公开(公告)号：US5635346A

公开(公告)日：1997-06-03

申请号：US372723

申请日：1995-01-17

申请人： David C. Leahy ,  John A. Todd ,  Michael E. Jolley ,  Dinesh O. Shah ,  Delia R. Bethell ,  Terukatsu Arima

发明人： David C. Leahy ,  John A. Todd ,  Michael E. Jolley ,  Dinesh O. Shah ,  Delia R. Bethell ,  Terukatsu Arima

IPC分类号： A61K39/00 ,  C07K14/005 ,  C07K14/18 ,  G01N33/53 ,  G01N33/543 ,  G01N33/551 ,  G01N33/553 ,  G01N33/576 ,  C12Q1/70

CPC分类号： C07K14/005 ,  G01N33/5767 ,  C12N2770/24222

摘要： New assays for diagnosing NANBH utilizing novel peptide fragments derived from polypeptide antigens reactive to antibodies present in the sera of infected patients are disclosed. In producing these peptides, the portion of the polypeptide contributing to high backgrounds is deleted thereby resulting in assays with an exceptionally high signal to background ratio.

摘要翻译： 公开了利用衍生自对感染患者血清中存在的抗体具有反应性的多肽抗原的新肽片段来诊断NANBH的新的测定法。 在生产这些肽时，有助于高背景的多肽的部分被缺失，从而导致具有非常高的信号与背景比的测定。

公开(公告)号：US5101850A

公开(公告)日：1992-04-07

申请号：US430551

申请日：1989-11-01

申请人： John A. Todd

发明人： John A. Todd

IPC分类号： B01D35/153

CPC分类号： B01D35/153 ,  Y10T137/0486 ,  Y10T137/794

摘要： A liquid shutoff safety interlock device is provided which ensures that fluid flow to a filter is stopped prior to filter removal without requiring the use of a complex and expensive filter valve assembly and without requiring any substantial modification of existing components. The invention is particularly, though not exclusively, adapted to fuel dispensing equipment supplied by a remote pump and installed with a filter above and an impact valve below each fluid supply inlet. The liquid shutoff safety device of the present invention is placed between the impact valve and the filter so that in one position the device blocks access to the end of the filter and in another position provides filter access while at the same time tripping the latch arm to close the impact valve.

摘要翻译： 提供了一种液体截止安全联锁装置，其确保在过滤器移除之前停止流向过滤器的流体，而不需要使用复杂和昂贵的过滤阀组件，并且不需要对现有部件进行任何实质的修改。 本发明特别地但不排他地适用于由远程泵供应的燃料分配设备，并且在每个流体供应入口下方安装有过滤器和冲击阀。 本发明的液体关闭安全装置被放置在冲击阀和过滤器之间，使得在一个位置中，装置阻挡对过滤器端部的接近，并且在另一位置提供过滤器进入，同时使闩锁臂跳到 关闭冲击阀。

公开(公告)号：US07244577B2

公开(公告)日：2007-07-17

申请号：US10331907

申请日：2002-12-31

申请人： John A. Todd ,  John W. Hess ,  Charles T. Caskey ,  Roger D Cox ,  David Gerhold ,  Holly Hammond ,  Patricia Hey ,  Yoshihiko Kawaguchi ,  Tony R. Merriman ,  Michael L. Metzker ,  Yusuke Nakagawa ,  Michael S. Phillips ,  Rebecca C. J. Twells

发明人： John A. Todd ,  John W. Hess ,  Charles T. Caskey ,  Roger D Cox ,  David Gerhold ,  Holly Hammond ,  Patricia Hey ,  Yoshihiko Kawaguchi ,  Tony R. Merriman ,  Michael L. Metzker ,  Yusuke Nakagawa ,  Michael S. Phillips ,  Rebecca C. J. Twells

IPC分类号： G01N33/567

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

摘要： A novel receptor, “LDL-receptor-related protein-5” (“LRP-5”), is provided, along with encoding nucleic acid. The gene is associated with type 1 diabetes (insulin dependent diabetes mellitus), and experimental evidence provides indication that it is the IDDM susceptibility gene IDDM4. In various aspects the invention provides nucleic acid, including coding sequences, oligonucleotide primers and probes, polypeptides, pharmaceutical compositions, methods of diagnosis or prognosis, and other methods relating to and based on the gene, including methods of treatment of diseases in which the gene may be implicated, including autoimmune diseases, such as glomerulonephritis, diseases and disorders involving disruption of endocytosis and/or antigen presentation, diseases and disorders involving cytokine clearance and/or inflammation, viral infection, elevation of free fatty acids or hypercholesterolemia, osteoporosis, Alzheimer's disease, and diabetes.

摘要翻译： 提供了新的受体“LDL-受体相关蛋白-5”（“LRP-5”）以及编码核酸。 该基因与1型糖尿病（胰岛素依赖性糖尿病）相关，实验证据表明其是IDDM易感基因IDDM4。 在各个方面，本发明提供核酸，包括编码序列，寡核苷酸引物和探针，多肽，药物组合物，诊断或预后的方法，以及与该基因相关并基于该基因的其它方法，包括治疗其中基因 可能涉及自身免疫性疾病，例如肾小球性肾炎，涉及细胞内吞和/或抗原呈递破坏的疾病和病症，涉及细胞因子清除和/或炎症的疾病和病症，病毒感染，游离脂肪酸升高或高胆固醇血症，骨质疏松症，阿尔茨海默病 疾病和糖尿病。

公开(公告)号：US4223807A

公开(公告)日：1980-09-23

申请号：US10294

申请日：1979-02-08

申请人： Richard L. Caswell ,  John A. Todd

发明人： Richard L. Caswell ,  John A. Todd

IPC分类号： B67D7/08 ,  B67D5/08

CPC分类号： B67D7/08

摘要： Customer dispensing of either unleaded or one of two or more grades of leaded gasoline products is selected by rotatable selector knobs located on the dispenser housing. Individual meters are operative by the leaded and unleaded dispensing systems which are hydraulically isolated from each other. The separate selector knobs are associated with each of the leaded and unleaded dispensing systems and are effective when actuated to render the other system inoperative by an imposed mechanical interlock. Bothe meters operate a common computers for calculating the transaction data of each dispensing sale.

摘要翻译： 通过位于分配器壳体上的可旋转选择旋钮选择无铅或两种或更多级别的含铅汽油产品的客户分配。 单独的仪表由通过液压隔离的有铅和无铅分配系统操作。 单独的选择器旋钮与每个有铅和无铅分配系统相关联，并且当被致动以使另一个系统由施加的机械互锁不起作用时是有效的。 Bothe仪表操作常用的计算机，用于计算每个分销销售的交易数据。

公开(公告)号：US4131216A

公开(公告)日：1978-12-26

申请号：US791812

申请日：1977-04-28

申请人： William J. Gerstenmaier ,  John A. Todd

发明人： William J. Gerstenmaier ,  John A. Todd

IPC分类号： B67D7/06 ,  G01M3/28 ,  B67D5/14

CPC分类号： B67D7/06 ,  G01M3/2892

摘要： A system and method for detecting leaks in an underground piping network supplying liquid petroleum products pumped from an underground storage tank to an aboveground dispenser outlet. A highly sensitive flow detector situated in a parallel looped bypass arrangement is selectively operated for ascertaining existence or non-existence of a piping leak. Following a sufficient time lapse of non-dispensing for enabling temperature stabilization of the piping network to occur, the detector is actuated in a controlled sequence of go, no-go steps that culminates in ascertaining existence or non-existence of a piping leak while at the same time eliminating any false indication occasioned by detector malfunction.

摘要翻译： 一种用于检测地下管网中泄漏的系统和方法，该地下管道网络将从地下储罐泵送的液化石油产品供应到地上分配器出口。 选择性地操作位于并联环路旁路装置中的高灵敏度流量检测器，以确定管道泄漏的存在或不存在。 经过足够的不分配时间后，可以实现管网的温度稳定化，检测器以受控制的顺序执行，最终确定管道泄漏的存在或不存在，同时在 同时消除由检测器故障引起的任何错误指示。

公开(公告)号：US06545137B1

公开(公告)日：2003-04-08

申请号：US09060299

申请日：1998-04-15

申请人： John A. Todd ,  John W. Hess ,  Charles T. Caskey ,  Roger D Cox ,  David Gerhold ,  Holly Hammond ,  Patricia Hey ,  Yoshihiko Kawaguchi ,  Tony R. Merriman ,  Michael L. Metzker ,  Yusuke Nakagawa ,  Michael S. Phillips ,  Rebecca C.J. Twells

发明人： John A. Todd ,  John W. Hess ,  Charles T. Caskey ,  Roger D Cox ,  David Gerhold ,  Holly Hammond ,  Patricia Hey ,  Yoshihiko Kawaguchi ,  Tony R. Merriman ,  Michael L. Metzker ,  Yusuke Nakagawa ,  Michael S. Phillips ,  Rebecca C.J. Twells

IPC分类号： C07H2104

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

摘要： A novel receptor, “LDL-receptor related protein-3” (“LRP-3”), is provided, along with encoding nucleic acid. The gene is associated with type 1 diabetes (insulin dependent diabetes mellitus), and experimental evidence provides indication that it is the IDDM susceptibility gene IDDM4. In various aspects the invention provides nucleic acid, including coding sequences, oligonucleotide primers and probes, polypeptides, pharmaceutical compositions, methods of diagnosis or prognosis, and other methods relating to and based on the gene, including methods of treatment of diseases in which the gene may be implicated, including autoimmune diseases, such as glomerulonephritis, diseases and disorders involving disruption of endocytosis and/or antigen presentation, diseases and disorders involving cytokine clearance and/or inflammation, viral infection, elevation of free fatty acids or hypercholesterolemia, osteoporosis, Alzheimer's disease, and diabetes.

摘要翻译： 提供了新的受体“LDL-受体相关蛋白-3”（“LRP-3”）以及编码核酸。 该基因与1型糖尿病（胰岛素依赖性糖尿病）相关，实验证据表明其是IDDM易感基因IDDM4。 在各个方面，本发明提供核酸，包括编码序列，寡核苷酸引物和探针，多肽，药物组合物，诊断或预后的方法，以及与该基因相关并基于该基因的其它方法，包括治疗其中基因 可能涉及自身免疫性疾病，例如肾小球性肾炎，涉及细胞内吞和/或抗原呈递破坏的疾病和病症，涉及细胞因子清除和/或炎症的疾病和病症，病毒感染，游离脂肪酸升高或高胆固醇血症，骨质疏松症，阿尔茨海默病 疾病和糖尿病。

公开(公告)号：US5816174A

公开(公告)日：1998-10-06

申请号：US690589

申请日：1996-07-25

申请人： Ervin M. Smith ,  John A. Todd ,  Dennis K. Troy ,  Phillip L. Brookshire

发明人： Ervin M. Smith ,  John A. Todd ,  Dennis K. Troy ,  Phillip L. Brookshire

IPC分类号： G07F19/00 ,  E05G1/00

CPC分类号： G07F19/20 ,  G07F19/201

摘要： Automated attendant terminals and a mounting system for such terminals. Each attendant terminal is substantially L-shaped and comprises a housing formed by front, opposing side, rear, and first and second contact surfaces. The first and second contact surfaces form the recessed portion of the L-shape. When used in connection with the mounting system of the present invention, the first contact surfaces and/or the second contact surfaces of each terminal contacts the surfaces of the support mechanism (such as a pole) to result in a "back-to-back" orientation of the terminals. The support mechanism includes opposing surfaces for such engagement with the contact surfaces of the terminals. The mounting system also includes an attachment mechanism which connects the terminals to the poles in this orientation. The attachment mechanism is only accessible through the interior of the housings of the terminals to thereby provide a secure island automated attendant terminal system.

摘要翻译： 自动话务员终端和这种终端的安装系统。 每个服务员终端大致为L形，并且包括由前部，相对侧面，后部以及第一和第二接触表面形成的壳体。 第一和第二接触表面形成L形的凹部。 当与本发明的安装系统结合使用时，每个端子的第一接触表面和/或第二接触表面接触支撑机构（例如极）的表面以导致“背对背 “终端方向。 支撑机构包括用于与端子的接触表面接合的相对表面。 该安装系统还包括一个连接机构，该连接机构将端子以这种方向连接到极点。 附接机构只能通过端子的壳体的内部进入，从而提供安全的岛式自动化服务员终端系统。

公开(公告)号：US5747240A

公开(公告)日：1998-05-05

申请号：US411913

申请日：1995-03-28

申请人： John A. Kink ,  Terence E. Ryan ,  John A. Todd ,  Badr Saeed

发明人： John A. Kink ,  Terence E. Ryan ,  John A. Todd ,  Badr Saeed

IPC分类号： C07K14/00 ,  C07K14/02 ,  C07K14/10 ,  C07K14/18 ,  C12N1/21 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  G01N33/53 ,  G01N33/576 ,  C12Q1/70 ,  G01N33/551

CPC分类号： C07K14/005 ,  G01N33/5767 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/23 ,  C07K2319/40 ,  C12N2770/24222

摘要： An assay for detection of serum antibodies having specificity to hepatitis C viral antigens utilizes the carboxy-terminal 102 amino acids of the c33c region of nonstructural gene 3 of HCV containing substantially all the epitopes of the gene 3 protein. In the preferred embodiment the recombinant 102 amino acid peptide is coated onto a solid support, and incubated in the presence of serum obtained from a patient infected with HCV. The presence of antibodies bound to the antigen coated support is detected in a sandwich format utilizing a second reporter-conjugated antibody.

摘要翻译： 用于检测对丙型肝炎病毒抗原具有特异性的血清抗体的检测法利用HCV基因3蛋白基本上所有表位的非结构基因3的c33c区的羧基末端102个氨基酸。 在优选的实施方案中，将重组102氨基酸肽包被在固体支持物上，并在从感染HCV的患者获得的血清存在下温育。 使用第二报告基因共轭抗体以夹心形式检测与抗原包被的载体结合的抗体的存在。

公开(公告)号：US5332008A

公开(公告)日：1994-07-26

申请号：US13582

申请日：1993-02-04

申请人： John A. Todd ,  William H. Constantine

发明人： John A. Todd ,  William H. Constantine

IPC分类号： B67D7/04 ,  B65B3/18

CPC分类号： B67D7/0486 ,  Y10T137/86324

摘要： A service station dispenser for gasoline with a vapor collection system is disclosed which processes the electrical signal typically produced by the fuel meter which represents the volume flow rate of fuel to the tank to control the displacement volume of an electrically driven vacuum pump so that a simple vacuum intake disposed preferably inside, but not sealed with, the filler neck can be used to collect only the vapors displaced from the fuel tank by the fuel. The vacuum pump is controlled by a digital processor which prestarts the vacuum pump after a customer demands dispensing to establish a vacuum at the vacuum intake is established by the time fueling is allowed to take place so as have an immediate vacuum available to assist recovery of an initial rush of vapor displaced by commencement of fueling. Once fuel flow starts, the digital processor operates the vacuum pump to produce a vapor flow rate having a proportional relationship with the flow rate of the fuel.

摘要翻译： 公开了一种具有蒸气收集系统的用于汽油的维修站分配器，其处理通常由燃料计量器产生的电信号，其表示到罐的燃料的体积流量以控制电动真空泵的排量，使得简单 真空吸入器优选地设置在内部而不是用填充物颈部密封，可用于仅收集由燃料从燃料箱排出的蒸气。 真空泵由数字处理器控制，该数字处理器在客户要求分配之后提供真空泵，在真空吸入时建立真空，这是通过允许进行燃料发生的时间建立的，以便具有可立即提供的真空以辅助回收 由于开始加油而最初的蒸气排放。 一旦燃料流量开始，数字处理器操作真空泵以产生与燃料的流速成比例关系的蒸汽流量。

公开(公告)号：US5301722A

公开(公告)日：1994-04-12

申请号：US813575

申请日：1991-12-26

申请人： John A. Todd ,  Deborah A. Joines

发明人： John A. Todd ,  Deborah A. Joines

IPC分类号： B60S5/02 ,  B67D7/32 ,  B67D7/78 ,  F02B3/06 ,  B67D5/04

CPC分类号： B67D7/3209 ,  B60S5/02 ,  B67D7/78 ,  F02B3/06 ,  Y10T137/5762

摘要： An apparatus for the collection of fuel spillings that originate from fuel dispensing apparatus, including gasoline and diesel fuel service station pumps which incorporates a filtering system for preventing solids from accumulating in the bottom of the spill collection pan and allowing fill material to be placed between the collection reservoir of the spill collecting pan and the fuel pumps which contributes to the fire prevention features of this apparatus.

摘要翻译： 一种用于收集来自燃料分配装置的燃料溢出的装置，包括汽油和柴油燃料服务站泵，其包括用于防止固体积聚在溢出物收集盘底部的过滤系统，并允许填充材料置于 溢流收集盘的收集池和燃料泵，有助于该装置的防火功能。