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1.发明授权Use of the repressor glxR for the synthesis of lysine in Corynebacterium glutamicum 有权在谷氨酸棒杆菌中使用阻遏物glxR用于合成赖氨酸公开(公告)号：US07192749B2
公开(公告)日：2007-03-20
申请号：US10514076
申请日：2003-05-13
申请人： Corinna Klopprogge , Oskar Zelder , Burkhard Kröger , Hartwig Schröder , Stefan Häfner , Heung-Shick Lee
发明人： Corinna Klopprogge , Oskar Zelder , Burkhard Kröger , Hartwig Schröder , Stefan Häfner , Heung-Shick Lee
CPC分类号： C07K14/34
摘要： Isolated polypeptide sequence having the sequence of SEQ ID NO:1 or muteins thereof having the ability to bind cAMP and repress the expression of the aceB gene of C. glutamicum and which can be obtained from SEQ ID NO:1 by inserting, deleting or substituting up to 20% of the amino acids.
摘要翻译： 具有SEQ ID NO：1的序列的分离的多肽序列或其突变蛋白具有结合cAMP的能力并抑制谷氨酸棒杆菌的aceB基因的表达，并且可以通过插入，缺失或替代从SEQ ID NO：1获得 高达20％的氨基酸。
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2.发明授权Methods for producing sulphurous fine chemicals by fermentation using metH-coding cornyeform bacteria 有权使用metH编码玉米角质细菌通过发酵生产硫化精细化学品的方法公开(公告)号：US07485444B2
公开(公告)日：2009-02-03
申请号：US10511302
申请日：2003-04-16
CPC分类号： C12N9/1007 , C12P13/12
摘要： The invention relates to methods for the fermentative production of sulfur-containing fine chemicals, in particular L-methionine, by using bacteria which express a nucleotide sequence coding for a methionine synthase (metH) gene.
摘要翻译： 本发明涉及通过使用表达编码甲硫氨酸合成酶（metH）基因的核苷酸序列的细菌来发酵生产含硫精细化学品，特别是L-甲硫氨酸的方法。
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3.发明授权公开(公告)号：US07381549B2
公开(公告)日：2008-06-03
申请号：US10525710
申请日：2003-08-26
摘要： The invention relates to methods for the fermentative production of sulfur-containing fine chemicals, in particular L-methionine, by using bacteria which express a nucleotide sequence coding for a methionine synthase (metH) gene.
摘要翻译： 本发明涉及通过使用表达编码甲硫氨酸合成酶（metH）基因的核苷酸序列的细菌来发酵生产含硫精细化学品，特别是L-甲硫氨酸的方法。
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公开(公告)号：US20060223149A1
公开(公告)日：2006-10-05
申请号：US10511302
申请日：2003-04-16
CPC分类号： C12N9/1007 , C12P13/12
摘要： The invention relates to methods for the fermentative production of sulfur-containing fine chemicals, in particular L-methionine, by using bacteria which express a nucleotide sequence coding for a methionine synthase (metH) gene.
摘要翻译： 本发明涉及通过使用表达编码甲硫氨酸合成酶（metH）基因的核苷酸序列的细菌来发酵生产含硫精细化学品，特别是L-甲硫氨酸的方法。
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5.发明授权Method for the production of sulpher-containing fine chemicals by fermentation 有权通过发酵生产含有精液的精细化学品的方法公开(公告)号：US07635580B2
公开(公告)日：2009-12-22
申请号：US10514489
申请日：2003-05-23
CPC分类号： C12N9/1085 , C12P13/12 , C12R1/15
摘要： The invention relates to methods for the production of sulfur-containing fine chemicals, in particular L-methionine, by fermentation using bacteria in which a nucleotide sequence encoding an S-adenosylmethionine synthase (metK) gene is expressed.
摘要翻译： 本发明涉及通过使用表达编码S-腺苷甲硫氨酸合成酶（metK）基因的核苷酸序列的细菌的发酵来生产含硫精细化学物质，特别是L-甲硫氨酸的方法。
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6.发明授权Gene variants coding for proteins from the metabolic pathway of fine chemicals 有权编码精细化学物质代谢途径蛋白质的基因变体公开(公告)号：US07566557B2
公开(公告)日：2009-07-28
申请号：US10583404
申请日：2004-12-16
申请人： Corinna Klopprogge , Oskar Zelder , Burkhard Kröger , Hartwig Schröder , Stefan Haefner , Uwe Ruffer , Claudia Isabella Graef , Gregor Haberhauer
发明人： Corinna Klopprogge , Oskar Zelder , Burkhard Kröger , Hartwig Schröder , Stefan Haefner , Uwe Ruffer , Claudia Isabella Graef , Gregor Haberhauer
CPC分类号： C07K14/34
摘要： The present invention relates to mutated nucleic acids and proteins of the metabolic pathway of fine chemicals, to processes for preparing genetically modified producer organisms, to processes for preparing fine chemicals by culturing genetically modified organisms, and to genetically modified organisms themselves.
摘要翻译： 本发明涉及精细化学品的代谢途径的突变核酸和蛋白质，制备经遗传修饰的生物体生物体的方法，通过培养经遗传修饰的生物体来制备精细化学品的方法以及转基因生物本身。
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公开(公告)号：US07510854B2
公开(公告)日：2009-03-31
申请号：US11239674
申请日：2005-09-28
申请人： Markus Pompejus , Burkhard Kröger , Hartwig Schröder , Oskar Zelder , Gregor Haberhauer , Jun-Won Kim , Heung Shick-Lee , Byung-Joon Hwang
发明人： Markus Pompejus , Burkhard Kröger , Hartwig Schröder , Oskar Zelder , Gregor Haberhauer , Jun-Won Kim , Heung Shick-Lee , Byung-Joon Hwang
摘要： Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MP proteins, mutated MP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MP genes in this organism.
摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型MP蛋白的分离的核酸分子，称为MP核酸分子。 本发明还提供反义核酸分子，含有MP核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还进一步提供分离的MP蛋白，突变的MP蛋白，融合蛋白，抗原肽和用于基于该生物体中MP基因的遗传工程改进谷氨酸棒球菌产生所需化合物的方法。
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公开(公告)号：US20090246836A1
公开(公告)日：2009-10-01
申请号：US10582822
申请日：2004-12-15
摘要： The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
摘要翻译： 本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。
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公开(公告)号：US07323559B2
公开(公告)日：2008-01-29
申请号：US11591868
申请日：2006-11-02
申请人： Oskar Zelder , Markus Pompejus , Hartwig Schröder , Burkhard Kröger , Corinna Klopprogge , Gregor Haberhauer
发明人： Oskar Zelder , Markus Pompejus , Hartwig Schröder , Burkhard Kröger , Corinna Klopprogge , Gregor Haberhauer
CPC分类号： C12N9/00 , C07K14/34 , C12N9/0006 , C12P13/08
摘要： The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.
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公开(公告)号：US07141663B2
公开(公告)日：2006-11-28
申请号：US10494675
申请日：2002-10-31
申请人： Oskar Zelder , Markus Pompejus , Hartwig Schröder , Burkhard Kröger , Corinna Klopprogge , Gregor Haberhauer
发明人： Oskar Zelder , Markus Pompejus , Hartwig Schröder , Burkhard Kröger , Corinna Klopprogge , Gregor Haberhauer
摘要： The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.
摘要翻译： 本发明涉及新颖的核酸分子，其用于构建遗传改良的微生物的用途，以及借助所述遗传改良的微生物制备精细化学品，特别是氨基酸的方法。
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