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1.发明授权Coatings for implantable devices comprising polymers of lactic acid and methods for fabricating the same 有权用于包含乳酸聚合物的可植入装置的涂层及其制造方法公开(公告)号：US09408949B2
公开(公告)日：2016-08-09
申请号：US14476623
申请日：2014-09-03
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Syed F. A. Hossainy , Yiwen Tang , Eugene T. Michal , Thierry Glauser , Stephen D. Pacetti , Jessica DesNoyer
CPC classification number: A61L31/10 , A61F2250/0067 , A61L27/28 , A61L27/34 , A61L29/08 , A61L29/085 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2420/00 , A61L2420/02 , A61L2420/06 , C08L67/04
Abstract: Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising polymers of lactic acid.
Abstract translation: 公开了用于可植入医疗装置的涂层及其制造方法，所述涂层包含乳酸聚合物。
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公开(公告)号：US20150151030A1
公开(公告)日：2015-06-04
申请号：US14605666
申请日：2015-01-26
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Lothar W. Kleiner , John Stankus , Nam D. Pham , Michael H. Ngo , Bozena Zofia Maslanka , Syed Faiyaz Ahmed Hossainy , Mikael Trollsas , Yiwen Tang
IPC: A61L31/16 , A61L31/14 , A61L31/10 , A61K31/436 , A61K47/34
CPC classification number: A61L31/16 , A61K31/436 , A61K47/34 , A61L31/10 , A61L31/148 , A61L2300/416 , C08L67/04
Abstract: The present invention relates to implantable medical devices coated with polymer having tunable hydrophobicity and their use in the treatment of vascular diseases.
Abstract translation: 本发明涉及涂覆有具有可调谐疏水性的聚合物的可植入医疗装置及其在治疗血管疾病中的用途。
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3.发明申请Polymer Blends For Drug Delivery Stent Matrix With Improved Thermal Stability 审中-公开用于具有改进的热稳定性的药物递送支架基质的聚合物共混物公开(公告)号：US20140335143A1
公开(公告)日：2014-11-13
申请号：US14279234
申请日：2014-05-15
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Florencia Lim , Bozena Z. Maslanka , Yiwen Tang , O. Mikael Trollsas
IPC: A61L31/10
CPC classification number: A61L31/10 , A61L2420/02 , A61L2420/06 , C08L67/04 , C09D167/04 , C08L2666/18
Abstract: Various embodiments of the present invention generally relate to a polymer blend composition used for coating a medical device that exhibits improved thermal stability. The invention also encompasses implantable medical devices coated the aforementioned coating.
Abstract translation: 本发明的各种实施方案一般涉及用于涂覆显示改善的热稳定性的医疗装置的聚合物共混物组合物。 本发明还包括涂覆上述涂层的可植入医疗装置。
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公开(公告)号：US20130230564A1
公开(公告)日：2013-09-05
申请号：US13770988
申请日：2013-02-19
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： Lothar W. Kleiner , Yiwen Tang , Syed Faiyaz Ahmed Hossainy , Florencia Lim , Michael Huy Ngo , O. Mikael Trollsas
IPC: A61L31/10
CPC classification number: A61L31/10 , A61L31/16 , A61L2300/416 , C08L67/04 , C08L77/12
Abstract: The present invention provides a coating comprising a semi-crystalline polymer on an implantable device and methods of making and using the same.
Abstract translation: 本发明提供一种包含可植入装置上的半结晶聚合物的涂层及其制备和使用方法。
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5.发明申请DRUG ELUTING IMPLANTABLE MEDICAL DEVICE WITH HEMOCOMPATIBLE AND/OR PROHEALING TOPCOAT 审中-公开具有可致死性和/或前列腺素的药物可植入医疗器械公开(公告)号：US20130178832A1
公开(公告)日：2013-07-11
申请号：US13737872
申请日：2013-01-09
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Lothar W. Kleiner , Yiwen Tang
IPC: A61M25/00
CPC classification number: A61M25/0045 , A61L31/10 , A61L31/16 , A61L2300/608 , A61L2420/08 , C08L67/04
Abstract: The present invention relates to implantable medical devices coated with polymer having hemocompatible and/or prohealing moieties appended thereto and to their use in the treatment of vascular diseases.
Abstract translation: 本发明涉及涂覆有附着于其上的具有血液相容性和/或预热部分的聚合物的可植入医疗器械及其在治疗血管疾病中的用途。
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Patent Agency Ranking
公开(公告)号：US20180154051A1
公开(公告)日：2018-06-07
申请号：US15797218
申请日：2017-10-30
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Syed F.A. Hossainy , Fuh-Wei Tang , Lothar W. Kleiner , Thierry Glauser , Yiwen Tang , Wouter E. Roorda , Stephen D. Pacetti , Gina Zhang , Yung-Ming Chen , Andrew F. McNiven , Sean A. McNiven , Brandon J. Yoe
CPC classification number: A61L31/10 , A61L27/40 , A61L27/44 , A61L27/50 , A61L27/54 , A61L31/12 , A61L31/14 , A61L31/16 , A61L2300/00
Abstract: The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix that include designing and creating a predetermined initial morphology (IM) profile in a polymeric matrix. The teachings indicate, inter alia, that control over the release rate of agents can provide for an improved control over the administration of agents as well as have an effect upon the mechanical integrity and absorption rate of the polymeric matrix.
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公开(公告)号：US09821091B2
公开(公告)日：2017-11-21
申请号：US13953656
申请日：2013-07-29
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Syed F. A. Hossainy , Fuh-Wei Tang , Lothar W. Kleiner , Thierry Glauser , Yiwen Tang , Wouter E. Roorda , Stephen D. Pacetti , Gina Zhang , Yung-Ming Chen , Andrew F. McNiven , Sean A. McNiven , Brandon J. Yoe
CPC classification number: A61L31/10 , A61L27/40 , A61L27/44 , A61L27/50 , A61L27/54 , A61L31/12 , A61L31/14 , A61L31/16 , A61L2300/00
Abstract: The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix. The methods relate to the application of pressure, and optionally, in combination with heat, to a polymeric coating.
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公开(公告)号：US09539332B2
公开(公告)日：2017-01-10
申请号：US14621301
申请日：2015-02-12
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen Dirk Pacetti , Yiwen Tang , Syed Faiyaz Ahmed Hossainy
IPC: A61F2/00 , A61K39/00 , A61F2/06 , A61F2/02 , A61K38/22 , A61K38/00 , A61K31/44 , A61K31/445 , A61K47/34 , A61L27/34 , A61L27/50 , A61L31/10 , A61L31/14 , A61K31/436 , C08K5/1575 , C09D167/00
CPC classification number: A61K47/34 , A61K31/436 , A61L27/34 , A61L27/502 , A61L31/10 , A61L31/141 , C08K5/1575 , C08L67/04 , C09D167/00
Abstract: A biocompatible plasticizer useful for forming a coating composition with a biocompatible polymer is provided. The coating composition may also include a biobeneficial polymer and/or a bioactive agent. The coating composition can form a coating on an implantable device. The implantable device can be used to treat or prevent a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
Abstract translation: 提供了可用于形成具有生物相容性聚合物的涂料组合物的生物相容性增塑剂。 涂料组合物还可以包括生物有益的聚合物和/或生物活性剂。 涂料组合物可以在可植入装置上形成涂层。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍，胆管阻塞 ，输尿管阻塞，肿瘤阻塞或其组合。
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公开(公告)号：US20150150989A1
公开(公告)日：2015-06-04
申请号：US14621301
申请日：2015-02-12
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen Dirk Pacetti , Yiwen Tang , Syed Faiyaz Ahmed Hossainy
IPC: A61K47/34 , C09D167/00 , C08K5/1575 , A61K31/436
CPC classification number: A61K47/34 , A61K31/436 , A61L27/34 , A61L27/502 , A61L31/10 , A61L31/141 , C08K5/1575 , C08L67/04 , C09D167/00
Abstract: A biocompatible plasticizer useful for forming a coating composition with a biocompatible polymer is provided. The coating composition may also include a biobeneficial polymer and/or a bioactive agent. The coating composition can form a coating on an implantable device. The implantable device can be used to treat or prevent a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof
Abstract translation: 提供了可用于形成具有生物相容性聚合物的涂料组合物的生物相容性增塑剂。 涂料组合物还可以包括生物有益的聚合物和/或生物活性剂。 涂料组合物可以在可植入装置上形成涂层。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍，胆管阻塞 ，输尿管阻塞，肿瘤阻塞或其组合
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10.发明申请Methods of treatment of polymeric coatings for control of agent release rates 审中-公开处理聚合物涂层以控制药剂释放速率的方法公开(公告)号：US20140004250A1
公开(公告)日：2014-01-02
申请号：US13953656
申请日：2013-07-29
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Syed F.A. Hossainy , Fuh-Wei Tang , Lothar W. Kleiner , Thierry Glauser , Yiwen Tang , Wouter E. Roorda , Stephen D. Pacetti , Gina Zhang , Yung-Ming Chen , Andrew F. McNiven , Sean A. McNiven , Brandon J. Yoe
IPC: A61L31/10
CPC classification number: A61L31/10 , A61L27/40 , A61L27/44 , A61L27/50 , A61L27/54 , A61L31/12 , A61L31/14 , A61L31/16 , A61L2300/00
Abstract: The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix that include designing and creating a predetermined initial morphology (IM) profile in a polymeric matrix. The teachings indicate, inter alia, that control over the release rate of agents can provide for an improved control over the administration of agents as well as have an effect upon the mechanical integrity and absorption rate of the polymeric matrix.
Abstract translation: 本公开教导了控制来自聚合物基质的试剂的释放速率的方法，其包括在聚合物基质中设计和产生预定的初始形态（IM）分布。 教导尤其表明，对药剂释放速率的控制可以提供对药剂施用的改进控制，以及对聚合物基质的机械完整性和吸收速率的影响。
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