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    Vaccine comprising monocyte or immature myeloid cells (IMC) which were loaded with the ligand of natural killer T cell and antigen
    1.
    发明授权
    Vaccine comprising monocyte or immature myeloid cells (IMC) which were loaded with the ligand of natural killer T cell and antigen 有权
    包含单核细胞或未成熟骨髓细胞（IMC）的疫苗，其装载有天然杀伤T细胞和抗原的配体

    公开(公告)号：US09518126B2

    公开(公告)日：2016-12-13

    申请号：US12279166

    申请日：2007-11-28

    申请人： Chang-Yuil Kang ,  Hyun-Jeong Ko ,  Jung-Mi Lee ,  Yeon-Jeong Kim

    发明人： Chang-Yuil Kang ,  Hyun-Jeong Ko ,  Jung-Mi Lee ,  Yeon-Jeong Kim

    IPC分类号： A61K31/164 ,  C12N5/0786 ,  A61K39/00 ,  C07K16/32

    CPC分类号： C07K16/32 ,  A61K31/164 ,  A61K39/00 ,  A61K2039/5154 ,  A61K2039/5158 ,  C12N5/0645 ,  C12N2501/999 ,  Y02A50/412 ,  Y02A50/464 ,  Y02A50/472 ,  Y02A50/476

    摘要： The present invention relates to an immuno-therapeutic and prophylactic vaccine comprising monocytes or immature myeloid cells (IMCs) loaded with the ligand of natural killer T cell and an antigen for the prevention and treatment of infectious disease or cancer, more precisely, an immuno-therapeutic and prophylactic vaccine comprising monocytes or IMCs loaded with α-galactosylceramide (αGalCer), a kind of glycolipid and a natural killer T cell ligand, and antigen. Monocytes or immature myeloid cells (IMCs) therein, which are easily obtainable, unlike dendritic cells, not only induce a significant level of cytotoxic T lymphocyte responses but also have a prophylactic and therapeutic effect on malignant tumor. Therefore, the immuno-therapeutic and prophylactic vaccine of the present invention can be effectively used as an immunotherapeutic agent.

    摘要翻译： 本发明涉及包含负载天然杀伤T细胞配体的单核细胞或未成熟骨髓细胞（IMC）的免疫治疗和预防性疫苗，以及用于预防和治疗感染性疾病或癌症的抗原，更准确地说， 包含装载有α-半乳糖神经酰胺（αGalCer），一种糖脂和天然杀伤T细胞配体的单核细胞或IMC的治疗和预防性疫苗和抗原。 与树突状细胞不同，易于获得的单核细胞或未成熟骨髓细胞（IMC）不仅诱导显着水平的细胞毒性T淋巴细胞应答，而且对恶性肿瘤具有预防和治疗作用。 因此，本发明的免疫治疗和预防性疫苗可以有效地用作免疫治疗剂。

    SYSTEM AND METHOD FOR RECOMMENDING BLOG
    2.
    发明申请
    SYSTEM AND METHOD FOR RECOMMENDING BLOG 审中-公开
    用于推荐博客的系统和方法

    公开(公告)号：US20130036121A1

    公开(公告)日：2013-02-07

    申请号：US13564411

    申请日：2012-08-01

    申请人： Yeon Jeong KIM ,  Joongoo LEE

    发明人： Yeon Jeong KIM ,  Joongoo LEE

    IPC分类号： G06F17/30

    CPC分类号： G06F16/954

    摘要： Provided is a system and method for recommending a blog. The blog recommendation system includes a segmentation unit to classify blogs according to at least one category of age and gender of a user, an extraction unit to extract a plurality of search terms retrieved by a user corresponding to the category, a cluster unit to learn the search terms into a document in the classified blogs and to group the search terms into at least one cluster, a generation unit to generate a blog pool related to the search terms included in the cluster, and a recommendation unit to provide the user with at least one blog in the blog pool as a recommended blog.

    摘要翻译： 提供了一种用于推荐博客的系统和方法。 博客推荐系统包括分类单元，用于根据用户的年龄和性别的至少一类分类博客;提取单元，提取由与该类别相对应的用户检索的多个搜索词;群集单元，用于学习 将分类博客中的文档搜索到分组博客中的文档，并将搜索项分组为至少一个群集，生成单元以生成与包括在群集中的搜索项相关的博客池，以及推荐单元，用于至少向用户提供 博客池中的一个博客作为推荐博客。

    B cell-based vaccine loaded with the ligand of natural killer T cell and antigen
    4.
    发明授权
    B cell-based vaccine loaded with the ligand of natural killer T cell and antigen 有权
    以B细胞为基础的疫苗，加载有天然杀伤T细胞和抗原的配体

    公开(公告)号：US08003093B2

    公开(公告)日：2011-08-23

    申请号：US11718391

    申请日：2006-04-27

    申请人： Chang-Yuil Kang ,  Yeonseok Chung ,  Hyun-Jeong Ko ,  Yeon-Jeong Kim ,  Byung-Seok Kim ,  Sung-Youl Ko

    发明人： Chang-Yuil Kang ,  Yeonseok Chung ,  Hyun-Jeong Ko ,  Yeon-Jeong Kim ,  Byung-Seok Kim ,  Sung-Youl Ko

    IPC分类号： A01N63/02 ,  A61K39/00 ,  A61K39/02 ,  A61K39/12

    CPC分类号： A61K39/0011 ,  A61K39/00 ,  A61K2039/5156 ,  Y02A50/412 ,  Y02A50/464 ,  Y02A50/472

    摘要： The present invention relates to a B cell-based vaccine loaded with the ligand of natural killer T cell and antigen for the prevention and treatment of disease, more precisely, an immunotherapeutic and prophylactic vaccine mediated by B cells loaded with α-galactosylceramide, a kind of glycolipid which can stimulate natural killer T cells. A vaccine composition of the present invention can be effectively used as an antitumor immunotherapeutic agent. B cells therein, which are easily obtainable compared with dendritic cells, not only induce a similar level of cytotoxic T lymphocyte response to that of the conventional dendritic cell-based vaccine but also have a prophylactic and therapeutic effect on solid tumor and metastatic tumor.

    摘要翻译： 本发明涉及一种负载有天然杀伤T细胞配体的B细胞疫苗和用于预防和治疗疾病的抗原，更具体地说，涉及一种由装载有α-半乳糖神经酰胺的B细胞介导的免疫治疗和预防性疫苗 的可以刺激天然杀伤T细胞的糖脂。 本发明的疫苗组合物可以有效地用作抗肿瘤免疫治疗剂。 B细胞与树突细胞相比容易获得，不仅诱导与常规树突状细胞基疫苗相似的细胞毒性T淋巴细胞水平的水平，而且对实体瘤和转移性肿瘤具有预防和治疗作用。

    B CELL-BASED VACCINE LOADED WITH THE LIGAND OF NATURAL KILLER T CELL AND ANTIGEN
    10.
    发明申请
    B CELL-BASED VACCINE LOADED WITH THE LIGAND OF NATURAL KILLER T CELL AND ANTIGEN 有权
    基于B细胞的疫苗与天然杀伤细胞和抗原的配体

    公开(公告)号：US20100028380A1

    公开(公告)日：2010-02-04

    申请号：US11718391

    申请日：2006-04-27

    申请人： Chang-Yuil Kang ,  Yeonseok Chung ,  Hyun-Jeong Ko ,  Yeon-Jeong Kim ,  Byung-Seok Kim ,  Sung-Youl Ko

    发明人： Chang-Yuil Kang ,  Yeonseok Chung ,  Hyun-Jeong Ko ,  Yeon-Jeong Kim ,  Byung-Seok Kim ,  Sung-Youl Ko

    IPC分类号： A61K39/12 ,  A61K39/00 ,  A61K39/02

    CPC分类号： A61K39/0011 ,  A61K39/00 ,  A61K2039/5156 ,  Y02A50/412 ,  Y02A50/464 ,  Y02A50/472

    摘要： The present invention relates to a B cell-based vaccine loaded with the ligand of natural killer T cell and antigen for the prevention and treatment of disease, more precisely, an immunotherapeutic and prophylactic vaccine mediated by B cells loaded with α-galactosylceramide, a kind of glycolipid which can stimulate natural killer T cells. A vaccine composition of the present invention can be effectively used as an antitumor immunotherapeutic agent. B cells therein, which are easily obtainable compared with dendritic cells, not only induce a similar level of cytotoxic T lymphocyte response to that of the conventional dendritic cell-based vaccine but also have a prophylactic and therapeutic effect on solid tumor and metastatic tumor.

    摘要翻译： 本发明涉及一种装载有天然杀伤T细胞配体的B细胞疫苗和用于预防和治疗疾病的抗原，更具体地说，涉及一种由装载有α-半乳糖神经酰胺的B细胞介导的免疫治疗和预防性疫苗 的可以刺激天然杀伤T细胞的糖脂。 本发明的疫苗组合物可以有效地用作抗肿瘤免疫治疗剂。 B细胞与树突细胞相比容易获得，不仅诱导与常规树突状细胞基疫苗相似的细胞毒性T淋巴细胞水平的水平，而且对实体瘤和转移性肿瘤具有预防和治疗作用。