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公开(公告)号：US20180154051A1
公开(公告)日：2018-06-07
申请号：US15797218
申请日：2017-10-30
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Syed F.A. Hossainy , Fuh-Wei Tang , Lothar W. Kleiner , Thierry Glauser , Yiwen Tang , Wouter E. Roorda , Stephen D. Pacetti , Gina Zhang , Yung-Ming Chen , Andrew F. McNiven , Sean A. McNiven , Brandon J. Yoe
CPC classification number: A61L31/10 , A61L27/40 , A61L27/44 , A61L27/50 , A61L27/54 , A61L31/12 , A61L31/14 , A61L31/16 , A61L2300/00
Abstract: The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix that include designing and creating a predetermined initial morphology (IM) profile in a polymeric matrix. The teachings indicate, inter alia, that control over the release rate of agents can provide for an improved control over the administration of agents as well as have an effect upon the mechanical integrity and absorption rate of the polymeric matrix.
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公开(公告)号：US09833344B2
公开(公告)日：2017-12-05
申请号：US15280845
申请日：2016-09-29
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： Lothar W. Kleiner
IPC: A61L31/04 , B05D1/18 , A61F2/06 , A61F2/915 , A61L27/28 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/16 , B05D3/00 , B05D5/00 , B05D7/24 , B05D7/00 , A61F2/07 , A61F2/30
CPC classification number: A61F2/915 , A61F2/07 , A61F2/30 , A61F2002/30065 , A61F2002/3067 , A61F2002/91583 , A61L27/28 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/148 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/606 , B05D1/18 , B05D3/007 , B05D5/00 , B05D7/24 , B05D7/544 , C08L67/04
Abstract: A stent made from an ultra high molecular weight bioabsorbable polymer is disclosed herein. The bioabsorbable polymer can have a Mw greater than 1 million g/mole or greater than 2 million g/mole. Methods of making the ultra high molecular weight polymer stent without degrading the molecular weight are further disclosed.
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公开(公告)号：US09821091B2
公开(公告)日：2017-11-21
申请号：US13953656
申请日：2013-07-29
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Syed F. A. Hossainy , Fuh-Wei Tang , Lothar W. Kleiner , Thierry Glauser , Yiwen Tang , Wouter E. Roorda , Stephen D. Pacetti , Gina Zhang , Yung-Ming Chen , Andrew F. McNiven , Sean A. McNiven , Brandon J. Yoe
CPC classification number: A61L31/10 , A61L27/40 , A61L27/44 , A61L27/50 , A61L27/54 , A61L31/12 , A61L31/14 , A61L31/16 , A61L2300/00
Abstract: The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix. The methods relate to the application of pressure, and optionally, in combination with heat, to a polymeric coating.
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公开(公告)号：US09561611B2
公开(公告)日：2017-02-07
申请号：US14740063
申请日：2015-06-15
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Lothar W. Kleiner
IPC: B29C47/06 , B29C47/00 , A61F2/06 , B29C49/04 , B29C47/26 , B29C55/24 , B29C55/04 , B29C49/22 , B32B27/00 , A61L31/06 , A61L31/14 , C08L67/04 , C08L71/02 , B29C47/14 , B29C47/56 , B29C47/70 , B32B27/36 , B29K96/00 , B29L31/00 , A61F2/82 , A61F2/915
CPC classification number: B29C47/0004 , A61F2/06 , A61F2/82 , A61F2002/91566 , A61F2210/0004 , A61F2210/0076 , A61L31/06 , A61L31/148 , B29C47/0009 , B29C47/0023 , B29C47/0054 , B29C47/0057 , B29C47/06 , B29C47/145 , B29C47/26 , B29C47/56 , B29C47/707 , B29C49/04 , B29C49/22 , B29C55/04 , B29C55/24 , B29K2096/00 , B29L2031/7546 , B32B27/00 , B32B27/36 , C08L67/04 , C08L71/02 , Y10T428/1393
Abstract: A bioabsorbable scaffold composed of a multilayer structure of alternating layers of different polymers is disclosed. The multilayer structure can have 20 to 1000 layers and the individual thickness of the layers can be 0.2 to 5 microns. A method of making the scaffold including a layer multiplying extrusion process is disclosed.
Abstract translation: 公开了由不同聚合物的交替层的多层结构构成的生物可吸收支架。 多层结构可以具有20至1000层，并且层的单独厚度可以为0.2至5微米。 公开了一种制造包括层叠挤出工艺的支架的方法。
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公开(公告)号：US09387282B2
公开(公告)日：2016-07-12
申请号：US14182211
申请日：2014-02-17
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Lothar W. Kleiner , Syed F. A. Hossainy , Mikael Trollsas , Stephen D. Pacetti
CPC classification number: A61L31/148 , A61L31/10 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2420/02 , A61L2420/08 , C08L67/04
Abstract: The present invention provides an absorbable coating for an implantable device and the methods of making and using the same.
Abstract translation: 本发明提供了一种用于可植入装置的可吸收涂层及其制造和使用方法。
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Patent Agency Ranking
公开(公告)号：US09067002B2
公开(公告)日：2015-06-30
申请号：US14185699
申请日：2014-02-20
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： O. Mikael Trollsas , Lothar W. Kleiner , Syed F. A. Hossainy
CPC classification number: A61L31/10 , A61L27/34 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2400/18 , A61L2420/08 , C08L67/04
Abstract: An aliphatic polyester polymer for stent coating is described.
Abstract translation: 描述了用于支架涂层的脂族聚酯聚合物。
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公开(公告)号：US20140186417A1
公开(公告)日：2014-07-03
申请号：US14185699
申请日：2014-02-20
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： O. Mikael Trollsas , Lothar W. Kleiner , Syed F.A. Hossainy
CPC classification number: A61L31/10 , A61L27/34 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2400/18 , A61L2420/08 , C08L67/04
Abstract: An aliphatic polyester polymer for stent coating is described.
Abstract translation: 描述了用于支架涂层的脂族聚酯聚合物。
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公开(公告)号：US20130317590A1
公开(公告)日：2013-11-28
申请号：US13956152
申请日：2013-07-31
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Bin Huang , Lothar W. Kleiner , John Stankus
CPC classification number: A61L31/14 , A61L2/08 , A61L2/081 , A61L2/087 , A61L29/085 , A61L29/16 , A61L31/04 , A61L31/042 , A61L31/10 , A61L31/16 , A61L2300/30 , A61L2300/428
Abstract: Stents and delivery systems with reduced chemical degradation and methods of sterilizing the same are disclosed.
Abstract translation: 公开了具有降低化学降解的支架和递送系统及其灭菌方法。
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9.发明申请公开(公告)号：US20150157771A1
公开(公告)日：2015-06-11
申请号：US14624063
申请日：2015-02-17
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Syed F.A. Hossainy , O. Mikael Trollsas , Lothar W. Kleiner
CPC classification number: A61L31/148 , A61F2/82 , A61L27/34 , A61L27/58 , A61L29/085 , A61L29/148 , A61L31/048 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/602 , C08L1/286 , C08L5/08 , C08L89/00 , C09D101/286 , C09D105/08 , C09D189/00
Abstract: The present invention provides an implantable device having a biosoluble coating comprising a polyelectrolyte and a counterion and the methods of making and using the same.
Abstract translation: 本发明提供了具有包含聚电解质和抗衡离子的生物可溶性涂层的可植入装置及其制备和使用方法。
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公开(公告)号：US08865148B2
公开(公告)日：2014-10-21
申请号：US14149533
申请日：2014-01-07
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Lothar W. Kleiner , Syed Hossainy , Stephen Pacetti , Jessica DesNoyer
IPC: A61K31/74 , C08L77/12 , A61K9/08 , A61K31/337 , A61K47/48 , A61K31/4745 , A61K47/34 , A61K9/10 , A61K9/00
CPC classification number: A61K47/48207 , A61K9/0024 , A61K9/08 , A61K9/10 , A61K31/337 , A61K31/4745 , A61K31/727 , A61K47/34 , A61K47/593 , A61K47/595 , A61K47/60 , C08L77/12 , C08L2205/02 , C08L2666/20
Abstract: A therapeutic agent delivery system formed of a specific type of poly(ester amide) (PEA), a therapeutic agent, and a water miscible solvent is described herein. A method of delivering the therapeutic agent delivery system by delivering the therapeutic agent delivery system formed of a PEA polymer, a therapeutic agent, and a water miscible solvent to a physiological environment and separating the phase of the therapeutic agent delivery system to form a membrane from the polymer to contain the therapeutic agent within the physiological environment is also described. Additionally disclosed is a kit including a syringe and a therapeutic agent delivery system within the syringe.
Abstract translation: 本文描述了由特定类型的聚（酯酰胺）（PEA），治疗剂和水混溶性溶剂形成的治疗剂递送系统。 通过将由PEA聚合物，治疗剂和水混溶性溶剂形成的治疗剂递送系统递送到生理环境来递送治疗剂递送系统的方法，并分离治疗剂递送系统的相以形成膜 还描述了在生理环境中含有治疗剂的聚合物。 另外公开了一种试剂盒，其包括注射器内的注射器和治疗剂递送系统。
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