公开(公告)号：US09138183B2

公开(公告)日：2015-09-22

申请号：US13020704

申请日：2011-02-03

申请人： Edward M. McKenna ,  Bo Chen ,  Youzhi Li ,  Paul Stanley Addison

发明人： Edward M. McKenna ,  Bo Chen ,  Youzhi Li ,  Paul Stanley Addison

IPC分类号： A61B5/00 ,  A61B5/1455 ,  A61B5/01 ,  A61B5/0205 ,  A61B5/024 ,  A61B5/16

CPC分类号： A61B5/02055 ,  A61B5/01 ,  A61B5/0205 ,  A61B5/02433 ,  A61B5/14552 ,  A61B5/165 ,  A61B5/6814 ,  A61B5/6826 ,  A61B5/6838 ,  A61B5/7203 ,  A61B5/7257 ,  A61B5/726

摘要： A combined physiological sensor and methods for detecting one or more physiological characteristics of a subject are provided. The combined sensor (e.g., a forehead sensor) may be used to detect and/or calculate at least one of a pulse blood oxygen saturation level, a regional blood oxygen saturation level, a respiration rate, blood pressure, an electrical physiological signal (EPS), a pulse transit time (PTT), body temperature associated with the subject, a depth of consciousness (DOC) measurement, any other suitable physiological parameter, and any suitable combination thereof. The combined sensor may include a variety of individual sensors, such as electrodes, optical detectors, optical emitters, temperature sensors, and/or other suitable sensors. The sensors may be advantageously positioned in accordance with a number of different geometries. The combined sensor may also be coupled to a monitoring device, which may receive and/or process one or more output signals from the individual sensors to display information about the medical condition of the subject. In addition, several techniques may be employed to prevent or limit interference between the individual sensors and their associated input and/or output signals.

摘要翻译： 提供组合的生理传感器和用于检测受试者的一种或多种生理特征的方法。 组合的传感器（例如，前额传感器）可用于检测和/或计算脉搏血氧饱和度水平，区域血氧饱和度水平，呼吸速率，血压，电生理信号（EPS ），脉搏传播时间（PTT），与受试者相关的体温，意识深度（DOC）测量，任何其它合适的生理参数及其任何合适的组合。 组合的传感器可以包括各种单独的传感器，例如电极，光学检测器，光发射器，温度传感器和/或其它合适的传感器。 可以根据多个不同的几何形状有利地定位传感器。 组合的传感器还可以耦合到监视设备，监视设备可以接收和/或处理来自各个传感器的一个或多个输出信号以显示关于对象的医疗状况的信息。 此外，可以采用几种技术来防止或限制各个传感器及其相关的输入和/或输出信号之间的干扰。

公开(公告)号：US09072433B2

公开(公告)日：2015-07-07

申请号：US13030385

申请日：2011-02-18

申请人： Bo Chen ,  Youzhi Li ,  Daniel Lisogurski

发明人： Bo Chen ,  Youzhi Li ,  Daniel Lisogurski

IPC分类号： A61B5/02 ,  A61B5/022 ,  A61B5/024 ,  A61B5/021

CPC分类号： A61B5/02255 ,  A61B5/02108 ,  A61B5/022 ,  A61B5/02422

摘要： Embodiments of the present disclosure relate to a system and method for determining a physiologic parameter of a patient. Specifically, embodiments provided herein include blood pressure cuffs that are adapted to be used in conjunction with a photoplethysmography sensor. The cuff as provided may be configured to be placed over the sensor and/or aligned in a specific manner relative to the sensor. Alternatively, the cuffs may include integral optical components.

摘要翻译： 本公开的实施例涉及用于确定患者的生理参数的系统和方法。 具体地，本文提供的实施例包括适于与光电容积描记传感器结合使用的血压袖带。 所提供的袖带可以被配置为放置在传感器上方和/或以相对于传感器的特定方式对准。 或者，袖带可以包括一体的光学部件。

公开(公告)号：US20120215082A1

公开(公告)日：2012-08-23

申请号：US13030385

申请日：2011-02-18

申请人： Bo Chen ,  Youzhi Li ,  Daniel Lisogurski

发明人： Bo Chen ,  Youzhi Li ,  Daniel Lisogurski

IPC分类号： A61B5/1455

CPC分类号： A61B5/02255 ,  A61B5/02108 ,  A61B5/022 ,  A61B5/02422

摘要： Embodiments of the present disclosure relate to a system and method for determining a physiologic parameter of a patient. Specifically, embodiments provided herein include blood pressure cuffs that are adapted to be used in conjunction with a photoplethysmography sensor. The cuff as provided may be configured to be placed over the sensor and/or aligned in a specific manner relative to the sensor. Alternatively, the cuffs may include integral optical components.

摘要翻译： 本公开的实施例涉及用于确定患者的生理参数的系统和方法。 具体地，本文提供的实施例包括适于与光电容积描记传感器结合使用的血压袖带。 所提供的袖带可以被配置为放置在传感器上方和/或以相对于传感器的特定方式对准。 或者，袖带可以包括一体的光学部件。

公开(公告)号：US20120071739A1

公开(公告)日：2012-03-22

申请号：US12888226

申请日：2010-09-22

申请人： Bo Chen ,  Edward M. McKenna ,  Youzhi Li ,  Daniel Lisogurski

发明人： Bo Chen ,  Edward M. McKenna ,  Youzhi Li ,  Daniel Lisogurski

IPC分类号： A61B5/1455

CPC分类号： A61B5/14552 ,  A61B5/0205 ,  A61B5/02427 ,  A61B5/14551 ,  A61B2560/02

摘要： The present disclosure describes techniques that may provide more accurate estimates of arterial oxygen saturation using pulse oximetry by switching between a wavelength spectrum of at least a first and a second light source so that the arterial oxygen saturation estimates at low (e.g., in the range below 75%), medium (e.g., greater than or equal to 75% and less than or equal to 84%), and high (e.g., greater than 84% range) arterial oxygen saturation values are more accurately calculated. In one embodiment, light emitted from a near 660 nm and a near 900 nm emitter pair may be used when the arterial oxygen saturation range is high. In another embodiment, light emitted from a near 730 nm and a near 900 nm emitter pair may be used when the arterial oxygen saturation range is low. In yet another embodiment, light emitted from both a near 660 nm-900 nm emitter pair and light emitted from a near 730 nm-900 nm emitter pair may be used when the arterial oxygen saturation range is in the middle range. Priming techniques may also be used to reduce or eliminate start up delays of certain oximetry system components.

摘要翻译： 本公开描述了可以通过在至少第一和第二光源的波长光谱之间切换使得使用脉搏血氧饱和度更准确地估计动脉血氧饱和度的技术，使得动脉血氧饱和度估计为低（例如，在下面的范围内 75％），中等（例如，大于或等于75％且小于或等于84％）和高（例如，大于84％的范围）动脉血氧饱和度值被更准确地计算。 在一个实施例中，当动脉血氧饱和度范围高时，可以使用从近660nm和近900nm发射体对发射的光。 在另一个实施例中，当动脉血氧饱和度范围低时，可以使用从近730nm和近900nm发射体对发射的光。 在另一个实施例中，当动脉血氧饱和度范围在中间范围时，可以使用从近660nm-900nm发射体对发射的光和从近730nm-900nm发射体对发射的光。 引发技术也可用于减少或消除某些血氧饱和度系统组件的启动延迟。

公开(公告)号：US09282924B2

公开(公告)日：2016-03-15

申请号：US13077164

申请日：2011-03-31

申请人： Andy S. Lin ,  Youzhi Li ,  Bo Chen ,  Daniel Lisogurski ,  Friso Schlottau

发明人： Andy S. Lin ,  Youzhi Li ,  Bo Chen ,  Daniel Lisogurski ,  Friso Schlottau

IPC分类号： A61B5/1455 ,  A61B5/00

CPC分类号： A61B5/14551 ,  A61B5/6826 ,  A61B2560/0252 ,  A61B2560/0266

摘要： Embodiments of the present disclosure relate to techniques for controlling the temperature of light sources within physiological sensors in order to regulate the wavelengths emitted by the light sources. The sensors may include a temperature control element that is designed to provide heating and/or cooling to the light sources. The sensors also may include a temperature sensor designed to detect the temperature of the light sources. Based on the detected temperature, a controller can vary the amount of heating and/or cooling provided by the temperature control element to maintain the temperature of the light sources at a desired temperature or within a desired temperature range.

摘要翻译： 本公开的实施例涉及用于控制生理传感器内的光源的温度以便调节由光源发射的波长的技术。 传感器可以包括被设计成向光源提供加热和/或冷却的温度控制元件。 传感器还可以包括设计用于检测光源的温度的温度传感器。 基于检测到的温度，控制器可以改变由温度控制元件提供的加热和/或冷却量，以将光源的温度保持在期望的温度或期望的温度范围内。

公开(公告)号：US09248249B2

公开(公告)日：2016-02-02

申请号：US12480377

申请日：2009-06-08

申请人： Youzhi Li ,  Bo Chen

发明人： Youzhi Li ,  Bo Chen

IPC分类号： A61M16/04 ,  A61B10/00

CPC分类号： A61M16/0463 ,  A61B10/0051 ,  A61B2010/0061 ,  A61M16/0434 ,  A61M16/0479 ,  A61M16/0484 ,  A61M16/0486

摘要： Various embodiments of a secretion collection and/or sample analysis device are provided for point-of-care collection and/or analysis of secretions collected from the airways of intubated patients. The disclosed embodiments include a variety of placements of the device with respect to a tracheal tube that include in a secretion reservoir, between an evacuation conduit and the secretion reservoir, and connected in series after the evacuation conduit and the secretion reservoir. Certain embodiments may include a lab-on-a-chip device that analyzes secretions via polymerase chain reaction (PCR) based DNA sequencing.

摘要翻译： 提供分泌物收集和/或样品分析装置的各种实施方案用于从插管患者的气道收集的分泌物的收集点和/或分析。 所公开的实施例包括装置相对于包括在分泌物储存器中的排气管和分泌储器之间的气管插管的各种放置，并且在抽空导管和分泌储器之后串联连接。 某些实施方案可以包括通过基于聚合酶链反应（PCR）的DNA测序来分析分泌物的片上实验室装置。

公开(公告)号：US09186068B2

公开(公告)日：2015-11-17

申请号：US13310859

申请日：2011-12-05

申请人： Youzhi Li ,  Bo Chen ,  Lockett Wood ,  Ulf Borg

发明人： Youzhi Li ,  Bo Chen ,  Lockett Wood ,  Ulf Borg

IPC分类号： A61B5/1455 ,  A61B5/00 ,  A61B5/029

CPC分类号： A61B5/0095 ,  A61B5/029

摘要： A patient monitoring system may provide photoacoustic sensing based on an indicator dilution to determine one or more physiological parameters of a subject. The system may detect an acoustic pressure signal, which may include one or more thermo-dilution responses, one or more hemo-dilution responses, or a combination thereof. For example, a thermo-dilution indicator and/or a hemo-dilution indicator may be used to determine one or more hemodynamic parameters. In a further example, an isotonic indicator and a hypertonic indicator may be used to determine one or more hemodynamic parameters of the subject.

摘要翻译： 患者监测系统可以基于指示剂稀释提供光声感测以确定受试者的一个或多个生理参数。 该系统可以检测声压信号，其可以包括一个或多个热稀释响应，一个或多个血稀释响应或其组合。 例如，可以使用热稀释指示剂和/或血稀释指示剂来确定一个或多个血液动力学参数。 在另一个实例中，等渗指示剂和高渗指示剂可用于确定受试者的一个或多个血液动力学参数。

公开(公告)号：US08588878B2

公开(公告)日：2013-11-19

申请号：US12944945

申请日：2010-11-12

申请人： Youzhi Li ,  Bo Chen ,  Edward M. McKenna ,  Paul Stanley Addison

发明人： Youzhi Li ,  Bo Chen ,  Edward M. McKenna ,  Paul Stanley Addison

IPC分类号： A61B5/1455

CPC分类号： A61B5/14551 ,  A61B5/7203 ,  A61B5/726

摘要： Methods and systems are provided that allow for the simultaneous calculation of pulse and regional blood oxygen saturation. An oximeter system that includes a sensor with a plurality of emitters and detectors may be used to calculate a pulse and/or regional blood oxygen saturation. A plurality of light signals may be emitted from light emitters. A first light signal may be received at a first light detector and a second light signal may be received at a second light detector. A pulse and/or regional blood oxygen saturation value may be calculated based on the received first and/or second light signals. The pulse and regional blood oxygen saturation values may be calculated substantially simultaneously. The calculated pulse and regional blood oxygen saturation values as well as other blood oxygen saturation values may be displayed simultaneously in a preconfigured portion of a display.

摘要翻译： 提供了允许同时计算脉搏和局部血氧饱和度的方法和系统。 包括具有多个发射器和检测器的传感器的血氧计系统可用于计算脉搏和/或区域血氧饱和度。 可以从发光体发射多个光信号。 可以在第一光检测器处接收第一光信号，并且可以在第二光检测器处接收第二光信号。 可以基于接收的第一和/或第二光信号计算脉搏和/或区域血氧饱和度值。 可以基本上同时计算脉搏和区域血氧饱和度值。 计算出的脉冲和区域血氧饱和度值以及其他血氧饱和度值可以同时显示在显示器的预配置部分中。

公开(公告)号：US20130144147A1

公开(公告)日：2013-06-06

申请号：US13310849

申请日：2011-12-05

申请人： Youzhi Li ,  Bo Chen ,  Lockett Wood ,  Ulf Borg

发明人： Youzhi Li ,  Bo Chen ,  Lockett Wood ,  Ulf Borg

IPC分类号： A61B5/05

CPC分类号： A61B5/0095 ,  A61B5/02028 ,  A61B5/0205 ,  A61B5/0261 ,  A61B5/0275 ,  A61B5/028 ,  A61B5/029 ,  A61B5/14546 ,  A61B5/1455 ,  A61B2560/0223

摘要： A patient monitoring system may provide photoacoustic sensing based on an indicator dilution to determine one or more physiological parameters of a subject. The system may detect an acoustic pressure signal, which may include one or more thermo-dilution responses, one or more hemo-dilution responses, or a combination thereof. For example, a thermo-dilution indicator and/or a hemo-dilution indicator may be used to determine one or more hemodynamic parameters. In a further example, an isotonic indicator and a hypertonic indicator may be used to determine one or more hemodynamic parameters of the subject.

公开(公告)号：US08434488B2

公开(公告)日：2013-05-07

申请号：US12480394

申请日：2009-06-08

申请人： Youzhi Li ,  Bo Chen

发明人： Youzhi Li ,  Bo Chen

IPC分类号： A61M16/04 ,  A61M16/00

CPC分类号： A61M16/0463 ,  A61M16/0057 ,  A61M16/0434 ,  A61M16/0443 ,  A61M16/0445 ,  A61M16/0475 ,  A61M16/0479 ,  A61M16/0484 ,  A61M16/0486 ,  A61M16/0858 ,  A61M2205/3331

摘要： Various embodiments of a tracheal tube capable of suctioning accumulated mucus secretions from the airway of intubated patients are provided. Disclosed embodiments include a variety of endrotracheal tubes with integral suction lumens terminating in ports optimally located at the distal end of the endrotracheal tubes between a Murphy's Eye and a cuff. During intubation, the foregoing features, among others, of the tracheal tube may have the effect of preventing bacterial colonization of the respiratory airway and the subsequent development of ventilator associated pneumonia (VAP) in the lungs.

摘要翻译： 提供能够从插管患者的气道吸入累积的粘液分泌物的气管管的各种实施方案。 公开的实施例包括具有整体抽吸腔的各种气管内管，其终止于最佳位于墨菲眼和袖带之间的气管内管的远端的端口中。 在插管期间，气管插管的前述特征可能具有防止呼吸气道细菌定居和随后在肺中发展呼吸机相关性肺炎（VAP）的作用。