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27 条记录 (耗时 0.016 秒)

    Cellulose derivative
    1.
    发明授权
    Cellulose derivative 有权
    纤维素衍生物

    公开(公告)号：US08378091B2

    公开(公告)日：2013-02-19

    申请号：US11997830

    申请日：2006-08-03

    申请人： Hiroaki Kaneko ,  Eiichi Kitazono ,  Masaya Ito ,  Yoshihiko Sumi

    发明人： Hiroaki Kaneko ,  Eiichi Kitazono ,  Masaya Ito ,  Yoshihiko Sumi

    IPC分类号： C08B7/00 ,  C07H1/00

    CPC分类号： C08B11/20 ,  A61L31/042 ,  C08B15/05 ,  C08L1/00

    摘要： A cellulose derivative which has a suitable elastic modulus and viscosity when it is dissolved in water and is useful as an adhesion barrier.The cellulose derivative has a molecular weight of 5×103 to 5×106 and is composed of a repeating unit represented by the following formula (1): wherein R1, R2 and R3 are each independently selected from the group consisting of the following formulas (a), (b), (c) and (d) in predetermined amount: (X in the formula (c) is an alkali metal, and R4 and R5 in the formula (d) are each independently an alkyl group or alkenyl group having 10 to 28 carbon atoms).

    摘要翻译： 当纤维素衍生物溶于水中时具有合适的弹性模量和粘度并且可用作粘合屏障。 纤维素衍生物的分子量为5×10 3〜5×10 6，由下述式（1）表示的重复单元构成：其中，R 1，R 2，R 3各自独立地选自下述式 a），（b），（c）和（d））：（式（c）中的X是碱金属，式（d）中的R 4和R 5各自独立地为烷基或烯基 具有10至28个碳原子）。

    NONWOVEN FABRIC AND PROCESS FOR PRODUCING THE SAME
    3.
    发明申请
    NONWOVEN FABRIC AND PROCESS FOR PRODUCING THE SAME 失效
    非织造织物及其制造方法

    公开(公告)号：US20080272520A1

    公开(公告)日：2008-11-06

    申请号：US12168720

    申请日：2008-07-07

    申请人： Shinya Komura ,  Takanori Miyoshi ,  Yoshihiko Sumi ,  Hiroyoshi Minematsu

    发明人： Shinya Komura ,  Takanori Miyoshi ,  Yoshihiko Sumi ,  Hiroyoshi Minematsu

    IPC分类号： B29C47/00

    CPC分类号： D04H3/02 ,  D01D5/0038 ,  D01D5/247 ,  D01D5/253 ,  D01F1/08 ,  D01F6/625 ,  D04H1/4382 ,  D04H1/4391 ,  Y10T442/608 ,  Y10T442/614

    摘要： A process for production of a nonwoven fabric, which comprises a step wherein a thermoplastic polymer is dissolved in a mixed solvent composed of a volatile good solvent and a volatile poor solvent, a step wherein the resulting solution is spun by an electrospinning method and a step wherein a nonwoven fabric accumulated on a collecting sheet is obtained, is employed to provide a nonwoven fabric having a surface area sufficiently large as a matrix for cell culturing in the field of regenerative medicine, with large gaps between filaments and a low apparent density suitable for cell culturing.

    摘要翻译： 一种无纺布的制造方法，其特征在于，包括将热塑性聚合物溶解在由挥发性良溶剂和挥发性不良溶剂组成的混合溶剂中的工序，其中所得溶液通过静电纺丝法和步骤 其中收集在收集片上的无纺织物用于提供表面积足够大的无纺织物作为再生医学领域的细胞培养基质，细丝间隙大，表观密度低 细胞培养。

    Chemical compound containing a superoxide scavenger and an organic nitrate or nitrite moiety
    5.
    发明授权
    Chemical compound containing a superoxide scavenger and an organic nitrate or nitrite moiety 失效
    含有超氧化物清除剂和有机硝酸盐或亚硝酸盐部分的化合物

    公开(公告)号：US06346634B1

    公开(公告)日：2002-02-12

    申请号：US09561910

    申请日：2000-05-01

    申请人： Zhi Zhang ,  Declan P. Naughton ,  Yoshihiko Sumi ,  Atsushi Imaizumi

    发明人： Zhi Zhang ,  Declan P. Naughton ,  Yoshihiko Sumi ,  Atsushi Imaizumi

    IPC分类号： C07C5002

    CPC分类号： A61K47/52

    摘要： Compounds for use in the treatment of heart disease include a superoxide scavenger and an organic nitrate or nitrite moiety. The compounds can be represented by the formula (A)n(B)m, in which A is a superoxide scavenger, B is an organic nitrate or organic nitrite moiety, and n and m are values between 1 and 8. These compounds do not suffer from the problem of patient tolerance that is associated with the use of conventional agents such as organic nitrates.

    摘要翻译： 用于治疗心脏病的化合物包括超氧化物清除剂和有机硝酸盐或亚硝酸盐部分。 化合物可以由式（A）n（B）m表示，其中A是超氧化物清除剂，B是有机硝酸盐或有机亚硝酸盐部分，n和m是1和8之间的值。这些化合物不 患有与使用常规药剂如有机硝酸盐有关的患者耐受性的问题。

    Monoclonal antibody specific to human .alpha..sub.2 -plasmin inhibitor
    6.
    发明授权
    Monoclonal antibody specific to human .alpha..sub.2 -plasmin inhibitor 失效
    对人α2-纤溶酶抑制剂特异性的单克隆抗体

    公开(公告)号：US5534255A

    公开(公告)日：1996-07-09

    申请号：US716694

    申请日：1991-06-17

    申请人： Yoshihiko Sumi ,  Yukiya Koike ,  Yataro Ichikawa ,  Nobuhiko Yoshida ,  Nobuo Aoki

    发明人： Yoshihiko Sumi ,  Yukiya Koike ,  Yataro Ichikawa ,  Nobuhiko Yoshida ,  Nobuo Aoki

    IPC分类号： A61K38/00 ,  C07K14/81 ,  C07K16/38 ,  C12P21/08 ,  A61K39/00 ,  C07K16/00

    CPC分类号： C07K16/38 ,  C07K14/8121 ,  A61K38/00 ,  Y10S530/864 ,  Y10S530/866

    摘要： This invention provides a monoclonal antibody or its fragment specific to a human .alpha..sub.2 -plasmin inhibitor, said antibody having the function of specifically blocking that site of the human .alpha..sub.2 -plasmin inhibitor which inhibits the fibrinolytic activity of plasmin, and of suppressing said fibrinolytic activity inhibiting function of said .alpha..sub.2 -plasmin inhibitor, and also a hybridoma capable of producing the monoclonal antibody. Said monoclonal antibody or its fragment is useful for the immunological determination of a human .alpha..sub.2 -plasmin inhibitor, the separation or recovery of a human .alpha..sub.2 -plasmin inhibitor from a liquid containing the human .alpha..sub.2 -plasmin inhibitor, and the treatment of a thrombotic disease.

    摘要翻译： 本发明提供了对人α2-纤溶酶抑制剂特异性的单克隆抗体或其片段，所述抗体具有特异性阻断人α2-纤溶酶抑制剂的位点的功能，其抑制纤溶酶的纤维蛋白溶解活性，并抑制所述纤维蛋白溶解 所述α2-纤溶酶抑制剂的活性抑制功能，以及能够产生单克隆抗体的杂交瘤。 所述单克隆抗体或其片段可用于免疫测定人α2-纤溶酶抑制剂，从含有人α2-纤溶酶抑制剂的液体中分离或回收人α2-纤溶酶抑制剂，以及治疗 血栓性疾病

    Method of separating activated human protein C
    7.
    依法登记的发明
    Method of separating activated human protein C 失效

    公开(公告)号：USH1148H

    公开(公告)日：1993-03-02

    申请号：US815870

    申请日：1992-01-03

    申请人： Kenji Wakabayashi ,  Yoshihiko Sumi ,  Yataro Ichikawa ,  Yoichi Sakata ,  Nobuo Aoki

    发明人： Kenji Wakabayashi ,  Yoshihiko Sumi ,  Yataro Ichikawa ,  Yoichi Sakata ,  Nobuo Aoki

    IPC分类号： C07K16/40 ,  C12N9/64

    CPC分类号： C12N9/6464 ,  C07K16/40 ,  C12Y304/21069

    摘要： A method of separating activated human protein C, which comprises bringing a mixture containing activated human protein C having a gamma-carboxyglutamic acid (Gla) domain in the presence of a calcium ion into contact with a fixed antibody comprising an insoluble carrier and fixed thereto an antibody to a complex of human protein C and a calcium ion bound to the Gla domain whereby the activated human protein C is captured by the fixed antibody in the form in which the calcium ion is bound to the Gla domain. A method is also provided for separating activated human protein C from a mixture containing human protein C and activated human protein C, which comprises bringing a first mixture containing human protein C and activated human protein C having a Gla domain into contact with a first fixed antibody comprising an insoluble carrier and fixed thereto a first antibody to human protein C but not to activated human protein C to form a second mixture substantially free from human protein C while the human protein C is captured by the first fixed antibody, and bringing the second mixture in the presence of a calcium ion into contact with a second fixed antibody comprising an insoluble carrier and fixed thereto a second antibody to a complex of human protein C and a calcium ion bound at the Gla domain, whereby the activated human protein C is captured by the second fixed antibody in the form in which the calcium ion is bound to the Gla domain.

    Immunological determination of free human protein S and C4bp-protein S complex
    8.
    发明授权
    Immunological determination of free human protein S and C4bp-protein S complex 失效
    游离人蛋白S和C4bp蛋白S复合物的免疫测定

    公开(公告)号：US5187067A

    公开(公告)日：1993-02-16

    申请号：US670383

    申请日：1991-03-14

    申请人： Yukiya Koike ,  Kenji Wakabayashi ,  Yoshihiko Sumi ,  Yataro Ichikawa

    发明人： Yukiya Koike ,  Kenji Wakabayashi ,  Yoshihiko Sumi ,  Yataro Ichikawa

    IPC分类号： C07K16/18 ,  C07K16/36 ,  C12N5/18

    CPC分类号： C07K16/18 ,  C07K16/36 ,  Y10S436/821 ,  Y10S436/824

    摘要： A method of immunologically determining free human protein S in an assay sample, which comprises contacting a primary antibody fixed to an insoluble solid carrier and a labelled secondary antibody with the assay sample, the primary and secondary antibodies having the property of binding to different epitopes of free human protein S, and one of the primary and secondary antibodies being a monoclonal antibody having the property of not binding to a complex of the human protein S and human complement cofactor C4b-binding protein (C4bp) but specifically binding to the free human protein S. Also provided is a method of immunologically determining a complex of human protein S and human complement cofactor C4b-binding protein (C4bp) in an assay sample, which comprises contacting a primary antibody fixed to an insoluble solid carrier and a labelled secondary antibody with the assay sample, one of the primary and secondary antibodies being a monoclonal antibody having the property of not binding to free human protein S and human complement cofactor C4b-binding protein (C4bp) but binding specifically to the complex, and the other being an antibody having the property of binding to the human complement cofactor C4b-binding protein (4Cbp).

    摘要翻译： 一种在测定样品中免疫测定游离人蛋白S的方法，其包括将固定在不溶性固体载体上的第一抗体与标记的第二抗体与测定样品接触，所述第一抗体和第二抗体具有结合不同表位的性质 游离人蛋白S，其中一种和第二种抗体是具有不与人类蛋白S和人补体辅因子C4b结合蛋白（C4bp）的复合物结合但与结合游离人蛋白质的特异性的单克隆抗体 还提供了在测定样品中免疫测定人蛋白S和人补体辅因子C4b结合蛋白（C4bp）的复合物的方法，其包括将固定于不溶性固体载体的第一抗体和标记的第二抗体与 测定样品，其中一种和第二种抗体是具有不结合特性的单克隆抗体 g释放人蛋白S和人补体辅因子C4b结合蛋白（C4bp），但与复合物特异性结合，另一种是具有与人补体辅因子C4b结合蛋白（4Cbp）结合的性质的抗体。