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    Receiver Plate With Multiple Cross-Sections
    1.
    发明申请
    Receiver Plate With Multiple Cross-Sections 有权
    接收板与多个横截面

    公开(公告)号：US20150064081A1

    公开(公告)日：2015-03-05

    申请号：US14514853

    申请日：2014-10-15

    Applicant: EMD Millipore Corporation

    Inventor： Christopher A. Scott ,  Brian Foley

    IPC: B01L3/00

    CPC classification number: B01L3/50255 ,  B01L3/5085 ,  B01L2200/025 ,  B01L2200/0678 ,  B01L2200/0684 ,  B01L2200/141 ,  B01L2300/0681 ,  B01L2300/0829 ,  B01L2300/0858

    Abstract: A multi-well assembly including a filter plate and receiver plate. Each plate includes a plurality of wells, which, when the filter plate is placed in nesting relationship with the receiver plate, each filter plate well has a corresponding receiver plate well into which it extends. The receiver plate wells are of a non-uniform cross-section in order to increase the gap between the outer walls of the filter plate wells and the inner walls of a corresponding receiver plate well when the receiver plate and filter plate are in nesting relationship. The increased gap size reduces wicking and cross-contamination. A multi-section well of maximum cross-section in an upper region and a minimized cross-section in a lower region, with a gradual transition between the regions, is thus provided. The multi-well assembly of the present invention also improves the repeatability of positioning the filter plate and receiver plate in proper nesting relationship and provides stability during handling, mixing and shaking operations.

    Abstract translation: 包括过滤板和接收板的多孔组件。 每个板包括多个孔，当过滤板与接收板放置成嵌套关系时，每个过滤板井具有相应的容纳板，井中延伸。 接收器板孔具有不均匀的横截面，以便当接收板和过滤板处于嵌套关系时，增加过滤板孔的外壁和对应的接收器板的内壁之间的间隙。 增加的间隙大小减少芯吸和交叉污染。 因此，提供了在上部区域中的最大横截面的多部分井和在下部区域中具有逐渐过渡的区域中的最小化横截面。 本发明的多孔组件还提高了将过滤板和接收板定位成适当的嵌套关系的重复性，并且在处理，混合和摇动操作期间提供了稳定性。

    Receiver plate with multiple cross-sections
    6.
    发明授权
    Receiver plate with multiple cross-sections 有权

    公开(公告)号：US09138742B2

    公开(公告)日：2015-09-22

    申请号：US14514853

    申请日：2014-10-15

    Applicant: EMD Millipore Corporation

    Inventor： Christopher A. Scott ,  Brian Foley

    IPC: B01L3/00

    CPC classification number: B01L3/50255 ,  B01L3/5085 ,  B01L2200/025 ,  B01L2200/0678 ,  B01L2200/0684 ,  B01L2200/141 ,  B01L2300/0681 ,  B01L2300/0829 ,  B01L2300/0858

    Abstract: A multi-well assembly including a filter plate and receiver plate. Each plate includes a plurality of wells, which, when the filter plate is placed in nesting relationship with the receiver plate, each filter plate well has a corresponding receiver plate well into which it extends. The receiver plate wells are of a non-uniform cross-section in order to increase the gap between the outer walls of the filter plate wells and the inner walls of a corresponding receiver plate well when the receiver plate and filter plate are in nesting relationship. The increased gap size reduces wicking and cross-contamination. A multi-section well of maximum cross-section in an upper region and a minimized cross-section in a lower region, with a gradual transition between the regions, is thus provided. The multi-well assembly of the present invention also improves the repeatability of positioning the filter plate and receiver plate in proper nesting relationship and provides stability during handling, mixing and shaking operations.

    DEVICE SUITABLE FOR VACUUM ASSISTED FILTRATION
    8.
    发明申请
    DEVICE SUITABLE FOR VACUUM ASSISTED FILTRATION 有权

    公开(公告)号：US20210299614A1

    公开(公告)日：2021-09-30

    申请号：US16328502

    申请日：2017-10-05

    Applicant: EMD Millipore Corporation

    Inventor： Christopher A. Scott ,  Kurt Greenizen ,  Paul Sydlowski

    IPC: B01D63/08 ,  B01D61/18 ,  B01D61/20

    Abstract: A funnel-less filtration device that attaches directly to a storage container such as a cell culture media bottle. The device includes a filter collar containing one or more membranes, an inlet with a coupling device for attaching the filter device to a supply of liquid to be filtered, an outlet at a lower portion of the collar, a vacuum port in the collar below the membrane(s) and a filtered vent in the collar above the membrane(s). Optionally, the device may include a filtrate reservoir attached to the outlet, preferably by a threaded connection. Optionally, the upper opening to the filter collar is selectively and removably sealed with a lid until used. The lid is then removed the filter device inverted over a storage container such as cell culture media bottle and the two are attached via the upper opening of the filter collar. The assembly is then inverted so the supply container is above the filter device. Upon subjecting the sample in the bottle to a driving force such as vacuum, the sample flows through the filtration element, and into a filtrate reservoir below the outlet of the filter collar.

    All-In-One Sample Preparation Device And Method
    10.
    发明申请
    All-In-One Sample Preparation Device And Method 有权
    一体式样品制备装置及方法

    公开(公告)号：US20140017151A1

    公开(公告)日：2014-01-16

    申请号：US14031458

    申请日：2013-09-19

    Applicant: EMD Millipore Corporation

    Inventor： Christopher A. Scott ,  Timothy K. Nadler ,  Kurt Greenizen ,  Louis Bonhomme ,  Sara D. Gutierrez ,  Masaharu Mabuchi ,  David Briggs ,  Phillip Clark ,  Ralph T. Scaduto

    IPC: G01N1/34

    CPC classification number: G01N1/34 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  B01D2315/02 ,  B01L3/5021 ,  B01L3/5085 ,  B01L2300/0618 ,  B01L2300/0681 ,  C07K1/16 ,  C07K1/22 ,  G01N1/405 ,  G01N1/4077 ,  G01N2001/4088 ,  Y10T436/25375

    Abstract: Sample preparation device that allows for a complete bind, wash, elute, buffer-exchange and concentration process to be carried out without sample transfer between multiple devices. The device includes a reservoir, a column for holding chromatography media, a holder region for holding a filtration device, and an outlet. The filtration device plugs into the holder region of the centrifugal device, and the assembly can be placed in an optional holder. The assembly, with or without the optional holder, can be placed in a conventional centrifuge tube for centrifugation. The entire bind, wash, elute, buffer exchange and concentration steps can be carried out with the apparatus without any pipette transfers (and the associated sample losses. The sample preparation device also can be used for binding and washing steps, in which case the filtration device is not needed, and for buffer exchange and concentration steps, in which case the media is not needed.

    Abstract translation: 允许完全结合，洗涤，洗脱，缓冲交换和浓缩过程的样品制备装置，在多个装置之间没有样品转移的情况下进行。 该装置包括储存器，用于保持色谱介质的柱，用于保持过滤装置的保持器区域和出口。 过滤装置插入到离心装置的保持器区域中，并且组件可以放置在可选的保持器中。 具有或不具有任选的保持器的组件可以放置在用于离心的常规离心管中。 整个结合，洗涤，洗脱，缓冲液交换和浓缩步骤可以在没有任何移液管转移（和相关样品损失）的情况下进行，样品制备装置也可用于结合和洗涤步骤，在这种情况下，过滤 设备不需要，并且用于缓冲区交换和集中步骤，在这种情况下不需要介质。

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