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    DIGITAL ASSAYS FOR MUTATION DETECTION
    1.
    发明申请
    DIGITAL ASSAYS FOR MUTATION DETECTION 有权
    数字检测用于检测

    公开(公告)号：US20140309128A1

    公开(公告)日：2014-10-16

    申请号：US14210199

    申请日：2014-03-13

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： John Regan ,  Samantha Cooper ,  Austin So ,  Ryan Koehler ,  Luz Montesclaros

    IPC: C12Q1/68

    CPC classification number: C12Q1/6858 ,  C12Q2545/114 ,  C12Q2561/101 ,  C12Q2563/159

    Abstract: Provided herein are methods, compositions, and kits for detecting alleles using a single probe or a single primer set. Also, provided herein are methods, compositions, and kits for detecting allelic variants using a single probe or a single primer set. Also, provided herein are methods, compositions, and kits for determining a polymerization error rate.

    Abstract translation: 本文提供了使用单个探针或单一引物组检测等位基因的方法，组合物和试剂盒。 此外，本文提供的是使用单个探针或单个引物组检测等位基因变体的方法，组合物和试剂盒。 此外，本文提供了用于确定聚合误差率的方法，组合物和试剂盒。

    Amplification reporter with base-pairing oligomers
    3.
    发明授权
    Amplification reporter with base-pairing oligomers 有权

    公开(公告)号：US11085070B2

    公开(公告)日：2021-08-10

    申请号：US16834854

    申请日：2020-03-30

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： John F. Regan ,  Dianna Maar ,  Dawne N. Shelton ,  Tina C. Legler ,  Samantha Cooper ,  Wei Yang ,  Eli A. Hefner ,  Niels Klitgord

    IPC: C12Q1/68 ,  C12Q1/6818 ,  C12Q1/6823 ,  C12Q1/6848

    Abstract: System, including methods, apparatus, and compositions, for performing amplification assays with an amplification reporter including a first oligomer and a second oligomer capable of base-pairing with one another below a melting temperature of the reporter. The reporter may have a detectable photoluminescence that is affected, such as reduced, by base-pairing of the first and second oligomers with one another. A target, such as a nucleic acid target sequence, may be amplified in at least one volume, such as a plurality of partitions, above the melting temperature, and photoluminescence of the reporter may be detected from the at least one volume below the melting temperature. A property of the target, such as a concentration of the target, may be determined based on the photoluminescence detected.

    Amplification assay with a probe competitor
    7.
    发明授权
    Amplification assay with a probe competitor 有权

    公开(公告)号：US09868981B2

    公开(公告)日：2018-01-16

    申请号：US15181173

    申请日：2016-06-13

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Samantha Cooper ,  Wei Yang ,  Jennifer Berman

    IPC: C12Q1/68 ,  G06F19/22

    CPC classification number: C12Q1/6827 ,  G06F19/22 ,  C12Q2537/16 ,  C12Q2545/107

    Abstract: Methods and compositions for detecting an allelic form of a target. In an exemplary method, partitions may be created that collectively contain at least one first allelic form and a second allelic form of a target. Each partition may contain (i) a same probe capable of binding specifically to each of the first and second allelic forms of the target and (ii) a competitor configured to bind selectively to the second allelic form relative to the first allelic form and to block binding of the probe to the second allelic form. The first allelic form of the target may be amplified in the partitions. A signal may be detected from a label of the probe while the label is contained by the partitions. A number of partitions that are positive (or negative) for the at least one first allelic form may be determined based on the signal.

    Digital assays for mutation detection
    10.
    发明授权
    Digital assays for mutation detection 有权
    数字检测用于突变检测

    公开(公告)号：US09347095B2

    公开(公告)日：2016-05-24

    申请号：US14210199

    申请日：2014-03-13

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： John Regan ,  Samantha Cooper ,  Austin So ,  Ryan Koehler ,  Luz Montesclaros

    IPC: C12P19/34 ,  C12Q1/68

    CPC classification number: C12Q1/6858 ,  C12Q2545/114 ,  C12Q2561/101 ,  C12Q2563/159

    Abstract: Provided herein are methods, compositions, and kits for detecting alleles using a single probe or a single primer set. Also, provided herein are methods, compositions, and kits for detecting allelic variants using a single probe or a single primer set. Also, provided herein are methods, compositions, and kits for determining a polymerization error rate.

    Abstract translation: 本文提供了使用单个探针或单一引物组检测等位基因的方法，组合物和试剂盒。 此外，本文提供的是使用单个探针或单个引物组检测等位基因变体的方法，组合物和试剂盒。 此外，本文提供了用于确定聚合误差率的方法，组合物和试剂盒。

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