公开(公告)号：US11932881B2

公开(公告)日：2024-03-19

申请号：US17646773

申请日：2022-01-03

申请人： SHAN DONG UNIVERSITY ,  Bloomage Biotechnology Corporation Limited

发明人： Juzheng Sheng ,  Xueping Guo ,  Jianqun Deng ,  Fengshan Wang ,  Zhen Lu ,  Ranran Du ,  Liu Sun ,  Yuanjun Sun

IPC分类号： C12N9/00 ,  C12N9/10 ,  C12N15/10 ,  C12N15/70 ,  C12P19/64

CPC分类号： C12N9/1051 ,  C12N15/102 ,  C12N15/70 ,  C12P19/64 ,  C12N2800/101

摘要： A heparin skeleton synthase originates from Neisseria animaloris, with an amino acid sequence as shown in SEQ ID NO.2 and a nucleotide sequence of the coding gene as shown in SEQ ID NO.1. Its recombinant expression level is 6.8 times that of the existing heparin skeleton synthase KfiA from Escherichia coli K5, and total enzyme activity per fermentation liquor is 5.22 times that of the heparin skeleton synthase KfiA. The heparin skeleton synthase mutants obtained through site-directed mutagenesis of the sites No. 16, No. 25, No. 30, No. 111, No. 165, and No. 172 in the amino acid sequence of the said heparin skeleton synthase all have high expression levels.

公开(公告)号：US20240076706A1

公开(公告)日：2024-03-07

申请号：US18261847

申请日：2021-12-07

申请人： SHAN DONG UNIVERSITY

发明人： Yuzhong ZHANG ,  Fang ZHAO ,  Xiulan CHEN ,  Haining SUN ,  Xiaoyan SONG ,  Pingyi LI

IPC分类号： C12P19/14 ,  C12N9/24

CPC分类号： C12P19/14 ,  C12N9/248 ,  C12R2001/20

摘要： MLX1034 is from Polaribacter sp. Q13, and has the amino acid sequence of the 1,3/1,4-xylanase MLX1034 is listed in SEQ ID NO.1; a nucleotide sequence of the gene is listed in SEQ ID NO.2; the 1,3/1,4-xylanase MLX1034 in the invention is capable of efficiently and specifically degrading 1,3/1,4-xylan and producing xylooligosaccharides with DP values above one; in addition, the physical and chemical properties of the 1,3/1,4-xylanase MLX1034 are stable enough to hydrolyze 1,3/1,4-xylan at room temperature; the 1,3/1,4-xylanase MLX1034 is suitable for the industrial production of red algal xylooligosaccharides at low energy costs.

公开(公告)号：US20230092630A1

公开(公告)日：2023-03-23

申请号：US16957998

申请日：2019-11-13

申请人： SHAN DONG UNIVERSITY

发明人： Ranran ZHOU ,  Yaping LI ,  Yong WANG ,  Yusong LI ,  Xuezheng HUANG ,  Juanjuan SUN

IPC分类号： G06F30/373 ,  G06F30/367 ,  G06N3/12

摘要： A parallel analog circuit automatic optimization method based on genetic algorithm and machine learning comprises global optimization based on genetic algorithm and local optimization based on machine learning, with the global optimization and the local optimization performed alternately. The global optimization based on genetic algorithm utilizes parallel SPICE simulations to improve the optimization efficiency while guaranteeing the optimization accuracy, combined with parallel computing. The local optimization based on machine learning establishes a machine learning model near the global optimal point obtained by the global optimization, and uses the machine learning model to replace the SPICE simulator, thus reducing the time costs brought by a large number of simulations.

公开(公告)号：US20220278241A1

公开(公告)日：2022-09-01

申请号：US17753192

申请日：2020-06-28

申请人： SHAN DONG UNIVERSITY

发明人： Yifei ZHANG ,  Aimin SONG ,  Haotian LING ,  Qingpu WANG

IPC分类号： H01L29/872 ,  H01L29/47 ,  H01L29/24 ,  H01Q15/00 ,  G02F1/015

摘要： A tuning method for active metamaterials using IGZO Schottky diodes, wherein the IGZO Schottky diode comprises a substrate, a Schottky electrode, amorphous IGZO active layer, and an ohmic electrode from the bottom up. The method comprises steps as follows: (1) Metamaterials are used as the Schottky electrodes, and amorphous IGZO active layers are used to fully cover the capacitive gap structures in the metamaterials; such capacitive structures in the metamaterials are bonded to the amorphous IGZO active layers to form Shottky barriers; (2) The resulting IGZO Schottky diodes from step (1) are used to tune the metamaterials dynamically.

公开(公告)号：US11084830B2

公开(公告)日：2021-08-10

申请号：US16765095

申请日：2018-10-12

申请人： SHAN DONG UNIVERSITY

发明人： Xinyong Liu ,  Dongwei Kang ,  Peng Zhan ,  Gaoshan Wu ,  Zhao Wang

IPC分类号： A61K31/519 ,  C07D495/04 ,  A61P31/18 ,  C07D401/12 ,  C07D491/048

摘要： The present invention belongs to the field of pharmaceutical technology, specifically disclosing five-membered non-aromatic pyrimidines compounds with the general formulas I. Also including theirs polycrystalline and eutectic, prodrugs and derivatives with same biologically functional, methods for their preparation, and compositions containing one or more of these compounds in the drugs application of treatment and prevention of human immunodeficiency virus.

公开(公告)号：US20230148297A1

公开(公告)日：2023-05-11

申请号：US17645215

申请日：2021-12-20

申请人： SHAN DONG UNIVERSITY

发明人： Shishen Yan ,  Yufeng Tian ,  Lihui Bai ,  Yibo Fan ,  Xiang Han

IPC分类号： G11C11/16 ,  H01L43/04 ,  H01L43/06 ,  H01L43/10 ,  G11C11/18 ,  G11C11/56 ,  H01F10/32 ,  H03K19/18

CPC分类号： G11C11/161 ,  H01L43/04 ,  H01L43/06 ,  H01L43/10 ,  G11C11/1675 ,  G11C11/18 ,  G11C11/5607 ,  H01F10/3254 ,  H01F10/3268 ,  H03K19/18 ,  H03K19/20

摘要： The present invention relates to a kind of magnetic heterojunction structure and the method of controlling and achieving spin logic and multiple-state storage functions. The said single magnetic heterojunction structure comprises the substrate, in-plane anti-ferromagnetic layer, in-plane ferromagnetic layer, nonmagnetic layer, vertical ferromagnetic layer, and vertical anti-ferromagnetic layer respectively from the bottom up; the said in-plane ferromagnetic layer and the said vertical ferromagnetic layer are coupled together through the said nonmagnetic layer in the middle; in-plane exchange biases, namely exchange biases in the plane, exist between the said in-plane ferromagnetic layer and the said in-plane anti-ferromagnetic layer, and out-of-plane exchange biases, namely exchange biases out of the plane, exist between the said vertical ferromagnetic layer and the said vertical anti-ferromagnetic layer.

公开(公告)号：US20230067045A1

公开(公告)日：2023-03-02

申请号：US17757821

申请日：2020-03-03

申请人： SHAN DONG UNIVERSITY

发明人： Dongwei KANG ,  Xinyong LIU ,  Peng ZHAN

IPC分类号： C07D495/04 ,  A61P31/18

摘要： The present invention belongs to the field of pharmaceutical technology, specifically disclosing a class of thienopyrimidine compounds with the general formula I, theirs stereoisomeric forms, stereoisomeric mixtures and pharmaceutically acceptable salts, hydrates and solvents. Also including theirs polycrystalline and eutectic, prodrugs and derivatives with same biologically functional, methods for their preparation, and compositions containing one or more of these compounds in the drugs application of treatment and prevention of human immunodeficiency virus (HIV).

公开(公告)号：US20230061859A1

公开(公告)日：2023-03-02

申请号：US17757824

申请日：2020-03-03

申请人： SHAN DONG UNIVERSITY

发明人： Xinyong LIU ,  Dongwei KANG ,  Peng ZHAN ,  Zhao WANG ,  Guoxiong LI

IPC分类号： C07D471/04

摘要： The invention relates to pyrido[2,3-d]pyrimidine compound WB3 and its preparation method and application. The structure of WB3 is as follows, and the invention also relates to a pharmaceutical composition of WB3. Moreover, the invention also provides applications of the WB3 in the preparation of drugs for the treatment and prevention of HIV.

公开(公告)号：US11922986B2

公开(公告)日：2024-03-05

申请号：US17645215

申请日：2021-12-20

申请人： SHAN DONG UNIVERSITY

发明人： Shishen Yan ,  Yufeng Tian ,  Lihui Bai ,  Yibo Fan ,  Xiang Han

IPC分类号： G11C11/16 ,  G11C11/18 ,  G11C11/56 ,  H01F10/32 ,  H03K19/18 ,  H03K19/20 ,  H10N50/85 ,  H10N52/00 ,  H10N52/80

CPC分类号： G11C11/161 ,  G11C11/1675 ,  G11C11/18 ,  G11C11/5607 ,  H01F10/3254 ,  H01F10/3268 ,  H03K19/18 ,  H10N50/85 ,  H10N52/00 ,  H10N52/80 ,  H03K19/20

摘要： The present invention relates to a kind of magnetic heterojunction structure and the method of controlling and achieving spin logic and multiple-state storage functions. The said single magnetic heterojunction structure comprises the substrate, in-plane anti-ferromagnetic layer, in-plane ferromagnetic layer, nonmagnetic layer, vertical ferromagnetic layer, and vertical anti-ferromagnetic layer respectively from the bottom up; the said in-plane ferromagnetic layer and the said vertical ferromagnetic layer are coupled together through the said nonmagnetic layer in the middle; in-plane exchange biases, namely exchange biases in the plane, exist between the said in-plane ferromagnetic layer and the said in-plane anti-ferromagnetic layer, and out-of-plane exchange biases, namely exchange biases out of the plane, exist between the said vertical ferromagnetic layer and the said vertical anti-ferromagnetic layer.

公开(公告)号：US11762261B2

公开(公告)日：2023-09-19

申请号：US17445785

申请日：2021-08-24

申请人： SHAN DONG UNIVERSITY

发明人： Zhengping Wang ,  Xuezhi Zhao ,  Fapeng Yu ,  Xun Sun ,  Xinguang Xu

IPC分类号： G02F1/39 ,  H01S3/00 ,  G02F1/35 ,  G02F1/377

CPC分类号： G02F1/392 ,  G02F1/353 ,  G02F1/3544 ,  G02F1/39 ,  G02F1/395 ,  H01S3/0092 ,  G02F1/377

摘要： The invention is related to a parametric light generation method and its application and belongs to the technical field of laser and nonlinear optics. The generation method comprises steps as follows: a nonlinear optical material that meets the sum-frequency phase-matched conditions, namely it shall satisfy the energy conservation condition ωp+ωi=ωs and the momentum conservation condition npωp+niωi=nsωs simultaneously, is provided; laser light with a wavelength of λp is injected into the said nonlinear optical material as pump light; then, the material will output signal light with a wavelength of λS, namely the tunable sum-frequency parametric light. With sum-frequency as the basic principle, the invention can realize frequency up-conversion and obtain visible and UV light sources through simple infrared light sources easily.