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    METHOD FOR SCREENING FOR COMPOUNDS THAT INHIBIT NEURODEGENERATION
    1.
    发明申请
    METHOD FOR SCREENING FOR COMPOUNDS THAT INHIBIT NEURODEGENERATION 审中-公开
    用于筛选不抑制神经元的化合物的方法

    公开(公告)号：US20110223630A1

    公开(公告)日：2011-09-15

    申请号：US12997297

    申请日：2009-06-12

    申请人： Anatoly Nikolaev ,  Marc Tessier-Lavigne

    发明人： Anatoly Nikolaev ,  Marc Tessier-Lavigne

    IPC分类号： C12Q1/02

    CPC分类号： G01N33/5058 ,  G01N33/6896

    摘要： Methods for screening for compounds that inhibit neurodegeneration are presented. Shedding of APP can be a useful marker for neurodegeneration and compounds that inhibit shedding of APP are useful as inhibitors of neurodegeneration. Such compounds may be useful in treatment and/or prevention of various neurological diseases, disorders and neuronal damage and may enhance growth, regeneration or survival of mammalian neuronal cells or tissue.

    摘要翻译： 提出了筛选抑制神经变性的化合物的方法。 APP的脱落可能是神经变性的有用标志物，并且抑制APP脱落的化合物可用作神经退行性抑制剂。 这样的化合物可用于治疗和/或预防各种神经疾病，病症和神经元损伤，并且可以增强哺乳动物神经细胞或组织的生长，再生或存活。

    Promoters of neural regeneration
    5.
    发明授权
    Promoters of neural regeneration 失效

    公开(公告)号：US06512004B2

    公开(公告)日：2003-01-28

    申请号：US09900268

    申请日：2001-07-06

    申请人： Hong-jun Song ,  Mu-ming Poo ,  Guo-li Ming ,  Marc Tessier-Lavigne ,  Zhigang He

    发明人： Hong-jun Song ,  Mu-ming Poo ,  Guo-li Ming ,  Marc Tessier-Lavigne ,  Zhigang He

    IPC分类号： A61K3135

    CPC分类号： A61K31/70

    摘要： The invention provides methods and compositions for promoting neural cell growth and/or regeneration. The general methods involve contacting with an activator of a cyclic nucleotide dependent protein kinase a neural cell subject to growth repulsion mediated by a neural cell growth repulsion factor. The activator may comprise a direct or an indirect activator of the protein kinase; the repulsion factor typically comprises one or more natural, endogenous proteins mediating localized repulsion or inhibition of neural cell growth; and the target cells are generally vertebrate neurons, typically injured mammalian neurons. The subject compositions include mixtures comprising a neural cell, an activator of a cyclic nucleotide dependent protein kinase and a neural cell growth repulsion factor.

    Promoters of neural regeneration
    7.
    发明授权
    Promoters of neural regeneration 失效
    神经再生的启动子

    公开(公告)号：US06268352B1

    公开(公告)日：2001-07-31

    申请号：US09145820

    申请日：1998-09-02

    申请人： Hong-jun Song ,  Mu-Ming Poo ,  Guo-li Ming ,  Marc Tessier-Lavigne ,  Zhigang He

    发明人： Hong-jun Song ,  Mu-Ming Poo ,  Guo-li Ming ,  Marc Tessier-Lavigne ,  Zhigang He

    IPC分类号： A61K3170

    CPC分类号： A61K31/70

    摘要： The invention provides methods and compositions for promoting neural cell growth and/or regeneration. The general methods involve contacting with an activator of a cyclic nucleotide dependent protein kinase a neural cell subject to growth repulsion mediated by a neural cell growth repulsion factor. The activator may comprise a direct or an indirect activator of the protein kinase; the repulsion factor typically comprises one or more natural, endogenous proteins mediating localized repulsion or inhibition of neural cell growth; and the target cells are generally vertebrate neurons, typically injured mammalian neurons. The subject compositions include mixtures comprising a neural cell, an activator of a cyclic nucleotide dependent protein kinase and a neural cell growth repulsion factor.

    摘要翻译： 本发明提供促进神经细胞生长和/或再生的方法和组合物。 一般方法包括与环核苷酸依赖性蛋白激酶的激活剂接触受到由神经细胞生长排斥因子介导的生长排斥的神经细胞的接触。 活化剂可以包含蛋白激酶的直接或间接激活剂; 排斥因子通常包含介导局部排斥或抑制神经细胞生长的一种或多种天然的内源性蛋白质; 并且靶细胞通常是脊椎动物神经元，通常是受损的哺乳动物神经元。 主题组合物包括包含神经细胞，环核苷酸依赖性蛋白激酶的激活剂和神经细胞生长排斥因子的混合物。

    Gene trap vectors
    8.
    发明授权
    Gene trap vectors 有权
    基因陷阱载体

    公开(公告)号：US06248934B1

    公开(公告)日：2001-06-19

    申请号：US09191652

    申请日：1998-11-13

    申请人： Marc Tessier-Lavigne ,  William C. Skarnes ,  Kevin Mitchell ,  Philip A. Leighton

    发明人： Marc Tessier-Lavigne ,  William C. Skarnes ,  Kevin Mitchell ,  Philip A. Leighton

    IPC分类号： C12N1500

    CPC分类号： C12N15/1051 ,  A01K2217/05 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/04 ,  C07K2319/60 ,  C12N15/62 ,  C12N15/85 ,  C12N2800/60 ,  C12N2840/203 ,  C12N2840/44 ,  C12Q1/6897

    摘要： The invention provides methods and compositions for expressing targeted gene products in vertebrate neurons. The compositions include gene trap vectors comprising a polynucleotide comprising promoterless selectable marker and axon reporter encoding sequences, which may be operatively joined to an internal ribosome-entry site, and may comprise a splice acceptor site located 5′ to the selectable marker and axon reporter encoding sequences. The methods include methods of expressing an axon reporter in a cell by transferring the subject vectors into an embryonic stem cell and incubating the cell under conditions whereby the cell or a progeny of the cell differentiates into a neuron comprising an axon or dendrites, and the neuron expresses the axon reporter under the transcriptional control of the gene; and specifically detecting the axon reporter in the axon or dendrites. Neuronal specific expression may also be effected in disclosed binary systems.

    摘要翻译： 本发明提供用于在脊椎动物神经元中表达靶基因产物的方法和组合物。 组合物包括基因捕获载体，其包含多核苷酸，其包含无启动子选择标记和轴突报道子编码序列，其可以可操作地连接到内部核糖体进入位点，并且可以包含位于选择性标记5'的剪接受体位点和轴突报告基因编码 序列。 所述方法包括通过将受试载体转移到胚胎干细胞中并在细胞或细胞的后代分化为包含轴突或树突的神经元和神经元的条件下孵育细胞来在细胞中表达轴突报告物的方法 在基因的转录控制下表达轴突记者; 并具体检测轴突或树突中的轴突记录。 神经元特异性表达也可以在公开的二元系统中进行。