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公开(公告)号：US20130067608A1
公开(公告)日：2013-03-14
申请号：US13587215
申请日：2012-08-16
Applicant: Bruno DOMON , Aiqun LI , Tao HE , Ian MCCAFFERY
Inventor： Bruno DOMON , Aiqun LI , Tao HE , Ian MCCAFFERY
IPC: A61K39/395 , C12N15/12 , C12N15/52 , C12N15/113 , C12N5/12 , C12N1/19 , C12N1/21 , C12N5/10 , C12N5/071 , C12N5/09 , G01N33/566 , G01N33/574 , C40B30/04 , G01N33/53 , C12Q1/68 , C07K14/435 , C07K16/18 , A61K38/17 , A61P35/00 , A01K67/00 , C12N9/00
CPC classification number: C07K14/47 , A61K38/00 , A61K39/00 , C07K16/18 , C07K16/3046 , C07K2317/734 , C12N15/113 , C12N2310/14 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N33/57419
Abstract: The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibodies binds to CCAT. The present invention provides that CCAT is used as targets for screening agents that modulates the CCAT activities. Further the present invention provides methods for treating diseases associated with colon.
Abstract translation: 本发明提供了诊断和检测与结肠相关疾病的方法。 本发明提供在结肠疾病（CCAT）中差异表达的一种或多种蛋白质或其片段，肽或核酸分子，并且抗体结合CCAT。 本发明提供CCAT用作调节CCAT活性的筛选剂的靶标。 此外，本发明提供了治疗与结肠相关疾病的方法。
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公开(公告)号：US08110373B2
公开(公告)日：2012-02-07
申请号：US12504826
申请日：2009-07-17
Applicant: Steve Ruben , Candy N. Lee , Bruno Domon
Inventor： Steve Ruben , Candy N. Lee , Bruno Domon
IPC: G01N33/574
CPC classification number: G01N33/57484 , A61K38/00 , A61K47/6843 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C12N15/113 , C12N2310/14 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , G01N33/574 , G01N33/57423 , G01N33/6893 , G01N2500/10 , Y10T436/143333
Abstract: Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro.
Abstract translation: 提供了与健康细胞相比，用于诊断和治疗与疾病细胞中癌症相关靶（CAT）不同表达相关的疾病，特别是癌症的方法和组合物。 还提供了CAT的拮抗剂和激动剂，以及用于筛选在体内或体外调节CAT水平或活性的药剂的方法。
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公开(公告)号：US20080219992A1
公开(公告)日：2008-09-11
申请号：US12070053
申请日：2008-02-13
Applicant: Kim Alving , Steve Ruben , Ian McCaffery , Bruno Domon
Inventor： Kim Alving , Steve Ruben , Ian McCaffery , Bruno Domon
IPC: A61K39/395 , A61P35/00 , C07K14/47 , A61K38/17 , C12N15/12 , C12Q1/68 , G01N33/566 , C07K16/18 , C12N5/16 , C12N5/10
CPC classification number: C07K14/4748 , G01N33/57438
Abstract: The present invention provides a method for diagnosing and detecting diseases associated with pancreas. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in pancreatic diseases (PCAST) and antibodies binds to PCAST. The present invention provides that PCAST is used as targets for screening agents that modulates the PCAST activities. Further the present invention provides methods for treating diseases associated with pancreas.
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4.发明申请公开(公告)号：US20060029988A1
公开(公告)日：2006-02-09
申请号：US10912582
申请日：2004-08-06
Applicant: Bruno Domon , Ian McCaffery , Vaibhav Narayan , Scott Patterson
Inventor： Bruno Domon , Ian McCaffery , Vaibhav Narayan , Scott Patterson
IPC: G01N33/574
CPC classification number: G01N33/57438 , A61K2039/505 , C07K16/2896 , C07K2317/73 , G01N2800/52
Abstract: Methods and compositions for diagnosing, detecting and treating a pancreatic disease associated with differential expression of E-cadherin in comparison to healthy cells. Also provided are antagonists or agonists of E-cadherin, and methods for screening agents that modulate the E-cadherin level or activity in vivo or in vitro.
Abstract translation: 与健康细胞相比，用于诊断，检测和治疗与E-钙粘蛋白差异表达相关的胰腺疾病的方法和组合物。 还提供了E-钙粘蛋白的拮抗剂或激动剂，以及用于在体内或体外调节E-钙粘蛋白水平或活性的筛选剂的方法。
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公开(公告)号：US09377469B2
公开(公告)日：2016-06-28
申请号：US14579206
申请日：2014-12-22
Applicant: Joel Louette , John Charles Rogers , Scott M. Peterman , Bruno Domon , Elodie Duriez
Inventor： Joel Louette , John Charles Rogers , Scott M. Peterman , Bruno Domon , Elodie Duriez
CPC classification number: G01N33/6848 , B82Y15/00 , C07K2/00 , G01N30/7233 , G01N30/8665 , G01N30/8675 , G01N33/532 , G01N33/68 , G01N2458/15 , H01J49/0009 , H01J49/0031 , H01J49/0036 , Y10T436/25 , Y10T436/25125
Abstract: Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.
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Patent Agency Ranking
公开(公告)号：US20150148260A1
公开(公告)日：2015-05-28
申请号：US14579206
申请日：2014-12-22
Applicant: Joel Louette , John Charles Rogers , Scott M. Peterman , Bruno Domon , Elodie Duriez
Inventor： Joel Louette , John Charles Rogers , Scott M. Peterman , Bruno Domon , Elodie Duriez
CPC classification number: G01N33/6848 , B82Y15/00 , C07K2/00 , G01N30/7233 , G01N30/8665 , G01N30/8675 , G01N33/532 , G01N33/68 , G01N2458/15 , H01J49/0009 , H01J49/0031 , H01J49/0036 , Y10T436/25 , Y10T436/25125
Abstract: Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.
Abstract translation: 在使用与报告物偶联的标记肽的质谱法和通用报道分子中，分析物的定量，包括但不限于肽，多肽和蛋白质。
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公开(公告)号：US20130105684A1
公开(公告)日：2013-05-02
申请号：US13805059
申请日：2011-07-07
Applicant: Joel Louette , John Charles Rogers , Scott M. Peterman , Bruno Domon , Elodie Duriez
Inventor： Joel Louette , John Charles Rogers , Scott M. Peterman , Bruno Domon , Elodie Duriez
IPC: G01N33/68
CPC classification number: G01N33/6848 , B82Y15/00 , C07K2/00 , G01N30/7233 , G01N30/8665 , G01N30/8675 , G01N33/532 , G01N33/68 , G01N2458/15 , H01J49/0009 , H01J49/0031 , H01J49/0036 , Y10T436/25 , Y10T436/25125
Abstract: Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.
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公开(公告)号：US07960100B1
公开(公告)日：2011-06-14
申请号：US12077323
申请日：2008-03-17
Applicant: Bruno Domon , Aiqun Li , Tao He , Ian McCaffery
Inventor： Bruno Domon , Aiqun Li , Tao He , Ian McCaffery
IPC: C12Q1/00 , G01N33/574
CPC classification number: C07K14/47 , A61K38/00 , A61K39/00 , C07K16/18 , C07K16/3046 , C07K2317/734 , C12N15/113 , C12N2310/14 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N33/57419
Abstract: The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibodies binds to CCAT. The present invention provides that CCAT is used as targets for screening agents that modulates the CCAT activities. Further the present invention provides methods for treating diseases associated with colon.
Abstract translation: 本发明提供了诊断和检测与结肠相关疾病的方法。 本发明提供在结肠疾病（CCAT）中差异表达的一种或多种蛋白质或其片段，肽或核酸分子，并且抗体结合CCAT。 本发明提供CCAT用作调节CCAT活性的筛选剂的靶标。 此外，本发明提供了治疗与结肠相关疾病的方法。
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公开(公告)号：US07807392B1
公开(公告)日：2010-10-05
申请号：US11905216
申请日：2007-09-28
Applicant: Bruno Domon , Elizabeth Joseloff , Aiqun Li , Tao He
Inventor： Bruno Domon , Elizabeth Joseloff , Aiqun Li , Tao He
IPC: G01N33/574
CPC classification number: G01N33/57423
Abstract: The present invention provides a method for diagnosing and detecting diseases associated with lung. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in lung cancer (LCAT) and antibodies binds to LCATs. The present invention provides that LCATs are used as targets for screening agents that modulates the LCAT activities. Further the present invention provides methods for treating diseases associated with lung.
Abstract translation: 本发明提供了诊断和检测与肺相关疾病的方法。 本发明提供在肺癌（LCAT）中差异表达的一种或多种蛋白质或其片段，肽或核酸分子，并且抗体结合LCAT。 本发明提供LCAT作为调节LCAT活性的筛选剂的靶标。 此外，本发明提供了治疗与肺相关疾病的方法。
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公开(公告)号：US07776555B1
公开(公告)日：2010-08-17
申请号：US11822094
申请日：2007-07-02
Applicant: Bruno Domon , Steve Ruben , Charles E. Birse , Yeoun Jin Kim , Tao He , Ian McCaffery
Inventor： Bruno Domon , Steve Ruben , Charles E. Birse , Yeoun Jin Kim , Tao He , Ian McCaffery
IPC: G01N33/53
CPC classification number: G01N33/57419
Abstract: The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibodies binds to CCAT. The present invention provides that CCAT is used as targets for screening agents that modulates the CCAT activities. Further the present invention provides methods for treating diseases associated with colon.
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