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公开(公告)号：US11905551B2
公开(公告)日：2024-02-20
申请号：US17508674
申请日：2021-10-22
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Ronald Lebofsky , Jeremy Agresti , George Karlin-Neumann
IPC: C12Q1/6806 , C12Q1/6811 , C12Q1/6853 , C12Q1/686 , C12Q1/6832 , C12Q1/682
CPC classification number: C12Q1/6806 , C12Q1/682 , C12Q1/686 , C12Q1/6811 , C12Q1/6832 , C12Q1/6853 , C12Q1/6853 , C12Q2525/161 , C12Q2525/301 , C12Q2531/119 , C12Q2563/159 , C12Q2563/179 , C12Q2565/537
Abstract: Improved multiple displacement amplification (MDA) reagents and methods are provided.
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公开(公告)号：US09944998B2
公开(公告)日：2018-04-17
申请号：US14341677
申请日：2014-07-25
Applicant: Bio-Rad Laboratories, Inc.
Inventor： George Karlin-Neumann , Svilen Tzonev
IPC: C12N15/10 , C12Q1/70 , C12Q1/68 , G01N33/569
CPC classification number: C12Q1/703 , C12N15/102 , C12Q1/6827 , C12Q1/70 , C12Q1/701 , C12Q2600/156 , G01N33/56983 , G01N2458/10 , Y02A50/54 , Y02A50/58 , Y02A50/60 , C12Q2531/113 , C12Q2537/143 , C12Q2537/165 , C12Q2563/159
Abstract: Provided herein are methods, compositions, systems, and kits for recombination assays, many of which involve amplification reactions such as PCR or droplet digital PCR.
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公开(公告)号：US20180238865A1
公开(公告)日：2018-08-23
申请号：US15752108
申请日：2016-08-18
Applicant: Bio-Rad Laboratories, inc.
Inventor： Jan Zur Megede , George Karlin-Neumann
IPC: G01N33/542 , G01N33/58
CPC classification number: G01N33/542 , G01N33/581 , G01N33/582 , G01N2333/57 , G01N2333/575
Abstract: Methods of detecting an analyte in a sample are provided. In one embodiment, the method comprises forming a partition comprising the sample, a binding agent capable of emitting a signal when bound to the analyte, and a marker capable of identifying the partition; allowing the binding agent to bind to the analyte, if present; and detecting the presence of the analyte in the sample by detecting the signal emitted from the binding agent in the partition.
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公开(公告)号：US10280451B2
公开(公告)日：2019-05-07
申请号：US14991818
申请日：2016-01-08
Applicant: Bio-Rad Laboratories, Inc. , J. David Gladstone Institutes
Inventor： Jennifer Berman , Samantha Cooper , George Karlin-Neumann , Yuichiro Miyaoka , Bruce Conklin , Josh Shinoff
IPC: C12Q1/68 , C12Q1/6827 , C12Q1/6809 , C12N15/10 , C12N15/63
Abstract: Methods, compositions, and kits are provided for quantification of genome editing.
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公开(公告)号：US20160060621A1
公开(公告)日：2016-03-03
申请号：US14749472
申请日：2015-06-24
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Jeremy Agresti , Samantha Cooper , George Karlin-Neumann , Nick Heredia , Ronald Lebofsky
IPC: C12N15/10
CPC classification number: C12N15/1065 , C12Q1/6806 , C12Q1/6853 , C12Q2521/531 , C12Q2525/161 , C12Q2525/204 , C12Q2535/122 , C12Q2565/629 , C12Q2563/149 , C12Q2563/159 , C12Q2563/179 , C12Q2565/514
Abstract: Methods, compositions, and kits are provided for nucleic acid analysis, including single cell analysis.
Abstract translation: 提供了用于核酸分析的方法，组合物和试剂盒，包括单细胞分析。
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Patent Agency Ranking
公开(公告)号：US12227792B2
公开(公告)日：2025-02-18
申请号：US18381371
申请日：2023-10-18
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Ronald Lebofsky , Jeremy Agresti , George Karlin-Neumann
IPC: C12Q1/6806 , C12Q1/6811 , C12Q1/682 , C12Q1/6832 , C12Q1/6853 , C12Q1/686
Abstract: Improved multiple displacement amplification (MDA) reagents and methods are provided.
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公开(公告)号：US11236383B2
公开(公告)日：2022-02-01
申请号：US16352600
申请日：2019-03-13
Applicant: Bio-Rad Laboratories, Inc. , J. David Gladstone Institutes
Inventor： Jennifer Berman , Samantha Cooper , George Karlin-Neumann , Yuichiro Miyaoka , Bruce Conklin , Josh Shinoff
IPC: C12Q1/68 , C12Q1/6827 , C12Q1/6809 , C12N15/10 , C12N15/63
Abstract: Methods, compositions, and kits are provided for quantification of genome editing.
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公开(公告)号：US11186862B2
公开(公告)日：2021-11-30
申请号：US16012610
申请日：2018-06-19
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Ronald Lebofsky , Jeremy Agresti , George Karlin-Neumann
IPC: C12Q1/6806 , C12Q1/6811 , C12Q1/6853 , C12Q1/686 , C12Q1/6832 , C12Q1/682
Abstract: Improved multiple displacement amplification (MDA) reagents and methods are provided.
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公开(公告)号：US20250043362A1
公开(公告)日：2025-02-06
申请号：US18793760
申请日：2024-08-03
Applicant: Bio-Rad Laboratories, Inc.
Inventor： George Karlin-Neumann , Ronald Lebofsky , Mona Shahbazian , Mina Rostamza
IPC: C12Q1/6886 , C12Q1/6806 , C12Q1/6809 , C12Q1/686 , G01N21/64
Abstract: The invention provides methods for the detection of molecular targets by digital PCR (dPCR) with a blocker for non-target molecules. Each target is provided with a unique mixture of probes. The blocker binds to a non-target molecule and blocks it from contributing to fluorescence from partitions. Two or more colors of fluorescence intensity are read, and two colors of fluorescence intensity are plotted as a 2D plot. In the plot, different targets contribute well-resolved clusters. Each cluster in the plot essentially lies a long its own radius allowing for radial multiplexing. The use of a blocker selects against the detection of non-target molecules and improves the resolution of radial multiplexing, allowing multiple targets to be detected.
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公开(公告)号：US10809250B2
公开(公告)日：2020-10-20
申请号：US15752108
申请日：2016-08-18
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Jan zur Megede , George Karlin-Neumann
IPC: G01N33/542 , G01N33/58
Abstract: Methods of detecting an analyte in a sample are provided. In one embodiment, the method comprises forming a partition comprising the sample, a binding agent capable of emitting a signal when bound to the analyte, and a marker capable of identifying the partition; allowing the binding agent to bind to the analyte, if present; and detecting the presence of the analyte in the sample by detecting the signal emitted from the binding agent in the partition.
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