公开(公告)号：US20190263858A1

公开(公告)日：2019-08-29

申请号：US16332506

申请日：2017-09-13

Applicant: DSM IP ASSETS B.V.

Inventor： Marc HEIDL ,  Eileen JACKSON

IPC: C07K5/083 ,  C07K5/097

Abstract: The present invention relates to novel compounds which effectively inhibit the melanin synthesis in human melanocytes and are thus suitable for the treatment of senile lentigines, for smoothening skin color irregularities and/or for lightening natural skin color.

公开(公告)号：US20250161232A1

公开(公告)日：2025-05-22

申请号：US18838971

申请日：2023-02-21

Applicant: DSM IP Assets B.V.

Inventor： Linda HAENDEL ,  Peter Louis HOUSTON ,  Eileen JACKSON ,  Lise Anne KOHLER ,  Christine MENDROK-EDINGER ,  Fabiola PORTA ,  Pascal Christian SIEBER ,  Christos TSEKOU ,  Angela WILDERMANN

IPC: A61K31/07 ,  A61K8/49 ,  A61K8/67 ,  A61K47/22 ,  A61K47/26 ,  A61Q19/00

Abstract: The present invention relates to a new formulation, which comprises a high amount of retinol, which has a defined mixture of cis and trans isomers, in a specific solvent and in the presence of mixed tocopherol.

公开(公告)号：US20180353563A1

公开(公告)日：2018-12-13

申请号：US16060096

申请日：2016-12-09

Applicant: DSM IP ASSETS B.V.

Inventor： Remo CAMPICHE ,  Dominik IMFELD ,  Eileen JACKSON ,  Eliane Ursula WANDELER

IPC: A61K38/05 ,  A61K8/06 ,  A61K8/64 ,  A61K8/55 ,  A61K9/107 ,  A61K47/24 ,  A61P17/08 ,  A61P17/10 ,  A61Q19/00

CPC classification number: A61K38/05 ,  A61K8/062 ,  A61K8/55 ,  A61K8/64 ,  A61K9/107 ,  A61K47/24 ,  A61P17/08 ,  A61P17/10 ,  A61Q19/00 ,  A61Q19/008 ,  A61Q19/02

Abstract: The present invention relates to a novel use of proline containing dipeptides for the prevention and/or treatment of skin conditions associated with altered, damaged or malfunctioning sebaceous glands.

公开(公告)号：US20180319829A1

公开(公告)日：2018-11-08

申请号：US15774649

申请日：2016-11-23

Applicant: DSM IP ASSETS B.V.

Inventor： Stéphanie BOUDON ,  Eileen JACKSON ,  Rolf SCHUETZ ,  Jürgen Herbert VOLLHARDT ,  Peter WIKSTROEM ,  Eliane Ursula WANDELER

IPC: C07F9/6553 ,  A61K8/55 ,  A61K31/67 ,  A61Q19/00 ,  A61Q19/08 ,  C07F9/30 ,  A61K31/662 ,  C07F9/572 ,  A61K31/675 ,  C07C53/18

CPC classification number: C07F9/655354 ,  A61K8/55 ,  A61K8/64 ,  A61K31/662 ,  A61K31/67 ,  A61K31/675 ,  A61Q19/00 ,  A61Q19/08 ,  C07C53/18 ,  C07F9/306 ,  C07F9/5728

Abstract: This invention relates to compounds that are selective inhibitors of Matrix Metalloprotease-12 (MMP-12), to cosmetic and pharmaceutical compositions containing them, and to their use in the prevention and/or treatment of ailments associated with MMP-12. Formula (I).

公开(公告)号：US20250134834A1

公开(公告)日：2025-05-01

申请号：US18838710

申请日：2023-02-21

Applicant: DSM IP Assets B.V.

Inventor： Linda HAENDEL ,  Peter Louis HOUSTON ,  Eileen JACKSON ,  Lise Anne KOHLER ,  Christine MENDROK-EDINGER ,  Fabiola PORTA ,  Pascal Christian SIEBER ,  Christos TSEKOU ,  Angela WILDERMANN

IPC: A61K31/07 ,  A61K8/37 ,  A61K8/67 ,  A61K47/14 ,  A61K47/22 ,  A61K47/24 ,  A61K47/44 ,  A61Q19/00

Abstract: The present invention relates to a new formulation, which comprises a high amount of retinol, which has a defined mixture of cis and trans isomers, in a specific solvent and in the presence of mixed tocopherol.

公开(公告)号：US20200308222A1

公开(公告)日：2020-10-01

申请号：US16759851

申请日：2018-10-29

Applicant: DSM IP ASSETS B.V.

Inventor： Marc HEIDL ,  Eileen JACKSON

IPC: C07K5/117 ,  A61K8/64 ,  A61Q5/00 ,  A61Q19/00

Abstract: The present invention relates to novel tetrapeptides as well as the use thereof as antimicrobial agents.

公开(公告)号：US20180344604A1

公开(公告)日：2018-12-06

申请号：US15777987

申请日：2016-12-09

Applicant: DSM IP ASSETS B.V.

Inventor： Stephanie BOUDON ,  Marc HEIDL ,  Eileen JACKSON

IPC: A61K8/49 ,  A61K8/42

CPC classification number: A61K8/4913 ,  A61K8/42 ,  A61K8/492 ,  A61Q19/08 ,  C07D207/16

Abstract: The present invention relates to novel selective 11-beta-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors and the use thereof to prevent age-induced skin structure and function defects.

公开(公告)号：US20250152493A1

公开(公告)日：2025-05-15

申请号：US18838904

申请日：2023-02-21

Applicant: DSM IP Assets B.V.

Inventor： Linda HAENDEL ,  Peter Louis HOUSTON ,  Eileen JACKSON ,  Lise Anne KOHLER ,  Christine MENDROK-EDINGER ,  Fabiola PORTA ,  Pascal Christian SIEBER ,  Christos TSEKOU ,  Angela WILDERMANN

IPC: A61K8/67

Abstract: The present invention relates to a new formulation, which comprises a high amount of retinol, which has a defined mixture of cis and trans isomers, in a specific solvent and in the presence of mixed tocopherol.

公开(公告)号：US20250040538A1

公开(公告)日：2025-02-06

申请号：US18715377

申请日：2022-12-05

Applicant: DSM IP ASSETS B.V.

Inventor： Christine MENDROK-EDINGER ,  Eileen JACKSON ,  Angela WILDERMANN ,  Peter Louis HOUSTON

IPC: A01N31/04 ,  A01P1/00 ,  A61K8/67 ,  A61K31/07 ,  A61P31/00 ,  A61Q17/00

Abstract: The present invention relates to novel compositions comprising mixtures of cis and trans isomers of retinol, particularly with a cis/trans ratio of less than 1:100, as well as the use of said compositions for preservation.

公开(公告)号：US20180362428A1

公开(公告)日：2018-12-20

申请号：US16062463

申请日：2016-12-14

Applicant: DSM IP ASSETS B.V.

Inventor： Igor BENDIK ,  Piero GEOTTI-BIANCHINI ,  Marc HEIDL ,  Eileen JACKSON ,  Alexander SCHLIFKE-POSCHALKO

IPC: C07C33/48 ,  A61K8/34 ,  A61Q19/08 ,  C07F5/02 ,  C07C29/64

CPC classification number: C07C33/486 ,  A61K8/34 ,  A61K8/345 ,  A61K8/67 ,  A61Q19/08 ,  C07C29/64 ,  C07F5/027

Abstract: Novel biaromatic compounds, which are vitamin D analogs, processes for their preparation and cosmetic, dermatological and pharmaceutical preparations containing one or more of these compounds.