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公开(公告)号：US08603970B2
公开(公告)日：2013-12-10
申请号：US12820727
申请日：2010-06-22
申请人： Paul Habermann , Gerhard Seipke , Roland Kurrle , Gunter Muller , Mark Sommerfeld , Norbert Tennagels , Georg Tschank , Ulrich Werner
发明人： Paul Habermann , Gerhard Seipke , Roland Kurrle , Gunter Muller , Mark Sommerfeld , Norbert Tennagels , Georg Tschank , Ulrich Werner
摘要： The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the addition and/or substitution of negatively and positively charged amino acid residues and by an amidation of the C-terminal carboxy group of the B chain and histidine in position 8 of the insulin A chain. The invention also relates to the production and use thereof.
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2.发明授权IL-4 receptor for the therapy, prophylaxis and diagnosis of allergic, viral, and bacterial diseases and of fungal infections 失效用于治疗，预防和诊断过敏，病毒和细菌疾病以及真菌感染的IL-4受体公开(公告)号：US06210661B1
公开(公告)日：2001-04-03
申请号：US08692446
申请日：1996-08-05
IPC分类号： A61K4500
CPC分类号： G01N33/6893 , A61K38/177 , A61K38/1793 , A61K38/217 , A61K39/35 , B01D53/502 , G01N33/566 , G01N33/56905 , G01N33/56911 , G01N33/56961 , G01N33/56983 , G01N33/6866 , G01N33/6869 , G01N2800/24 , Y02A50/41 , Y02A50/412 , Y02A50/423 , A61K2300/00
摘要： The IL-4 receptor for the therapy, prophylaxis and diagnosis of allergic, viral, parasitic and bacterial diseases and of fungal infections. The invention relates to the il-4 receptor or variants thereof for the therapy, prophylaxis and diagnosis of allergic, viral, parasitic and bacterial diseases and of fungal infections.
摘要翻译： 用于治疗，预防和诊断过敏性，病毒性，寄生性和细菌性疾病以及真菌感染的IL-4受体。 本发明涉及用于治疗，预防和诊断过敏，病毒，寄生和细菌疾病和真菌感染的il-4受体或其变体。
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3.发明授权Magnetic protein conjugates, a process for the preparation thereof, and the use thereof 失效磁性蛋白质缀合物，其制备方法及其用途
公开(公告)号：US5672687A
公开(公告)日：1997-09-30
申请号：US375232
申请日：1995-01-19
IPC分类号： C12P21/08 , A61K9/50 , A61K38/00 , A61K38/22 , A61K38/36 , A61K39/395 , A61K39/44 , A61K47/48 , A61P7/00 , A61P35/02 , C07K1/113 , C07K14/00 , C07K14/42 , C07K14/475 , C07K14/52 , C07K14/575 , C07K16/00 , C07K16/18 , C07K16/28 , C07K17/06 , C07K17/14 , C12N5/00 , C12N5/06 , G01N33/543 , G01N33/547 , G01N33/553
CPC分类号： G01N33/54353 , A61K47/48007 , A61K47/48715 , A61K9/5094 , C07K1/1133 , C07K17/06 , C12N5/0087 , G01N33/5434 , G01N2446/90
摘要： The invention relates to magnetic protein conjugates of the formula I ##STR1## in which M represents a dispersible magnetically reacting material or particle which carries aminogroups, Ig represents a protein which carries one or more mercapto groups, and X represents an organic chemical structure which links the two ligands by chemical means, to a process for the preparation of protein conjugates of the formula I, and to the use of conjugates of this type for removing cells or soluble bioorganic molecules or components from aqueous salt solutions or body fluids, and to the use thereof within the framework of a diagnostic method or as a diagnostic aid.
摘要翻译： 本发明涉及式I的磁性蛋白质缀合物，其中M代表携带氨基的可分散的磁性反应材料或颗粒，Ig代表携带一个或多个巯基的蛋白质，X代表有机化学结构， 通过化学方法将两个配体连接到制备式I的蛋白质缀合物的方法中，以及使用这种用于从盐水溶液或体液中除去细胞或可溶性生物有机分子或组分的共轭物，以及 在诊断方法或诊断辅助框架内的使用。
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4.发明授权Use of the IL-4 receptor for the therapy prophylaxis and diagnosis of allergic viral parasitic and bacterial diseases and of fungal infections 有权IL-4受体用于预防和诊断过敏性，病毒性，寄生性和细菌性疾病以及真菌感染的用途公开(公告)号：US06328954B1
公开(公告)日：2001-12-11
申请号：US09363192
申请日：1999-07-29
IPC分类号： A61K4500
CPC分类号： G01N33/6893 , A61K38/177 , A61K38/1793 , A61K38/217 , A61K39/35 , B01D53/502 , G01N33/566 , G01N33/56905 , G01N33/56911 , G01N33/56961 , G01N33/56983 , G01N33/6866 , G01N33/6869 , G01N2800/24 , Y02A50/41 , Y02A50/412 , Y02A50/423 , A61K2300/00
摘要： The use of the IL-4 receptor for the therapy, prophylaxis and diagnosis of allergic, viral, parasitic and bacterial diseases and of fungal infections. The invention relates to the use of the IL-4 receptor or of derivatives thereof for the therapy, prophylaxis and diagnosis of allergic, viral, parasitic and bacterial diseases and of fungal infections.
摘要翻译： IL-4受体用于治疗，预防和诊断过敏性，病毒性，寄生性和细菌性疾病以及真菌感染的用途本发明涉及IL-4受体或其衍生物在治疗，预防中的用途 并诊断过敏，病毒，寄生虫和细菌性疾病以及真菌感染。
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公开(公告)号：US06294172B1
公开(公告)日：2001-09-25
申请号：US08383678
申请日：1995-02-01
申请人： Klaus Bosslet , Roland Kurrle , Hans Harald Sedlacek , Ernst-Jurgen Kanzy , Takako Katoh , Hans Ulrich Schorlemmer , Gerhard Luben
发明人： Klaus Bosslet , Roland Kurrle , Hans Harald Sedlacek , Ernst-Jurgen Kanzy , Takako Katoh , Hans Ulrich Schorlemmer , Gerhard Luben
IPC分类号： A61K39395
CPC分类号： C07K16/3007 , A61K39/0011 , A61K47/6851 , A61K51/1045 , A61K2123/00 , C07K16/30 , C07K16/303 , G01N33/57415 , G01N33/57423 , G01N33/57438 , G01N33/57449 , G01N33/57492
摘要： Monoclonal antibodies with specificity for membrane-associated antigens and methods of using them in detection of tumor-associated antigens arc described.
摘要翻译： 描述了具有膜相关抗原特异性的单克隆抗体及其在肿瘤相关抗原检测中的应用。
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公开(公告)号：US09644017B2
公开(公告)日：2017-05-09
申请号：US12820722
申请日：2010-06-22
申请人： Paul Habermann , Gerhard Seipke , Roland Kurrle , Gunter Muller , Mark Sommerfeld , Norbert Tennagels , Georg Tschank , Ulrich Werner
发明人： Paul Habermann , Gerhard Seipke , Roland Kurrle , Gunter Muller , Mark Sommerfeld , Norbert Tennagels , Georg Tschank , Ulrich Werner
摘要： The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the following features: a) the B chain end consists of an amidated basic amino acid residue such as lysine or arginine amide; b) the N-terminal amino acid residue of the insulin A chain is a lysine or arginine radical; c) the amino acid position A8 is occupied by a histidine radical; d) the amino acid position A21 is occupied by a glycine radical; and e) one or more substitutions and/or additions of negatively charged amino acid residues are carried out in the positions A5, A15, A18, B-1, B0, B1, B2, B3 and B4.
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7.发明申请公开(公告)号：US20110173722A1
公开(公告)日：2011-07-14
申请号：US12820727
申请日：2010-06-22
申请人： Paul HABERMANN , Gerhard SEIPKE , Roland KURRLE , Gunter MULLER , Mark SOMMERFELD , Norbert TENNAGELS , Georg TSCHANK , Ulrich WERNER
发明人： Paul HABERMANN , Gerhard SEIPKE , Roland KURRLE , Gunter MULLER , Mark SOMMERFELD , Norbert TENNAGELS , Georg TSCHANK , Ulrich WERNER
IPC分类号： A61K38/28 , C07K14/62 , C12P21/06 , C07H21/04 , C12N15/63 , C07K14/47 , A61P3/10 , A61P19/00 , A01H11/00 , C12N1/00 , A01H5/00
CPC分类号： C07K14/62
摘要： The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the addition and/or substitution of negatively and positively charged amino acid residues and by an amidation of the C-terminal carboxy group of the B chain and histidine in position 8 of the insulin A chain. The invention also relates to the production and use thereof.
摘要翻译： 本发明涉及具有基础时间作用特征的新型胰岛素类似物，其特征在于负和带正电荷的氨基酸残基的添加和/或取代以及B链和组氨酸的C端羧基的酰胺化 在胰岛素A链的位置8。 本发明还涉及其生产和使用。
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8.发明申请公开(公告)号：US20110077197A1
公开(公告)日：2011-03-31
申请号：US12820722
申请日：2010-06-22
申请人： Paul HABERMANN , Gerhard SEIPKE , Roland KURRLE , Gunter MULLER , Mark SOMMERFELD , Norbert TENNAGELS , Georg TSCHANK , Ulrich WERNER
发明人： Paul HABERMANN , Gerhard SEIPKE , Roland KURRLE , Gunter MULLER , Mark SOMMERFELD , Norbert TENNAGELS , Georg TSCHANK , Ulrich WERNER
摘要： The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the following features: a) the B chain end consists of an amidated basic amino acid residue such as lysine or arginine amide; b) the N-terminal amino acid residue of the insulin A chain is a lysine or arginine radical; c) the amino acid position A8 is occupied by a histidine radical; d) the amino acid position A21 is occupied by a glycine radical; and e) one or more substitutions and/or additions of negatively charged amino acid residues are carried out in the positions A5, A15, A18, B-1, B0, B1, B2, B3 and B4.
摘要翻译： 本发明涉及具有基础时间作用特征的新型胰岛素类似物，其特征在于具有以下特征：a）B链末端由酰胺化的碱性氨基酸残基如赖氨酸或精氨酸酰胺组成; b）胰岛素A链的N-末端氨基酸残基是赖氨酸或精氨酸基; c）氨基酸位置A8被组氨酸基团占据; d）氨基酸位置A21被甘氨酸基团占据; 和e）在位置A5，A15，A18，B-1，B0，B1，B2，B3和B4中进行带负电荷的氨基酸残基的一个或多个取代和/或添加。
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公开(公告)号：US5547852A
公开(公告)日：1996-08-20
申请号：US235321
申请日：1994-04-29
IPC分类号： A61K38/00 , A61P37/00 , C07K14/54 , C12N15/09 , C12P21/02 , G01N33/50 , C12Q1/02 , A61K45/05 , G01N33/567
CPC分类号： C07K14/5434 , A61K38/00
摘要： The present invention relates to a composition containing the p40 subunit of interleukin-12, hereinafter referred to as p40/IL-12 and to methods of diagnosis and treatment of disorders associated with disregulation of the immune system.
摘要翻译： 本发明涉及包含白细胞介素-12的p40亚单位（以下称为p40 / IL-12）的组合物，以及诊断和治疗与免疫系统失调相关的病症的方法。
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10.发明授权公开(公告)号：US08633156B2
公开(公告)日：2014-01-21
申请号：US12820727
申请日：2010-06-22
申请人： Paul Habermann , Gerhard Seipke , Roland Kurrle , Gunter Muller , Mark Sommerfeld , Norbert Tennagels , Georg Tschank , Ulrich Werner
发明人： Paul Habermann , Gerhard Seipke , Roland Kurrle , Gunter Muller , Mark Sommerfeld , Norbert Tennagels , Georg Tschank , Ulrich Werner
CPC分类号： C07K14/62
摘要： The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the addition and/or substitution of negatively and positively charged amino acid residues and by an amidation of the C-terminal carboxy group of the B chain and histidine in position 8 of the insulin A chain. The invention also relates to the production and use thereof.
摘要翻译： 本发明涉及具有基础时间作用特征的新型胰岛素类似物，其特征在于负和带正电荷的氨基酸残基的添加和/或取代以及B链和组氨酸的C端羧基的酰胺化 在胰岛素A链的位置8。 本发明还涉及其生产和使用。
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