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公开(公告)号：US09244195B2
公开(公告)日：2016-01-26
申请号：US13490517
申请日：2012-06-07
CPC分类号： G02C7/049 , B29D11/00346 , G02B1/043 , G02C2202/16
摘要： The invention is related to a method for making a silicone hydrogel contact lens having a nano-textured surface which mimics the surface texture of cornea of human eye. A method of the invention comprises creating a prime coating having nano-textures through controlled imbibition and/or depositions of a reactive polymeric coating material and fixing the nano-textures by crosslinking a hydrophilic polymeric material onto the prime coating to form a crosslinked polymeric coating that perserves the nano-textures of the prime coating and provides a nano-textured surface to the contact lens.
摘要翻译： 本发明涉及制备具有模仿人眼角膜表面纹理的纳米纹理表面的硅酮水凝胶隐形眼镜的方法。 本发明的方法包括通过控制的吸收和/或沉积反应性聚合物涂层来形成具有纳米纹理的初始涂层，并通过将亲水性聚合物材料交联到初始涂层上来固定纳米纹理以形成交联的聚合物涂层 维持主涂层的纳米纹理，并为隐形眼镜提供纳米纹理表面。
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公开(公告)号：US08529057B2
公开(公告)日：2013-09-10
申请号：US13193651
申请日：2011-07-29
申请人： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo N. Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
发明人： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo N. Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC分类号： G02C7/00
CPC分类号： C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
摘要： The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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公开(公告)号：US20120026457A1
公开(公告)日：2012-02-02
申请号：US13193651
申请日：2011-07-29
申请人： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo N. Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
发明人： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo N. Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
CPC分类号： C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
摘要： The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
摘要翻译： 本发明涉及制备其上具有交联亲水性涂层的硅氧水凝胶隐形眼镜的成本有效的方法。 本发明的方法涉及在具有带正电荷的氮杂环丁烷基团的水溶性，高度支化，热交联的亲水性聚合物材料存在下，在约40℃的温度下，在水溶液中加热硅酮水凝胶隐形眼镜 在约140℃下进行足够的时间以将可热交联的亲水聚合物材料共价连接到硅氧烷水凝胶隐形眼镜的表面上，通过共价连接，每个共价键在一个氮杂环丁烷基团和一个反应性官能团之间形成， 和/或靠近硅酮水凝胶隐形眼镜的表面，从而在硅氧水凝胶隐形眼镜上形成交联的亲水涂层。 这种方法可以有利地在高压釜中直接在密封的透镜包装中实现。
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公开(公告)号：US07780879B2
公开(公告)日：2010-08-24
申请号：US12316993
申请日：2008-12-18
摘要： The instant invention pertains to a method and a fluid composition for producing contact lenses with improved lens quality and with increased product yield. The method of the invention involves adding a phospholipid into a fluid composition including a lens-forming material in an amount sufficient to reduce an averaged mold separation force by at least about 40% in comparison with that without the phospholipids.
摘要翻译： 本发明涉及一种用于制造具有改善的镜片质量和增加的产品产量的隐形眼镜的方法和流体组合物。 本发明的方法包括将磷脂添加到包含透镜形成材料的流体组合物中，其量足以将平均的模具分离力与没有磷脂的模具分离力相比降低至少约40％。
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公开(公告)号：US09156213B2
公开(公告)日：2015-10-13
申请号：US13303186
申请日：2011-11-23
IPC分类号： B29D11/00
CPC分类号： B29D11/00038 , B29D11/00865
摘要： The invention provides a method of coating and thereby affecting the surface properties of a substrate such as a contact lens or other ophthalmic device. The method comprises the steps of generating an atmospheric plasma flow from a working gas and controlling the continuity of the atmospheric plasma flow with a power generator, and, introducing the atmospheric plasma flow to a substrate surface.
摘要翻译： 本发明提供一种涂覆方法，从而影响诸如隐形眼镜或其它眼科装置的基底的表面性质。 该方法包括以下步骤：从工作气体产生大气等离子体流，并用发电机控制大气等离子体流的连续性，以及将大气等离子体流引入衬底表面。
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公开(公告)号：US08647658B2
公开(公告)日：2014-02-11
申请号：US12229769
申请日：2008-08-27
CPC分类号： G02B1/043 , A61K9/0048 , A61L12/04 , B29D11/00067
摘要： The present invention relates to improved contact lens products which not only have initial insertion comfort but also are comfortable to wear for more than about 6 hours. The invention is achieved by packaging and storing a hydrogel lens with two or more leachable polymeric lubricants incorporated therein in a relatively viscous packaging solution including a relatively low molecular weight polyethylene glycol (PEG) and a viscosity-enhancing hydrophilic polymer. The present invention also provides methods for making contact lens products of the invention.
摘要翻译： 本发明涉及改进的隐形眼镜产品，其不仅具有初始插入舒适性，而且佩戴舒适时间超过约6小时。 本发明通过将包含两种或更多种可浸出的聚合润滑剂的水凝胶透镜包装并储存在包含相对低分子量聚乙二醇（PEG）和增粘亲水性聚合物的相对粘稠的包装溶液中来实现。 本发明还提供了制造本发明隐形眼镜产品的方法。
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公开(公告)号：US08480227B2
公开(公告)日：2013-07-09
申请号：US13193653
申请日：2011-07-29
IPC分类号： G02C7/00
CPC分类号： C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
摘要： The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.
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公开(公告)号：US08440735B2
公开(公告)日：2013-05-14
申请号：US12834998
申请日：2010-07-13
IPC分类号： C08F2/46 , C08F290/06 , C08J3/28 , G02B1/06 , G02B1/04
摘要： The instant invention pertains to a method and a fluid composition for producing contact lenses with improved lens quality and with increased product yield. The method of the invention involves adding a phospholipid into a fluid composition including a lens-forming material in an amount sufficient to reduce an averaged mold separation force by at least about 40% in comparison with that without the phospholipids.
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公开(公告)号：US08409599B2
公开(公告)日：2013-04-02
申请号：US12917504
申请日：2010-11-02
申请人： Daqing Wu , Xinming Qian , John Dallas Pruitt
发明人： Daqing Wu , Xinming Qian , John Dallas Pruitt
IPC分类号： A61C8/00
CPC分类号： G02C7/04 , G02B1/043 , C08L101/14
摘要： The invention provides a cost-effective method for applying a hydrophilic coating onto a silicone hydrogel contact lens based on Fenton chemistry. The hydrophilic coating is covalently attached onto the contact lens at room temperature without UV irradiation. The invention also provides silicone hydrogel contact lenses having a hydrophilic coating obtained according to the method of the invention.
摘要翻译： 本发明提供了一种基于Fenton化学将亲水性涂层施加到硅酮水凝胶隐形眼镜上的成本有效的方法。 亲水涂层在室温下共价附着在隐形眼镜上，无紫外线照射。 本发明还提供了具有根据本发明方法获得的亲水涂层的硅酮水凝胶隐形眼镜。
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公开(公告)号：US20120314185A1
公开(公告)日：2012-12-13
申请号：US13490517
申请日：2012-06-07
CPC分类号： G02C7/049 , B29D11/00346 , G02B1/043 , G02C2202/16
摘要： The invention is related to a method for making a silicone hydrogel contact lens having a nano-textured surface which mimics the surface texture of cornea of human eye. A method of the invention comprises creating a prime coating having nano-textures through controlled imbibition and/or depositions of a reactive polymeric coating material and fixing the nano-textures by crosslinking a hydrophilic polymeric material onto the prime coating to form a crosslinked polymeric coating that perserves the nano-textures of the prime coating and provides a nano-textured surface to the contact lens.
摘要翻译： 本发明涉及制备具有模仿人眼角膜表面纹理的纳米纹理表面的硅酮水凝胶隐形眼镜的方法。 本发明的方法包括通过控制的吸收和/或沉积反应性聚合物涂层来形成具有纳米纹理的初始涂层，并通过将亲水性聚合物材料交联到初始涂层上来固定纳米纹理以形成交联的聚合物涂层 维持主涂层的纳米纹理，并为隐形眼镜提供纳米纹理表面。
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