Abstract:
A series of monocyclic or bicyclic diamine-substituted thieno[2,3-d]pyrimidine and isothiazolo[5,4-d]pyrimidine derivatives are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.
Abstract:
The present invention relates to processes for the preparation of oxindoles and ortho-substituted anilines and their use as intermediates for syntheses. The invention further relates to a process for the preparation of compounds of formula (4): where a mixture of an aniline (compound of formula Q) is reacted with a thioether (compound of formula W): in the presence of a chlorinating agent and an organic solvent at a reaction temperature in the range above −65° C. In a subsequent process, this compound is further reacted in the presence of an acid catalyst to give the indole of formula (7) or the oxindole of formula (8):
Abstract:
Optically active cyclic amines of the formula (I) or salts thereof in which A, R0, R are each as defined in claim 1, and R0 and A, or R and A, or R0 and R may also form rings, where R and the NH—R0 group on the two ring carbon atoms marked with an asterisk (*) in each case are arranged in cis arrangement to one another and the stereochemical configuration on these carbon atoms is different from the racemic configuration, can be prepared effectively by a process, which comprises converting an imine (a racemic imine) of the formula (II) in which A, R0 and R are each as defined in formula (I), in the presence of hydrogen or a hydrogen donor and a nonenzymatic catalyst which comprises a catalytically active optically active complex of one or more transition metals from the group of ruthenium, rhodium, palladium, iridium, osmium, platinum, iron, nickel and samarium with organic ligands, to the compound of the formula (I).
Abstract:
A process for the preparation of the compounds of the formula (I), or salts thereof, wherein R represents a hydrogen atom or difluoromethanesulfonyl, characterized in that compounds of the formula (II), or salts thereof, wherein R has the same definition as aforementioned, and n represents 0 or 1, are reacted in the presence of hydrogen peroxide and acetic acid.
Abstract:
The invention relates to a process for the preparation of a compound of formula (I): Which comprises reaction of a compound of formula (II) with a compound of the formula (III) in the presence of a chlorinating agent, followed by reaction of the resultant compound of the formula (IV) with a compound of formula (V) in the presence of a base: wherein the various symbols are as defined in claim 1.
Abstract:
A method for the correction of average brightness or brightness uniformity variations in electroluminescent (EL) displays comprising: a) providing an EL display having one or more light-emitting elements responsive to a multi-valued input signal for causing the light-emitting elements to emit light at a plurality of brightness levels; b) measuring the brightness of each light-emitting element at two or more, but fewer than all possible, different input signal values; c) employing the measured brightness values to estimate a maximum input signal value at which the light-emitting element will not emit more than a predefined minimum brightness and the rate at which the brightness of the light-emitting element increases above the predefined minimum brightness in response to increases in the value of the input signal; and d) using the estimated maximum input signal value at which the light-emitting element will not emit light more than the predefined minimum brightness and the rate at which the brightness of the light-emitting element increases above the predefined minimum brightness in response to increases in the value of the input signal to modify the input signal to a corrected input signal to correct the light output of the light-emitting elements.
Abstract:
This invention includes methods and systems for processing hydrogel biomedical devices, such as ophthalmic lenses using polyethylene glycol to facilitate release of the devices from a mold part.
Abstract:
A system for the correction of brightness and uniformity variations in OLED displays is described, comprising: a) an OLED display including a plurality of light-emitting elements; b) a non-volatile memory having uniformity correction information for the OLED display stored therein and permanently associated with and physically attached to the OLED display; and c) a controller connected to the OLED display and to the non-volatile memory for reading the information from the non-volatile memory, receiving an input signal, correcting the input signal using the information to form a corrected input signal, and transmitting the corrected input signal to the OLED display. Also described are OLED display device units comprising an OLED display and a permanently associated non-volatile memory, and a method for the correction of brightness and uniformity variations in OLED displays.