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公开(公告)号：US20090298052A1
公开(公告)日：2009-12-03
申请号：US11569992
申请日：2005-06-06
申请人： David Atkins , John Backus , Robert Belly , Steven Rosen , Robert White
发明人： David Atkins , John Backus , Robert Belly , Steven Rosen , Robert White
IPC分类号： C12Q1/68
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/16
摘要： A method of diagnosing the presence or predicting the course of breast cancer by measuring the expression of a combination of Marker genes comprising a tissue-specific gene and a non-tissue specific gene in a cell or tissue sample derived from a patient. In one aspect of the invention, the genes are mammaglobin and CK19. Kits, nucleic acid primers and probes and controls are provided.
摘要翻译： 通过测量源自患者的细胞或组织样品中包含组织特异性基因和非组织特异性基因的标记基因的组合的表达来诊断存在或预测乳腺癌病程的方法。 在本发明的一个方面，基因是乳腺球蛋白和CK19。 提供试剂盒，核酸引物和探针和对照。
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公开(公告)号：US20170023083A1
公开(公告)日：2017-01-26
申请号：US14806807
申请日：2015-07-23
摘要： A planar flexure member for resisting rotation about a central axis thereof includes, in various embodiments, a central portion comprising a plurality of attachment points; and at least one serpentine flexure arm extending from the central portion in a plane. The arm(s) terminate in an arcuate mounting rail that includes a series of attachment points. The rails are positioned in opposition to to each other to partially define and occupy a planar circular envelope radially displaced from but surrounding the central portion of the flexure member. A portion of the serpentine arms may extend to (or substantially to) the envelope between the mounting rails.
摘要翻译： 在各种实施例中，用于抵抗围绕其中心轴的旋转的平面弯曲构件包括包括多个附接点的中心部分; 以及从平面中的中心部分延伸的至少一个蛇形挠曲臂。 该臂终止于包括一系列连接点的弧形安装轨道。 轨道彼此相对定位，以部分地限定和占据从弯曲构件的中心部分径向偏移但围绕着弯曲构件的中心部分的平面圆形包围。 蛇形臂的一部分可以延伸到（或基本上）到安装轨道之间的封套。
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3.发明申请公开(公告)号：US20100153267A1
公开(公告)日：2010-06-17
申请号：US12690372
申请日：2010-01-20
申请人： Shuan Ghaidan , Robert White , Robert Walls
发明人： Shuan Ghaidan , Robert White , Robert Walls
IPC分类号： G06Q40/00
CPC分类号： G07F7/10 , G06Q20/105 , G06Q20/20 , G06Q20/28 , G06Q20/349 , G06Q20/363 , G06Q20/40 , G06Q20/409 , G07F7/127
摘要： A method of loading pre-authorized funds into an integrated circuit (IC) payment card includes interfacing the IC payment card to a loading device. The method further includes receiving a cash payment to cover a proposed load transaction, and operating the loading device to load pre-authorized funds into the IC payment card on an off-line basis.
摘要翻译： 将预授权资金加载到集成电路（IC）支付卡中的方法包括将IC支付卡连接到加载设备。 该方法还包括接收现金支付以支付建议的负载交易，以及操作装载设备以将在线离线的预授权资金加载到IC支付卡中。
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公开(公告)号：US07729768B2
公开(公告)日：2010-06-01
申请号：US11385986
申请日：2006-03-20
申请人： Robert White , George Savage , Mark Zdeblick
发明人： Robert White , George Savage , Mark Zdeblick
IPC分类号： A61N1/00
CPC分类号： H01L41/1136 , A61N1/30 , A61N1/32 , A61N1/3785
摘要： Implantable cardiac motion powered piezoelectric energy sources are provided. An aspects of embodiments of the subject implantable energy sources is that they include a piezoelectric transducer that converts cardiac mechanical energy to electrical energy. The subject energy sources find use in a variety of applications, including providing power to a wide range of implantable devices.
摘要翻译： 提供了植入式心脏运动动力压电能源。 可植入能源的实施方案的一个方面是它们包括将心脏机械能转化为电能的压电换能器。 主题能源可用于各种应用，包括向广泛的可植入装置提供动力。
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公开(公告)号：US20100009044A1
公开(公告)日：2010-01-14
申请号：US12530056
申请日：2007-03-06
CPC分类号： A21D10/025 , A21D2/188 , A21D6/001 , A21D8/06
摘要： The invention concerns a ready-for-use bakery dough product, which can be cooked in a microwave and which is prepared from a mixture comprising—from 11 to 25% flour,—from 0.5 to 2.0% of baking powder—from 10 to 40% of sugar,—from 0.1 to 0.8% of a polymer of methylcellulose and hydroxypropyl Methylcellulose,—the remaining being oil, egg, flavour, starch, salt, emulsifier and water.
摘要翻译： 本发明涉及一种可以使用的面包生面团产品，其可以在微波炉中烹饪，并且由包含11-25％面粉的混合物制备，0.5至2.0％的烘焙粉 - 10-40 ％的糖，0.1至0.8％的甲基纤维素和羟丙基甲基纤维素的聚合物，剩余的是油，蛋，香料，淀粉，盐，乳化剂和水。
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公开(公告)号：US20080044393A1
公开(公告)日：2008-02-21
申请号：US11050911
申请日：2005-02-04
CPC分类号： C07K14/4708 , A01K67/0275 , A01K67/0276 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/0306 , C12N15/8509 , C12N2830/008
摘要： Duchenne muscular dystrophy (DMD) is a progressive muscle disease that is caused by severe defects in the dystrophin gene and results in the patient's death by the third decade. The present invention utilizes the Double Mutant mice (DM) as an appropriate human model for DMD as these mice are deficient for both dystrophin and utrophin (mdx/+, utrn −/−), die at 3 months of age and suffer from severe muscle weakness, pronounced growth retardation, kyphosis, weight loss, slack posture, and immobility. Expression from a transgene of novel human retinal dystrophin Dp260 was shown to prevent premature death and reduce the severe muscular dystrophy phenotype to a mild clinical myopathy. Electromyography, histology, radiography, magnetic resonance imaging, and behavior studies concluded that DM transgenic mice grew normally, had normal spinal curvature and mobility, and had reduced muscle pathology. EMG and histologic data from transgenic DM mice showed decreased abnormalities to levels typical of mild myopathy, while the DM mice exhibited severe abnormalities commonly seen in human dystrophinopathies. The transgenic DM mice also had measurable movement levels comparable to those of untreated mdx mice and controls.
摘要翻译： Duchenne肌营养不良（DMD）是由肌营养不良蛋白基因的严重缺陷引起的进行性肌肉疾病，并导致患者在第三个十年内死亡。 本发明利用双重突变体小鼠（DM）作为DMD的合适人类模型，因为这些小鼠在肌营养不良蛋白和utrophin（mdx / +，utrn - / - ）中都是缺陷的，在3个月龄时死亡，并且患有严重的肌肉 虚弱，发育迟缓，驼背，体重减轻，松弛姿势和不动。 显示来自新型人视网膜肌营养不良蛋白Dp260的转基因的表达可预防过早死亡，并将严重的肌营养不良症表型降低至轻度临床肌病。 肌电图，组织学，放射成像，磁共振成像和行为研究得出结论，DM转基因小鼠正常生长，脊柱弯曲和移动性正常，肌肉病理学减少。 来自转基因DM小鼠的EMG和组织学数据显示轻度肌病典型的异常降低，而DM小鼠在人类肌营养不良症中常见的严重异常。 转基因小鼠也具有与未处理的mdx小鼠和对照相当的可测量运动水平。
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公开(公告)号：US20070181466A1
公开(公告)日：2007-08-09
申请号：US11595818
申请日：2006-11-09
申请人： Shan Wang , Nader Pourmand , Robert White
发明人： Shan Wang , Nader Pourmand , Robert White
CPC分类号： B03C1/0335 , B03C2201/18 , B03C2201/22
摘要： The present invention provides a magnetic sifter that is small in scale, enables three-dimensional flow in a direction normal to the substrate, allows relatively higher capture rates and higher flow rates, and provides a relatively easy method of releasing captured biomolecules. The magnetic sifter includes at least one substrate. Each substrate contains a plurality of slits, each of which extends through the substrate. The sifter also includes a plurality of magnets attached to the bottom surface of the substrate. These magnets are located proximal to the openings of the slits. An electromagnetic source controls the magnitude and direction of magnetic field gradient generated by the magnets. Either one device may be used, or multiple devices may be used in series. In addition, the magnetic sifter may be used in connection with a detection chamber.
摘要翻译： 本发明提供一种规模小的磁选筛机，使得能够沿垂直于基底的方向进行三维流动，允许相对较高的捕获率和较高的流速，并且提供了一种相对容易的释放捕获的生物分子的方法。 磁选机包括至少一个衬底。 每个基板包含多个狭缝，每个狭缝延伸穿过基板。 筛子还包括附着到基底的底表面的多个磁体。 这些磁体位于缝隙的开口附近。 电磁源控制由磁体产生的磁场梯度的大小和方向。 可以使用一个设备，或者可以串联使用多个设备。 此外，磁选机可以与检测室结合使用。
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公开(公告)号：US20060219417A1
公开(公告)日：2006-10-05
申请号：US11086619
申请日：2005-03-22
申请人： Raymond Thompson , Peter Kosmicki , Jeffrey Dawson , Scott Cook , Edwin Kreis , Michael Kollath , Joe Schutte , Robert White
发明人： Raymond Thompson , Peter Kosmicki , Jeffrey Dawson , Scott Cook , Edwin Kreis , Michael Kollath , Joe Schutte , Robert White
IPC分类号： A01B63/112
CPC分类号： A01B59/042 , A01B63/14 , G01L5/136
摘要： A draft force sensor is provided for a coupling member coupled between a towing vehicle and a towed earth engaging implement, such as a scraper. The draft force sensor includes first and second bores extending through the coupling member. Each bore has a horizontal axis which extends perpendicular to a main fore-and-aft axis of the coupling member. The second bore is positioned above the first bore and spaced apart from the first bore. Each of the bores is surrounded by an outer cylindrical wall. Four electrical strain gauges are spaced apart and placed on the wall of each of the bores. A center line bisects an axis line which extends between the axes of the first and second bores. The axis of each bore is spaced apart from the center line by a distance which is less than a diameter of the bores. The strain gauges are connected electrically in a circuit which generates a draft force signal in response to draft forces applied to the coupling member.
摘要翻译： 提供牵引力传感器用于耦合在牵引车辆和拖曳地球接合工具（例如刮刀）之间的联接构件。 牵引力传感器包括延伸穿过联接构件的第一和第二孔。 每个孔具有垂直于联接构件的主要前后轴线延伸的水平轴线。 第二孔位于第一孔的上方并与第一孔隔开。 每个孔都被一个外圆柱形的墙围起来。 四个电气应变计间隔开并放置在每个孔的壁上。 中心线将在第一和第二孔的轴线之间延伸的轴线平分。 每个孔的轴线与中心线间隔一个小于孔直径的距离。 应变计在电路中电连接，该电路响应于施加到联接构件的牵引力而产生牵伸力信号。
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公开(公告)号：US20060217776A1
公开(公告)日：2006-09-28
申请号：US11385986
申请日：2006-03-20
申请人： Robert White , George Savage , Mark Zdeblick
发明人： Robert White , George Savage , Mark Zdeblick
IPC分类号： A61N1/00
CPC分类号： H01L41/1136 , A61N1/30 , A61N1/32 , A61N1/3785
摘要： Implantable cardiac motion powered piezoelectric energy sources are provided. Aspects of embodiments of the subject implantable energy sources is that they include a piezoelectric transducer that converts cardiac mechanical energy to electrical energy. The subject energy sources find use in a variety of applications, including providing power to a wide range of implantable devices.
摘要翻译： 提供了植入式心脏运动动力压电能源。 可植入能源的实施方案的方面是它们包括将心脏机械能转化为电能的压电换能器。 主题能源可用于各种应用，包括向广泛的可植入装置提供动力。
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10.发明授权公开(公告)号：US07038344B2
公开(公告)日：2006-05-02
申请号：US10474486
申请日：2002-01-29
申请人： Wolfgang Winkler , Hartmut Nitzsche , Heinz Seibert , Klaus Vollmer , Martin Huber , Cornelia Lula , Michael Kupferer , Robert White
发明人： Wolfgang Winkler , Hartmut Nitzsche , Heinz Seibert , Klaus Vollmer , Martin Huber , Cornelia Lula , Michael Kupferer , Robert White
IPC分类号： H02K11/00
CPC分类号： H02K5/225 , H02K5/08 , H02K5/148 , H02K5/1672 , H02K11/024 , H02K11/026
摘要： Functional elements are difficult to mount on a housing based on known methods, on which at least one functional element for an electric motor is situated. A housing is configured such that functional elements to be mounted on the housing are mountable on the housing from the outside.
摘要翻译： 基于已知的方法，功能元件难以安装在壳体上，其中至少一个用于电动机的功能元件位于该壳体上。 壳体被构造成使得要安装在壳体上的功能元件可从外部安装在壳体上。
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