDA RAVINDRA N , QI HONGBO , CHANG LINDA L , LIU PING , ARMSTRONG HELEN M , JEWELL JAMES P , LANZA THOMAS J JR
IPC分类号： A61K31/165 , A61K31/27 , A61K31/40 , A61K31/4015 , A61K31/403 , A61K31/405 , A61K31/415 , A61K31/4192 , A61K31/4196 , A61K31/42 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/4402 , A61K31/4409 , A61K31/4436 , A61K31/445 , A61K31/4453 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/50 , A61K31/501 , A61K31/505 , A61K31/5377 , A61K31/553 , A61P1/04 , A61P1/10 , A61P1/16 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/24 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/06 , A61P13/12 , A61P15/00 , A61P15/10 , A61P17/00 , A61P19/02 , A61P19/06 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , C07C233/12 , C07C233/13 , C07C235/06 , C07C235/18 , C07C235/20 , C07C235/34 , C07C235/74 , C07C235/78 , C07C237/06 , C07C255/55 , C07C255/60 , C07C271/14 , C07C271/22 , C07C275/30 , C07C311/03 , C07C323/41 , C07D207/27 , C07D209/08 , C07D209/34 , C07D209/52 , C07D209/94 , C07D211/34 , C07D213/36 , C07D213/40 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/89 , C07D215/06 , C07D231/12 , C07D233/36 , C07D233/70 , C07D233/80 , C07D237/14 , C07D237/28 , C07D237/32 , C07D239/34 , C07D249/04 , C07D249/08 , C07D249/12 , C07D249/18 , C07D261/08 , C07D261/20 , C07D263/58 , C07D267/14 , C07D277/20 , C07D277/30 , C07D277/36 , C07D277/64 , C07D277/74 , C07D295/12 , C07D295/13 , C07D295/14 , C07D295/15 , C07D401/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D513/04 , C07D521/00 , C07C233/05 , C07D213/02 , C07D213/62 , C07D401/02
CPC分类号： C07D213/64 , C07C233/13 , C07C235/06 , C07C235/20 , C07C235/34 , C07C235/74 , C07C235/78 , C07C237/06 , C07C255/55 , C07C255/60 , C07C271/14 , C07C271/22 , C07C275/30 , C07C311/03 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D209/34 , C07D209/94 , C07D211/34 , C07D213/65 , C07D213/68 , C07D215/06 , C07D231/12 , C07D233/56 , C07D233/70 , C07D237/28 , C07D237/32 , C07D239/34 , C07D249/04 , C07D249/08 , C07D249/12 , C07D263/58 , C07D267/14 , C07D277/30 , C07D277/36 , C07D295/13 , C07D295/15 , C07D513/04
摘要： Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson s disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.
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8.发明授权Guanidinium binaphtol derivatives as alanine racemase mimics for optical resolution of amino alcohols and optical inversion of amino acids 有权胍联萘酚衍生物作为丙氨酸消旋酶对氨基醇的仿Stereomerentrennung和氨基酸立体声反转
公开(公告)号：EP2017244B1
公开(公告)日：2013-03-27
申请号：EP08101348.4
申请日：2008-02-07
申请人： Aminologics Co. Ltd.
发明人： Kim, Kwan Mook , Tang, Lijun
IPC分类号： C07C279/18 , C07C275/32 , C07B55/00 , C07B57/00 , C07C213/10 , C07C215/08 , C07C215/28 , C07C217/48 , C07C227/34 , C07C229/22 , C07C229/36 , C07C233/02 , C07D233/64 , C07C235/18 , C07C237/06 , C07D235/18 , C07D233/02
CPC分类号： C07C279/18 , C07B55/00 , C07B57/00 , C07B2200/07 , C07C213/10 , C07C217/48 , C07C227/34 , C07C275/32 , C07D233/02 , C07D235/18 , C07C215/08 , C07C215/28 , C07C229/22 , C07C229/36
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9.发明公开4-Aminophenol derivatives and processes for preparing the same 失效4-氨基苯酚衍生物和Verfahren zu ihrer Herstellung。
公开(公告)号：EP0374048A1
公开(公告)日：1990-06-20
申请号：EP89403469.3
申请日：1989-12-13
IPC分类号： C07D333/38 , C07D333/24 , C07D333/68 , C07D207/337 , C07C235/38 , C07C235/18 , C07C235/28 , A61K31/16 , A61K31/38 , A61K31/40
CPC分类号： C07D207/337 , C07C233/25 , C07C233/27 , C07C235/38 , C07D209/18 , C07D209/42 , C07D333/24 , C07D333/38 , C07D333/70
摘要： There are disclosed a 4-aminophenol derivative of the formula:
(wherein R¹ and R² each represent a lower alkyl group, Y represents a single bonding arm, a lower alkylene group or a lower alkenylene group, R³ represents a thienyl group or pyrrolyl group which may be also substituted with a lower alkyl group; benzothienyl group, indolyl group; or a phenyl group which is substituted with 1 to 2 groups selected from a lower alkoxy group and a lower alkanoyloxy group; or Y-R³ represents integrally an alkyl group with 6 to 9 carbon atoms; or a hydrocarbon group with 5 to 14 carbon atoms having 2 or 3 double bonds) or a pharmacologically acceptable salt thereof, and processes for preparing the same.摘要翻译： 公开了下式的4-氨基苯酚衍生物：其中R 1和R 2各自表示低级烷基，Y表示单键结合臂，低级亚烷基或低级亚烯基， R 3表示也可以被低级烷基取代的噻吩基或吡咯基;苯并噻吩基，吲哚基或被1〜2个选自低级烷氧基和低级烷酰氧基取代的苯基 基团或YR 3整体表示碳原子数6〜9的烷基或具有2或3个双键的碳原子数5〜14的烃基）或其药理学上可接受的盐，及其制备方法。
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公开(公告)号：EP0276065B1
公开(公告)日：1990-06-06
申请号：EP88300163.8
申请日：1988-01-11
IPC分类号： C07C49/84 , C07C59/92 , C07C65/40 , C07C69/738 , C07C69/76 , C07C217/02 , C07C235/18 , C07C235/28 , C07C245/00 , C07C255/11
CPC分类号： C07D257/04 , C07C45/45 , C07C45/46 , C07C45/67 , C07C45/673 , C07C45/71 , C07C49/84 , C07C65/40 , C07C247/00 , C07C255/00 , C07C317/00 , C07C323/00 , C07D295/088 , C07C49/86 , C07C49/835 , C07C49/825
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