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    Cellulose derivative
    2.
    发明授权
    Cellulose derivative 有权
    纤维素衍生物

    公开(公告)号：US08378091B2

    公开(公告)日：2013-02-19

    申请号：US11997830

    申请日：2006-08-03

    Applicant: Hiroaki Kaneko ,  Eiichi Kitazono ,  Masaya Ito ,  Yoshihiko Sumi

    Inventor： Hiroaki Kaneko ,  Eiichi Kitazono ,  Masaya Ito ,  Yoshihiko Sumi

    IPC: C08B7/00 ,  C07H1/00

    CPC classification number: C08B11/20 ,  A61L31/042 ,  C08B15/05 ,  C08L1/00

    Abstract: A cellulose derivative which has a suitable elastic modulus and viscosity when it is dissolved in water and is useful as an adhesion barrier.The cellulose derivative has a molecular weight of 5×103 to 5×106 and is composed of a repeating unit represented by the following formula (1): wherein R1, R2 and R3 are each independently selected from the group consisting of the following formulas (a), (b), (c) and (d) in predetermined amount: (X in the formula (c) is an alkali metal, and R4 and R5 in the formula (d) are each independently an alkyl group or alkenyl group having 10 to 28 carbon atoms).

    Abstract translation: 当纤维素衍生物溶于水中时具有合适的弹性模量和粘度并且可用作粘合屏障。 纤维素衍生物的分子量为5×10 3〜5×10 6，由下述式（1）表示的重复单元构成：其中，R 1，R 2，R 3各自独立地选自下述式 a），（b），（c）和（d））：（式（c）中的X是碱金属，式（d）中的R 4和R 5各自独立地为烷基或烯基 具有10至28个碳原子）。

    CELLULOSE DERIVATIVE
    4.
    发明申请
    CELLULOSE DERIVATIVE 有权
    纤维素衍生物

    公开(公告)号：US20100279982A1

    公开(公告)日：2010-11-04

    申请号：US11997830

    申请日：2006-08-03

    Applicant: Hiroaki Kaneko ,  Eiichi Kitazono ,  Masaya Ito ,  Yoshihiko Sumi

    Inventor： Hiroaki Kaneko ,  Eiichi Kitazono ,  Masaya Ito ,  Yoshihiko Sumi

    IPC: A61K31/717 ,  C08B15/05 ,  A61P41/00

    CPC classification number: C08B11/20 ,  A61L31/042 ,  C08B15/05 ,  C08L1/00

    Abstract: A cellulose derivative which has a suitable elastic modulus and viscosity when it is dissolved in water and is useful as an adhesion barrier.The cellulose derivative has a molecular weight of 5×103 to 5×106 and is composed of a repeating unit represented by the following formula (1): wherein R1, R2 and R3 are each independently selected from the group consisting of the following formulas (a), (b), (c) and (d) in predetermined amount: (X in the formula (c) is an alkali metal, and R4 and R5 in the formula (d) are each independently an alkyl group or alkenyl group having 10 to 28 carbon atoms).

    Abstract translation: 当纤维素衍生物溶于水中时具有合适的弹性模量和粘度并且可用作粘合屏障。 纤维素衍生物的分子量为5×10 3〜5×10 6，由下述式（1）表示的重复单元构成：其中，R 1，R 2，R 3各自独立地选自下述式 a），（b），（c）和（d））：（式（c）中的X是碱金属，式（d）中的R 4和R 5各自独立地为烷基或烯基 具有10至28个碳原子）。

    Cellulose derivative and hydrogel thereof
    7.
    发明授权
    Cellulose derivative and hydrogel thereof 失效
    纤维素衍生物及其水凝胶

    公开(公告)号：US08709450B2

    公开(公告)日：2014-04-29

    申请号：US12808613

    申请日：2008-12-17

    Applicant: Hiroaki Kaneko ,  Nobuyuki Endo ,  Masaya Ito

    Inventor： Hiroaki Kaneko ,  Nobuyuki Endo ,  Masaya Ito

    IPC: C08B11/193 ,  C08B1/00 ,  C08B11/15 ,  C08B11/12 ,  A61K9/00

    CPC classification number: A61L27/20 ,  A61L27/52 ,  A61L31/042 ,  A61L31/145 ,  C08B11/12 ,  C08L1/26

    Abstract: The invention is a cellulose derivative wherein some of the carboxyl groups of the cellulose derivative carboxymethylcellulose are replaced with —CO—NH—X—CO—Y—Z, and a hydrogel of the same. In the formula, X is a C1-10 divalent hydrocarbon group, Y is a divalent group derived from polyalkylene oxide having oxygen atoms at both ends, and Z is a C1-24 hydrocarbon group or —CO—R4, where R4 is a C1-23 hydrocarbon group. The hydrogel has excellent viscoelasticity and can be injected into prescribed sites with injecting devices such as syringes, and it can thus be utilized as a medical gel or adhesion barrier.

    Abstract translation: 本发明是纤维素衍生物羧甲基纤维素的一些羧基被-CO-NH-X-CO-Y-Z代替的纤维素衍生物及其水凝胶。 在该式中，X是C 1-10二价烃基，Y是衍生自在两端具有氧原子的聚环氧烷烃，Z是C1-24烃基或-CO-R4的二价基团，其中R4是C1 -23烃基。 水凝胶具有优异的粘弹性，并且可以用诸如注射器的注射装置注射到规定的位置，因此可以用作医用凝胶或粘附屏障。

    Polysaccharide derivative and hydrogel thereof
    8.
    发明授权
    Polysaccharide derivative and hydrogel thereof 失效
    多糖衍生物及其水凝胶

    公开(公告)号：US08748409B2

    公开(公告)日：2014-06-10

    申请号：US13263929

    申请日：2010-04-19

    Applicant: Hiroaki Kaneko ,  Masaya Ito

    Inventor： Hiroaki Kaneko ,  Masaya Ito

    IPC: A61K31/70 ,  C07H5/04

    CPC classification number: A61L27/52 ,  A61K9/0024 ,  A61K47/36 ,  A61L27/20 ,  A61L31/042 ,  A61L31/145 ,  C08B37/0072 ,  C08J3/075 ,  C08J2305/08 ,  C08L5/08

    Abstract: Disclosed are a polysaccharide derivative obtained by substituting some of the carboxyl groups of a carboxy polysaccharide with —NH—X—CO—Y—Z; and a hydrogel thereof. Here, X is a C1-10 hydrocarbon group, Y is a polyalkylene oxide having oxygen atoms at both ends, and Z is a C1-24 hydrocarbon group or —CO—R2, with R2 being a C1-23 hydrocarbon group. The hydrogel has excellent viscoelasticity and can be injected into a predetermined location with an injection device such as a syringe, and thus can be advantageously used as a medical gel or an adhesion barrier.

    Abstract translation: 公开了通过用-NH-X-CO-Y-Z取代羧基多糖的一些羧基得到的多糖衍生物; 及其水凝胶。 这里，X是C 1-10烃基，Y是在两端具有氧原子的聚环氧烷烃，Z是C1-24烃基或-CO-R2，R2是C1-23烃基。 水凝胶具有优异的粘弹性，并且可以通过诸如注射器的注射装置注射到预定位置，因此可以有利地用作医用凝胶或粘合屏障。

    POLYSACCHARIDE DERIVATIVE AND HYDROGEL THEREOF
    9.
    发明申请
    POLYSACCHARIDE DERIVATIVE AND HYDROGEL THEREOF 失效
    多糖衍生物和水合物

    公开(公告)号：US20120035128A1

    公开(公告)日：2012-02-09

    申请号：US13263929

    申请日：2010-04-19

    Applicant: Hiroaki Kaneko ,  Masaya Ito

    Inventor： Hiroaki Kaneko ,  Masaya Ito

    IPC: A61K31/726 ,  C08B37/08 ,  A61K31/728 ,  A61K6/00 ,  A61K47/36 ,  C12N1/00 ,  A61L24/08 ,  C08B37/00 ,  A61P41/00

    CPC classification number: A61L27/52 ,  A61K9/0024 ,  A61K47/36 ,  A61L27/20 ,  A61L31/042 ,  A61L31/145 ,  C08B37/0072 ,  C08J3/075 ,  C08J2305/08 ,  C08L5/08

    Abstract: Disclosed are a polysaccharide derivative obtained by substituting some of the carboxyl groups of a carboxy polysaccharide with —NH—X—CO—Y—Z; and a hydrogel thereof. Here, X is a C1-10 hydrocarbon group, Y is a polyalkylene oxide having oxygen atoms at both ends, and Z is a C1-24 hydrocarbon group or —CO—R2, with R2 being a C1-23 hydrocarbon group. The hydrogel has excellent viscoelasticity and can be injected into a predetermined location with an injection device such as a syringe, and thus can be advantageously used as a medical gel or an adhesion barrier.

    Abstract translation: 公开了通过用-NH-X-CO-Y-Z取代羧基多糖的一些羧基得到的多糖衍生物; 及其水凝胶。 这里，X是C 1-10烃基，Y是在两端具有氧原子的聚环氧烷烃，Z是C1-24烃基或-CO-R2，R2是C1-23烃基。 水凝胶具有优异的粘弹性，并且可以通过诸如注射器的注射装置注射到预定位置，因此可以有利地用作医用凝胶或粘合屏障。

    HYDROGEL OF POLYSACCHARIDE DERIVATIVE
    10.
    发明申请
    HYDROGEL OF POLYSACCHARIDE DERIVATIVE 审中-公开
    多糖衍生物的氢化物

    公开(公告)号：US20110301121A1

    公开(公告)日：2011-12-08

    申请号：US13202234

    申请日：2009-09-18

    Applicant: Nobuyuki Endo ,  Masaya Ito ,  Hiroaki Kaneko ,  Hitoshi Hirata ,  Michiro Yamamoto

    Inventor： Nobuyuki Endo ,  Masaya Ito ,  Hiroaki Kaneko ,  Hitoshi Hirata ,  Michiro Yamamoto

    IPC: A61K31/717 ,  A61P25/00 ,  A61P41/00

    CPC classification number: A61L31/042 ,  A61K31/715 ,  A61K31/717 ,  A61L31/145 ,  A61L2430/32 ,  C08B15/05

    Abstract: A nerve dysfunction repairing material including a hydrogel of a polysaccharide derivative that has, in a 0.5 wt % aqueous solution, a complex modulus of 1 to 1000 N/m2 and a loss factor of 0.01 to 2.0 as measured at an angular velocity of 10 rad/sec using a dynamic viscoelasticity measuring apparatus. The nerve dysfunction repairing material can be a hydrogel injectable through a syringe, has excellent retention in the body, and has a restorative effect on the function of damaged or degenerated nerves.

    Abstract translation: 一种神经功能障碍修复材料，其包括多糖衍生物的水凝胶，所述多糖衍生物在0.5重量％水溶液中的复数模量为1〜1000N / m 2，损失因子为0.01〜2.0，以角速度为10rad /秒，使用动态粘弹性测量装置。 神经功能障碍修复材料可以是通过注射器注射的水凝胶，在身体中具有优异的保留性，并且对损伤或退化的神经的功能具有恢复性作用。

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