公开(公告)号：US10064890B2

公开(公告)日：2018-09-04

申请号：US14364992

申请日：2012-12-13

Applicant: AMORPHICAL LTD

Inventor： Amir Sagi ,  Assaf Shechter ,  Galit Shaltiel-Gold ,  Michal Daniely ,  Oren Meiron

IPC: A61K33/10 ,  A61K31/663 ,  A61K35/612

Abstract: Provided are methods for treating calcium malabsorption and conditions associated with calcium malabsorption, employing the administration of a composition containing stable amorphous calcium carbonate. Further provided are methods for increasing bone mineral density in a bone metabolism associated disorders, diseases or conditions, employing the administration of said composition in combination with a bone resorption inhibitor.

公开(公告)号：US09550878B2

公开(公告)日：2017-01-24

申请号：US14418034

申请日：2013-08-07

Applicant: AMORPHICAL LTD.

Inventor： Oren Meiron ,  Binyamin Ashkenazi

IPC: C01F11/18 ,  C08K3/26 ,  C09C1/02 ,  B82Y30/00 ,  A61K33/10 ,  C08K5/092 ,  C08K5/17 ,  C08K5/521 ,  C08K5/5399 ,  C08L5/00 ,  D21H17/00

CPC classification number: C09C1/021 ,  A23L33/16 ,  A23V2002/00 ,  A61K33/10 ,  B82Y30/00 ,  C01F11/182 ,  C01F11/183 ,  C01F11/185 ,  C01P2002/02 ,  C01P2002/72 ,  C01P2002/82 ,  C01P2004/30 ,  C01P2004/62 ,  C01P2004/64 ,  C01P2006/22 ,  C01P2006/36 ,  C01P2006/82 ,  C08K3/26 ,  C08K5/092 ,  C08K5/175 ,  C08K5/521 ,  C08K5/5399 ,  C08K2003/265 ,  C08L5/00 ,  C09D17/004 ,  C09J11/04 ,  D21H17/74

Abstract: Provided is a method for preparing a stable amorphous calcium carbonate (ACC), which can be obtained either in suspension or as a powder. The method comprises stepwise combination of a soluble calcium salt, a soluble carbonate, a first and second stabilizer, and a water miscible organic solvent as described herein. The present invention further relates to stable ACC suspensions and dry powders produced by the method of the present invention.

Abstract translation: 提供一种制备稳定的无定形碳酸钙（ACC）的方法，其可以以悬浮液或粉末形式获得。 该方法包括如本文所述的可溶性钙盐，可溶性碳酸盐，第一和第二稳定剂以及水混溶性有机溶剂的逐步组合。 本发明还涉及通过本发明的方法制备的稳定的ACC悬浮液和干粉。

公开(公告)号：US10688124B2

公开(公告)日：2020-06-23

申请号：US16050651

申请日：2018-07-31

Applicant: AMORPHICAL LTD.

Inventor： Amir Sagi ,  Assaf Shechter ,  Galit Shaltiel-Gold ,  Michal Daniely ,  Oren Meiron

IPC: A61K33/10 ,  A61K35/612 ,  A61K31/663

Abstract: Provided are methods for treating calcium malabsorption and conditions associated with calcium malabsorption, employing the administration of a composition containing stable amorphous calcium carbonate. Further provided are methods for increasing bone mineral density in a bone metabolism associated disorders, diseases or conditions, employing the administration of said composition in combination with a bone resorption inhibitor.

公开(公告)号：US20150056306A1

公开(公告)日：2015-02-26

申请号：US14364992

申请日：2012-12-13

Applicant: AMORPHICAL LTD

Inventor： Amir Sagi ,  Assaf Shechter ,  Galit Shaltiel-Gold ,  Michal Daniely ,  Oren Meiron

IPC: A61K33/10 ,  A61K31/663

CPC classification number: A61K33/10 ,  A61K31/663 ,  A61K35/612

Abstract: Provided are methods for treating calcium malabsorption and conditions associated with calcium malabsorption, employing the administration of a composition containing stable amorphous calcium carbonate. Further provided are methods for increasing bone mineral density in a bone metabolism associated disorders, diseases or conditions, employing the administration of said composition in combination with a bone resorption inhibitor.

Abstract translation: 提供了用于治疗钙吸收不良的方法和与钙吸收不良相关的病症，使用含有稳定的无定形碳酸钙的组合物。 进一步提供的是使用与骨吸收抑制剂组合施用所述组合物来增加骨代谢相关障碍，疾病或病症中的骨矿物质密度的方法。

公开(公告)号：US10125262B2

公开(公告)日：2018-11-13

申请号：US15370623

申请日：2016-12-06

Applicant: AMORPHICAL LTD.

Inventor： Oren Meiron ,  Binyamin Ashkenazi

IPC: C01F11/18 ,  C09C1/02 ,  B82Y30/00 ,  A61K33/10 ,  C08K3/26 ,  C08K5/092 ,  C08K5/17 ,  C08K5/521 ,  C08K5/5399 ,  C08L5/00 ,  D21H17/00 ,  A23L33/16 ,  C09D17/00 ,  C09J11/04

Abstract: Provided is a method for preparing a stable amorphous calcium carbonate (ACC), which can be obtained either in suspension or as a powder. The method comprises stepwise combination of a soluble calcium salt, a soluble carbonate, a first and second stabilizer, and a water miscible organic solvent as described herein. The present invention further relates to stable ACC suspensions and dry powders produced by the method of the present invention.

公开(公告)号：US20170081520A1

公开(公告)日：2017-03-23

申请号：US15370623

申请日：2016-12-06

Applicant: AMORPHICAL LTD.

Inventor： Oren Meiron ,  Binyamin Ashkenazi

IPC: C09C1/02 ,  C09D17/00 ,  A61K33/10 ,  C08K3/26 ,  A23L33/16 ,  C08K5/092 ,  C08K5/17 ,  C09J11/04 ,  D21H17/00 ,  C01F11/18 ,  C08K5/521

CPC classification number: C09C1/021 ,  A23L33/16 ,  A23V2002/00 ,  A61K33/10 ,  B82Y30/00 ,  C01F11/182 ,  C01F11/183 ,  C01F11/185 ,  C01P2002/02 ,  C01P2002/72 ,  C01P2002/82 ,  C01P2004/30 ,  C01P2004/62 ,  C01P2004/64 ,  C01P2006/22 ,  C01P2006/36 ,  C01P2006/82 ,  C08K3/26 ,  C08K5/092 ,  C08K5/175 ,  C08K5/521 ,  C08K5/5399 ,  C08K2003/265 ,  C08L5/00 ,  C09D17/004 ,  C09J11/04 ,  D21H17/74

Abstract: Provided is a method for preparing a stable amorphous calcium carbonate (ACC), which can be obtained either in suspension or as a powder. The method comprises stepwise combination of a soluble calcium salt, a soluble carbonate, a first and second stabilizer, and a water miscible organic solvent as described herein. The present invention further relates to stable ACC suspensions and dry powders produced by the method of the present invention.

公开(公告)号：US20150166762A1

公开(公告)日：2015-06-18

申请号：US14418034

申请日：2013-08-07

Applicant: AMORPHICAL LTD.

Inventor： Oren Meiron ,  Binyamin Ashkenazi

IPC: C08K3/26 ,  C08K5/521 ,  C08K5/092 ,  A23L1/304 ,  C08K5/17 ,  C08L5/00 ,  D21H17/00 ,  A61K33/10 ,  C08K5/5399

CPC classification number: C09C1/021 ,  A23L33/16 ,  A23V2002/00 ,  A61K33/10 ,  B82Y30/00 ,  C01F11/182 ,  C01F11/183 ,  C01F11/185 ,  C01P2002/02 ,  C01P2002/72 ,  C01P2002/82 ,  C01P2004/30 ,  C01P2004/62 ,  C01P2004/64 ,  C01P2006/22 ,  C01P2006/36 ,  C01P2006/82 ,  C08K3/26 ,  C08K5/092 ,  C08K5/175 ,  C08K5/521 ,  C08K5/5399 ,  C08K2003/265 ,  C08L5/00 ,  C09D17/004 ,  C09J11/04 ,  D21H17/74

Abstract: Provided is a method for preparing a stable amorphous calcium carbonate (ACC), which can be obtained either in suspension or as a powder. The method comprises stepwise combination of a soluble calcium salt, a soluble carbonate, a first and second stabilizer, and a water miscible organic solvent as described herein. The present invention further relates to stable ACC suspensions and dry powders produced by the method of the present invention.

Abstract translation: 提供一种制备稳定的无定形碳酸钙（ACC）的方法，其可以以悬浮液或粉末形式获得。 该方法包括如本文所述的可溶性钙盐，可溶性碳酸盐，第一和第二稳定剂以及水混溶性有机溶剂的逐步组合。 本发明还涉及通过本发明的方法制备的稳定的ACC悬浮液和干粉。