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公开(公告)号：US20180208568A1
公开(公告)日：2018-07-26
申请号：US15925517
申请日：2018-03-19
Applicant: ABIDE THERAPEUTICS, INC. , THE SCRIPPS RESEARCH INSTITUTE
Inventor： Justin S. CISAR , Cheryl A. GRICE , Todd K. JONES , Micah J. NIPHAKIS , Jae Won CHANG , Kenneth M. LUM , Benjamin F. CRAVATT
IPC: C07D295/205 , C07D491/107 , C07C271/10 , C07D471/10 , C07D471/04 , C07D413/10 , C07D413/06 , C07D407/06 , C07D405/14 , C07D403/10 , C07D401/10 , C07D401/04 , C07D317/58 , C07D317/46 , C07D307/79 , C07D295/26 , C07D271/06 , C07D263/32 , C07D261/08 , C07D241/04 , C07D231/56 , C07D231/16 , C07D231/12 , C07D215/46 , C07D215/42 , C07D213/55 , C07D213/40 , C07D213/38 , C07D207/14 , C07D207/09 , C07D205/04 , C07C271/12 , C07D487/04
CPC classification number: C07D295/205 , C07C271/10 , C07C271/12 , C07D205/04 , C07D207/09 , C07D207/14 , C07D213/38 , C07D213/40 , C07D213/55 , C07D215/42 , C07D215/46 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D295/26 , C07D307/79 , C07D317/46 , C07D317/58 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/14 , C07D407/06 , C07D413/06 , C07D413/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
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公开(公告)号：US20170190669A1
公开(公告)日：2017-07-06
申请号：US15312998
申请日：2015-05-20
Applicant: ABIDE THERAPEUTICS, INC. , THE SCRIPPS RESEARCH INSTITUTE
Inventor： Dale L. BOGER , Katerina OTRUBOVA , Justin S. CISAR , Cheryl A. GRICE , Todd K. JONES
IPC: C07D231/14 , C07D491/107 , C07D403/12 , C07D417/12 , C07D405/12 , C07D401/12
CPC classification number: C07D231/14 , C07D231/12 , C07D231/16 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/12 , C07D491/10 , C07D491/107
Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of one or more of MAGL, ABHD6, and FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain, solid tumors and/or obesity.
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3.发明申请公开(公告)号：US20170183353A1
公开(公告)日：2017-06-29
申请号：US15313012
申请日：2015-05-20
Applicant: ABIDE THERAPEUTICS, INC. , THE SCRIPPS RESEARCH INSTITUTE
Inventor： Benjamin F. CRAVATT , Armand B. COGNETTA , Jonathan J. HULCE , Micah J. NIPHAKIS , Todd K. JONES , Cheryl A. GRICE
IPC: C07D487/04 , C12Q1/34
CPC classification number: C07D487/04 , C12Q1/34
Abstract: Provided herein are N-hydroxy bicyclic hydantoin carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of serine hydrolases. Furthermore, the subject compounds and compositions are useful for the treatment of one or more of cancer, pain, diabetes, obesity/metabolic syndrome, epilepsy, traumatic brain injury, and inflammation.
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公开(公告)号：US20230312499A1
公开(公告)日：2023-10-05
申请号：US18053582
申请日：2022-11-08
Applicant: H. Lundbeck A/S , THE SCRIPPS RESEARCH INSTITUTE
Inventor： Justin S. CISAR , Cheryl A. GRICE , Todd K. JONES , Micah J. NIPHAKIS , Jae Won CHANG , Kenneth M. LUM , Benjamin F. CRAVATT
IPC: C07D295/205 , C07C271/12 , C07D317/46 , C07D317/58 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D471/04 , C07D471/10 , C07D261/08 , C07D487/04 , C07D263/32 , C07D205/04 , C07D491/107 , C07D207/14 , C07D271/06 , C07D307/79 , C07D405/14 , C07D215/42 , C07D213/40 , A61P25/22 , C07D295/26 , C07D213/55 , C07D401/04 , C07D407/06 , C07D413/06 , C07C271/10 , C07D207/09 , C07D213/38 , C07D215/46 , C07D401/10 , C07D403/10 , C07D413/10
CPC classification number: C07D295/205 , C07C271/12 , C07D317/46 , C07D317/58 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D471/04 , C07D471/10 , C07D261/08 , C07D487/04 , C07D263/32 , C07D205/04 , C07D491/107 , C07D207/14 , C07D271/06 , C07D307/79 , C07D405/14 , C07D215/42 , C07D213/40 , A61P25/22 , C07D295/26 , C07D213/55 , C07D401/04 , C07D407/06 , C07D413/06 , C07C271/10 , C07D207/09 , C07D213/38 , C07D215/46 , C07D401/10 , C07D403/10 , C07D413/10
Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.
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公开(公告)号：US20200270223A1
公开(公告)日：2020-08-27
申请号：US16717813
申请日：2019-12-17
Inventor： Justin S. CISAR , Cheryl A. GRICE , Todd K. JONES , Micah J. NIPHAKIS , Jae Won CHANG , Kenneth M. LUM , Benjamin F. CRAVATT
IPC: C07D295/205 , C07C271/12 , C07D317/46 , C07D317/58 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D471/04 , C07D471/10 , C07D261/08 , C07D487/04 , C07D263/32 , C07D205/04 , C07D491/107 , C07D207/14 , C07D271/06 , C07D307/79 , C07D405/14 , C07D215/42 , C07D213/40 , C07D295/26 , C07D213/55 , C07D401/04 , C07D407/06 , C07D413/06 , C07C271/10 , C07D207/09 , C07D213/38 , C07D215/46 , C07D401/10 , C07D403/10 , C07D413/10
Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
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Patent Agency Ranking
公开(公告)号：US20210188793A1
公开(公告)日：2021-06-24
申请号：US17195351
申请日：2021-03-08
Inventor： Justin S. CISAR , Cheryl A. GRICE , Todd K. JONES , Micah J. NIPHAKIS , Jae Won CHANG , Kenneth M. LUM , Benjamin F. CRAVATT
IPC: C07D295/205 , C07C271/12 , C07D317/46 , C07D317/58 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D471/04 , C07D471/10 , C07D261/08 , C07D487/04 , C07D263/32 , C07D205/04 , C07D491/107 , C07D207/14 , C07D271/06 , C07D307/79 , C07D405/14 , C07D215/42 , C07D213/40 , A61P25/22 , C07D295/26 , C07D213/55 , C07D401/04 , C07D407/06 , C07D413/06 , C07C271/10 , C07D207/09 , C07D213/38 , C07D215/46 , C07D401/10 , C07D403/10 , C07D413/10
Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.
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公开(公告)号：US20180327410A1
公开(公告)日：2018-11-15
申请号：US15777199
申请日：2016-11-18
Applicant: ABIDE THERAPEUTICS, INC.
Inventor： Cheryl A. GRICE , Todd K. JONES , Katherine K. DUNCAN , Olivia D. WEBER , Justin S. CISAR , Jeffrey E. MERIT
IPC: C07D487/04 , C07D487/10 , C07D403/06 , C07D519/00 , C07D401/14 , C07D403/14 , C07D417/14
CPC classification number: C07D487/04 , C07D401/14 , C07D403/06 , C07D403/14 , C07D417/14 , C07D487/10 , C07D519/00
Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.
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公开(公告)号：US20170327500A1
公开(公告)日：2017-11-16
申请号：US15593239
申请日：2017-05-11
Applicant: Abide Therapeutics, Inc.
Inventor： Justin S. CISAR , Cheryl A. GRICE , Todd K. JONES , Olivia D. WEBER , Daniel J. BUZARD , Michael B. SHAGHAFI
IPC: C07D471/10 , C07D519/00
CPC classification number: C07D471/10 , C07D519/00
Abstract: Provided herein are spirocycle compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
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公开(公告)号：US20180327416A1
公开(公告)日：2018-11-15
申请号：US15777201
申请日：2016-11-18
Applicant: ABIDE THERAPEUTICS, INC.
Inventor： Cheryl A. GRICE , Todd K. JONES , Katharine K. DUNCAN , Justin S. CISAR , Jeffrey E. MERIT , Olivia D. WEBER
IPC: C07D487/10 , C07D487/04 , C07D471/10 , C07D519/00 , C07D403/06 , C07D491/08 , C07D231/40 , C07D231/38 , C07D403/12 , C07D417/12 , C07D401/12 , C07D413/12
CPC classification number: C07D487/10 , C07D231/38 , C07D231/40 , C07D401/12 , C07D403/06 , C07D403/12 , C07D413/12 , C07D417/12 , C07D471/10 , C07D487/04 , C07D491/08 , C07D498/08 , C07D519/00
Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.
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公开(公告)号：US20170334874A1
公开(公告)日：2017-11-23
申请号：US15672165
申请日：2017-08-08
Applicant: Abide Therapeutics, Inc.
Inventor： Justin S. CISAR , Cheryl A. GRICE , Todd K. JONES , Olivia D. WEBER , Dong-Hui WANG
IPC: C07D295/205 , C07D207/08 , C07D471/10 , C07D417/04 , C07D403/04 , C07D401/04 , C07D295/26 , C07D265/30 , C07D211/62 , C07D211/58 , C07D211/38 , C07D211/14 , C07D207/16 , C07D207/14 , C07D207/12 , C07D487/04 , C07D498/08
CPC classification number: C07D295/205 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/14 , C07D211/38 , C07D211/58 , C07D211/62 , C07D265/30 , C07D295/26 , C07D401/04 , C07D403/04 , C07D417/04 , C07D471/10 , C07D487/04 , C07D498/08
Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
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