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公开(公告)号：US10072040B2
公开(公告)日：2018-09-11
申请号：US14643858
申请日：2015-03-10
Applicant: AbbVie Inc.
Inventor： Thomas W. von Geldern , Dale J. Kempf , Kennan C. Marsh
IPC: C07H17/08 , A61K31/7048
CPC classification number: C07H17/08 , A61K31/7048
Abstract: The present invention pertains to derivatives of tylosin A. In particular, the present invention pertains to compounds having a structure of Formula (I). The present invention also pertains to compositions comprising derivatives of tylosin A and methods of treating or preventing conditions or disorders using such compounds and compositions.
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公开(公告)号：US20150259374A1
公开(公告)日：2015-09-17
申请号：US14643858
申请日：2015-03-10
Applicant: AbbVie Inc.
Inventor： Thomas W. von Geldern , Dale J. Kempf , Kennan C. Marsh
IPC: C07H17/08
CPC classification number: C07H17/08 , A61K31/7048
Abstract: The present invention pertains to derivatives of tylosin A. In particular, the present invention pertains to compounds having a structure of Formula (I). The present invention also pertains to compositions comprising derivatives of tylosin A and methods of treating or preventing conditions or disorders using such compounds and compositions.
Abstract translation: 本发明涉及泰乐菌素A的衍生物。特别地，本发明涉及具有式（I）结构的化合物。 本发明还涉及包含泰乐菌素A衍生物的组合物以及使用这些化合物和组合物治疗或预防病症或障碍的方法。
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公开(公告)号：US20140194349A1
公开(公告)日：2014-07-10
申请号：US14204892
申请日：2014-03-11
Applicant: AbbVie Inc.
Inventor： David A. DeGoey , Charles A. Flentge , William J. Flosi , David J. Grampovnik , Dale J. Kempf , Larry L. Klein , Ming C. Yeung , John T. Randolph , Xiu C. Wang , Su Yu
IPC: C07D213/56 , A61K31/443 , A61K45/06 , A61K31/426 , C07D401/12 , C07D407/12 , A61K31/444 , A61K31/4418
CPC classification number: C07D213/56 , A61K31/426 , A61K31/4418 , A61K31/443 , A61K31/444 , A61K45/06 , C07C311/16 , C07D213/38 , C07D213/85 , C07D231/08 , C07D239/22 , C07D277/06 , C07D277/30 , C07D307/16 , C07D307/20 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D407/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/10 , C07D493/04 , C07F9/58 , C07F9/65515 , C07F9/65583 , C07K5/0207
Abstract: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
Abstract translation: 公开了式的化合物作为HIV蛋白酶抑制剂。 还公开了用于抑制HIV感染的方法和组合物。
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公开(公告)号：US20160200757A1
公开(公告)日：2016-07-14
申请号：US15065337
申请日：2016-03-09
Applicant: AbbVie Inc.
Inventor： Thomas W. von Geldern , Dale J. Kempf , Kennan C. Marsh
IPC: C07H17/08
CPC classification number: C07H17/08 , A61K31/7048
Abstract: The present invention pertains to derivatives of tylosin A. In particular, the present invention pertains to compounds having a structure of Formula (I). The present invention also pertains to compositions comprising derivatives of tylosin A and methods of treating or preventing conditions or disorders using such compounds and compositions.
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公开(公告)号：US08741938B2
公开(公告)日：2014-06-03
申请号：US13954100
申请日：2013-07-30
Applicant: AbbVie Inc.
Inventor： Dale J. Kempf , Charles A. Flentge , John T. Randolph , Peggy Huang , Larry L. Klein
IPC: A61K31/426 , C07D277/30
CPC classification number: C07D277/30 , A61K31/426 , A61K31/427 , A61K45/06 , C07C53/18 , C07D213/30 , C07D231/12 , C07D233/64 , C07D263/32 , C07D277/24 , C07D277/38 , C07D277/587 , C07D333/16 , C07D417/04
Abstract: Novel compounds of formula 1 or a pharmaceutically acceptable salt thereof inhibit cytochrome P450 monooxygenase.
Abstract translation: 新的式1化合物或其药学上可接受的盐抑制细胞色素P450单加氧酶。
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Patent Agency Ranking
公开(公告)号：US20130317071A1
公开(公告)日：2013-11-28
申请号：US13954100
申请日：2013-07-30
Applicant: AbbVie Inc.
Inventor： Dale J. Kempf , Charles A. Flentge , John T. Randolph , Peggy Huang , Larry L. Klein
IPC: C07D277/587 , A61K31/426 , A61K31/427 , A61K45/06
CPC classification number: C07D277/30 , A61K31/426 , A61K31/427 , A61K45/06 , C07C53/18 , C07D213/30 , C07D231/12 , C07D233/64 , C07D263/32 , C07D277/24 , C07D277/38 , C07D277/587 , C07D333/16 , C07D417/04
Abstract: Novel compounds of formula 1 or a pharmaceutically acceptable salt thereof inhibit cytochrome P450 monooxygenase.
Abstract translation: 新的式1化合物或其药学上可接受的盐抑制细胞色素P450单加氧酶。
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公开(公告)号：US10238677B2
公开(公告)日：2019-03-26
申请号：US15542208
申请日：2016-01-08
Applicant: AbbVie Inc. , Liverpool School of Tropical Medicine
Inventor： Thomas W. Von Geldern , Dale J. Kempf , Kennan C. Marsh , Mark John Taylor , Stephen Andrew Ward , Louise Ford , Joseph Turner
IPC: A61K31/365 , A61K31/7048 , C07H17/08
Abstract: The present invention pertains to prevention of and/or treatment for filariasis. In particular, the present invention pertains to the use of tylosin A and its analogs and derivatives to prevent or treat filarial worm infection and/or diseases associated with filarial worm infection. The present invention also pertains to pharmaceutical compositions comprising tylosin A or an analog or derivative thereof for use in preventing or treating filarial worm infection and/or diseases associated with filarial worm infection.
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公开(公告)号：US09309279B2
公开(公告)日：2016-04-12
申请号：US14170199
申请日：2014-01-31
Applicant: AbbVie, Inc. , Enanta Pharmaceuticals, Inc.
Inventor： Yiyin Ku , Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , Dale J. Kempf , David J. Grampovnik , Ying Sun , Dong Liu , Yonghua Gai , Yat Sun Or , Seble H. Wagaw , Kenneth Engstrom , Tim Grieme , Ahmad Sheikh , Jianzhang Mei
IPC: C07K1/113 , C07D487/04
CPC classification number: C07K1/113 , C07D487/04
Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
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公开(公告)号：US20140243340A1
公开(公告)日：2014-08-28
申请号：US14273182
申请日：2014-05-08
Applicant: AbbVie Inc.
Inventor： Larry L. Klein , Hui-Ju CHEN , Ming C. YEUNG , Charles A. Flentge , John T. Randolph , Peggy Huang , Douglas K. Hutchinson , Dale J. Kempf
IPC: A61K31/5377 , A61K31/4439 , A61K31/4178 , A61K45/06 , A61K31/4164 , A61K31/506 , A61K31/496 , A61K31/4525 , C07D417/12 , C07D277/30
CPC classification number: A61K31/5377 , A61K31/4164 , A61K31/4178 , A61K31/4439 , A61K31/4525 , A61K31/496 , A61K31/506 , A61K45/06 , C07D213/79 , C07D277/24 , C07D277/30 , C07D277/593 , C07D417/12
Abstract: The present invention features compounds of formula I or pharmaceutically acceptable salts, solvates or prodrugs thereof, and methods of using the same to inhibit the metabolizing activities of CYP enzymes. The present invention also features methods of using these compounds, salts, solvates or prodrugs to improve the pharmacokinetics of drugs that are metabolized by CYP enzymes.
Abstract translation: 本发明的特征在于式I化合物或其药学上可接受的盐，溶剂合物或前药，以及使用该化合物抑制CYP酶代谢活性的方法。 本发明还涉及使用这些化合物，盐，溶剂合物或前药来改善由CYP酶代谢的药物的药代动力学的方法。
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公开(公告)号：US20140148573A1
公开(公告)日：2014-05-29
申请号：US14170199
申请日：2014-01-31
Applicant: Enanta Pharmaceuticals, Inc. , AbbVie, Inc.
Inventor： Yiyin Ku , Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , Dale J. Kempf , David J. Grampovnik , Ying Sun , Dong Liu , Yonghua Gai , Yat Sun Or , Seble H. Wagaw , Kenneth Engstrom , Tim Grieme , Ahmad Sheikh , Jianzhang Mei
IPC: C07K1/113
CPC classification number: C07K1/113 , C07D487/04
Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
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