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公开(公告)号：US20110082143A1
公开(公告)日：2011-04-07
申请号：US12896244
申请日：2010-10-01
Applicant: Chung-Ming Sun , Min-Liang Kuo
Inventor： Chung-Ming Sun , Min-Liang Kuo
IPC: A61K31/4184 , C07D231/56 , C07D413/06 , C07D403/10 , C07D401/10 , C07D409/14 , C07D413/14 , A61K31/416 , A61K31/5377 , A61K31/454 , A61K31/423 , A61P35/00
CPC classification number: C07D231/56 , C07D235/20 , C07D235/26 , C07D235/28 , C07D235/30 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/14 , C07D413/04 , C07D413/14 , C07D421/14
Abstract: Bicyclic heteroaryl compounds of formula (I) shown below are disclosed. Each variable in formula (I) is defined in the specification. Also disclosed is treatment of cancer with these compounds.
Abstract translation: 公开了式（I）的双环杂芳基化合物。 式（I）中的每个变量在说明书中定义。 还公开了用这些化合物治疗癌症。
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公开(公告)号：US08383662B2
公开(公告)日：2013-02-26
申请号：US12896244
申请日：2010-10-01
Applicant: Chung-Ming Sun , Min-Liang Kuo , Yufeng Jane Tseng
Inventor： Chung-Ming Sun , Min-Liang Kuo , Yufeng Jane Tseng
IPC: A61K31/416 , A61K31/4184 , C07D235/04 , C07D209/02
CPC classification number: C07D231/56 , C07D235/20 , C07D235/26 , C07D235/28 , C07D235/30 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/14 , C07D413/04 , C07D413/14 , C07D421/14
Abstract: Bicyclic heteroaryl compounds of formula (I) shown below are disclosed. Each variable in formula (I) is defined in the specification. Also disclosed is treatment of cancer with these compounds.
Abstract translation: 公开了式（I）的双环杂芳基化合物。 式（I）中的每个变量在说明书中定义。 还公开了用这些化合物治疗癌症。
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公开(公告)号：US07825261B2
公开(公告)日：2010-11-02
申请号：US11949070
申请日：2007-12-03
Applicant: Chung-Ming Sun , Min-Liang Kuo
Inventor： Chung-Ming Sun , Min-Liang Kuo
IPC: C07D231/56
CPC classification number: C07D231/56 , C07D403/04 , C07D403/06 , C07D405/04
Abstract: This invention relates to indazole compounds of formula (I) or (II) shown below. Each variable in formula (I) or (II) is defined in the specification. These compounds can be used to treat cancer.
Abstract translation: 本发明涉及以下所示的式（I）或（II）的吲唑化合物。 式（I）或（II）中的每个变量在说明书中定义。 这些化合物可用于治疗癌症。
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公开(公告)号：US20080132501A1
公开(公告)日：2008-06-05
申请号：US11949070
申请日：2007-12-03
Applicant: Chung-Ming Sun , Min-Liang Kuo
Inventor： Chung-Ming Sun , Min-Liang Kuo
IPC: A61K31/535 , A61K31/415 , C07D231/56 , C07D413/12 , C07D403/04 , A61K31/4164
CPC classification number: C07D231/56 , C07D403/04 , C07D403/06 , C07D405/04
Abstract: This invention relates to indazole compounds of formula (I) or (II) shown below. Each variable in formula (I) or (II) is defined in the specification. These compounds can be used to treat cancer.
Abstract translation: 本发明涉及以下所示的式（I）或（II）的吲唑化合物。 式（I）或（II）中的每个变量在说明书中定义。 这些化合物可用于治疗癌症。
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5.发明授权公开(公告)号：US08440692B2
公开(公告)日：2013-05-14
申请号：US12448088
申请日：2007-12-07
Applicant: Sheng-Chu Kuo , Che-Ming Teng , Kuo-Hsiung Lee , Li-Jiau Huang , Li-Chen Chou , Chih-Shiang Chang , Chung-Ming Sun , Tian-Shung Wu , Shiow-Lin Pan , Tzong-Der Way , Jang-Chang Lee , Jing-Gung Chung , Jai-Sing Yang , Chien-Ting Chen , Ching-Che Huang , Shih-Ming Huang
Inventor： Sheng-Chu Kuo , Che-Ming Teng , Kuo-Hsiung Lee , Li-Jiau Huang , Li-Chen Chou , Chih-Shiang Chang , Chung-Ming Sun , Tian-Shung Wu , Shiow-Lin Pan , Tzong-Der Way , Jang-Chang Lee , Jing-Gung Chung , Jai-Sing Yang , Chien-Ting Chen , Ching-Che Huang , Shih-Ming Huang
CPC classification number: C07F9/6561 , C07D215/233 , C07D421/04 , C07D491/056 , C07F9/60
Abstract: 2-aryl-4-quinolones are converted into phosphates by reacting with tetrabenzyl pyrophosphate to form dibenzyl phosphates thereof, which are then subject to hydrogenation to replace dibenzyl groups with H, followed by reacting with Amberlite IR-120 (Na+ form) to form disodium salts. The results of preliminary screening revealed that these phosphates showed significant anti-cancer activity. A novel intermediate, 2-selenophene 4-quinolone and Λ/, Λ/-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones are also synthesized. These novel intermediates exhibited significant anticancer activities.
Abstract translation: 2-芳基-4-喹诺酮通过与焦磷酸四苄酯反应而形成磷酸盐，形成其二苄基磷酸酯，然后进行氢化，用H代替二苄基，然后与Amberlite IR-120（Na +形式）反应形成二钠 盐。 初步筛选结果表明，这些磷酸盐显示出显着的抗癌活性。 还合成了一种新的中间体2-硒吩-4-喹诺酮和2-苯基-4-喹诺酮的λ/，λ/二烷基氨基烷基衍生物。 这些新型中间体显示出显着的抗癌活性。
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Patent Agency Ranking
6.发明申请NOVEL HYDROPHILIC DERIVATIVES OF 2-ARYL-4-QUINOLONES AS ANTICANCER AGENTS 有权作为抗原剂的2-亚芳基-4-喹啉酮的新型疏水衍生物公开(公告)号：US20100168064A1
公开(公告)日：2010-07-01
申请号：US12448088
申请日：2007-12-07
Applicant: Sheng-Chu Kuo , Che-Ming Teng , Kuo-Hsiung Lee , Li-Jiau Huang , Li-Chen Chou , Chih-Shiang Chang , Chung-Ming Sun , Tian-Shung Wu , Shiow-Lin Pan , Tzong-Der Way , Jang-Chang Lee , Jing-Gung Chung , Jai-Sing Yang , Chien-Ting Chen , Ching-Che Huang , Shih-Ming Huang
Inventor： Sheng-Chu Kuo , Che-Ming Teng , Kuo-Hsiung Lee , Li-Jiau Huang , Li-Chen Chou , Chih-Shiang Chang , Chung-Ming Sun , Tian-Shung Wu , Shiow-Lin Pan , Tzong-Der Way , Jang-Chang Lee , Jing-Gung Chung , Jai-Sing Yang , Chien-Ting Chen , Ching-Che Huang , Shih-Ming Huang
IPC: A61K31/675 , C07F9/09 , A61K31/47 , A61P35/00 , A61P35/02 , C07D421/04 , C07D215/233
CPC classification number: C07F9/6561 , C07D215/233 , C07D421/04 , C07D491/056 , C07F9/60
Abstract: 2-aryl-4-quinolones are converted into phosphates by reacting with tetrabenzyl pyrophosphate to form dibenzyl phosphates thereof, which are then subject to hydrogenation to replace dibenzyl groups with H, followed by reacting with Amberlite IR-120 (Na+ form) to form disodium salts. The results of preliminary screening revealed that these phosphates showed significant anti-cancer activity. A novel intermediate, 2-selenophene 4-quinolone and Λ/, Λ/-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones are also synthesized. These novel intermediates exhibited significant anticancer activities.
Abstract translation: 2-芳基-4-喹诺酮通过与焦磷酸四苄酯反应而形成磷酸盐，形成其二苄基磷酸酯，然后进行氢化，用H代替二苄基，然后与Amberlite IR-120（Na +形式）反应形成二钠 盐。 初步筛选结果表明，这些磷酸盐显示出显着的抗癌活性。 还合成2-苯基-4-喹诺酮的新型中间体2-硒吩-4-喹诺酮和Λ/，Λ/二烷基氨基烷基衍生物。 这些新型中间体显示出显着的抗癌活性。
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公开(公告)号：USD586265S1
公开(公告)日：2009-02-10
申请号：US29284742
申请日：2007-09-14
Applicant: I-Shun Lin , I Liu , Chung-Ming Sun
Designer： I-Shun Lin , I Liu , Chung-Ming Sun
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公开(公告)号：US20050276224A1
公开(公告)日：2005-12-15
申请号：US10710019
申请日：2004-06-13
Applicant: Sam Shiaw-Shiang Jiang , Chung-Ming Sun
Inventor： Sam Shiaw-Shiang Jiang , Chung-Ming Sun
CPC classification number: H04L1/1858 , H04L1/1803 , H04L1/1812 , H04L1/1845 , H04L1/189
Abstract: A first peer successively transmits a predetermined number of more than one identical instances of a data block to a second peer. The second peer receives at least two of the predetermined number of identical instances of the data block. The second peer combines more than one corrupted received data block to form a complete instance of the original data block.
Abstract translation: 第一对等体连续地向第二对等体发送数据块的多于一个的相同实例的预定数量。 第二对等体接收数据块的预定数量的相同实例中的至少两个。 第二对等体组合了多个受损的接收数据块，以形成原始数据块的完整实例。
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公开(公告)号：US20080075276A1
公开(公告)日：2008-03-27
申请号：US11526106
申请日：2006-09-25
Applicant: Chung-Ming Sun
Inventor： Chung-Ming Sun
IPC: H04L9/28
CPC classification number: H04L9/3226
Abstract: A method for controlling the switch of the electronic device includes the following steps: Step (a): Providing a portable cipher code generating device and an electronic device; the cipher code generating device includes a first time-generating unit and an operating-hour unit capable of providing an input while the electronic device includes a cipher-code decoding device; Step (b): By the use of the operating-hour unit, inputting an operating-hour parameter and acquiring a time-parameter to make the cipher code generating device figure out a cipher-code set; Step (c): Providing the cipher-code decoding device with an indicatory parameter; Step (d): Performing comparison between the indicatory parameter and the cipher-code set; Step (e): The electronic device performs the action of the operating-hour parameter when the indicatory parameter is corresponding with the cipher-code set, and the electronic device does not perform the action of the operating-hour parameter when the indicatory parameter is not corresponding with the cipher-code set.
Abstract translation: 一种用于控制电子设备的开关的方法包括以下步骤：步骤（a）：提供便携式密码产生装置和电子装置; 该密码生成装置包括第一时间生成单元和能够在电子设备包括密码解码装置的同时提供输入的操作小时单元; 步骤（b）：通过使用营业时间单位输入营业时间参数并获取时间参数，使密码生成装置找出密码集; 步骤（c）：向密码解码装置提供指示参数; 步骤（d）：执行指示参数与密码集的比较; 步骤（e）：当指示参数与密码集相对应时，电子设备执行操作时参数的动作，当指示参数为“否”时，电子设备不执行运行时参数的动作 不对应密码集。
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公开(公告)号：USD483759S1
公开(公告)日：2003-12-16
申请号：US29171240
申请日：2002-11-19
Applicant: Chung-Ming Sun
Designer： Chung-Ming Sun
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