公开(公告)号：US12127530B2

公开(公告)日：2024-10-29

申请号：US17800709

申请日：2021-02-17

申请人： Joz B.V.

发明人： Rob Elling

IPC分类号： A01K1/01

CPC分类号： A01K1/0128

摘要： Manure collecting device, comprising a manure pick-up device for picking up manure from a floor of an animal accommodation, and a reservoir for collecting therein manure picked up by the manure pick-up device, wherein the manure pick-up device comprises a housing, comprising a receiving opening to be arranged close to the floor for the purpose of receiving manure in the housing therethrough, a delivery opening arranged close to the reservoir for the purpose of delivering the picked-up manure to the reservoir therethrough, and an at least partially cylindrical inner wall, wherein the inner wall extends at least between the receiving opening and the delivery opening, and a rotatably movable body with a central shaft and at least one arm extending radially relative to the shaft between the shaft and the inner wall, wherein the manure pick-up device is configured such that, while the body moves in rotating manner, the manure is picked up close to the receiving opening by means of the arm and is transported through the housing to the reservoir in co-action with the inner wall.

公开(公告)号：US12123050B2

公开(公告)日：2024-10-22

申请号：US18283172

申请日：2022-03-29

申请人： PIXELGEN TECHNOLOGIES AB

发明人： Simon Fredriksson ,  Filip Karlsson

IPC分类号： C12Q1/6837 ,  C12Q1/6841

CPC分类号： C12Q1/6837 ,  C12Q1/6841

摘要： Provided herein is probe system comprising: a population of nucleic acid molecules that have an extendible end, a first set of barcoded particles that each have a nucleotide sequence comprising: (i) a binding sequence that is complementary to the extendible end of the nucleic acid molecules, (ii) a unique particle identifier sequence, and (iii) a first template sequence, and a second set of barcoded particles that each have a nucleotide sequence comprising: (i) the first template sequence and (ii) a unique particle identifier sequence. In use, extension of the nucleic acid molecules using the first set of barcoded particles of as a template produces extensions products that contain the complement of a unique particle identifier sequence of a particle and the complement of the first template sequence. Methods of using the probe system to map binding events in or on a cellular sample are also provided.

公开(公告)号：US12122725B2

公开(公告)日：2024-10-22

申请号：US17612789

申请日：2020-12-11

申请人： ARDEX Group GmbH

发明人： Stephen Alan Brooks ,  Rüdiger Oberste-Padtberg ,  Jörg Sieksmeier ,  Hubert Motzet ,  Michael Pomberg

IPC分类号： C04B7/32 ,  C01F7/46 ,  C02F1/00 ,  C02F11/08 ,  C02F11/123 ,  C02F11/13 ,  C04B7/02 ,  C04B7/24 ,  C04B7/40 ,  C04B7/43 ,  C04B7/44 ,  C04B7/51 ,  C04B7/52 ,  C04B14/06 ,  C04B14/28 ,  C04B24/26 ,  C04B28/06 ,  C04B28/14 ,  F23G5/027 ,  F27B7/08 ,  F27B7/36 ,  C02F101/10 ,  C04B111/00 ,  C04B111/60

CPC分类号： C04B7/323 ,  C01F7/46 ,  C02F1/008 ,  C02F11/08 ,  C02F11/123 ,  C02F11/13 ,  C04B7/02 ,  C04B7/24 ,  C04B7/32 ,  C04B7/40 ,  C04B7/434 ,  C04B7/4423 ,  C04B7/51 ,  C04B7/52 ,  C04B7/525 ,  C04B14/06 ,  C04B14/28 ,  C04B24/2611 ,  C04B24/2641 ,  C04B28/06 ,  C04B28/065 ,  C04B28/14 ,  C04B28/146 ,  C04B28/147 ,  F23G5/0273 ,  F27B7/08 ,  F27B7/36 ,  C01P2002/72 ,  C02F2101/10 ,  C02F2209/02 ,  C04B2111/00637 ,  C04B2111/00646 ,  C04B2111/60 ,  F23G2201/20

摘要： The invention relates to a method of producing a binder comprising the steps of preparing (20) a residual material comprising amorphous alumina-rich and/or aluminium hydroxide-rich constituents, heating (30) the residual material to produce a fired material, the heating (30) of the residual material being at a temperature of >800° C.

公开(公告)号：US12116409B2

公开(公告)日：2024-10-15

申请号：US17408113

申请日：2021-08-20

申请人： Redwood Bioscience, Inc.

发明人： David Rabuka ,  Robert George Edward Holgate ,  Francis Joseph Carr

IPC分类号： C07K16/00 ,  A61K39/395 ,  A61K39/40 ,  C07K16/28 ,  C07K17/02 ,  C07K17/08 ,  C07K17/10 ,  C12N9/16 ,  C12P21/08

CPC分类号： C07K16/2803 ,  C07K16/2851 ,  C07K17/02 ,  C07K17/08 ,  C07K17/10 ,  C12N9/16 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00 ,  C12Y301/06

摘要： The present disclosure provides antibodies specific for an epitope present on CD22. The antibodies are useful in various treatment, diagnostic, and monitoring applications, which are also provided.

公开(公告)号：US12116344B2

公开(公告)日：2024-10-15

申请号：US18029842

申请日：2021-10-01

申请人： Azafaros B.V.

发明人： Robert Hett ,  Fritz Blatter ,  Jennifer Robin ,  Kyle Landskroner

IPC分类号： C07D211/46

CPC分类号： C07D211/46 ,  C07B2200/13

摘要： The present invention relates to a crystalline form of compound (I) and a method of making the crystalline form of compound (I). The invention also provides pharmaceutical compositions comprising the crystalline form of compound (I). Furthermore, the invention relates to methods of using this crystalline form of compound (I) as a medicament and in the treatment of a disease involving abnormal levels of glucosylceramide and/or higher levels of glycosphingolipids.

公开(公告)号：US12110522B2

公开(公告)日：2024-10-08

申请号：US16962792

申请日：2019-01-11

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Tess Branon ,  Alice Y. Ting

IPC分类号： C12N9/00 ,  G01N33/58 ,  G01N33/68

CPC分类号： C12N9/93 ,  C12Y603/04015 ,  G01N33/58 ,  G01N33/6842

摘要： Engineered promiscuous biotin ligases and methods of using them in proximity labeling are described. In particular, the invention provides novel biotin ligase variants having increased promiscuous biotinylation activity capable of proximity labeling of proteins in live cells in as little as 10 minutes.

公开(公告)号：US12109347B2

公开(公告)日：2024-10-08

申请号：US17880574

申请日：2022-08-03

申请人： The Regents of the University of California

发明人： Shant Vartanian

IPC分类号： A61B17/11 ,  A61B17/00 ,  A61B90/00 ,  A61M1/36 ,  A61M39/02

CPC分类号： A61M1/3655 ,  A61B17/11 ,  A61M1/3661 ,  A61M39/0208 ,  A61B2017/00862 ,  A61B2017/00867 ,  A61B2017/00876 ,  A61B2017/1107 ,  A61B2017/1139 ,  A61B2090/3966 ,  A61M2039/0223

摘要： Provided herein are novel devices for the formation of arteriovenous fistulas, which may aid subjects in need of hemodialysis. The novel devices are provided in a non-surgical procedure, greatly decreasing the cost and increasing the convenience of placing an arteriovenous fistula. The devices are atraumatic, and consist of a sutureless anastomosis device and conduit. Methods and tools for placing the devices in vivo are disclosed, including a magnetic-assisted method.

公开(公告)号：US12104202B2

公开(公告)日：2024-10-01

申请号：US17394797

申请日：2021-08-05

申请人： OXFORD NANOPORE TECHNOLOGIES PLC

发明人： Robert Osborne ,  Esther Musgrave-Brown

IPC分类号： C12Q1/6827 ,  C12Q1/6869 ,  G16B30/00

CPC分类号： C12Q1/6827 ,  C12Q1/6869 ,  G16B30/00 ,  C12Q1/6827 ,  C12Q2521/501 ,  C12Q2535/122 ,  C12Q2537/165 ,  C12Q1/6869 ,  C12Q2521/501 ,  C12Q2535/122 ,  C12Q2537/165

摘要： Described herein, among other things, is a method of sequencing, comprising: concatenating a plurality of fragments of genomic DNA to produce concatenated DNA; sequencing the concatenated DNA to produce a plurality of sequence reads, wherein at least some of the sequence reads comprise: at least the sequence of the 3′ and/or 5′ ends of a fragment that corresponds to the locus of interest and sequence of one or both of the fragments that flank the fragment in the concatenated DNA; and grouping the sequence reads that corresponds to the locus of interest using, for each of the grouped sequence reads: the 3′ and/or 5′ end sequences; and/or the flanking sequence.

公开(公告)号：US12104072B2

公开(公告)日：2024-10-01

申请号：US16646521

申请日：2018-10-08

申请人： SURREY NANOSYSTEMS LIMITED

发明人： Ben Poul Jensen ,  Fiona-Mairéad McKenna ,  William John Kristian Ludlam

IPC分类号： C09D131/04 ,  B05D1/02 ,  B05D3/04 ,  B05D3/14 ,  B05D5/06 ,  C08K3/04 ,  C09D7/20 ,  C09D7/61 ,  F24S70/20 ,  G02B1/111

CPC分类号： C09D131/04 ,  B05D1/02 ,  B05D3/0486 ,  B05D3/148 ,  B05D5/06 ,  C08K3/04 ,  C09D7/20 ,  C09D7/61 ,  F24S70/20 ,  G02B1/111

摘要： A method of coating a substrate includes the steps of: (i) providing a suspension of dye and a binder in a solvent, wherein the ratio of dye to binder is greater than 40 wt % and the dye is uniformly dispersed in the solvent; (ii) spray-coating the suspension onto the substrate with the majority of the solvent evaporating during the spray coating step to result in a coating of dye and binder on the substrate having a density of up to 0.75 gcm-3; and (iii) continuing step (ii) until the coating thickness is at least 30 micrometres; wherein the dye does not include any carbon nanotubes.

公开(公告)号：US12097206B2

公开(公告)日：2024-09-24

申请号：US17667136

申请日：2022-02-08

申请人： KATHOLIEKE UNIVERSITEIT LEUVEN ,  UNIVERSITY HOSPITAL ANTWERP

发明人： Berten Ceulemens ,  Lieven Lagae

IPC分类号： A61K31/5513 ,  A61K31/135 ,  A61K31/137 ,  A61K31/19 ,  A61K31/36 ,  A61K31/551 ,  A61K45/06 ,  C12Q1/6883

CPC分类号： A61K31/5513 ,  A61K31/135 ,  A61K31/137 ,  A61K31/19 ,  A61K31/36 ,  A61K31/551 ,  A61K45/06 ,  C12Q1/6883 ,  C12Q2600/156 ,  A61K31/137 ,  A61K2300/00

摘要： A method of treating and/or preventing Dravet Syndrome in a patient such as a patient previously diagnosed with Dravet Syndrome, by administering an effective dose of fenfluramine or its pharmaceutically acceptable salt to that patient. Dravet Syndrome patients are typically children under the age of 18 and are treated at a preferred dose of less than about 0.5 to about 0.01 mg/kg/day.