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公开(公告)号：US11591623B2
公开(公告)日：2023-02-28
申请号：US16801969
申请日：2020-02-26
发明人： Izuho Hatada , Sumiyo Morita , Takuro Horii
IPC分类号： C12N15/85 , C12N15/90 , C07K16/18 , C12N5/10 , C12N9/10 , C12N15/09 , C07K16/44 , C12N1/00 , C12N15/11
摘要： A DNA methylation editing kit comprises: (1) a fusion protein of inactivated CRISPR-associated endonuclease Cas9 (dCas9) having no nuclease activity and a tag peptide array in which plural tag peptides are linked by linkers, or an RNA or DNA coding therefor; (2) a fusion protein(s) of a tag peptide-binding portion and a methylase or demethylase, or an RNA(s) or DNA(s) coding therefor; and (3) a guide RNA(s) (gRNA(s)) comprising a sequence complementary to a DNA sequence within 1 kb of a desired site of methylation or demethylation, or a DNA(s) expressing the gRNA(s).
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公开(公告)号：US11559602B2
公开(公告)日：2023-01-24
申请号：US16461527
申请日：2017-11-16
申请人： Tokyo Metropolitan Industrial Technology Research Institute , National University Corporation Gunma University
IPC分类号： A61L24/10 , A61K9/00 , A61K47/02 , A61K47/22 , A61K47/42 , A61L31/14 , A61K9/06 , A61L27/24 , A61L31/04
摘要： The purpose of the present invention is to provide an injectable sol into a body, suited for delivery through a catheter, and usable for tissue perforation closure, ulcer protection, or vascular embolization. Provided are a sol for tissue perforation closure, a sol for ulcer protection, and a sol for vascular embolization, each containing from 0.6 mass % to 3 mass % of a collagen, water, from 200 mM to 330 mM sodium chloride, and a buffer and having a pH from 6.0 to 9.0.
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公开(公告)号：US11267840B1
公开(公告)日：2022-03-08
申请号：US17464810
申请日：2021-09-02
发明人： Masahiko Oshige , Ichiro Matsuo , Hiroaki Horiuchi , Shinji Katsura , Fumio Sugawara , Kengo Sakaguchi
摘要： There is provided with a compound. The compound is represented by formula or a salt thereof. R1 is an aliphatic hydrocarbon group having 10 to 26 carbon atoms.
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公开(公告)号：US20220064203A1
公开(公告)日：2022-03-03
申请号：US17462279
申请日：2021-08-31
发明人： Hiroaki HORIUCHI , Masahiko OSHIGE , Ichiro MATSUO , Tetsuo OKUTSU , Shinji KATSURA , Toshitada YOSHIHARA , Seiji TOBITA , Fumio SUGAWARA , Kengo SAKAGUCHI
摘要： There is provided with a compound represented by Formula or a salt thereof; where A is a linking group represented as —X—NHCO— where X is a C1 to C6 alkylene group, each of R1, R2, R4, R5, R7, R8, R10, and R11 is a hydrogen atom, each of R3, R6, and R9 is a substituent of Formula; R12 is selected from a group of substituents represented by Formulae, R13 is a sulfo group, Ra, Rb, and Rc are substituents independently selected from C1 to C6 alkyl groups, and Rd is a hydrogen atom or a C1 to C6 alkyl group, and Rx is a substituent represented by General Formula.
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公开(公告)号：US20210262015A1
公开(公告)日：2021-08-26
申请号：US16320528
申请日：2017-06-01
发明人： Masayasu Kuwahara
IPC分类号： C12Q1/6827
摘要： A method for detecting a gene mutation(s), the method comprising the steps of: hybridizing a single-stranded circular DNA and a primer with a target polynucleotide containing a first region and a second region adjacent to the 3′-side of the first region and containing a mutation; performing a nucleic acid amplification reaction by rolling circle amplification based on formation of a complex of the target polynucleotide, the primer, and the single-stranded circular DNA; and detecting amplified nucleic acid with a detection reagent. In this method, the single-stranded circular DNA contains a sequence complementary to the first region of the target polynucleotide, a primer-binding sequence adjacent to the 5′-side thereof, and preferably a sequence complementary to a detection reagent-binding sequence. The oligonucleotide primer contains a region having a sequence complementary to the second region of the target polynucleotide, and a region adjacent to the 3′-side thereof and having a sequence complementary to the primer-binding sequence of the single-stranded circular DNA.
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公开(公告)号：US20210054061A1
公开(公告)日：2021-02-25
申请号：US17050384
申请日：2019-04-15
申请人： NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY , NIIGATA UNIVERSITY , NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY , KAWASAKI GAKUENN EDUCATIONAL FOUNDATION
发明人： Masakiyo SAKAGUCHI , Shinichi TOYOOKA , Shuta TOMIDA , Kazuhiko SHIEN , Hiroki SATO , Rie KINOSHITA , Junichiro FUTAMI , Kota ARAKI , Mikio OKAZAKI , Eisaku KONDO , Yusuke INOUE , Akira YAMAUCHI
摘要： Provided is a substance capable of effectively suppressing cancer metastasis or a pharmaceutical composition that effectively acts on an inflammatory disease. The pharmaceutical composition is a pharmaceutical composition containing, as an active ingredient, an antibody or an antibody fragment thereof having antigen-binding activity for an S100A8/A9 heterodimer, and blocks interaction between S100A8/A9 and a group of receptors therefor, to thereby strongly suppress cancer metastasis both in vitro and in vivo, or alleviate inflammation. That is, the anti-S100A8/A9 antibody or the antibody fragment thereof can strongly suppress cancer metastasis or alleviate inflammation, by virtue of its blocking action on the interaction between S100A8/A9 and the group of receptors therefor.
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公开(公告)号：US10597719B2
公开(公告)日：2020-03-24
申请号：US15560837
申请日：2016-03-23
发明人： Masayasu Kuwahara
IPC分类号： C12Q1/68 , C12Q1/6876 , C12Q1/6844
摘要： An RNA detection kit comprising: (i) a single-stranded circular DNA template containing: a sequence of 10 to 30 bases complementary to a first portion of a target RNA; a primer-binding sequence of 7 to 8 bases adjacent to 5′-side thereof; and a sequence complementary to a detection reagent-binding sequence such as a guanine quadruplex-forming sequence; (ii) an oligonucleotide primer containing: a sequence of 8 to 15 bases complementary to a second portion adjacent to the 3′-side of the first portion of the target RNA; and a sequence of 7 to 8 bases adjacent to 3′-side thereof and complementary to the primer-binding sequence of the single-stranded circular DNA template; and (iii) a detection reagent such as a guanine quadruplex-binding reagent; is provided.
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8.发明申请公开(公告)号：US20190367808A1
公开(公告)日：2019-12-05
申请号：US16415083
申请日：2019-05-17
申请人： Denka Company Limited , National Institutes For Quantum And Radiological Science And Technology , National University Corporation Gunma University
发明人： Wataru Kada , Kenta Miura , Osamu Hanaizumi , Tomihiro Kamiya , Takahiro Satoh , Junichi Susaki , Suzuya Yamada
摘要： Provided are a charged particle radiation measuring method and a charged particle radiation measuring device using a scintillator comprising a phosphor in which the main component is a SiAlON phosphor.
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公开(公告)号：US10478478B2
公开(公告)日：2019-11-19
申请号：US15941089
申请日：2018-03-30
发明人： Sei-ichiro Motegi
摘要： An effective amount of botulinum toxin type B is administered to a subject in need thereof for treating Raynaud's phenomenon. Botulinum toxin type B may be in a form of an injection, and may be locally administered to a disease affected site, in a dose of 200 to 400 units per disease affected site.
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10.发明授权公开(公告)号：US10450253B2
公开(公告)日：2019-10-22
申请号：US16323299
申请日：2017-02-16
发明人： Hideki Amii , Kazuki Komoda , Masafumi Kobayashi , Yutaka Nakamura , Ryusuke Obinata , Akinori Harada
IPC分类号： C07C29/38 , C07C31/125 , C07C33/46 , C07C35/48 , C07C43/23 , C07C209/68 , C07C211/48 , C07C231/12 , C07C233/15 , C07C41/30 , C07C209/78
摘要： A simple production process is provided of a perfluoroalkyl compound that uses monohydroperfluoroalkane as a starting material, the perfluoroalkyl compound being an important intermediate of organic electronic materials, medicine, agricultural chemicals, functional polymer materials and the like. With monohydroperfluoroalkane is reacted a base and then a carbonyl compound to produce an alcohol having a perfluoroalkyl group. For example, potassium hydroxide is made to interact with trifluoromethane, and a reaction with a carbonyl compound is induced to produce an alcohol having a trifluoromethyl group.
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