公开(公告)号：US06185628B2

公开(公告)日：2001-02-06

申请号：US09237636

申请日：1999-01-26

申请人： G. Byron Sands ,  Peter J. Brown ,  Don A. Dykes ,  Andrew L. Love ,  Kevin W. Eyres

发明人： G. Byron Sands ,  Peter J. Brown ,  Don A. Dykes ,  Andrew L. Love ,  Kevin W. Eyres

IPC分类号： G06F300

CPC分类号： G06F13/105

摘要： A computer system implements a standard modem without the use of a microcontroller. Instead, a digital signal processor is provided on an expansion card, but with direct links to the computer system itself. The code usually implemented in the microcontroller is instead implemented as a virtual modem controller to be called by the operating system of the computer itself. Further, this virtual modem controller includes a virtualized UART, that appears to the operating system software as a hardware UART, with entry points for calls to replace input/output instructions. In this way, standard device driver code written to execute input/output operations is easily converted to operate with the “virtualized” UART.

摘要翻译： 计算机系统在不使用微控制器的情况下实现标准调制解调器。 相反，在扩展卡上提供数字信号处理器，而是直接连接到计算机系统本身。 通常在微控制器中实现的代码被实现为由计算机本身的操作系统调用的虚拟调制解调器控制器。 此外，该虚拟调制解调器控制器包括虚拟化UART，其作为硬件UART在操作系统软件中出现，具有用于替换输入/输出指令的调用的入口点。 以这种方式，写入执行输入/输出操作的标准设备驱动程序代码很容易转换为使用“虚拟化”UART进行操作。

公开(公告)号：US6112260A

公开(公告)日：2000-08-29

申请号：US791590

申请日：1997-01-31

申请人： Arnold R. Colterjohn ,  Peter J. Brown ,  Douglas E. Stewart

发明人： Arnold R. Colterjohn ,  Peter J. Brown ,  Douglas E. Stewart

IPC分类号： G06F13/10 ,  G06F7/02 ,  G06F13/14

CPC分类号： G06F13/105

摘要： A computer system implements a standard modem without the use of a microcontroller. Instead, a digital signal processor is provided on an expansion card, but with direct links to the computer system itself. The code usually implemented in the microcontroller is instead implemented as a virtual modem controller to be called by the operating system of the computer itself. Further, this virtual modem controller includes a virtualized UART, that appears to the operating system software as a hardware UART, and the operating system driver software need not even have its input and output instructions replaced. Instead, debug registers are provided as breakpoints whenever an input/output instruction is executed to the I/O port range at which the UART would normally appear.

摘要翻译： 计算机系统在不使用微控制器的情况下实现标准调制解调器。 相反，在扩展卡上提供数字信号处理器，而是直接连接到计算机系统本身。 通常在微控制器中实现的代码被实现为由计算机本身的操作系统调用的虚拟调制解调器控制器。 此外，该虚拟调制解调器控制器包括虚拟化UART，其作为硬件UART在操作系统软件中出现，并且操作系统驱动器软件甚至不需要更换其输入和输出指令。 相反，每当对UART通常出现的I / O端口范围执行输入/输出指令时，调试寄存器就被提供为断点。

公开(公告)号：US4269605A

公开(公告)日：1981-05-26

申请号：US52474

申请日：1979-06-27

申请人： Peter D. G. Dean ,  Peter J. Brown ,  Vasilis Bouriotis

发明人： Peter D. G. Dean ,  Peter J. Brown ,  Vasilis Bouriotis

IPC分类号： C07K14/47 ,  C07K14/805 ,  G01N33/72 ,  G01N33/66

CPC分类号： C07K14/805 ,  C07K14/47 ,  G01N33/723 ,  Y10S530/816

摘要： Glycoproteins, especially glycosylated hemoglobins, are separated from non-glycosylated proteins, by complexing with a dihydroxyboryl reactive agent. The resulting complex can be separated physically from the non-glycosylated protein, making possible the determination of glycosylated hemoglobin content of lysed blood; a reactive agent and a kit are described for use in such determination and as a monitor in the control of diabetic treatment. The invention can also be used preparatively to isolate glycoproteins.

摘要翻译： 通过与二羟基硼烷反应剂络合，糖蛋白，特别是糖基化血红蛋白与非糖基化蛋白质分离。 所得到的复合物可以与非糖基化蛋白物理分离，使得裂解血液中糖基化血红蛋白含量的测定成为可能; 描述了用于这种测定的反应剂和试剂盒以及用于控制糖尿病治疗的监测器。 本发明也可以制备性地用于分离糖蛋白。

公开(公告)号：US09466269B2

公开(公告)日：2016-10-11

申请号：US14702196

申请日：2015-05-01

申请人： Peter J. Brown, Jr.

发明人： Peter J. Brown, Jr.

IPC分类号： G10D1/08 ,  G10H3/18

CPC分类号： G10D1/085 ,  G10H1/32 ,  G10H3/18 ,  G10H3/181

摘要： An instant access guitar system allowing easy access to cavities in the body portion of the electric guitar. The cavities are covered by plates, a pick guard, flexible laminates or other suitable cover materials. The covers are held in place by magnets that magnetically attach to magnetic material mounted in the guitar body. The appearance of the guitar may be changed by changing the pick guard and the decorative laminate on the headstock. The sound of the guitar may be changed by having unique pickups and wiring releases pre-built in multiple configurations on multiple pick guards as modules to change in and out of the guitar at will with no tools or solder.

摘要翻译： 即时访问吉他系统，可以方便地访问电吉他身体部分的空腔。 空腔由板，拾取护罩，柔性层压板或其他合适的覆盖材料覆盖。 盖子通过磁性地固定在安装在吉他体上的磁性材料上的磁体保持在适当位置。 可以通过改变头架上的拾取护罩和装饰层压板来改变吉他的外观。 吉他的声音可以通过在多个拾音保护装置上以多种配置预先构建的独特的拾音器和接线释放作为模块来改变，以便在没有工具或焊接的情况下随意地改变和移出吉他。

公开(公告)号：US4898949A

公开(公告)日：1990-02-06

申请号：US151512

申请日：1988-02-18

申请人： John J. Wright ,  Sing-Yuen Sit ,  Neelakantan Balasubramanian ,  Peter J. Brown

发明人： John J. Wright ,  Sing-Yuen Sit ,  Neelakantan Balasubramanian ,  Peter J. Brown

IPC分类号： A61K31/41 ,  A61P3/06 ,  C02F11/00 ,  C07D257/04 ,  C07D405/06 ,  C07F9/6524

CPC分类号： C07D257/04 ,  C07D405/06 ,  C07F9/6524

摘要： This invention provides novel tetrazole intermediates of the formula ##STR1## wherein R.sup.1 and R.sup.4 each are independently hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or trifluoromethyl;R.sup.2,R.sup.3,R.sup.5 and R.sup.6 each are independently hydrogen, halogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy;B is hydrogen, C.sub.1-4 alkoxycarbonyl, CH.sub.2 Y or CH.sub.2 Z;Y is hydrogen, hydroxyl or X;Z is ##STR2## X is bromo, chloro or iodo; R.sup.10 is C.sub.1-4 alkyl; andR.sup.11 is phenyl which is unsubstituted or substituted by one or two C.sub.1-4 alkyl or chloro substituents.and processes thereof which are useful for the preparation of antihypercholesterolemic agents.

摘要翻译： 本发明提供了式（Ia）的新型四唑中间体，其中R 1和R 4各自独立地为氢，卤素，C 1-4烷基，C 1-4烷氧基或三氟甲基; R2，R3，R5和R6各自独立地为氢，卤素，C1-4烷基或C1-4烷氧基; B是氢，C 1-4烷氧基羰基，CH 2 Y或CH 2 Z; Y是氢，羟基或X; Z是X，Y是溴，氯或碘; R 10是C 1-4烷基; 并且R 11是未被取代或被一个或两个C 1-4烷基或氯取代基取代的苯基。 及其制备抗高胆固醇血症药物的方法。

公开(公告)号：US20150356955A1

公开(公告)日：2015-12-10

申请号：US14702196

申请日：2015-05-01

申请人： Peter J. Brown, JR.

发明人： Peter J. Brown, JR.

IPC分类号： G10D1/08

CPC分类号： G10D1/085 ,  G10H1/32 ,  G10H3/18 ,  G10H3/181

摘要： An instant access guitar system allowing easy access to cavities in the body portion of the electric guitar. The cavities are covered by plates, a pick guard, flexible laminates or other suitable cover materials. The covers are held in place by magnets that magnetically attach to magnetic material mounted in the guitar body. The appearance of the guitar may be changed by changing the pick guard and the decorative laminate on the headstock. The sound of the guitar may be changed by having unique pickups and wiring releases pre-built in multiple configurations on multiple pick guards as modules to change in and out of the guitar at will with no tools or solder.

摘要翻译： 即时访问吉他系统，可以方便地访问电吉他身体部分的空腔。 空腔由板，拾取护罩，柔性层压板或其他合适的覆盖材料覆盖。 盖子通过磁性地固定在安装在吉他体上的磁性材料上的磁体保持在适当位置。 可以通过改变头架上的拾取护罩和装饰层压板来改变吉他的外观。 吉他的声音可以通过在多个拾音保护装置上以多种配置预先构建的独特的拾音器和接线释放作为模块来改变，以便在没有工具或焊接的情况下随意地改变和移出吉他。

公开(公告)号：US5326760A

公开(公告)日：1994-07-05

申请号：US31439

申请日：1993-03-15

申请人： Andrew B. McElroy ,  Peter J. Brown ,  David H. Drewry ,  James M. Salovich ,  Frank J. Schoenen

发明人： Andrew B. McElroy ,  Peter J. Brown ,  David H. Drewry ,  James M. Salovich ,  Frank J. Schoenen

IPC分类号： C07C237/06 ,  C07D209/48 ,  C07D209/66 ,  C07D213/40 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02 ,  C07D487/04 ,  C07F7/18 ,  A61K31/395 ,  A61K31/40

CPC分类号： C07D209/48 ,  C07C237/06 ,  C07D209/66 ,  C07D213/40 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02 ,  C07D487/04 ,  C07F7/1852 ,  C07F7/1856

摘要： Aminobutanoic acids of the following formula (I): ##STR1## where R.sup.1 -R.sup.5 are a variety of substituents, novel intermediates, a pharmaceutical composition for treating inflammatory diseases, demyelinating diseases, and tumor metastasis, methods for such treatment and processes for preparing compounds of formula (I).

摘要翻译： 下式（I）的氨基丁酸：其中R1-R5是多种取代基，新型中间体，用于治疗炎性疾病，脱髓鞘疾病和肿瘤转移的药物组合物，其用于治疗和治疗的方法 用于制备式（I）的化合物。

公开(公告)号：US5252560A

公开(公告)日：1993-10-12

申请号：US905933

申请日：1992-06-29

申请人： Peter L. Myers ,  Andrew B. McElroy ,  Michael Gregson ,  Peter J. Brown ,  Howard G. Davies ,  David H. Drewry ,  Michael A. Foley

发明人： Peter L. Myers ,  Andrew B. McElroy ,  Michael Gregson ,  Peter J. Brown ,  Howard G. Davies ,  David H. Drewry ,  Michael A. Foley

IPC分类号： A61K38/55 ,  A61K38/00 ,  A61P1/02 ,  A61P17/00 ,  A61P19/10 ,  A61P25/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D209/48 ,  C07D209/66 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/08 ,  A61K37/02 ,  C07D413/12

CPC分类号： C07K5/0222 ,  A61K38/00

摘要： Compounds are described of the formula ##STR1## wherein: R.sup.1 is C.sub.3-6 alkyl or C.sub.1-3 alkylthioC.sub.1-3 alkyl;R.sup.2 is an optionally substituted C.sub.1-6 alkyl or C.sub.1-6 alkoxy group, aryl, heteroaryl, arylC.sub.1-4 alkyl, heteroarylC.sub.1-4 alkyl or a side-chain of a natural .alpha.-amino acid;R.sup.3 is hydrogen, C.sub.1-6 alkyl, CHR.sup.4 COR.sup.5 (where R.sup.4 is a side-chain of a natural .alpha.-amino acid and R.sup.5 is hydroxyl, C.sub.1-6 alkoxy or NHR.sup.6 where R.sup.6 represents a hydrogen atom or a C.sub.1-6 alkyl group) or a group (CH.sub.2).sub.n X (where n is 1 to 6 and X is hydroxyl, C.sub.1-4 alkoxy, heteroaryl or a group NR.sup.7 R.sup.8 where R.sup.7 and R.sup.8 are each hydrogen or C.sub.1-6 alkyl or the group NR.sup.7 R.sup.8 forms a 5 to 7 membered cyclic amine); andHet is an optionally substituted cyclic imide where the cyclic imide ring system has the formula (i), (ii) or (iii) ##STR2## in which A, B, C and D are each CH or 1 or 2 of A, B, C and D represents N and the others represent CH, and E and F may each independently represent CH or N; and physiologically acceptable salts and solvates thereof.These compounds inhibit metalloproteases involved in tissue degradation. Compounds of the invention may be formulated for use in a variety of conditions involving tissue degradation including arthropathy, dermatological conditions, bone resorption, inflammatory diseases, tumour invasion and multiple sclerosis and related diseases involving myelin degradation, and in the promotion of wound healing.

公开(公告)号：US4939265A

公开(公告)日：1990-07-03

申请号：US430029

申请日：1989-11-01

申请人： John J. Wright ,  Sing-Yuen Sit ,  Neelakantan Balasubramanian ,  Peter J. Brown

发明人： John J. Wright ,  Sing-Yuen Sit ,  Neelakantan Balasubramanian ,  Peter J. Brown

IPC分类号： C07D257/04 ,  C07D405/06 ,  C07F9/6524

CPC分类号： C07D257/04 ,  C07D405/06 ,  C07F9/6524

摘要： This invention provides novel tetrazole intermediates of the formula ##STR1## wherein R.sup.1 and R.sup.4 each are independently hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or trifluoromethyl;R.sup.2, R.sup.3, R.sup.5 and R.sup.6 each are independently hydrogen, halogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy;B is hydrogen, C.sub.1-4 alkoxycarbonyl, CH.sub.2 Y or CH.sub.2 Z;Y is hydrogen, hydroxyl or X;Z is ##STR2## X is bromo, chloro or iodo; R.sup.10 is C.sub.1-4 alkyl; andR.sup.11 is phenyl which is unsubstituted or substituted by one or two C.sub.1-4 alkyl or chloro substituents.and processes thereof which are useful for the preparation of antihypercholesterolemic agents.

摘要翻译： 本发明提供式IMA图的新型四唑中间体，其中R 1和R 4各自独立地为氢，卤素，C 1-4烷基，C 1-4烷氧基或三氟甲基; R 2，R 3，R 5和R 6各自独立地为氢，卤素，C 1-4烷基或C 1-4烷氧基; B是氢，C 1-4烷氧基羰基，CH 2 Y或CH 2 Z; Y是氢，羟基或X; Z是X，Y是溴，氯或碘; R 10是C 1-4烷基; 并且R 11是未被取代或被一个或两个C 1-4烷基或氯取代基取代的苯基。 及其制备抗高胆固醇血症药物的方法。

公开(公告)号：US09697807B2

公开(公告)日：2017-07-04

申请号：US15284833

申请日：2016-10-04

申请人： Peter J. Brown, Jr.

发明人： Peter J. Brown, Jr.

IPC分类号： G10D1/08 ,  G10H3/18 ,  G10D3/12 ,  G10D3/14 ,  G10D3/04 ,  G10H1/32

CPC分类号： G10D1/085 ,  G10D3/02 ,  G10D3/04 ,  G10D3/12 ,  G10D3/146 ,  G10H1/32 ,  G10H3/18 ,  G10H3/181 ,  G10H2210/191

摘要： An instant access guitar system allowing easy access to cavities in the body portion of the electric guitar. The cavities are covered by plates, a pick guard, flexible laminates or other suitable cover materials. The covers are held in place by (1) cut-outs in the guitar body and (2) magnets that magnetically attach to magnetic material mounted in the guitar body. The appearance of the guitar may be changed by changing the pick guard and the decorative laminate on the headstock. The sound of the guitar may be changed by having unique pickups and wiring releases pre-built in multiple configurations on multiple pick guards as modules to change in and out of the guitar at will with no tools or solder.