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    Flow rate balanced, dynamically adjustable sheath delivery system for flow cytometry
    3.
    发明授权
    Flow rate balanced, dynamically adjustable sheath delivery system for flow cytometry 有权

    公开(公告)号：US10732088B2

    公开(公告)日：2020-08-04

    申请号：US16030174

    申请日：2018-07-09

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Daniel Nelson Fox ,  Nathan Michael Gaskill-Fox

    IPC: G01N1/28 ,  G01N15/14 ,  G01N15/00 ,  G01N15/10

    Abstract: Disclosed is a sheath delivery system that uses a continuous flow of sheath fluid into a pressurized internal reservoir that substantially matches the outflow of sheath fluid through the nozzle of a flow cytometer. A substantially constant level of the sheath fluid is maintained. If the sheath fluid level falls below a desired level, or goes above a desired level, a dampened control system is used to reach the desired level. In addition, air pressure in the pressurized internal container is controlled so that an external sheath container can be removed and refilled with additional sheath fluid without stopping the sheath delivery system 100. Differences in pressure are detected by a droplet camera, which measures the droplet breakoff point to determine the pressure of the sheath fluid in the nozzle.

    Multi-spectral filter profiling and quality control for flow cytometry
    4.
    发明授权
    Multi-spectral filter profiling and quality control for flow cytometry 有权

    公开(公告)号：US10429291B2

    公开(公告)日：2019-10-01

    申请号：US16247424

    申请日：2019-01-14

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Daniel Nelson Fox ,  Susan Hunter

    IPC: G01N15/10 ,  G01N15/14 ,  G01N15/00

    Abstract: Disclosed is a system and method for characterizing optical filters in a flow cytometer and optionally checking the operation of detectors in the flow cytometer. In some embodiments, the system may utilize an LED board having an opening through which the fluorescence and side scatter beams, rays, or images pass and light emitting diodes around the opening that emit light having different spectral profiles. The different spectral profiles allow the system to identify the optical filters that are placed in the flow cytometer, to verify detector operation, to assist in instrumentation troubleshooting, and to provide a quantitative reference for detector comparison.

    THRESHOLD SELECTOR FOR FLOW CYTOMETER
    5.
    发明申请
    THRESHOLD SELECTOR FOR FLOW CYTOMETER 有权
    流量计的阈值选择器

    公开(公告)号：US20170074776A1

    公开(公告)日：2017-03-16

    申请号：US15264326

    申请日：2016-09-13

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Daniel Nelson Fox

    IPC: G01N15/14 ,  G01N21/64

    CPC classification number: G01N15/1429 ,  G01N15/1425 ,  G01N15/147 ,  G01N2015/1006

    Abstract: Disclosed is a threshold selector that selects a threshold by generating a histogram from a detector signal and a flow cytometer. The detector signal includes both data and noise. A histogram is generated, which includes height data from the pulses of the detector signal as well as noise. The flow cytometer can be operated without samples to generate a histogram that includes only noise. The threshold signal can then be selected by selecting an intensity level on the histogram that is between the noise and data.

    Abstract translation: 公开了一种阈值选择器，其通过从检测器信号和流式细胞仪产生直方图来选择阈值。 检测器信号包括数据和噪声。 产生直方图，其包括来自检测器信号的脉冲的高度数据以及噪声。 流式细胞计数器可以在没有样品的情况下运行，以生成仅包含噪声的直方图。 然后可以通过选择噪声和数据之间的直方图上的强度级别来选择阈值信号。

    CONTINUOUS SAMPLE DELIVERY PERISTALTIC PUMP
    6.
    发明申请
    CONTINUOUS SAMPLE DELIVERY PERISTALTIC PUMP 审中-公开
    连续样品递送PERISALIC PUMP

    公开(公告)号：US20170051735A1

    公开(公告)日：2017-02-23

    申请号：US15242122

    申请日：2016-08-19

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Nathan Michael Gaskill-Fox ,  Daniel Nelson Fox

    IPC: F04B43/12 ,  F04B51/00 ,  F04B43/00

    CPC classification number: F04B43/1261 ,  F04B43/0072 ,  F04B43/1215 ,  F04B43/1276

    Abstract: A method and apparatus for pumping fluid through tubing are provided. The method includes orbiting first rollers around the periphery of a first disk at a first tangential speed in a first angular sector and a slower, second tangential speed in a second angular sector, orbiting second rollers around the periphery of a second disk at the second tangential speed, and increasing the pressure of fluid in tubing between one first roller and one second roller by causing the one first roller to fully compress the tubing at the first tangential speed and simultaneously causing the one second roller to fully compress the tubing at the second tangential speed. The apparatus includes a first disk with a recess in its periphery, the first angular sector with a nominal first radius, and a second angular sector with a nominal second radius; and a second disk with the nominal first radius and a recess in its periphery.

    Abstract translation: 提供了一种通过管道泵送流体的方法和装置。 该方法包括以第一角扇区中的第一切向速度围绕第一圆盘的圆周绕行第一滚轮，并且在第二角扇区中以较慢的第二切向速度围绕第一圆盘的绕第二滚轮旋转第二滚轮 通过使一个第一辊以第一切向速度完全压缩管道并同时使一个第二辊在第二切向下完全压缩管道，从而增加一个第一辊和一个第二辊之间的管道中的流体的压力 速度。 该装置包括在其周边具有凹部的第一盘，具有标称第一半径的第一角扇区和具有标称第二半径的第二角扇区; 以及具有标称第一半径的第二盘和在其周边的凹部。

    Continuous sample delivery peristaltic pump
    7.
    发明授权
    Continuous sample delivery peristaltic pump 有权

    公开(公告)号：US10309388B2

    公开(公告)日：2019-06-04

    申请号：US15242122

    申请日：2016-08-19

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Nathan Michael Gaskill-Fox ,  Daniel Nelson Fox

    IPC: F04B43/00 ,  F04B43/12

    Abstract: A method and apparatus for pumping fluid through tubing are provided. The method includes orbiting first rollers around the periphery of a first disk at a first tangential speed in a first angular sector and a slower, second tangential speed in a second angular sector, orbiting second rollers around the periphery of a second disk at the second tangential speed, and increasing the pressure of fluid in tubing between one first roller and one second roller by causing the one first roller to fully compress the tubing at the first tangential speed and simultaneously causing the one second roller to fully compress the tubing at the second tangential speed. The apparatus includes a first disk with a recess in its periphery, the first angular sector with a nominal first radius, and a second angular sector with a nominal second radius; and a second disk with the nominal first radius and a recess in its periphery.

    Multi-spectral filter profiling and quality control for flow cytometry
    8.
    发明授权
    Multi-spectral filter profiling and quality control for flow cytometry 有权

    公开(公告)号：US10180385B2

    公开(公告)日：2019-01-15

    申请号：US15234852

    申请日：2016-08-11

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Daniel Nelson Fox ,  Susan Hunter

    IPC: G01N15/10 ,  G01N15/14 ,  G01N15/00

    Abstract: Disclosed is a system and method for characterizing optical filters in a flow cytometer and optionally checking the operation of detectors in the flow cytometer. In some embodiments, the system may utilize an LED board having an opening through which the fluorescence and side scatter beams, rays, or images pass and light emitting diodes around the opening that emit light having different spectral profiles. The different spectral profiles allow the system to identify the optical filters that are placed in the flow cytometer, to verify detector operation, to assist in instrumentation troubleshooting, and to provide a quantitative reference for detector comparison.

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