公开(公告)号：US08440692B2

公开(公告)日：2013-05-14

申请号：US12448088

申请日：2007-12-07

Applicant: Sheng-Chu Kuo ,  Che-Ming Teng ,  Kuo-Hsiung Lee ,  Li-Jiau Huang ,  Li-Chen Chou ,  Chih-Shiang Chang ,  Chung-Ming Sun ,  Tian-Shung Wu ,  Shiow-Lin Pan ,  Tzong-Der Way ,  Jang-Chang Lee ,  Jing-Gung Chung ,  Jai-Sing Yang ,  Chien-Ting Chen ,  Ching-Che Huang ,  Shih-Ming Huang

Inventor： Sheng-Chu Kuo ,  Che-Ming Teng ,  Kuo-Hsiung Lee ,  Li-Jiau Huang ,  Li-Chen Chou ,  Chih-Shiang Chang ,  Chung-Ming Sun ,  Tian-Shung Wu ,  Shiow-Lin Pan ,  Tzong-Der Way ,  Jang-Chang Lee ,  Jing-Gung Chung ,  Jai-Sing Yang ,  Chien-Ting Chen ,  Ching-Che Huang ,  Shih-Ming Huang

IPC: A61K31/47 ,  C07F9/38

CPC classification number: C07F9/6561 ,  C07D215/233 ,  C07D421/04 ,  C07D491/056 ,  C07F9/60

Abstract: 2-aryl-4-quinolones are converted into phosphates by reacting with tetrabenzyl pyrophosphate to form dibenzyl phosphates thereof, which are then subject to hydrogenation to replace dibenzyl groups with H, followed by reacting with Amberlite IR-120 (Na+ form) to form disodium salts. The results of preliminary screening revealed that these phosphates showed significant anti-cancer activity. A novel intermediate, 2-selenophene 4-quinolone and Λ/, Λ/-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones are also synthesized. These novel intermediates exhibited significant anticancer activities.

Abstract translation: 2-芳基-4-喹诺酮通过与焦磷酸四苄酯反应而形成磷酸盐，形成其二苄基磷酸酯，然后进行氢化，用H代替二苄基，然后与Amberlite IR-120（Na +形式）反应形成二钠 盐。 初步筛选结果表明，这些磷酸盐显示出显着的抗癌活性。 还合成了一种新的中间体2-硒吩-4-喹诺酮和2-苯基-4-喹诺酮的λ/，λ/二烷基氨基烷基衍生物。 这些新型中间体显示出显着的抗癌活性。

公开(公告)号：US20100168064A1

公开(公告)日：2010-07-01

申请号：US12448088

申请日：2007-12-07

Applicant: Sheng-Chu Kuo ,  Che-Ming Teng ,  Kuo-Hsiung Lee ,  Li-Jiau Huang ,  Li-Chen Chou ,  Chih-Shiang Chang ,  Chung-Ming Sun ,  Tian-Shung Wu ,  Shiow-Lin Pan ,  Tzong-Der Way ,  Jang-Chang Lee ,  Jing-Gung Chung ,  Jai-Sing Yang ,  Chien-Ting Chen ,  Ching-Che Huang ,  Shih-Ming Huang

Inventor： Sheng-Chu Kuo ,  Che-Ming Teng ,  Kuo-Hsiung Lee ,  Li-Jiau Huang ,  Li-Chen Chou ,  Chih-Shiang Chang ,  Chung-Ming Sun ,  Tian-Shung Wu ,  Shiow-Lin Pan ,  Tzong-Der Way ,  Jang-Chang Lee ,  Jing-Gung Chung ,  Jai-Sing Yang ,  Chien-Ting Chen ,  Ching-Che Huang ,  Shih-Ming Huang

IPC: A61K31/675 ,  C07F9/09 ,  A61K31/47 ,  A61P35/00 ,  A61P35/02 ,  C07D421/04 ,  C07D215/233

CPC classification number: C07F9/6561 ,  C07D215/233 ,  C07D421/04 ,  C07D491/056 ,  C07F9/60

Abstract: 2-aryl-4-quinolones are converted into phosphates by reacting with tetrabenzyl pyrophosphate to form dibenzyl phosphates thereof, which are then subject to hydrogenation to replace dibenzyl groups with H, followed by reacting with Amberlite IR-120 (Na+ form) to form disodium salts. The results of preliminary screening revealed that these phosphates showed significant anti-cancer activity. A novel intermediate, 2-selenophene 4-quinolone and Λ/, Λ/-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones are also synthesized. These novel intermediates exhibited significant anticancer activities.

Abstract translation: 2-芳基-4-喹诺酮通过与焦磷酸四苄酯反应而形成磷酸盐，形成其二苄基磷酸酯，然后进行氢化，用H代替二苄基，然后与Amberlite IR-120（Na +形式）反应形成二钠 盐。 初步筛选结果表明，这些磷酸盐显示出显着的抗癌活性。 还合成2-苯基-4-喹诺酮的新型中间体2-硒吩-4-喹诺酮和Λ/，Λ/二烷基氨基烷基衍生物。 这些新型中间体显示出显着的抗癌活性。

公开(公告)号：US09224773B2

公开(公告)日：2015-12-29

申请号：US13420279

申请日：2012-03-14

Applicant: Shih-Chieh Chang ,  Jian-Shin Tsai ,  Chih-Chang Huang ,  Ing-Ju Lee ,  Ching-Yao Sun ,  Jyun-Ru Wu ,  Ching-Che Huang ,  Szu-An Wu ,  Ying-Lang Wang

Inventor： Shih-Chieh Chang ,  Jian-Shin Tsai ,  Chih-Chang Huang ,  Ing-Ju Lee ,  Ching-Yao Sun ,  Jyun-Ru Wu ,  Ching-Che Huang ,  Szu-An Wu ,  Ying-Lang Wang

IPC: H01L27/146

CPC classification number: H01L27/1464 ,  H01L27/1462 ,  H01L27/14623 ,  H01L27/14636 ,  H01L27/14643 ,  H01L27/14683 ,  H01L27/14685

Abstract: A device includes a semiconductor substrate having a front side and a backside. A photo-sensitive device is disposed at a surface of the semiconductor substrate, wherein the photo-sensitive device is configured to receive a light signal from the backside of the semiconductor substrate, and convert the light signal to an electrical signal. An amorphous-like adhesion layer is disposed on the backside of the semiconductor substrate. The amorphous-like adhesion layer includes a compound of nitrogen and a metal. A metal shielding layer is disposed on the backside of the semiconductor substrate and contacting the amorphous-like adhesion layer.

Abstract translation: 一种器件包括具有正面和背面的半导体衬底。 光敏器件设置在半导体衬底的表面处，其中光敏器件被配置为从半导体衬底的背面接收光信号，并将光信号转换为电信号。 在半导体衬底的背面设有非晶态粘接层。 非晶态粘合层包括氮和金属的化合物。 金属屏蔽层设置在半导体衬底的背面并与非晶态粘合层接触。

公开(公告)号：US20130134541A1

公开(公告)日：2013-05-30

申请号：US13420279

申请日：2012-03-14

Applicant: Shih-Chieh Chang ,  Jian-Shin Tsai ,  Chih-Chang Huang ,  Ing-Ju Lee ,  Ching-Yao Sun ,  Jyun-Ru Wu ,  Ching-Che Huang ,  Szu-An Wu ,  Ying-Lang Wang

Inventor： Shih-Chieh Chang ,  Jian-Shin Tsai ,  Chih-Chang Huang ,  Ing-Ju Lee ,  Ching-Yao Sun ,  Jyun-Ru Wu ,  Ching-Che Huang ,  Szu-An Wu ,  Ying-Lang Wang

IPC: H01L27/146 ,  H01L31/18

CPC classification number: H01L27/1464 ,  H01L27/1462 ,  H01L27/14623 ,  H01L27/14636 ,  H01L27/14643 ,  H01L27/14683 ,  H01L27/14685

Abstract: A device includes a semiconductor substrate having a front side and a backside. A photo-sensitive device is disposed at a surface of the semiconductor substrate, wherein the photo-sensitive device is configured to receive a light signal from the backside of the semiconductor substrate, and convert the light signal to an electrical signal. An amorphous-like adhesion layer is disposed on the backside of the semiconductor substrate. The amorphous-like adhesion layer includes a compound of nitrogen and a metal. A metal shielding layer is disposed on the backside of the semiconductor substrate and contacting the amorphous-like adhesion layer.

Abstract translation: 一种器件包括具有正面和背面的半导体衬底。 光敏器件设置在半导体衬底的表面处，其中光敏器件被配置为从半导体衬底的背面接收光信号，并将光信号转换为电信号。 在半导体衬底的背面设有非晶态粘接层。 非晶态粘合层包括氮和金属的化合物。 金属屏蔽层设置在半导体衬底的背面并与非晶态粘合层接触。