公开(公告)号：JP2000178238A

公开(公告)日：2000-06-27

申请号：JP35352499

申请日：1999-12-13

申请人： GRUENENTHAL GMBH

发明人： ZIMMER OSWALD DR ,  STRASBURGER WOLFGANG WERNER A ,  ENGLBERGER WERNER GUENTER DR ,  KOEGEL BABETTE-YVONNE DR

IPC分类号： A61K31/13 ,  A61K31/135 ,  A61P25/04 ,  C07C13/18 ,  C07C209/68 ,  C07C211/26 ,  C07C213/00 ,  C07C213/08 ,  C07C215/64 ,  C07C217/74 ,  C07C229/46

摘要： PROBLEM TO BE SOLVED: To provide a new substituted cycloheptene having biological effectiveness originated partially or mainly from δ-opiate receptor agonist and useful for analgesic use. SOLUTION: The objective substituted cycloheptene is expressed by formula I [R1 is OH, an O-(1-6C alkyl), an O-(3-7C cycloalkyl), an O-aryl, a 1-6C alkyl- COO or the like; R2 is a 1-6C alkyl, a 2-6C alkenylene-aryl or the like; R3 is (CH2)0-1-(5-7C cycloalkyl), (CH2)0-2-aryl or the like], e.g. 3-[6-(4-chloro-phenyl)-2- dimethylaminomethyl-cyclo-hept-1-enyl]-phenol. The compound of formula I can be produced by reacting a t-alcohol of formula II with an acid at 20-110 deg.C. The compound of formula II can be produced by reacting an aminoketone of formula III (R4 is same as R3 and the like) with an organometallic compound of formula IV (X is MgCl or the like; R5 is same as R1 and the like).

公开(公告)号：JPH10147557A

公开(公告)日：1998-06-02

申请号：JP23665397

申请日：1997-09-02

申请人： BASF AG

发明人： PREISS THOMAS DR ,  HENKELMANN JOCHEM DR ,  WULFF-DOERING JOACHIM DR ,  STUTZ SUSANNE DR

IPC分类号： C07D295/04 ,  B01J31/26 ,  C07C209/60 ,  C07C211/08 ,  C07C211/23 ,  C07C211/25 ,  C07C211/26 ,  C07C211/43 ,  C07C211/54

摘要： PROBLEM TO BE SOLVED: To obtain the subject compound useful as an industrial intermediate by reacting an alkyne with a carbonyl compound and amine in the presence of a nonsupported copper catalyst which brings a heterogeneous catalytic function. SOLUTION: The method for producing this compound reacts a compound shown by the formula R -C≡C-H (R is H, an alkyl or the like; R and R are each H, an alkyl, haloalkyl or the like; and R and R are each H, an alkyl or the like) (e.g. acetylene) with a mixture of a compound shown by formula I (e.g. paraformaldehyde) and compound shown by formula II (e.g. diethylamine) by the heterogeneous catalytic function rendered by a nonsupported copper catalyst derived from malachite [CuCO3 .Cu(OH)2 ] at a reaction temperature of 20 to 200 deg.C, to produce the objective N-alkyl- substituted aminoalkyne shown by formula III (e.g. N,N-diethylaminopropyne).

公开(公告)号：JP2728564B2

公开(公告)日：1998-03-18

申请号：JP50465092

申请日：1992-08-21

申请人： ENU PII ESU PHARM INC

发明人： NEMESU EDOWAADO EFU ,  UAN UEIJINEN BURATSUDOFUOODO SHII ,  BARANDORIN MANYUERU EFU

IPC分类号： G01N33/15 ,  A61K20060101 ,  A61K31/13 ,  A61K31/135 ,  A61K31/14 ,  A61K31/16 ,  A61K31/165 ,  A61K31/235 ,  A61K31/275 ,  A61K31/395 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/44 ,  A61K31/55 ,  A61K31/554 ,  A61K31/715 ,  A61K31/785 ,  A61K33/06 ,  A61K38/00 ,  A61K38/16 ,  A61K45/00 ,  A61P3/00 ,  A61P3/14 ,  A61P5/18 ,  A61P5/22 ,  A61P9/00 ,  A61P9/12 ,  A61P19/08 ,  A61P19/10 ,  A61P43/00 ,  C07C211/02 ,  C07C211/03 ,  C07C211/15 ,  C07C211/16 ,  C07C211/17 ,  C07C211/19 ,  C07C211/26 ,  C07C211/27 ,  C07C211/29 ,  C07C211/30 ,  C07C211/42 ,  C07C215/46 ,  C07C215/48 ,  C07C215/50 ,  C07C215/52 ,  C07C217/54 ,  C07C217/56 ,  C07C217/58 ,  C07C217/60 ,  C07C219/14 ,  C07C225/16 ,  C07C229/38 ,  C07C233/05 ,  C07C235/34 ,  C07C235/44 ,  C07C237/22 ,  C07C237/30 ,  C07C255/24 ,  C07C255/45 ,  C07C255/58 ,  C07C279/14 ,  C07C323/18 ,  C07C323/32 ,  C07D209/14 ,  C07D209/16 ,  C07D209/18 ,  C07D209/30 ,  C07D209/40 ,  C07D211/90 ,  C07D213/28 ,  C07D213/36 ,  C07D213/38 ,  C07D215/12 ,  C07D215/14 ,  C07D233/54 ,  C07D257/02 ,  C07D281/10 ,  C07D295/00 ,  C07D413/04 ,  C07H21/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/435 ,  C07K14/705 ,  C08G69/10 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12Q1/02 ,  C12R1/91 ,  G01N20060101 ,  G01N33/50 ,  G01N33/566 ,  G01N33/567 ,  G01N33/574 ,  G01N33/68 ,  G01N33/84

摘要： Method and composition useful for treating a patient having a disease characterized by an abnormal level of one or more components, the activity of which is regulated or affected by activity of one or more Ca 2+ receptors. Novel compounds useful in these methods and compositions are also provided. The method includes administering to the patient a therapeutically effective amount of a molecule active at one or more Ca 2+ receptors as an agonist or antagonist. Preferably, the molecule is able to act as either a selective agonist or antagonist at a Ca 2+ receptor of one or more but not all cells chosen from the group consisting of parathyroid cells, bone osteoclasts, juxtaglomerular kidney cells, proximal tubule kidney cells, keratinocytes, parafollicular thyroid cells and placental throphoblasts and a pharmaceutically acceptable carrier.

公开(公告)号：JP2637737B2

公开(公告)日：1997-08-06

申请号：JP17273187

申请日：1987-07-10

申请人： KINOIN GIOGISUZERU ESU BEGIESUZECHI TERUMEKEKU GIARA RUTO

发明人： DEJEE KORUBONICHI ,  PAARU KISHU ,  RAASUROO SEKERESHU ,  JURA PATSUPU ,  GAABORU KOBAACHI ,  ANDOREA SHAANTAANEE CHUTORU ,  SHAANDORU BIRAAGU ,  EEBA UDOBARI ,  IMURE BATA ,  KATARIN MAARUMAROSHI NEE KERUNERU ,  RAASUROO TARUDOSH

IPC分类号： C07C215/50 ,  A61K31/13 ,  A61K31/135 ,  A61K31/137 ,  A61K31/16 ,  A61K31/165 ,  A61K31/335 ,  A61K31/36 ,  A61P3/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  C07C20060101 ,  C07C27/00 ,  C07C67/00 ,  C07C209/00 ,  C07C209/08 ,  C07C209/24 ,  C07C209/26 ,  C07C209/62 ,  C07C209/68 ,  C07C211/00 ,  C07C211/03 ,  C07C211/16 ,  C07C211/26 ,  C07C211/27 ,  C07C211/29 ,  C07C211/43 ,  C07C213/00 ,  C07C217/10 ,  C07C217/54 ,  C07C217/56 ,  C07C217/58 ,  C07C227/10 ,  C07C227/16 ,  C07C229/34 ,  C07C229/38 ,  C07C231/00 ,  C07C231/12 ,  C07C233/42 ,  C07C233/43 ,  C07C233/67 ,  C07D311/48 ,  C07D317/00 ,  C07D317/48 ,  C07D317/58

公开(公告)号：JP2519022B2

公开(公告)日：1996-07-31

申请号：JP15703894

申请日：1994-07-08

申请人： HOFFMANN LA ROCHE

发明人： AEBI JOHANNES ,  GUERRY PHILIPE ,  JOLIDON SYNESE ,  MORAND OLIVIER

IPC分类号： A61K31/24 ,  A61K31/135 ,  A61K31/137 ,  A61K31/138 ,  A61K31/277 ,  A61P3/06 ,  A61P9/10 ,  C07C211/26 ,  C07C217/18 ,  C07C217/20 ,  C07C217/22 ,  C07C217/46 ,  C07C225/08 ,  C07C225/14 ,  C07C225/16 ,  C07C225/22 ,  C07C255/56

摘要： Use of compounds of the formula in which one of R and R is C1-7-alkyl and the other is C1-7-alkyl or C2-6-alkenylmethyl, L is C1-11-alkylene or C2-11-alkenylene which is optionally bonded via an O atom to the phenyl group, or L is 1,4-phenylene, n is 0 or, if L contains an O atom, n is 0 or 1, Q is C1-7-alkyl, C2-10-alkenyl or a group of the formula Q': R is H, halogen, CF3, CN or NO2, R and R are H, C1-4-alkyl or halogen, and R is H or, if R is H, H or halogen, and their pharmaceutically acceptable acid addition salts for producing cholesterol-lowering medicinal agents, and compounds covered by formula I.

公开(公告)号：JPH07316103A

公开(公告)日：1995-12-05

申请号：JP1977794

申请日：1994-01-21

申请人： BAYER AG

发明人： HERUMUUTO KURAUSU ,  NIKORAUSU MIYURAA ,  GERUHARUTO MARUTSUORUFU ,  BERUNHARUTO BAITSUKE

IPC分类号： C07C209/68 ,  C07B37/04 ,  C07B61/00 ,  C07C211/29 ,  C07C221/00 ,  C07C223/02 ,  C07C225/14 ,  C07C227/10 ,  C07C229/30 ,  C07C249/02 ,  C07C253/30 ,  C07C255/30 ,  C07C211/21 ,  C07C211/25 ,  C07C211/26 ,  C07C217/46 ,  C07C217/48 ,  C07C237/16 ,  C07C291/10 ,  C07C309/83 ,  C07C317/28

公开(公告)号：JPH07206762A

公开(公告)日：1995-08-08

申请号：JP272095

申请日：1995-01-11

申请人： HUELS CHEMISCHE WERKE AG

发明人： RAINAA GURASU ,  ERUMAA BUORUFU

IPC分类号： C07D295/02 ,  A61K31/13 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/5375 ,  C07C51/41 ,  C07C63/313 ,  C07C211/02 ,  C07C211/16 ,  C07C211/20 ,  C07C211/25 ,  C07C211/26 ,  C07C211/43 ,  C07C215/12 ,  C07D487/04 ,  C07D487/08 ,  C08G59/40 ,  C08G59/50 ,  C08G59/68 ,  C09D163/00

公开(公告)号：JPH06340592A

公开(公告)日：1994-12-13

申请号：JP14842093

申请日：1993-05-28

申请人： MITSUBISHI PETROCHEMICAL CO

发明人： TANIYAMA EIJI ,  OKANO KAZUYA

IPC分类号： C07C209/62 ,  C07C211/26 ,  C07C211/29 ,  C07C233/13 ,  C07C233/25

摘要： PURPOSE:To safely obtain the subject compound useful as an intermediate for producing medicines, agrochemicals, etc., at a low cost by hydrolyzing specific acetamides in the presence of a base. CONSTITUTION:Acetamides of formula I [X is halogen, lower-haloalkyl or lower-haloalkoxy; R is lower alkyl; (n) is 0-3] are hydrolyzed in the presence of a base such as sodium hydroxide to provide the objective compound of formula II. Furthermore, the base is used in an amount of 2-5mol based on 1mol acetamide of formula I and the hydrolytic temperature is preferably 100-200 deg.C.

公开(公告)号：JPH06506914A

公开(公告)日：1994-08-04

申请号：JP50327292

申请日：1991-12-31

IPC分类号： C07B51/00 ,  C07C22/04 ,  C07C31/13 ,  C07C33/05 ,  C07C33/34 ,  C07C57/26 ,  C07C69/00 ,  C07C69/145 ,  C07C69/157 ,  C07C69/96 ,  C07C211/26 ,  C07C229/36 ,  C07C233/04 ,  C07C255/31 ,  C07C271/22 ,  C07K1/04 ,  C07K1/06 ,  C07K1/14 ,  C07K7/06 ,  C07K14/00 ,  C07K7/10

公开(公告)号：JPH0643348B2

公开(公告)日：1994-06-08

申请号：JP20901285

申请日：1985-09-24

申请人： BASF AG

发明人： HANSU HAINAA BUYUUSUTO ,  FURITSUTSU FURIIDAA FURITSUKER ,  AKUSERU NIYURENBAHA

IPC分类号： C07D233/58 ,  A61K31/015 ,  A61K31/025 ,  A61K31/05 ,  A61K31/075 ,  A61K31/12 ,  A61K31/135 ,  A61K31/165 ,  A61K31/19 ,  A61K31/215 ,  A61K31/22 ,  A61K31/275 ,  A61K31/41 ,  A61K31/415 ,  A61K31/445 ,  A61K31/655 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  C07C1/00 ,  C07C13/48 ,  C07C17/00 ,  C07C25/24 ,  C07C27/00 ,  C07C33/38 ,  C07C39/23 ,  C07C43/14 ,  C07C43/20 ,  C07C43/215 ,  C07C43/23 ,  C07C43/30 ,  C07C45/00 ,  C07C45/44 ,  C07C45/71 ,  C07C47/238 ,  C07C47/27 ,  C07C47/273 ,  C07C47/277 ,  C07C47/548 ,  C07C47/57 ,  C07C47/575 ,  C07C49/225 ,  C07C49/237 ,  C07C49/255 ,  C07C49/798 ,  C07C49/813 ,  C07C49/835 ,  C07C49/84 ,  C07C57/50 ,  C07C57/74 ,  C07C59/54 ,  C07C65/19 ,  C07C65/28 ,  C07C67/00 ,  C07C69/14 ,  C07C69/618 ,  C07C69/76 ,  C07C209/00 ,  C07C211/26 ,  C07C233/00 ,  C07C233/11 ,  C07C235/34 ,  C07C235/38 ,  C07C239/06 ,  C07C241/00 ,  C07C247/22 ,  C07C247/24 ,  C07C255/34 ,  C07C255/37 ,  C07C255/50 ,  C07C255/53 ,  C07C255/54 ,  C07D257/04 ,  C07D263/06 ,  C07D277/24 ,  C07D295/10