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公开(公告)号：US12258404B2
公开(公告)日：2025-03-25
申请号：US16956797
申请日：2018-12-31
Applicant: AMGEN INC. , AMGEN RESEARCH (MUNICH) GMBH
Inventor： Tobias Raum , Tara Arvedson , Julie Bailis , Christoph Dahlhoff , Sandra Ross , Irwin Chen , Claudia Blümel , Elisabeth Nahrwold , Jochen Pendzialek , Joachim Wahl
Abstract: The present invention provides bispecific antibody constructs characterized by comprising a first domain binding to MUC17, a second domain binding to an extracellular epitope of the human and the Macaca CD3ε chain and optionally a third domain, which is a specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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公开(公告)号：US20230146593A1
公开(公告)日：2023-05-11
申请号：US17910698
申请日：2021-03-12
Applicant: AMGEN INC.
Inventor： Sophia K. Khaldoyanidi , Dirk Nagorsen , Tara Arvedson , Suresh Agarwal , Vijay Vishesh Upreti , Steven Yea
IPC: A61K39/395 , A61K38/17 , A61K45/06 , A61P35/00
CPC classification number: A61K39/3955 , A61K38/1793 , A61K45/06 , A61P35/00
Abstract: The present invention relates to medical combination products comprising (i) at least one antibody construct comprising at least one domain which binds to a target antigen expressed on the surface of a cell and at least one other domain which binds to CD3 as well as (ii) at least one molecule that is inhibitor/antagonist of TNF/TNFR reducing TNF/TNFR signaling and/or an inhibitor/antagonist of IL6/IL6R that reduces IL6/IL6R signaling, wherein a first dose of said inhibitor/antagonist is administered before administration of a first dose of said antibody construct. Furthermore, the invention provides therapeutic and preventive methods and medical uses of said combination products, as well as a kit comprising said at least one antibody construct and at least one antagonist/inhibitor of TNF or IL6 or its cognate receptor, wherein the interaction of said antagonist/inhibitor of TNF or an inhibitor/antagonist of IL6 with its cognate receptor reduces, mitigates, prevents, or treats cytokine release syndrome.
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公开(公告)号：US20220403035A1
公开(公告)日：2022-12-22
申请号：US17774232
申请日：2020-11-06
Applicant: AMGEN RESEARCH ( MUNICH) GMBH , AMGEN INC.
Inventor： Jonas Anlahr , Tara Arvedson , Julie Bailis , Matthew Chun , Igor D'Angelo , Christopher Dahlhoff , Stephanie Everts , Mattias Friedrich , Lars Gaedtke , Patrick Hoffmann , Rebecca Goldstein , Jonas Karl-Josef Honer , Roman Kischel , Matthias Klinger , Peter Kufer , Markus Muenz
IPC: C07K16/28
Abstract: The present invention provides bispecific antigen-binding molecules characterized by comprising a first and a second domain, each binding to any of CS1, BCMA, CD20, CD22, FLT3, CD123, CLL1, MSLN, CDH3 or EpCAM, a third domain binding to an extracellular epitope of the human and the Macaca CD3ε chain and optionally a fourth domain, which is a Fc modality. Moreover, the invention provides a polynucleotide, encoding the antigen-binding molecule, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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公开(公告)号：US11692031B2
公开(公告)日：2023-07-04
申请号：US16530006
申请日：2019-08-02
Applicant: AMGEN RESEARCH (MUNICH) GMBH , AMGEN INC.
Inventor： Christoph Dahlhoff , Claudia Blümel , Johannes Brozy , Tobias Raum , Elisabeth Nahrwold , Tara Arvedson , Irwin Chen , Sandra Ross , Julie Bailis
CPC classification number: C07K16/28 , A61P35/00 , C07K16/2809 , A61K2039/505 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2317/94
Abstract: The present invention relates to an antibody construct comprising a domain which binds to Claudin 18.2 (CLDN18.2) and another domain which binds to CD3. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for producing the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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5.发明申请公开(公告)号：US20230093169A1
公开(公告)日：2023-03-23
申请号：US17793757
申请日：2021-01-22
Applicant: AMGEN RESEARCH (MUNCH) GMBH , AMGEN INC.
Inventor： Benno Rattel , Matthias Friedrich , Oliver Thomas , Tara Arvedson , Jackson Egen , Jason DeVoss , Xiaoting Wang , Grit Lorenczewski
IPC: C07K16/28 , A61P35/00 , A61K31/573 , A61K39/395 , A61P37/06 , A61K38/17 , C07K16/24
Abstract: The present invention relates to medical combination products comprising (i) at least one antibody construct comprising at least one domain which binds to a target antigen expressed on the surface of a cell and at least one other domain which binds to CD3 as well as (ii) at least one molecule that is an antagonist of/an inhibitor of signaling, which is based on an interaction of TNF with its cognate receptor (TNFR), wherein the antagonisation or the inhibition of TNF or its cognate receptor prevents, reduces, or blocks TNF/TNFR mediated signalling. Furthermore, the invention provides therapeutic and preventive methods and medical uses of said combination products, as well as a kit comprising said at least one antibody construct and at least one antagonist/inhibitor of TNF or its cognate receptor, wherein the interaction of said antagonist/inhibitor of TNF with its cognate receptor reduces, mitigates, prevents, or treats cytokine release syndrome.
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Patent Agency Ranking
公开(公告)号：US20200055932A1
公开(公告)日：2020-02-20
申请号：US16530006
申请日：2019-08-02
Applicant: AMGEN RESEARCH (MUNICH) GMBH , AMGEN INC.
Inventor： Christoph Dahlhoff , Claudia Blümel , Johannes Brozy , Tobias Raum , Elisabeth Nahrwold , Tara Arvedson , Irwin Chen , Sandra Ross , Julie Bailis
Abstract: The present invention relates to an antibody construct comprising a domain which binds to Claudin 18.2 (CLDN18.2) and another domain which binds to CD3. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for producing the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20240174745A1
公开(公告)日：2024-05-30
申请号：US18316739
申请日：2023-05-12
Applicant: AMGEN RESEARCH (MUNICH) GMBH , AMGEN INC.
Inventor： Christoph Dahlhoff , Claudia Blümel , Johannes Brozy , Tobias Raum , Elisabeth Nahrwold , Tara Arvedson , Irwin Chen , Sandra Ross , Julie Bailis
CPC classification number: C07K16/28 , A61P35/00 , C07K16/2809 , A61K2039/505 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2317/94
Abstract: The present invention relates to an antibody construct comprising a domain which binds to Claudin 18.2 (CLDN18.2) and another domain which binds to CD3. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for producing the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20210130465A1
公开(公告)日：2021-05-06
申请号：US16956797
申请日：2018-12-31
Applicant: AMGEN INC. , AMGEN RESEARCH (MUNICH) GMBH
Inventor： Tobias Raum , Tara Arvedson , Julie Bailis , Christoph Dahlhoff , Sandra Ross , Irwin Chen , Claudia Blümel , Elisabeth Nahrwold , Jochen Pendzialek , Joachim Wahl
Abstract: The present invention provides bispecific antibody constructs characterized by comprising a first domain binding to MUC17, a second domain binding to an extracellular epitope of the human and the Macaca CD3E chain and optionally a third domain, which is a specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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公开(公告)号：US10597456B2
公开(公告)日：2020-03-24
申请号：US15476699
申请日：2017-03-31
Applicant: KITE PHARMA, Inc. , AMGEN INC.
Inventor： Jed Wiltzius , Ruben Alvarez Rodriguez , Alice Bakker , Lawren Wu , Tara Arvedson
IPC: C07K16/28 , C07K14/725 , C07K14/705 , A61K39/00 , C07K14/435 , C12N15/86
Abstract: Antigen binding molecules, chimeric receptors, and engineered immune cells are disclosed in accordance with the invention. The invention further relates to vectors, compositions, and methods of treatment and/or detection using the antigen binding molecules and engineered immune cells.
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公开(公告)号：US09688759B2
公开(公告)日：2017-06-27
申请号：US14866105
申请日：2015-09-25
Applicant: AMGEN INC.
Inventor： Tara Arvedson , Gregory Dyas , James B. Rottman , Barbra Sasu , Xiao-juan Bi , Grace Ki Jeong Lee , Jackie Z. Sheng
CPC classification number: C07K16/28 , A61K38/1816 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/70 , C07K2317/76 , G01N33/6872 , G01N33/90 , G01N2800/00
Abstract: Compositions for treating disorders of iron homeostasis are provided. More particularly, anti-ferroportin antibodies, compositions containing such antibodies, corresponding nucleic acids, vectors and host cells, and methods of making such antibodies are provided.
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