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1.发明授权公开(公告)号：US10077435B2
公开(公告)日：2018-09-18
申请号：US15386967
申请日：2016-12-21
Applicant: DSM IP ASSETS B.V.
Inventor： Alrik Pieter Los , Cornelis Maria Jacobus Sagt , Margot Elisabeth Francoise Schooneveld-Bergmans , Robbertus Antonius Damveld
CPC classification number: C12N9/2437 , C12N9/244 , C12N9/2445 , C12N9/2477 , C12P19/02 , C12P19/14 , C12Y302/01004 , C12Y302/01006 , C12Y302/01021 , C12Y302/01091 , Y02E50/17 , Y02E50/343
Abstract: The invention relates to a host cell comprising at least four different heterologous polynucleotides chosen from the group of polynucleotides encoding cellulases, hemicellulases and pectinases, wherein the host cell is capable of producing the at least four different enzymes chosen from the group of cellulases, hemicellulases and pectinases, wherein the host cell is a filamentous fungus and is capable of secretion of the at least four different enzymes. This host cell can suitably be used for the production of an enzyme composition that can be used in a process for the saccharification of cellulosic material.
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2.发明申请公开(公告)号：US20180066243A1
公开(公告)日：2018-03-08
申请号：US15815653
申请日：2017-11-16
Applicant: DSM IP ASSETS B.V.
Inventor： Alrik Pieter LOS , Cornelis Maria Jacobus Sagt , Margot Elisabeth Francoise Schooneveld-Bergmans , Robbertus Antonius Damveld
CPC classification number: C12N9/2437 , C12N9/244 , C12N9/2445 , C12N9/2477 , C12P19/02 , C12P19/14 , C12Y302/01004 , C12Y302/01006 , C12Y302/01021 , C12Y302/01091 , Y02E50/343
Abstract: The invention relates to a host cell comprising at least four different heterologous polynucleotides chose from the group of polynucleotides encoding cellulases, hemicellulases and pectinases, wherein the host cell is capable of producing the at least four different enzymes chosen from the group of cellulases, hemicellulases and pectinases, wherein the host cell is a filam-tous fungus and is capable of secretion of the at least four different enzymes. This host cell can suitably be used for the production of an enzyme composition that can be use in a process for the saccharification of cellulosic material.
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3.发明授权公开(公告)号：US09738881B2
公开(公告)日：2017-08-22
申请号：US14793786
申请日：2015-07-08
Applicant: DSM IP ASSETS B.V.
Inventor： Alrik Pieter Los , Cornelis Maria Jacobus Sagt , Margot Elisabeth Francoise Schoonneveld-Bergmans , Robbertus Antonius Damveld
CPC classification number: C12N9/2437 , C12N9/244 , C12N9/2445 , C12N9/2477 , C12P19/02 , C12P19/14 , C12Y302/01004 , C12Y302/01006 , C12Y302/01021 , C12Y302/01091 , Y02E50/343
Abstract: The invention relates to a host cell comprising at least four different heterologous polynucleotides chosen from the group of polynucleotides encoding cellulases, hemicellulases and pectinases, wherein the host cell is capable of producing the at least four different enzymes chosen from the group of cellulases, hemicellulases and pectinases, wherein the host cell is a filamentous fungus and is capable of secretion of the at least four different enzymes. This host cell can suitably be used for the production of an enzyme composition that can be used in a process for the saccharification of cellulosic material.
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4.发明授权公开(公告)号：US10920207B2
公开(公告)日：2021-02-16
申请号：US16016011
申请日：2018-06-22
Applicant: DSM IP ASSETS B.V.
Inventor： Alrik Pieter Los , Cornelis Maria Jacobus Sagt , Margot Elisabeth Francoise Schooneveld-Bergmans , Robbertus Antonius Damveld
Abstract: The invention relates to a host cell comprising at least four different heterologous polynucleotides chose from the group of polynucleotides encoding cellulases, hemicellulases and pectinases, wherein the host cell is capable of producing the at least four different enzymes chosen from the group of cellulases, hemicellulases and pectinases, wherein the host cell is a filam-tous fungus and is capable of secretion of the at least four different enzymes. This host cell can suitably be used for the production of an enzyme composition that can be use in a process for the saccharification of cellulosic material.
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Patent Agency Ranking
公开(公告)号：US09689005B2
公开(公告)日：2017-06-27
申请号：US14044722
申请日：2013-10-02
Applicant: DSM IP ASSETS B.V.
Inventor： Rene Verwaal , Liang Wu , Robbertus Antonius Damveld , Cornelis Maria Jacobus Sagt
Abstract: The present invention relates to a recombinant eukaryotic cell selected from a yeast of a filamentous fungus comprising a nucleotide sequence encoding a NAD(H)-dependent fumarate reductase that catalyzes the conversion of fumaric acid to succinic acid. The invention further relates to a process for the production of succinic acid wherein the eukaryotic cell according to the present invention is used.
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公开(公告)号：US09556459B2
公开(公告)日：2017-01-31
申请号：US14070770
申请日：2013-11-04
Applicant: DSM IP ASSETS B.V.
Inventor： Rene Verwaal , Liang Wu , Robbertus Antonius Damveld , Cornelis Maria Jacobus Sagt
Abstract: The present invention relates to a recombinant yeast comprising a nucleotide sequence encoding a heterologous enzyme that catalyses the conversion of malic acid to fumaric acid. The invention further relates to a process for the production of a dicarboxylic acid wherein the yeast according to the present invention is used.
Abstract translation: 本发明涉及包含编码异源酶的核苷酸序列的重组酵母，其催化苹果酸向富马酸的转化。 本发明还涉及一种生产二羧酸的方法，其中使用了本发明的酵母。
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7.发明授权公开(公告)号：US10035999B2
公开(公告)日：2018-07-31
申请号：US15815653
申请日：2017-11-16
Applicant: DSM IP ASSETS B.V.
Inventor： Alrik Pieter Los , Cornelis Maria Jacobus Sagt , Margot Elisabeth Francoise Schooneveld-Bergmans , Robbertus Antonius Damveld
CPC classification number: C12N9/2437 , C12N9/244 , C12N9/2445 , C12N9/2477 , C12P19/02 , C12P19/14 , C12Y302/01004 , C12Y302/01006 , C12Y302/01021 , C12Y302/01091 , Y02E50/17 , Y02E50/343
Abstract: The invention relates to a host cell comprising at least four different heterologous polynucleotides chose from the group of polynucleotides encoding cellulases, hemicellulases and pectinases, wherein the host cell is capable of producing the at least four different enzymes chosen from the group of cellulases, hemicellulases and pectinases, wherein the host cell is a filam-tous fungus and is capable of secretion of the at least four different enzymes. This host cell can suitably be used for the production of an enzyme composition that can be use in a process for the saccharification of cellulosic material.
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公开(公告)号：US20150197760A1
公开(公告)日：2015-07-16
申请号：US14408089
申请日：2013-06-17
Applicant: DSM IP ASSETS B.V.
Inventor： Alrik Pieter Los , Wilbert Herman Marie Heijne , Herman Jan Pel , Robbertus Antonius Damveld , Brenda Vonk
CPC classification number: C12N15/80 , C12N9/18 , C12N9/2408 , C12N9/2428 , C12N9/2434 , C12P1/02 , C12P21/02
Abstract: The present invention relates to isolated Rasamsonia promoter DNA sequences, to DNA constructs, vectors, and host cells comprising these promoters in operative association with coding sequences. The present invention also relates to methods for expressing a gene and/or producing a biological compound using the new promoters isolated. The present invention also relates to methods for altering the transcription level and/or regulation of an endogenous gene using the new promoter of the invention.
Abstract translation: 本发明涉及分离的Rasamsonia启动子DNA序列，涉及包含这些启动子的DNA构建体，载体和宿主细胞，其与编码序列有效结合。 本发明还涉及使用分离的新启动子来表达基因和/或生产生物化合物的方法。 本发明还涉及使用本发明的新启动子改变内源基因的转录水平和/或调节的方法。
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9.发明申请公开(公告)号：US20180298363A1
公开(公告)日：2018-10-18
申请号：US16016011
申请日：2018-06-22
Applicant: DSM IP ASSETS B.V.
Inventor： Alrik Pieter Los , Cornelis Maria Jacobus Sagt , Margot Elisabeth Francoise Schooneveld-Bergmans , Robbertus Antonius Damveld
Abstract: The invention relates to a host cell comprising at least four different heterologous polynucleotides chose from the group of polynucleotides encoding cellulases, hemicellulases and pectinases, wherein the host cell is capable of producing the at least four different enzymes chosen from the group of cellulases, hemicellulases and pectinases, wherein the host cell is a filam-tous fungus and is capable of secretion of the at least four different enzymes. This host cell can suitably be used for the production of an enzyme composition that can be use in a process for the saccharification of cellulosic material.
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