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公开(公告)号：US20100247590A1
公开(公告)日：2010-09-30
申请号：US12748685
申请日：2010-03-29
申请人： Douglas Robert Anton , Susan Daly , Robert J. Bianchini , Hong Wang , Pierre E. Rouviere , Scott D. Cunningham , Stephen R. Fahnestock , Tanja Maria Gruber
发明人： Douglas Robert Anton , Susan Daly , Robert J. Bianchini , Hong Wang , Pierre E. Rouviere , Scott D. Cunningham , Stephen R. Fahnestock , Tanja Maria Gruber
IPC分类号： A61K8/02 , A61K9/14 , A61Q17/04 , A61K8/64 , A61P17/10 , A61P31/10 , A61P31/04 , A61Q9/00 , A61Q5/00
CPC分类号： A61K8/64 , A61K8/19 , A61K2800/88 , A61K2800/884 , A61K2800/94 , A61Q5/10
摘要： The present invention relates to compositions and systems comprising peptide-based reagents for delivery of cosmetic benefit agents to human hair, human skin, or human nail.
摘要翻译： 本发明涉及包含用于向人类头发，人类皮肤或人类指甲递送化妆品有益剂的基于肽的试剂的组合物和系统。
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公开(公告)号：US08652455B2
公开(公告)日：2014-02-18
申请号：US13330171
申请日：2011-12-19
申请人： Robert DiCosimo , Scott D. Cunningham , Stephen R. Fahnestock , Tanja Maria Gruber , Mark S. Payne , Pierre E. Rouviere , Linda Jane Solomon , Hong Wang
发明人： Robert DiCosimo , Scott D. Cunningham , Stephen R. Fahnestock , Tanja Maria Gruber , Mark S. Payne , Pierre E. Rouviere , Linda Jane Solomon , Hong Wang
CPC分类号： C12N9/18 , C07K16/16 , C07K19/00 , C07K2319/01 , C11D3/38636 , C11D3/38681 , C12N9/14 , C12N9/2437 , C12P7/40 , C12P7/54
摘要： Disclosed herein are compositions and methods to target enzymatic peracid production to a target surface. The peracid benefit agent produced by the targeted perhydrolytic enzyme can be use for a variety of applications such as bleaching, whitening, disinfecting, destaining, deodorizing, and combinations thereof. Specifically, a fusion protein comprising a perhydrolytic enzyme and at least one peptidic component having affinity for a target surface (excluding body surfaces and oral care surfaces) is used in combination with a suitable substrate and a source of peroxygen to enzymatically produce a peracid on or near the surface of the target material. In a preferred aspect, the target surface is a cellulosic material.
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公开(公告)号：US20120317733A1
公开(公告)日：2012-12-20
申请号：US13330105
申请日：2011-12-19
申请人： Dexter A. Chisholm , Xiumin Cui , Scott D. Cunningham , Robert DiCosimo , Stephen R. Fahnestock , Tanja Maria Gruber , Yongqing Huang , Xueping Jiang , Anju Parthasarathy , Mark S. Payne , Pierre E. Rouviere , Hong Wang
发明人： Dexter A. Chisholm , Xiumin Cui , Scott D. Cunningham , Robert DiCosimo , Stephen R. Fahnestock , Tanja Maria Gruber , Yongqing Huang , Xueping Jiang , Anju Parthasarathy , Mark S. Payne , Pierre E. Rouviere , Hong Wang
CPC分类号： A61K8/66 , A61K8/22 , A61K8/38 , A61K8/64 , A61K38/46 , A61K38/465 , A61Q5/08 , A61Q5/10 , A61Q9/04 , A61Q15/00 , A61Q19/00 , A61Q19/02
摘要： Disclosed herein are compositions and methods to treat hair with a peracid-based benefit agent. The peracid benefit agent can be used for hair bleaching, hair weakening, hair removal, hair waiving, hair straightening or any combination thereof. The peracid may be enzymatically generated from a carboxylic acid ester substrate using an enzyme having perhydrolytic activity (perhydrolase) in the presence of a source of peroxygen. A fusion protein comprising the perhydrolase coupled to a hair-binding domain, either directly or through an optional linker, may be used to target the perhydrolytic activity to the hair surface.
摘要翻译： 本文公开了用基于过酸的有益试剂治疗毛发的组合物和方法。 过酸有益剂可用于头发漂白，头发削弱，脱毛，脱毛，头发矫直或其任何组合。 在过氧源的存在下，可以使用具有过水解活性的酶（过水解酶），由羧酸酯底物酶促产生过酸。 包含直接或通过任选的接头与毛发结合结构域偶联的过水解酶的融合蛋白可用于将头发表面的水解活性靶向。
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公开(公告)号：US20120321581A1
公开(公告)日：2012-12-20
申请号：US13330171
申请日：2011-12-19
申请人： Robert DiCosimo , Scott D. Cunningham , Stephen R. Fahnestock , Tanja Maria Gruber , Mark S. Payne , Pierre E. Rouviere , Linda Jane Solomon , Hong Wang
发明人： Robert DiCosimo , Scott D. Cunningham , Stephen R. Fahnestock , Tanja Maria Gruber , Mark S. Payne , Pierre E. Rouviere , Linda Jane Solomon , Hong Wang
CPC分类号： C12N9/18 , C07K16/16 , C07K19/00 , C07K2319/01 , C11D3/38636 , C11D3/38681 , C12N9/14 , C12N9/2437 , C12P7/40 , C12P7/54
摘要： Disclosed herein are compositions and methods to target enzymatic peracid production to a target surface. The peracid benefit agent produced by the targeted perhydrolytic enzyme can be use for a variety of applications such as bleaching, whitening, disinfecting, destaining, deodorizing, and combinations thereof. Specifically, a fusion protein comprising a perhydrolytic enzyme and at least one peptidic component having affinity for a target surface (excluding body surfaces and oral care surfaces) is used in combination with a suitable substrate and a source of peroxygen to enzymatically produce a peracid on or near the surface of the target material. In a preferred aspect, the target surface is a cellulosic material.
摘要翻译： 本文公开了将酶过氧酸生产靶向靶表面的组合物和方法。 由靶向的水解酶产生的过酸有益剂可用于各种应用，例如漂白，增白，消毒，脱色，除臭及其组合。 特别地，包含过水解酶和至少一种对靶表面（不包括身体表面和口腔护理表面）具有亲和性的肽成分的融合蛋白与合适的底物和过氧源组合使用以在其上或 靠近目标材料的表面。 在优选的方面，目标表面是纤维素材料。
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公开(公告)号：US20100247589A1
公开(公告)日：2010-09-30
申请号：US12732248
申请日：2010-03-26
申请人： STEPHEN R. FAHNESTOCK , Kari A. Fosser , Hong Wang , Pierre E. Rouviere , Tanja Maria Gruber , Douglas Robert Anton
发明人： STEPHEN R. FAHNESTOCK , Kari A. Fosser , Hong Wang , Pierre E. Rouviere , Tanja Maria Gruber , Douglas Robert Anton
CPC分类号： A61K8/25 , A61K8/0241 , A61K8/29 , A61K8/64 , A61K8/731 , A61K2800/412 , A61K2800/43 , A61K2800/614 , A61Q11/00 , C07K7/08 , C07K14/001
摘要： Oral care compositions, oral care systems, oral surface-binding peptides, and a method for applying particles to an oral surface are provided. The oral care system comprises at least one peptidic component comprising a first binding element having affinity for an oral surface and a second binding element having affinity for a ligand property of a particle.
摘要翻译： 提供了口腔护理组合物，口腔护理系统，口腔表面结合肽以及将颗粒施用于口腔表面的方法。 口腔护理系统包含至少一种肽组分，其包含对口腔表面具有亲和力的第一结合元件和对颗粒的配体性质具有亲和力的第二结合元件。
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公开(公告)号：US08354381B2
公开(公告)日：2013-01-15
申请号：US12732248
申请日：2010-03-26
申请人： Stephen R. Fahnestock , Kari A. Fosser , Hong Wang , Pierre E. Rouviere , Tanja Maria Gruber , Douglas Robert Anton
发明人： Stephen R. Fahnestock , Kari A. Fosser , Hong Wang , Pierre E. Rouviere , Tanja Maria Gruber , Douglas Robert Anton
CPC分类号： A61K8/25 , A61K8/0241 , A61K8/29 , A61K8/64 , A61K8/731 , A61K2800/412 , A61K2800/43 , A61K2800/614 , A61Q11/00 , C07K7/08 , C07K14/001
摘要： Oral care compositions, oral care systems, oral surface-binding peptides, and a method for applying particles to an oral surface are provided. The oral care system comprises at least one peptidic component comprising a first binding element having affinity for an oral surface and a second binding element having affinity for a ligand property of a particle.
摘要翻译： 提供了口腔护理组合物，口腔护理系统，口腔表面结合肽以及将颗粒施用于口腔表面的方法。 口腔护理系统包含至少一种肽组分，其包含对口腔表面具有亲和力的第一结合元件和对颗粒的配体性质具有亲和力的第二结合元件。
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公开(公告)号：US20120328534A1
公开(公告)日：2012-12-27
申请号：US13330261
申请日：2011-12-19
申请人： Lisa A. Butterick , Scott D. Cunningham , Robert DiCosimo , Kari A. Fosser , Tanja Maria Gruber , Sharon L. Haynie , Mark S. Payne , Pierre E. Rouviere , Hong Wang
发明人： Lisa A. Butterick , Scott D. Cunningham , Robert DiCosimo , Kari A. Fosser , Tanja Maria Gruber , Sharon L. Haynie , Mark S. Payne , Pierre E. Rouviere , Hong Wang
摘要： Disclosed herein are compositions and methods to treat an oral cavity surface with a peracid-based benefit agent. The peracid benefit agent can be use for oral surface bleaching, whitening, disinfecting, destaining, deodorizing, decreasing or removing biofilm, and combinations thereof. The peracid is enzymatically generated from a carboxylic acid ester substrate using a CE-7 carbohydrate esterase having perhydrolytic activity (perhydrolase) in the presence of a source of peroxygen. A fusion protein comprising the perhydrolase coupled to a peptidic component having affinity for an oral cavity surface, either directly or through an optional linker, may be used to target the perhydrolytic activity to the oral cavity surface.
摘要翻译： 本文公开了用基于过酸的有益试剂治疗口腔表面的组合物和方法。 过酸有益剂可用于口腔表面漂白，美白，消毒，脱色，除臭，减少或去除生物膜及其组合。 在过氧源的存在下，使用具有过水解活性的CE-7碳水化合物酯酶（过水解酶），由羧酸酯底物酶促产生过酸。 包含与直接或通过任选的接头对口腔表面具有亲和性的肽成分偶联的过水解酶的融合蛋白质可用于将过水解活性靶向口腔表面。
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公开(公告)号：US08663616B2
公开(公告)日：2014-03-04
申请号：US13330261
申请日：2011-12-19
申请人： Lisa A. Butterick , Scott D. Cunningham , Robert DiCosimo , Kari A. Fosser , Tanja Maria Gruber , Sharon L. Haynie , Mark S. Payne , Pierre E. Rouviere , Hong Wang
发明人： Lisa A. Butterick , Scott D. Cunningham , Robert DiCosimo , Kari A. Fosser , Tanja Maria Gruber , Sharon L. Haynie , Mark S. Payne , Pierre E. Rouviere , Hong Wang
摘要： Disclosed herein are compositions and methods to treat an oral cavity surface with a peracid-based benefit agent. The peracid benefit agent can be use for oral surface bleaching, whitening, disinfecting, destaining, deodorizing, decreasing or removing biofilm, and combinations thereof. The peracid is enzymatically generated from a carboxylic acid ester substrate using a CE-7 carbohydrate esterase having perhydrolytic activity (perhydrolase) in the presence of a source of peroxygen. A fusion protein comprising the perhydrolase coupled to a peptidic component having affinity for an oral cavity surface, either directly or through an optional linker, may be used to target the perhydrolytic activity to the oral cavity surface.
摘要翻译： 本文公开了用基于过酸的有益试剂治疗口腔表面的组合物和方法。 过酸有益剂可用于口腔表面漂白，美白，消毒，脱色，除臭，减少或去除生物膜及其组合。 在过氧源的存在下，使用具有过水解活性的CE-7碳水化合物酯酶（过水解酶），由羧酸酯底物酶促产生过酸。 包含与直接或通过任选的接头对口腔表面具有亲和力的肽成分偶联的过水解酶的融合蛋白可用于将过水解活性靶向口腔表面。
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9.发明申请公开(公告)号：US20100136621A1
公开(公告)日：2010-06-03
申请号：US12692665
申请日：2010-01-25
申请人： Qiong Cheng , Linda Jane Decarolis , Stephen R. Fahnestock , Tanja Maria Gruber , Lisa Diane Reiss , Pierre E. Rouviere
发明人： Qiong Cheng , Linda Jane Decarolis , Stephen R. Fahnestock , Tanja Maria Gruber , Lisa Diane Reiss , Pierre E. Rouviere
CPC分类号： C12P21/02 , C07K2319/50 , C12N9/90
摘要： Peptide tags, referred to here as inclusion body tags, are disclosed useful for the generation of insoluble fusion peptides. The fusion peptides comprise at least one inclusion body tag operably linked to a peptide of interest. Expression of the fusion peptide in a host cell results in a product that is insoluble and contained within inclusion bodies in the cell and/or cell lysate. The inclusion bodies may then be purified and the protein of interest may be isolated after cleavage from the inclusion body tag.
摘要翻译： 公开了用于产生不溶性融合肽的肽标签，这里称为包涵体标签。 融合肽包含可操作地连接到目的肽的至少一种包涵体标签。 融合肽在宿主细胞中的表达产生不溶性并且包含在细胞和/或细胞裂解物中的包涵体内的产物。 然后可以纯化包涵体，并且在从包涵体标签中切割后可以分离感兴趣的蛋白质。
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公开(公告)号：US20130157927A1
公开(公告)日：2013-06-20
申请号：US13771248
申请日：2013-02-20
申请人： STEPHEN R. FAHNESTOCK , Kari A. Fosser , Tanja Maria Gruber , Pierre E. Rouviere , Linda Jane Solomon
发明人： STEPHEN R. FAHNESTOCK , Kari A. Fosser , Tanja Maria Gruber , Pierre E. Rouviere , Linda Jane Solomon
IPC分类号： C07K19/00
CPC分类号： C07K19/00 , C07K1/1133 , Y10T428/2991
摘要： Compositions and methods are provided using fusion peptides comprising at least one multi-functional solubility tag having an effective number of cross-linkable cysteines residues. The multi-functional peptidic solubility tags facilitate efficient fusion peptide production, easier downstream processing of the fusion peptide, and provide functional surface properties when coupled to a target material while the cross-linkable cysteines provide enhanced durability when binding the fusion peptide to a target material.
摘要翻译： 使用包含至少一个具有有效数量的可交联半胱氨酸残基的多功能溶解性标签的融合肽提供组合物和方法。 多功能肽溶解度标签促进了有效的融合肽生产，更容易的融合肽的下游加工，并且当与靶材料偶联时提供功能性表面性质，而当将融合肽结合到靶材料上时，可交联半胱氨酸提供增强的耐久性 。
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