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1.发明授权公开(公告)号：US09592323B2
公开(公告)日：2017-03-14
申请号：US14109795
申请日：2013-12-17
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： Florencia Lim , Mikael O. Trollsas , Syed F.A. Hossainy , Stephen D. Pacetti
CPC classification number: A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/604 , A61L2300/606 , Y10T24/258 , C08L67/04
Abstract: The present invention provides a coating comprising a reservoir layer comprising a semi-crystalline polymer and a primer layer comprising an amorphous polymer on an implantable device and methods of making and using the same.
Abstract translation: 本发明提供一种包含储存层的涂层，其包含半结晶聚合物和在可植入装置上包含无定形聚合物的底漆层及其制备和使用该涂层的方法。
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公开(公告)号：US09358268B2
公开(公告)日：2016-06-07
申请号：US14299771
申请日：2014-06-09
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Deborah Kilpatrick , Syed Faiyaz Ahmed Hossainy , Irina Astafieva , Florian N. Ludwig , Paul M. Consigny , Jeffrey T. Ellis , Florencia Lim
CPC classification number: A61K38/1709 , A61K9/0019 , A61K9/1275 , A61K9/1617 , A61K9/1658 , A61M1/3472 , A61M1/3486 , A61M2202/0456 , A61K2300/00
Abstract: A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo A1 comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo A1 and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCA1) transporter expression in macrophages and protect ABCA1 from thiol-mediated degradation.
Abstract translation: 一种方法，包括向血液中引入脱脂高密度脂蛋白（HDL）和生物活性剂。 包含脱脂高密度脂蛋白（HDL）和适合于输送到血管中的辅助剂的组合物。 包含Apo A1的组合物，其包含适于与细胞表面结合位点相互作用的疏水性配体。 一种组合物，其包含Apo A1和选择用于增加巨噬细胞中ATP结合盒蛋白1（ABCA1）转运蛋白表达的一种试剂，并保护ABCA1免受硫醇介导的降解。
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公开(公告)号：US20160022449A1
公开(公告)日：2016-01-28
申请号：US14876661
申请日：2015-10-06
Applicant: Abbott Cardiovascular Systems, Inc.
Inventor： Florencia Lim , Mary Suh , Barbara Stamberg , Bin Huang
CPC classification number: A61F2/885 , A61F2/04 , A61F2/186 , A61F2/20 , A61F2/844 , A61F2/88 , A61F2/90 , A61F2/95 , A61F2/958 , A61F2/962 , A61F2002/043 , A61F2002/044 , A61F2002/046 , A61F2210/0004 , A61F2210/0076 , A61F2220/0008 , A61F2230/0069 , A61F2230/0091 , A61F2250/0015 , A61F2250/0018 , A61F2250/0028 , A61F2250/0039 , A61F2250/0067 , A61F2250/0098
Abstract: Devices and methods for treating a diseased tracheobronchial region in a mammal. The device can be a stent which can include a sustained-release material such as a polymer matrix with a treatment agent. The stent can be bioabsorbable and a treatment agent can be incorporated therewith. A treatment method can be delivery of a stent to a tracheobronchial region by a delivery device such as a catheter assembly.
Abstract translation: 用于治疗哺乳动物患病气管支气管区域的装置和方法。 该装置可以是可以包括缓释材料如具有治疗剂的聚合物基质的支架。 支架可以是生物可吸收的，并且可以并入治疗剂。 治疗方法可以是通过诸如导管组件的递送装置将支架递送到气管支气管区域。
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4.发明申请Polymer Blends For Drug Delivery Stent Matrix With Improved Thermal Stability 审中-公开用于具有改进的热稳定性的药物递送支架基质的聚合物共混物公开(公告)号：US20140335143A1
公开(公告)日：2014-11-13
申请号：US14279234
申请日：2014-05-15
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Florencia Lim , Bozena Z. Maslanka , Yiwen Tang , O. Mikael Trollsas
IPC: A61L31/10
CPC classification number: A61L31/10 , A61L2420/02 , A61L2420/06 , C08L67/04 , C09D167/04 , C08L2666/18
Abstract: Various embodiments of the present invention generally relate to a polymer blend composition used for coating a medical device that exhibits improved thermal stability. The invention also encompasses implantable medical devices coated the aforementioned coating.
Abstract translation: 本发明的各种实施方案一般涉及用于涂覆显示改善的热稳定性的医疗装置的聚合物共混物组合物。 本发明还包括涂覆上述涂层的可植入医疗装置。
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公开(公告)号：US20130230564A1
公开(公告)日：2013-09-05
申请号：US13770988
申请日：2013-02-19
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： Lothar W. Kleiner , Yiwen Tang , Syed Faiyaz Ahmed Hossainy , Florencia Lim , Michael Huy Ngo , O. Mikael Trollsas
IPC: A61L31/10
CPC classification number: A61L31/10 , A61L31/16 , A61L2300/416 , C08L67/04 , C08L77/12
Abstract: The present invention provides a coating comprising a semi-crystalline polymer on an implantable device and methods of making and using the same.
Abstract translation: 本发明提供一种包含可植入装置上的半结晶聚合物的涂层及其制备和使用方法。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20140193475A1
公开(公告)日：2014-07-10
申请号：US14203339
申请日：2014-03-10
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Mikael Trollsas , Michael Ngo , Florencia Lim
Abstract: The present invention provides an implantable article comprising an amorphous terpolymer and a semi-crystalline polymer. The amorphous terpolymer can be admixed with the semi-crystalline polymer or form a block copolymer with the semi-crystalline polymer.
Abstract translation: 本发明提供一种包含无定形三元共聚物和半结晶聚合物的可植入制品。 无定形三元共聚物可与半结晶聚合物混合，或与半结晶聚合物形成嵌段共聚物。
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7.发明申请公开(公告)号：US20140107592A1
公开(公告)日：2014-04-17
申请号：US14106029
申请日：2013-12-13
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Florencia Lim , Michael Ngo , Syed Faiyaz Ahmed Hossainy , Mikael Trollsas
CPC classification number: A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/00 , A61L2300/604 , C08L67/04
Abstract: The present invention provides a coating comprising a reservoir layer comprising a terpolymer comprising caprolactone and glycolide and a primer layer comprising an amorphous polymer on an implantable device and methods of making and using the same.
Abstract translation: 本发明提供一种包含储层的涂层，其包含含有己内酯和乙交酯的三元共聚物和在可植入装置上包含无定形聚合物的底漆层及其制备和使用的方法。
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公开(公告)号：US09833342B2
公开(公告)日：2017-12-05
申请号：US14876661
申请日：2015-10-06
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Florencia Lim , Mary Suh , Barbara Stamberg , Bin Huang
IPC: A61F2/04 , A61F2/88 , A61F2/844 , A61F2/90 , A61F2/958 , A61F2/18 , A61F2/20 , A61F2/95 , A61F2/962
CPC classification number: A61F2/885 , A61F2/04 , A61F2/186 , A61F2/20 , A61F2/844 , A61F2/88 , A61F2/90 , A61F2/95 , A61F2/958 , A61F2/962 , A61F2002/043 , A61F2002/044 , A61F2002/046 , A61F2210/0004 , A61F2210/0076 , A61F2220/0008 , A61F2230/0069 , A61F2230/0091 , A61F2250/0015 , A61F2250/0018 , A61F2250/0028 , A61F2250/0039 , A61F2250/0067 , A61F2250/0098
Abstract: Devices and methods for treating a diseased tracheobronchial region in a mammal. The device can be a stent which can include a sustained-release material such as a polymer matrix with a treatment agent. The stent can be bioabsorbable and a treatment agent can be incorporated therewith. A treatment method can be delivery of a stent to a tracheobronchial region by a delivery device such as a catheter assembly.
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公开(公告)号：US09504772B2
公开(公告)日：2016-11-29
申请号：US14203339
申请日：2014-03-10
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Mikael Trollsas , Michael Ngo , Florencia Lim
Abstract: The present invention provides an implantable article comprising an amorphous terpolymer and a semi-crystalline polymer. The amorphous terpolymer can be admixed with the semi-crystalline polymer or form a block copolymer with the semi-crystalline polymer.
Abstract translation: 本发明提供一种包含无定形三元共聚物和半结晶聚合物的可植入制品。 无定形三元共聚物可与半结晶聚合物混合，或与半结晶聚合物形成嵌段共聚物。
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10.发明申请Biodegradable Poly(Ester-Amide) And Poly(Amide) Coatings For Implantable Medical Devices With Enhanced Bioabsorption Times 审中-公开可生物降解的聚（酯 - 酰胺）和聚（酰胺）涂层，用于具有增强的生物吸收时间的可植入医疗器械公开(公告)号：US20150174299A1
公开(公告)日：2015-06-25
申请号：US14571196
申请日：2014-12-15
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： MICHAEL HUY NGO , Syed Faiyaz Ahmed Hossainy , Florencia Lim , O. Mikael Trollsas
IPC: A61L31/10
CPC classification number: A61L31/148 , A61L31/10 , A61L31/16 , A61L2300/602 , A61L2300/604 , A61L2420/06 , C08L77/00 , C08L77/12
Abstract: This invention is generally related to coating layers for implantable medical devices, such as drug delivery vascular stents, and methods of fabricating coated implantable medical devices. Specifically various embodiments of the present invention include methods of fabricating and modulating of coating layers to enhance bioabsorption. The coating layers include poly(ester-amide) and/or poly(amide) polymers.
Abstract translation: 本发明通常涉及用于可植入医疗装置的涂层，例如药物输送血管支架，以及制造涂覆的可植入医疗装置的方法。 具体地，本发明的各种实施方案包括制备和调节涂层以增强生物吸收的方法。 涂层包括聚（酯 - 酰胺）和/或聚（酰胺）聚合物。
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