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公开(公告)号：US20230162349A1
公开(公告)日：2023-05-25
申请号：US17534250
申请日：2021-11-23
发明人： Joshua Kempner , Jorge Ripoll
CPC分类号： G06T7/0012 , G01N21/6456 , G01N21/6486 , G06T7/11 , G06T7/70 , G06T7/62 , G02B5/20
摘要： Systems, apparatuses, and methods are described for 3D luminescence imaging, by identifying a preferred optical pair and optimizing a scanned image using the preferred optical pair. An optimal filter pair may be selected from a list of two or more optical filters. An acceptable threshold of information may be obtained using a subset of the list of two or more optical filters (e.g., an optimal filter pair). An imaging device may be configured with the optimal filter pair to produce a pair of luminescence images of a target sample. In addition, luminescence images may be pre-processed to reduce the time-cost of conventional processing techniques of luminescence images. One or more computing devices may generate initial prior data based on a pair of luminescence images. An output may include one or more output luminescent sources that have been refined and/or optimized from the initial prior data.
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公开(公告)号：US20230159762A1
公开(公告)日：2023-05-25
申请号：US18076700
申请日：2022-12-07
发明人： Nara Narayanan , Kevin Groves , Guojie Ho
IPC分类号： C09B23/16 , A61P35/00 , C07D403/14 , C07D409/08 , C07D209/90 , C07D403/08 , C07D401/08 , C07D333/74 , A61K49/00 , A61K51/04 , C07D209/92 , C07D333/50 , C09B1/00 , G01N33/58
CPC分类号： C09B23/16 , A61P35/00 , C07D403/14 , C07D409/08 , C07D209/90 , C07D403/08 , C07D401/08 , C07D333/74 , A61K49/0052 , A61K49/0058 , A61K51/0431 , A61K51/0434 , A61K51/0446 , A61K51/0497 , C07D209/92 , C07D333/50 , C09B1/002 , C09B1/005 , C09B23/166 , G01N33/582
摘要： This disclosure provides a family of compounds that absorb and fluoresce in the short wave infrared region (SWIR, optionally 1000 nm to 1300 nm), including hydrophilic compounds that exhibit absorption and emission spectral profiles in aqueous solutions substantially similar to those observed in organic solvents such as methanol or DMSO. The compounds can be chemically linked to biomolecules including proteins, nucleic acids, and therapeutic small molecules. The compounds are useful for imaging in a variety of medical, biological and diagnostic applications, including SWIR in vivo imaging of regions of interest within a mammal.
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公开(公告)号：US11639874B2
公开(公告)日：2023-05-02
申请号：US17501695
申请日：2021-10-14
发明人： David M. Aikens
摘要： Spectrometers include an optical assembly with optical elements arranged to receive light from a light source and direct the light along a light path to a multi-element detector, dispersing light of different wavelengths to different spatial locations on the multi-element detector. The optical assembly includes: (i) a collimator arranged in the light path to receive the light from the light source, the collimator including a mirror having a freeform surface; (2) a dispersive sub-assembly including an echelle grating, the dispersive sub-assembly being arranged in the light path to receive light from the collimator; and (3) a Schmidt telescope arranged in the light path to receive light from the dispersive sub-assembly and focus the light to a field, the multi-element detector being arranged at the field.
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公开(公告)号：US20220229197A1
公开(公告)日：2022-07-21
申请号：US17590480
申请日：2022-02-01
发明人： Richard Harazin
摘要： Presented herein are systems and methods that provide for calibration and/or testing of liquid scintillation counters (LSCs) using an electronic test source. In certain embodiments, the electronic test source described herein provides for emission of emulated radioactive event test pulses that emulate light pulses produced by a scintillator as a result of radioactive decay of a variety of different kinds of radioactive emitters (e.g., beta, alpha, and gamma emitters). Additionally, in certain embodiments, the systems and methods described herein provide for the emission of emulated background light (e.g., luminescence and after-pulses) from the electronic test source. The emulated radioactive event test pulses and, optionally, emulated background light can be used for the calibration and/or testing of LSCs, in place of hazardous radioactive material and/or volatile chemicals. Accordingly, the systems and methods described herein dramatically improve the calibration and/or testing of liquid scintillation counters.
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公开(公告)号：US11275188B2
公开(公告)日：2022-03-15
申请号：US16645399
申请日：2018-09-14
发明人： Richard Harazin
摘要： Presented herein are systems and methods that provide for calibration and/or testing of liquid scintillation counters (LSCs) using an electronic test source. In certain embodiments, the electronic test source described herein provides for emission of emulated radioactive event test pulses that emulate light pulses produced by a scintillator as a result of radioactive decay of a variety of different kinds of radioactive emitters (e.g., beta, alpha, and gamma emitters). Additionally, in certain embodiments, the systems and methods described herein provide for the emission of emulated background light (e.g., luminescence and after-pulses) from the electronic test source. The emulated radioactive event test pulses and, optionally, emulated background light can be used for the calibration and/or testing of LSCs, in place of hazardous radioactive material and/or volatile chemicals. Accordingly, the systems and methods described herein dramatically improve the calibration and/or testing of liquid scintillation counters.
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公开(公告)号：US20210381890A1
公开(公告)日：2021-12-09
申请号：US17400233
申请日：2021-08-12
发明人： Mahsa Farsad , David Aikens
摘要： A spectrometer with a Schmidt reflector is described. The spectrometer may include a Schmidt corrector and a dispersive element as separate components. Alternatively, the Schmidt corrector and dispersive element may be combined into a single optical component. The spectrometer may further include a field-flattener lens.
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公开(公告)号：US11181105B2
公开(公告)日：2021-11-23
申请号：US16679076
申请日：2019-11-08
摘要： Microfluidic circuit elements, such as a microvalve, micropump or microvent, formed of a microcavity divided by a diaphragm web into a first subcavity bounded by a first internal wall and a second subcavity bounded by a second internal wall, where the diaphragm web is characterized as a thin film having a first state contacting the first internal wall and a second state contacting the second internal wall and exhibiting essentially no elasticity in moving between the first state and the second state, the thin film web having been stretched beyond its yield point before or during use are provided. The disclosed elements enable faster and more efficient cycling of the diaphragm in the microcavity and increases the diaphragm surface area. In a preferred embodiment, the microfluidic circuit element is pneumatically driven and controls the motion of fluids in a microassay device.
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公开(公告)号：US20210327107A1
公开(公告)日：2021-10-21
申请号：US16339445
申请日：2018-03-30
发明人： Ali Behrooz
摘要： Presented herein are systems and methods for tomographic imaging of a region of interest in a subject using short-wave infrared light to provide for accurate reconstruction of absorption maps within the region of interest. The reconstructed absorption maps are representations of the spatial variation in tissue absorption within the region of interest. The reconstructed absorption maps can themselves be used to analyze anatomical properties and biological processes within the region of interest, and/or be used as input information about anatomical properties in order to facilitate data processing used to obtain images of the region of interest via other imaging modalities. For example, the reconstructed absorption maps may be incorporated into forward models that are used in tomographic reconstruction processing in fluorescence and other contrast-based tomographic imaging modalities. Incorporating reconstructed absorption maps into other tomographic reconstruction processing algorithms in this manner improves the accuracy of the resultant reconstructions.
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公开(公告)号：US20210270864A1
公开(公告)日：2021-09-02
申请号：US17060752
申请日：2020-10-01
摘要： An autosampler includes a sample carrier for receiving first and second sets of sample containers each having a top end, a side wall, and a visible indicium on its side wall. The autosampler includes: an optical sensor to read the visible indicia and to generate a corresponding output signal; a controller to receive the output signal; and a sampling system to withdraw a sample. The sample carrier supports the first and second sets of sample containers at different heights such that the indicia of the sample containers of the second set are located above the top ends of the sample containers of the first set, whereby the indicia of the sample containers of the second set are exposed to the optical sensor over the top ends of the sample containers of the first set, thereby enabling the optical sensor to read the indicia of the second set of sample containers.
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公开(公告)号：US20210270859A1
公开(公告)日：2021-09-02
申请号：US17188272
申请日：2021-03-01
发明人： Keith Ferrara
摘要： An autosampler includes a carrier for receiving a plurality of sample containers each having a top end and a visible indicium. The visible indicia are located below a top plane defined by the top ends. The autosampler includes: an optical sensor configured to read the visible indicia and to generate a corresponding output signal, and having a line of sight; a controller configured to receive the output signal; and a sampling system to withdraw a sample from the sample containers. The autosampler is operative to relatively move the optical sensor and/or the carrier such that the line of sight intersects the visible indicium of a selected one of the sample containers, wherein the line of sight extends: downward from a height above the height of the top plane; at an oblique angle to the top plane; and through a gap between the selected sample container and an adjacent sample container.
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